CA2875069C - Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent - Google Patents
Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent Download PDFInfo
- Publication number
- CA2875069C CA2875069C CA2875069A CA2875069A CA2875069C CA 2875069 C CA2875069 C CA 2875069C CA 2875069 A CA2875069 A CA 2875069A CA 2875069 A CA2875069 A CA 2875069A CA 2875069 C CA2875069 C CA 2875069C
- Authority
- CA
- Canada
- Prior art keywords
- thrombomodulin
- administration
- medicament
- anticancer agents
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/366—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-125316 | 2012-05-31 | ||
| JP2012125316 | 2012-05-31 | ||
| PCT/JP2013/063743 WO2013179910A1 (ja) | 2012-05-31 | 2013-05-17 | 抗癌剤に起因する末梢性神経障害性疼痛の予防及び／又は治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2875069A1 CA2875069A1 (en) | 2013-12-05 |
| CA2875069C true CA2875069C (en) | 2018-01-02 |
Family
ID=49673113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2875069A Active CA2875069C (en) | 2012-05-31 | 2013-05-17 | Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10709767B2 (online.php) |
| EP (1) | EP2857037B1 (online.php) |
| JP (3) | JP6124417B2 (online.php) |
| KR (1) | KR101672114B1 (online.php) |
| CN (1) | CN104394885B (online.php) |
| AU (1) | AU2013268725B2 (online.php) |
| BR (1) | BR112014028852A2 (online.php) |
| CA (1) | CA2875069C (online.php) |
| DK (1) | DK2857037T3 (online.php) |
| ES (1) | ES2743767T3 (online.php) |
| HU (1) | HUE045997T2 (online.php) |
| IL (1) | IL235984B (online.php) |
| IN (1) | IN2014DN10075A (online.php) |
| MX (1) | MX364934B (online.php) |
| NZ (1) | NZ702242A (online.php) |
| PL (1) | PL2857037T3 (online.php) |
| PT (1) | PT2857037T (online.php) |
| RU (1) | RU2595857C2 (online.php) |
| WO (1) | WO2013179910A1 (online.php) |
| ZA (1) | ZA201408769B (online.php) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN10075A (online.php) * | 2012-05-31 | 2015-08-21 | Univ Kinki | |
| JP6325036B2 (ja) * | 2016-08-19 | 2018-05-16 | 株式会社明治 | 抗がん剤に起因する末梢神経障害を改善するための組成物 |
| EP3603639A4 (en) * | 2017-03-31 | 2021-01-27 | Toray Industries, Inc. | THERAPEUTIC OR PROPHYLACTIC FOR PERIPHERAL NEUROPATHIA |
| AU2018389092B2 (en) * | 2017-12-19 | 2023-08-24 | Synergia Life Sciences Pvt. Ltd. | Vitamin K2 compositions for the treatment of drug induced neuropathy |
| WO2020067389A1 (ja) * | 2018-09-28 | 2020-04-02 | 旭化成ファーマ株式会社 | 抗悪性腫瘍剤による末梢神経障害の症状軽減及び／又は発症抑制のための医薬 |
| RU2707954C1 (ru) * | 2019-01-24 | 2019-12-02 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения онкологической боли |
| AU2022226352A1 (en) * | 2021-02-26 | 2023-09-07 | Vibrosense Dynamics Ab | Biomarker for prediction of chemotherapy-induced neuropathy |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988005053A1 (fr) * | 1987-01-08 | 1988-07-14 | Asahi Kasei Kogyo Kabushiki Kaisha | Peptide servant a accelerer l'activation de la proteine c avec de la thrombine |
| JP2738428B2 (ja) | 1987-01-08 | 1998-04-08 | 旭化成工業株式会社 | トロンビンによるプロテインｃの活性化を促進する作用を有するペプチド |
