CN104981249B - 抗微生物化合物、它们的合成及其应用 - Google Patents

抗微生物化合物、它们的合成及其应用 Download PDF

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Publication number
CN104981249B
CN104981249B CN201380070984.4A CN201380070984A CN104981249B CN 104981249 B CN104981249 B CN 104981249B CN 201380070984 A CN201380070984 A CN 201380070984A CN 104981249 B CN104981249 B CN 104981249B
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CN
China
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lys
boc
group
compound
hydrogen
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Expired - Fee Related
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CN201380070984.4A
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English (en)
Chinese (zh)
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CN104981249A (zh
Inventor
加延塔·哈达尔
查德拉迪施·歌施
高坦·贝拉古拉·曼朱纳特
帕德玛·阿卡佩迪
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BMH
Jawaharial Nehru Centre for Advanced Scientific Research
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BMH
Jawaharial Nehru Centre for Advanced Scientific Research
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Publication of CN104981249A publication Critical patent/CN104981249A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380070984.4A 2012-12-18 2013-12-18 抗微生物化合物、它们的合成及其应用 Expired - Fee Related CN104981249B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN5299/CHE/2012 2012-12-18
IN5299CH2012 2012-12-18
PCT/IB2013/061090 WO2014097178A1 (en) 2012-12-18 2013-12-18 Antimicrobial compounds, their synthesis and applications thereof

Publications (2)

Publication Number Publication Date
CN104981249A CN104981249A (zh) 2015-10-14
CN104981249B true CN104981249B (zh) 2018-06-19

Family

ID=54148251

Family Applications (1)

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CN201380070984.4A Expired - Fee Related CN104981249B (zh) 2012-12-18 2013-12-18 抗微生物化合物、它们的合成及其应用

Country Status (9)

Country Link
US (1) US9783490B2 (https=)
EP (1) EP2934563B1 (https=)
JP (1) JP6533466B2 (https=)
CN (1) CN104981249B (https=)
AU (1) AU2013365769B2 (https=)
BR (1) BR112015014391B1 (https=)
CA (1) CA2894202A1 (https=)
HK (1) HK1210437A1 (https=)
WO (1) WO2014097178A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105566149B (zh) * 2016-03-02 2017-05-24 郑州大学 具有抗菌活性的查尔酮阳离子抗菌肽模拟物及其制备方法
CN106995384B (zh) * 2017-04-21 2018-12-11 郑州大学 具有抗菌活性的二烷基阳离子两亲性抗菌肽模拟物及其制备方法
US20200354413A1 (en) 2017-12-15 2020-11-12 Dana-Farber Cancer Institute, Inc. Stabilized peptide-mediated targeted protein degradation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017888A1 (en) * 1993-12-30 1995-07-06 Smithkline Beecham Corporation Phenylmethyl hexanamides, and the use thereof
CN1284060A (zh) * 1997-12-12 2001-02-14 富士药品工业株式会社 新的金属蛋白酶抑制剂
CN102757477A (zh) * 2011-04-27 2012-10-31 首都医科大学 烯丙基半胱氨酰氨基酸甲酯衍生物及其合成方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59309867D1 (de) 1992-09-03 1999-12-16 Boehringer Ingelheim Pharma Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
US5663148A (en) 1994-07-12 1997-09-02 Abbott Laboratories Anaphylatoxin receptor ligands containing lipophilic residues
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
DE69612962T2 (de) * 1995-12-12 2001-11-15 Taiho Pharmaceutical Co. Ltd., Tokio/Tokyo Epoxysuccinamid-derivate oder deren salze und medikamente die diese enthalten
CA2217550A1 (en) * 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Cationic lipids for gene therapy
WO2001040198A2 (fr) * 1999-11-30 2001-06-07 Aventis Pharma S.A. Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens
JP2002161084A (ja) * 2000-11-28 2002-06-04 Sumitomo Pharmaceut Co Ltd 複素環誘導体
US7393836B2 (en) 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
GB0512751D0 (en) * 2005-06-22 2005-07-27 Glaxo Group Ltd New adjuvant
US8097582B2 (en) 2006-05-09 2012-01-17 Neobiotics Ab Peptide derivatives useful as antimicrobial agents and for treating wounds
AU2007304847A1 (en) * 2006-10-04 2008-04-10 Inimex Pharmaceuticals, Inc. Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity
EP2091917A1 (en) * 2006-12-11 2009-08-26 Wyeth a Corporation of the State of Delaware Ion channel modulators
EP2709619B1 (en) * 2011-05-16 2017-10-11 Cellceutix Corporation Compounds for use in treatment of mucositis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017888A1 (en) * 1993-12-30 1995-07-06 Smithkline Beecham Corporation Phenylmethyl hexanamides, and the use thereof
CN1284060A (zh) * 1997-12-12 2001-02-14 富士药品工业株式会社 新的金属蛋白酶抑制剂
CN102757477A (zh) * 2011-04-27 2012-10-31 首都医科大学 烯丙基半胱氨酰氨基酸甲酯衍生物及其合成方法和应用

Also Published As

Publication number Publication date
US9783490B2 (en) 2017-10-10
AU2013365769B2 (en) 2018-03-15
CA2894202A1 (en) 2014-06-26
JP6533466B2 (ja) 2019-06-19
US20150329478A1 (en) 2015-11-19
EP2934563A1 (en) 2015-10-28
EP2934563B1 (en) 2020-07-08
BR112015014391A2 (pt) 2017-07-11
WO2014097178A1 (en) 2014-06-26
CN104981249A (zh) 2015-10-14
AU2013365769A1 (en) 2015-07-02
JP2016504330A (ja) 2016-02-12
BR112015014391B1 (pt) 2020-11-03
HK1210437A1 (en) 2016-04-22
EP2934563A4 (en) 2016-08-17

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Granted publication date: 20180619

Termination date: 20201218