CA2883641C - Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 - Google Patents

Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 Download PDF

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Publication number
CA2883641C
CA2883641C CA2883641A CA2883641A CA2883641C CA 2883641 C CA2883641 C CA 2883641C CA 2883641 A CA2883641 A CA 2883641A CA 2883641 A CA2883641 A CA 2883641A CA 2883641 C CA2883641 C CA 2883641C
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Prior art keywords
tetrabenazine
dosage form
certain embodiments
deuterated
oral dosage
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CA2883641A
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English (en)
French (fr)
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CA2883641A1 (en
Inventor
Andreas Sommer
Chengzhi Zhang
John Carter
John Arthur
Margaret BRADBURY
Thomas Gant
Manouchehr Shahbaz
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Auspex Pharmaceuticals Inc
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Auspex Pharmaceuticals Inc
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Application filed by Auspex Pharmaceuticals Inc filed Critical Auspex Pharmaceuticals Inc
Priority to CA3124804A priority Critical patent/CA3124804C/en
Publication of CA2883641A1 publication Critical patent/CA2883641A1/en
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
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    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2883641A 2012-09-18 2013-09-18 Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 Active CA2883641C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3124804A CA3124804C (en) 2012-09-18 2013-09-18 Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261702586P 2012-09-18 2012-09-18
US61/702,586 2012-09-18
PCT/US2013/060387 WO2014047167A1 (en) 2012-09-18 2013-09-18 Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2

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CA3124804A Division CA3124804C (en) 2012-09-18 2013-09-18 Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2

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CA2883641A1 CA2883641A1 (en) 2014-03-27
CA2883641C true CA2883641C (en) 2021-09-14

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CA3124804A Active CA3124804C (en) 2012-09-18 2013-09-18 Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2

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US (10) US9346800B2 (OSRAM)
EP (2) EP2897615A4 (OSRAM)
JP (4) JP6362601B2 (OSRAM)
CN (3) CN111728971A (OSRAM)
AU (3) AU2013318182C1 (OSRAM)
BR (1) BR112015005894B1 (OSRAM)
CA (2) CA2883641C (OSRAM)
HK (1) HK1212232A1 (OSRAM)
IN (1) IN2015DN01662A (OSRAM)
NZ (1) NZ705372A (OSRAM)
WO (1) WO2014047167A1 (OSRAM)

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CA2883641C (en) 2012-09-18 2021-09-14 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2015084622A1 (en) 2013-12-03 2015-06-11 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds
US10166183B2 (en) 2014-02-07 2019-01-01 Auspex Pharmaceuticals, Inc. Pharmaceutical formulations
JP6635945B2 (ja) * 2014-05-06 2020-01-29 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 多動性運動障害を処置するためのｖｍａｔ２インヒビター
WO2015175505A1 (en) * 2014-05-15 2015-11-19 Lundbeck Llc Tetrabenazine modified release formulation
BR112016028119A2 (pt) 2014-06-06 2017-08-22 Res Triangle Inst Agonistas receptores de apelina (apj) e usos dos mesmos
EP3250562B1 (en) 2015-01-30 2024-11-27 Biomed Valley Discoveries, Inc. Crystalline 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1h-pyrrole-2-carboxylic acid [1-(3-chlorophenyl)-2-hydroxyethyl]amide hydrochloride salt
MA41557A (fr) * 2015-02-18 2017-12-26 Auspex Pharmaceuticals Inc Inhibiteurs diméthoxyphényles du transporteur vésiculaire des monoamines 2
HRP20221106T1 (hr) 2015-03-06 2022-11-25 Auspex Pharmaceuticals, Inc. Postupci liječenja abnormalnih nevoljnih poremećaja pokreta
MY189806A (en) * 2015-06-23 2022-03-08 Neurocrine Biosciences Inc Vmat2 inhibitors for treating neurological diseases or disorders
US10065952B2 (en) 2015-10-30 2018-09-04 Neurocrine Biosciences, Inc. Valbenazine salts and polymorphs thereof
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