| EP0285511B1 (en) | 1987-04-01 | 1992-11-25 | Mitsubishi Gas Chemical Company, Inc. | Immunoassay of thrombomodulin |
| DK299087D0 (da) | 1987-06-12 | 1987-06-12 | Novo Industri As | Proteins and derivatives thereof |
| JPS6445398A (en) | 1987-08-13 | 1989-02-17 | Kowa Co | Antithrombin-binding substance monoclonal antibody, hybridoma producing said antibody and method for purifying and measuring thrombin-binding substance utilizing said monoclonal antibody |
| JPH0720997B2 (ja) | 1988-08-29 | 1995-03-08 | 興和株式会社 | 新規なトロンビン結合性物質及びその製法 |
| JPH02255699A (ja) | 1989-03-28 | 1990-10-16 | Asahi Chem Ind Co Ltd | 新規血液抗凝固物質及びその製法 |
| AU643306B2 (en) | 1990-06-27 | 1993-11-11 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant polypeptides |
| JPH05213998A (ja) | 1990-08-03 | 1993-08-24 | Asahi Chem Ind Co Ltd | 新規なポリペプチド及びこれを有効成分とする 医薬組成物 |
| US5571786A (en) | 1990-08-16 | 1996-11-05 | Immuno Aktiengesellschaft | Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation |
| JPH05310787A (ja) | 1992-05-01 | 1993-11-22 | Asahi Chem Ind Co Ltd | 新規なポリペプチド |
| JPH06205692A (ja) | 1993-01-08 | 1994-07-26 | Asahi Chem Ind Co Ltd | 新規な抗ヒトトロンボモジュリンモノクロ−ナル抗体およびその抗体を用いたヒトトロンボモジュリンの高感度測定方法 |
| DE69434942T2 (de) | 1993-02-25 | 2007-11-29 | Abbott Laboratories, Abbott Park | Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben |
| JP3007785B2 (ja) | 1993-03-16 | 2000-02-07 | 旭化成工業株式会社 | トロンボモジュリン組成物およびその変性防止方法 |
| JPH083065A (ja) | 1994-04-20 | 1996-01-09 | Asahi Chem Ind Co Ltd | 肝臓障害に対する治療剤 |
| US5916874A (en) | 1994-04-20 | 1999-06-29 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for treating liver injury |
| DE69534016T2 (de) | 1994-04-20 | 2006-03-23 | Asahi Kasei Pharma Corp. | Verwendung von thrombomodulin gegen lebererkrankungen |
| JP2824392B2 (ja) | 1994-05-31 | 1998-11-11 | 旭化成工業株式会社 | トロンビンによるプロテインｃの活性化を促進する作用を有するペプチドを含有する培養上澄液 |
| US5872108A (en) | 1995-03-06 | 1999-02-16 | Interneuron Pharmaceuticals, Inc. | Reduction of infarct volume using citicoline |
| CA2213000A1 (en) | 1995-03-06 | 1996-09-12 | Interneuron Pharmaceuticals, Inc. | Reduction of infarct volume using citicoline |
| US5827832A (en) | 1995-03-06 | 1998-10-27 | Interneuron Pharmaceuticals, Inc. | Method of protecting brain tissue from cerebral infarction subsequent to ischemia |
| JP3789147B2 (ja) | 1995-04-11 | 2006-06-21 | 旭化成ファーマ株式会社 | 脊髄損傷後の神経障害に対する治療剤 |
| JPH08301783A (ja) | 1995-05-11 | 1996-11-19 | Mochida Pharmaceut Co Ltd | 吸収性骨疾患予防・治療剤 |
| EP0743066A3 (en) | 1995-05-16 | 1998-09-30 | Mitsui Pharmaceuticals, Inc. | Wound-healing agent |
| JP3931353B2 (ja) | 1995-06-30 | 2007-06-13 | 持田製薬株式会社 | 創傷治癒剤 |
| JP3745805B2 (ja) | 1995-10-24 | 2006-02-15 | 日本ケミカルリサーチ株式会社 | トロンボモジュリンの精製方法 |
| JPH101439A (ja) | 1996-06-11 | 1998-01-06 | Mochida Pharmaceut Co Ltd | 神経変性疾患治療剤 |
| JP4157644B2 (ja) | 1998-03-30 | 2008-10-01 | 旭化成ファーマ株式会社 | 高純度可溶性トロンボモジュリンの製造方法 |
| AU2001245319A1 (en) * | 2000-03-28 | 2001-10-08 | Eli Lilly And Company | Methods of treating diseases with activated protein c |
| US20020111296A1 (en) | 2000-08-31 | 2002-08-15 | Festoff Barry W. | Thrombomodulin analogs for use in recovery of spinal cord injury |
