CA2868356C - Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines - Google Patents

Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines Download PDF

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Publication number
CA2868356C
CA2868356C CA2868356A CA2868356A CA2868356C CA 2868356 C CA2868356 C CA 2868356C CA 2868356 A CA2868356 A CA 2868356A CA 2868356 A CA2868356 A CA 2868356A CA 2868356 C CA2868356 C CA 2868356C
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Prior art keywords
alkyl
group
cancer
compound
use according
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2868356A
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English (en)
French (fr)
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CA2868356A1 (en
Inventor
Marilyn D. Resh
Joseph Fraser Glickman
Elissaveta Petrova
Ouathek Ouerfelli
Original Assignee
Rockefeller University
Memorial Sloan Kettering Cancer Center
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Application filed by Rockefeller University, Memorial Sloan Kettering Cancer Center filed Critical Rockefeller University
Publication of CA2868356A1 publication Critical patent/CA2868356A1/en
Application granted granted Critical
Publication of CA2868356C publication Critical patent/CA2868356C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2868356A 2012-03-23 2013-03-14 Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines Expired - Fee Related CA2868356C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261614954P 2012-03-23 2012-03-23
US61/614,954 2012-03-23
PCT/US2013/031311 WO2013142253A2 (en) 2012-03-23 2013-03-14 TREATMENT OF PANCREATIC AND RELATED CANCERS WITH 5-ACYL-6,7-DIHYDROTHIENO[3,2-c]PYRIDINES

Publications (2)

Publication Number Publication Date
CA2868356A1 CA2868356A1 (en) 2013-09-26
CA2868356C true CA2868356C (en) 2020-06-23

Family

ID=49223442

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2868356A Expired - Fee Related CA2868356C (en) 2012-03-23 2013-03-14 Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines

Country Status (7)

Country Link
US (3) US9242994B2 (https=)
EP (1) EP2828267B1 (https=)
JP (1) JP6117334B2 (https=)
CN (1) CN104364257B (https=)
AU (1) AU2013235487B2 (https=)
CA (1) CA2868356C (https=)
WO (1) WO2013142253A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6117334B2 (ja) * 2012-03-23 2017-04-19 メモリアル スローン−ケタリング キャンサー センター 膵臓癌および関連するがんの５−アシル−６，７−ジヒドロチエノ［３，２−ｃ］ピリジンでの処置
WO2017218874A1 (en) * 2016-06-16 2017-12-21 Memorial Sloan-Kettering Cancer Center Hedgehog acyltransferase inhibitors and uses thereof
WO2021212010A2 (en) * 2020-04-17 2021-10-21 The Trustees Of Indiana University Small molecule antiviral drug treatment for human papillomavirus infections
EP4727553A2 (en) 2023-06-13 2026-04-22 The Trustees of Indiana University Small molecule antiviral drug treatment for human papillomavirus infections
WO2025153715A1 (en) * 2024-01-19 2025-07-24 Scenic Biotech Bv Heterocyclic pla2g15 inhibitors and their use in therapy, in the treatment of diseases characterized by lysosomal dysregulation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315274A1 (fr) 1975-06-27 1977-01-21 Parcor Nouveaux derives de la thieno (2,3-c) pyridine, leur preparation et leurs applications
US4749692A (en) 1977-06-22 1988-06-07 Sanofi, S.A. Therapeutic compositions having anti-thrombotic and anti-blood-platelet-aggregating activity
JP2001514631A (ja) * 1997-03-07 2001-09-11 ノボ ノルディスク アクティーゼルスカブ ４，５，６，７−テトラヒドロ−チエノ［３，２−ｃ］ピリジン誘導体類、それらの製造方法及び使用
DE102005009440A1 (de) 2005-03-02 2006-09-07 Merck Patent Gmbh Thienopyridinderivate
US8263607B2 (en) * 2007-05-22 2012-09-11 Astellas Pharma Inc. 1-substituted tetrahydroisoquinoline compound
WO2009073203A1 (en) 2007-12-04 2009-06-11 Amgen Inc. Trp-m8 receptor ligands and their use in treatments
AR070317A1 (es) * 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
TW200944530A (en) 2008-04-09 2009-11-01 Gruenenthal Chemie Substituted sulfonamide derivatives
HRP20120822T1 (hr) * 2008-10-24 2012-11-30 Grünenthal GmbH Supstituirani 4,5,6,7-tetrahidrotienopiridini kao kcnq2/3 modulatori za lijeäśenje boli, epilepsije i urinarne inkontinencije
WO2010101230A1 (ja) 2009-03-05 2010-09-10 アステラス製薬株式会社 キノキサリン化合物
EP2286808A1 (en) 2009-08-18 2011-02-23 Rheinische Friedrich-Wilhelms Universität Cytohesin inhibitors
DE102010013716A1 (de) 2010-03-31 2011-10-06 Rheinische Friedrich-Wilhelms-Universität Bonn Körperschaft des öffentlichen Rechts Verwendung von Cytohesin-Inhibitoren
JP6117334B2 (ja) * 2012-03-23 2017-04-19 メモリアル スローン−ケタリング キャンサー センター 膵臓癌および関連するがんの５−アシル−６，７−ジヒドロチエノ［３，２−ｃ］ピリジンでの処置

Also Published As

Publication number Publication date
EP2828267B1 (en) 2019-10-30
HK1207367A1 (en) 2016-01-29
WO2013142253A2 (en) 2013-09-26
US9242994B2 (en) 2016-01-26
CA2868356A1 (en) 2013-09-26
US20170252328A1 (en) 2017-09-07
US20160136142A1 (en) 2016-05-19
JP2015512399A (ja) 2015-04-27
US9943507B2 (en) 2018-04-17
AU2013235487A1 (en) 2014-10-09
EP2828267A2 (en) 2015-01-28
EP2828267A4 (en) 2015-10-28
WO2013142253A3 (en) 2013-11-14
US20150105419A1 (en) 2015-04-16
CN104364257B (zh) 2017-03-01
CN104364257A (zh) 2015-02-18
JP6117334B2 (ja) 2017-04-19
US9597320B2 (en) 2017-03-21
AU2013235487B2 (en) 2017-09-07

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Effective date: 20180221

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