JP6533466B2 - 抗菌性化合物、その合成およびその適用 - Google Patents

抗菌性化合物、その合成およびその適用 Download PDF

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Publication number
JP6533466B2
JP6533466B2 JP2015548841A JP2015548841A JP6533466B2 JP 6533466 B2 JP6533466 B2 JP 6533466B2 JP 2015548841 A JP2015548841 A JP 2015548841A JP 2015548841 A JP2015548841 A JP 2015548841A JP 6533466 B2 JP6533466 B2 JP 6533466B2
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Japan
Prior art keywords
bacteria
group
boc
compound
compounds
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JP2015548841A
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English (en)
Japanese (ja)
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JP2016504330A (ja
JP2016504330A5 (https=
Inventor
ハルダル，ジャヤンタ
ゴーシュ，チャンドラディシュ
ベラグラ マンジュナス，グータム
ベラグラ マンジュナス，グータム
アッカペッディ，パドマ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Health
Jawaharial Nehru Centre for Advanced Scientific Research
Original Assignee
UK Secretary of State for Health
Jawaharial Nehru Centre for Advanced Scientific Research
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2015548841A 2012-12-18 2013-12-18 抗菌性化合物、その合成およびその適用 Expired - Fee Related JP6533466B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN5299CH2012 2012-12-18
IN5299/CHE/2012 2012-12-18
PCT/IB2013/061090 WO2014097178A1 (en) 2012-12-18 2013-12-18 Antimicrobial compounds, their synthesis and applications thereof

Publications (3)

Publication Number Publication Date
JP2016504330A JP2016504330A (ja) 2016-02-12
JP2016504330A5 JP2016504330A5 (https=) 2017-01-26
JP6533466B2 true JP6533466B2 (ja) 2019-06-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015548841A Expired - Fee Related JP6533466B2 (ja) 2012-12-18 2013-12-18 抗菌性化合物、その合成およびその適用

Country Status (9)

Country Link
US (1) US9783490B2 (https=)
EP (1) EP2934563B1 (https=)
JP (1) JP6533466B2 (https=)
CN (1) CN104981249B (https=)
AU (1) AU2013365769B2 (https=)
BR (1) BR112015014391B1 (https=)
CA (1) CA2894202A1 (https=)
HK (1) HK1210437A1 (https=)
WO (1) WO2014097178A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105566149B (zh) * 2016-03-02 2017-05-24 郑州大学 具有抗菌活性的查尔酮阳离子抗菌肽模拟物及其制备方法
CN106995384B (zh) * 2017-04-21 2018-12-11 郑州大学 具有抗菌活性的二烷基阳离子两亲性抗菌肽模拟物及其制备方法
EP3724216A1 (en) 2017-12-15 2020-10-21 Dana Farber Cancer Institute, Inc. Stabilized peptide-mediated targeted protein degradation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0610487T3 (da) 1992-09-03 2000-05-15 Boehringer Ingelheim Pharma Nye aminosyrederivater, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende disse forbindelser
US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
JPH09507846A (ja) * 1993-12-30 1997-08-12 スミスクライン・ビーチャム・コーポレイション フェニルメチルヘキサンアミドおよびその使用
US5663148A (en) 1994-07-12 1997-09-02 Abbott Laboratories Anaphylatoxin receptor ligands containing lipophilic residues
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
JP3338452B2 (ja) 1995-12-12 2002-10-28 大鵬薬品工業株式会社 エポキシコハク酸アミド誘導体又はその塩及びこれを含有する医薬
CA2217550A1 (en) * 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Cationic lipids for gene therapy
WO1999031052A1 (fr) * 1997-12-12 1999-06-24 Fuji Yakuhin Kogyo Kabushiki Kaisha Nouveaux inhibiteurs de metalloproteinases
AU2180201A (en) * 1999-11-30 2001-06-12 Aventis Pharma S.A. Hydroxamic acid macrocyclic derivatives, preparation method and compositions containing same
JP2002161084A (ja) * 2000-11-28 2002-06-04 Sumitomo Pharmaceut Co Ltd 複素環誘導体
US7393836B2 (en) 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
GB0512751D0 (en) * 2005-06-22 2005-07-27 Glaxo Group Ltd New adjuvant
EP2019819A4 (en) * 2006-05-09 2011-01-19 Neobiotics Ab INNOVATIVE PEPTIDE DERIVATIVES AS ANTIMICROBIAL AGENTS FOR THE TREATMENT OF INJURIES
SG175573A1 (en) * 2006-10-04 2011-11-28 Inimex Pharmaceuticals Inc Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity
JP2010512417A (ja) * 2006-12-11 2010-04-22 ワイス エルエルシー イオンチャネルモジュレータ−
CN102757477B (zh) * 2011-04-27 2014-09-03 首都医科大学 烯丙基半胱氨酰氨基酸甲酯衍生物及其合成方法和应用
DK2709619T3 (en) * 2011-05-16 2018-01-15 Cellceutix Corp RELATIONSHIPS FOR USING THE TREATMENT OF MUCOSITIS

Also Published As

Publication number Publication date
US20150329478A1 (en) 2015-11-19
BR112015014391A2 (pt) 2017-07-11
HK1210437A1 (en) 2016-04-22
US9783490B2 (en) 2017-10-10
BR112015014391B1 (pt) 2020-11-03
AU2013365769B2 (en) 2018-03-15
EP2934563B1 (en) 2020-07-08
EP2934563A1 (en) 2015-10-28
WO2014097178A1 (en) 2014-06-26
AU2013365769A1 (en) 2015-07-02
CN104981249B (zh) 2018-06-19
JP2016504330A (ja) 2016-02-12
CA2894202A1 (en) 2014-06-26
CN104981249A (zh) 2015-10-14
EP2934563A4 (en) 2016-08-17

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