| WO2003061687A1 (fr) * | 2002-01-18 | 2003-07-31 | Asahi Kasei Pharma Corporation | Preparation a concentration elevee de thrombomoduline soluble |
| PT2017276E (pt) * | 2003-09-22 | 2011-04-05 | Euro Celtique Sa | Compostos de fenilcarboxamida úteis para o tratamento da dor |
| RU2007130722A (ru) * | 2005-02-16 | 2009-03-27 | Вайет (Us) | Способы и устройства для диагностики, прогнозирования и выбора лечения лейкоза |
| JP5453258B2 (ja) | 2007-07-13 | 2014-03-26 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | カンナビノイド受容体の複素環式モジュレーター |
| US9394267B2 (en) | 2007-07-13 | 2016-07-19 | The Cleveland Clinic Foundation | Heterocyclic modulators of cannabinoid receptors |
| KR20110008166A (ko) * | 2008-02-18 | 2011-01-26 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 화학요법의 결과로 발생하는 신경병적 통증의 치료를 위한 시그마 수용체 리간드에 결합하는 화합물들의 용도 |
| US20110144024A1 (en) * | 2008-07-16 | 2011-06-16 | Paion Deutschland Gmbh | Prevention and treatment of radiation injury |
| TWI438009B (zh) * | 2010-02-19 | 2014-05-21 | Teikoku Pharma Usa Inc | 紫杉烷前－乳劑調配物及其製造與使用之方法 |
| JP2011178687A (ja) * | 2010-02-26 | 2011-09-15 | Kochi Univ | 造血細胞移植に伴う疼痛の予防および／または治療剤 |
| US20110287110A1 (en) * | 2010-04-23 | 2011-11-24 | Mark Wesley Dewhirst | Combination cancer treatment |
| JP5924611B2 (ja) | 2010-06-16 | 2016-05-25 | 国立大学法人高知大学 | 造血細胞移植に伴う生着症候群の予防及び／又は治療のための医薬 |
| EP2598126A2 (en) * | 2010-07-30 | 2013-06-05 | Saint Louis University | Methods of treating pain |
| IN2014DN10075A (online.php) * | 2012-05-31 | 2015-08-21 | Univ Kinki |
-
2013
- 2013-05-17 IN IN10075DEN2014 patent/IN2014DN10075A/en unknown
- 2013-05-17 JP JP2014518384A patent/JP6124417B2/ja active Active
- 2013-05-17 PL PL13796572T patent/PL2857037T3/pl unknown
- 2013-05-17 CN CN201380028318.4A patent/CN104394885B/zh active Active
- 2013-05-17 DK DK13796572.9T patent/DK2857037T3/da active
- 2013-05-17 KR KR1020147032155A patent/KR101672114B1/ko active Active
- 2013-05-17 BR BR112014028852-6A patent/BR112014028852A2/pt not_active Application Discontinuation
- 2013-05-17 WO PCT/JP2013/063743 patent/WO2013179910A1/ja not_active Ceased
- 2013-05-17 NZ NZ702242A patent/NZ702242A/en unknown
- 2013-05-17 PT PT13796572T patent/PT2857037T/pt unknown
- 2013-05-17 HU HUE13796572A patent/HUE045997T2/hu unknown
- 2013-05-17 MX MX2014014505A patent/MX364934B/es active IP Right Grant
- 2013-05-17 ES ES13796572T patent/ES2743767T3/es active Active
- 2013-05-17 US US14/404,222 patent/US10709767B2/en active Active
- 2013-05-17 AU AU2013268725A patent/AU2013268725B2/en active Active
- 2013-05-17 RU RU2014148171/15A patent/RU2595857C2/ru active
- 2013-05-17 EP EP13796572.9A patent/EP2857037B1/en active Active
- 2013-05-17 CA CA2875069A patent/CA2875069C/en active Active
-
2014
- 2014-11-28 ZA ZA2014/08769A patent/ZA201408769B/en unknown
- 2014-11-30 IL IL235984A patent/IL235984B/en active IP Right Grant
-
2017
- 2017-03-31 JP JP2017071200A patent/JP6279788B2/ja active Active
-
2018
- 2018-01-17 JP JP2018005582A patent/JP6427284B2/ja active Active
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