CA2871429C - Crystalline microspheres and the process for manufacturing the same - Google Patents

Crystalline microspheres and the process for manufacturing the same Download PDF

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Publication number
CA2871429C
CA2871429C CA2871429A CA2871429A CA2871429C CA 2871429 C CA2871429 C CA 2871429C CA 2871429 A CA2871429 A CA 2871429A CA 2871429 A CA2871429 A CA 2871429A CA 2871429 C CA2871429 C CA 2871429C
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CA
Canada
Prior art keywords
microspheres
composition comprises
microsphere
mannitol
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2871429A
Other languages
English (en)
French (fr)
Other versions
CA2871429A1 (en
Inventor
Cecil W. Propst
Marc W. Meadows
Michael S. Todd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SPI Pharma Inc
Original Assignee
SPI Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SPI Pharma Inc filed Critical SPI Pharma Inc
Publication of CA2871429A1 publication Critical patent/CA2871429A1/en
Application granted granted Critical
Publication of CA2871429C publication Critical patent/CA2871429C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2871429A 2012-04-25 2013-04-25 Crystalline microspheres and the process for manufacturing the same Active CA2871429C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261638073P 2012-04-25 2012-04-25
US61/638,073 2012-04-25
US201361783603P 2013-03-14 2013-03-14
US61/783,603 2013-03-14
PCT/US2013/038257 WO2013163453A1 (en) 2012-04-25 2013-04-25 Crystalline microspheres and the process for manufacturing the same

Publications (2)

Publication Number Publication Date
CA2871429A1 CA2871429A1 (en) 2013-10-31
CA2871429C true CA2871429C (en) 2018-07-31

Family

ID=49483900

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2871429A Active CA2871429C (en) 2012-04-25 2013-04-25 Crystalline microspheres and the process for manufacturing the same

Country Status (9)

Country Link
US (5) US20150140097A1 (https=)
EP (2) EP3583935A1 (https=)
JP (2) JP6577865B2 (https=)
BR (1) BR112014026351B1 (https=)
CA (1) CA2871429C (https=)
ES (1) ES2729035T3 (https=)
IN (1) IN2014DN09416A (https=)
MX (1) MX359554B (https=)
WO (1) WO2013163453A1 (https=)

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IL219362A (en) 2012-04-23 2017-04-30 Verint Systems Ltd A system and method for predicting threatened points of interest
WO2013163453A1 (en) 2012-04-25 2013-10-31 Spi Pharma, Inc. Crystalline microspheres and the process for manufacturing the same
US10560842B2 (en) 2015-01-28 2020-02-11 Verint Systems Ltd. System and method for combined network-side and off-air monitoring of wireless networks
IL242354B (en) 2015-10-29 2019-09-26 Verint Systems Ltd System and method for identifying genuine base stations that serve rogue base stations
IL245299B (en) 2016-04-25 2021-05-31 Verint Systems Ltd A system and method for decoding communication transmitted in a wireless local communication network
EP3917500A2 (en) * 2019-01-31 2021-12-08 Elektrofi, Inc. Particle formation and morphology
EP4027978A1 (en) 2019-09-13 2022-07-20 Elektrofi, Inc. Compositions and methods for the delivery of therapeutic biologics for treatment of disease
US10639312B1 (en) * 2019-12-06 2020-05-05 Edenbridge Pharmaceuticals, LLC Finished pharmaceutical dosage form of a methenamine salt such as methenamine mandelate

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FR2670398B1 (fr) * 1990-12-14 1995-02-17 Roquette Freres Composition pulverulente directement compressible et procede d'obtention.
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US5780055A (en) 1996-09-06 1998-07-14 University Of Maryland, Baltimore Cushioning beads and tablet comprising the same capable of forming a suspension
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WO2002035991A2 (en) * 2000-10-30 2002-05-10 The Board Of Regents, The University Of Texas System Spherical particles produced by a hot-melt extrusion/spheronization process
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
KR20040098023A (ko) * 2002-03-26 2004-11-18 테바 파마슈티컬 인더스트리즈 리미티드 약물 미세입자
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MXPA05008187A (es) * 2003-01-29 2006-03-30 Spi Polyols Inc Composiciones de granulos de poliol y procesos de manufactura.
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
WO2005044193A2 (en) * 2003-10-28 2005-05-19 Spi Pharma, Inc. Product and process for increasing compactibility of carbohydrates
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MXPA06012992A (es) * 2004-05-12 2007-02-12 Baxter Int Microesferas que comprenden proteina y que muestran inyectabilidad en altas concentraciones de este agente.
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WO2008016637A1 (en) * 2006-08-01 2008-02-07 Appleton Papers Inc. Benefit agent containing delivery particle
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US20080181932A1 (en) 2007-01-30 2008-07-31 Drugtech Corporation Compositions for oral delivery of pharmaceuticals
CA2687794C (en) * 2007-05-28 2015-01-27 Jin Satomi Spherical particle of crystalline mannitol
JP5258268B2 (ja) 2007-11-19 2013-08-07 フロイント産業株式会社 球形粒の製造方法
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Also Published As

Publication number Publication date
EP2841057A4 (en) 2015-09-16
US20150140097A1 (en) 2015-05-21
EP2841057A1 (en) 2015-03-04
US20220151932A1 (en) 2022-05-19
JP2019112438A (ja) 2019-07-11
JP2015514809A (ja) 2015-05-21
BR112014026351B1 (pt) 2022-09-27
MX2014012805A (es) 2015-01-22
US12233163B2 (en) 2025-02-25
US11278496B2 (en) 2022-03-22
US20160015640A1 (en) 2016-01-21
JP6577865B2 (ja) 2019-09-18
US9089487B2 (en) 2015-07-28
US10245232B2 (en) 2019-04-02
CA2871429A1 (en) 2013-10-31
BR112014026351A2 (pt) 2017-06-27
EP3583935A1 (en) 2019-12-25
ES2729035T3 (es) 2019-10-29
IN2014DN09416A (https=) 2015-07-17
WO2013163453A1 (en) 2013-10-31
US20140099372A1 (en) 2014-04-10
US20190224126A1 (en) 2019-07-25
EP2841057B1 (en) 2019-03-20
MX359554B (es) 2018-10-02

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