CA2867891C - App specific bace inhibitors (asbis) and uses thereof - Google Patents

App specific bace inhibitors (asbis) and uses thereof Download PDF

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Publication number
CA2867891C
CA2867891C CA2867891A CA2867891A CA2867891C CA 2867891 C CA2867891 C CA 2867891C CA 2867891 A CA2867891 A CA 2867891A CA 2867891 A CA2867891 A CA 2867891A CA 2867891 C CA2867891 C CA 2867891C
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Prior art keywords
alzheimer
administration
use according
subject
disease
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CA2867891A
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English (en)
French (fr)
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CA2867891A1 (en
Inventor
Varghese John
Dale E. Bredesen
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Buck Institute for Research on Aging
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Buck Institute for Research on Aging
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Publication of CA2867891A1 publication Critical patent/CA2867891A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2867891A 2012-03-19 2013-03-15 App specific bace inhibitors (asbis) and uses thereof Active CA2867891C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261612848P 2012-03-19 2012-03-19
US61/612,848 2012-03-19
US201261728688P 2012-11-20 2012-11-20
US61/728,688 2012-11-20
PCT/US2013/032481 WO2013142370A1 (en) 2012-03-19 2013-03-15 APP SPECIFIC BACE INHIBITORS (ASBIs) AND USES THEREOF

Publications (2)

Publication Number Publication Date
CA2867891A1 CA2867891A1 (en) 2013-09-26
CA2867891C true CA2867891C (en) 2021-09-14

Family

ID=49223272

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2867891A Active CA2867891C (en) 2012-03-19 2013-03-15 App specific bace inhibitors (asbis) and uses thereof

Country Status (10)

Country Link
US (3) US10357508B2 (OSRAM)
EP (2) EP3607946B1 (OSRAM)
JP (2) JP6482458B2 (OSRAM)
KR (2) KR102160388B1 (OSRAM)
CN (2) CN104270945B (OSRAM)
AU (2) AU2013235422B2 (OSRAM)
CA (1) CA2867891C (OSRAM)
DK (1) DK2827711T3 (OSRAM)
ES (1) ES2745539T3 (OSRAM)
WO (1) WO2013142370A1 (OSRAM)

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CN104270945B (zh) * 2012-03-19 2017-03-29 巴克老龄化研究所 App特异性bace抑制剂(asbi)及其用途
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CN104800200B (zh) * 2014-01-23 2019-04-02 上海中医药大学 高良姜素的医药用途
JP6797408B2 (ja) 2014-11-06 2020-12-09 国立大学法人 長崎大学 新規アルツハイマー病治療薬
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CN106474101A (zh) * 2015-06-17 2017-03-08 海南医学院 高良姜素在治疗糖尿病脑病药物中的应用
KR101716571B1 (ko) * 2015-06-19 2017-03-15 단국대학교 천안캠퍼스 산학협력단 알츠하이머성 치매 예방 또는 치료용 약제학적 조성물
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CN111518793A (zh) * 2020-05-20 2020-08-11 谭骏 年轻人血源APPα-分泌酶在阿尔茨海默病中的应用
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Also Published As

Publication number Publication date
EP3607946A1 (en) 2020-02-12
CN106902108A (zh) 2017-06-30
CA2867891A1 (en) 2013-09-26
US20150306122A1 (en) 2015-10-29
CN104270945B (zh) 2017-03-29
EP2827711A4 (en) 2016-03-23
US10835546B2 (en) 2020-11-17
KR102160388B1 (ko) 2020-09-28
KR20200013807A (ko) 2020-02-07
KR20150002681A (ko) 2015-01-07
AU2013235422B2 (en) 2016-12-15
JP6482458B2 (ja) 2019-03-13
USRE49873E1 (en) 2024-03-19
EP3607946B1 (en) 2023-02-22
ES2745539T3 (es) 2020-03-02
JP2018035197A (ja) 2018-03-08
AU2013235422A1 (en) 2014-10-02
AU2017201599B2 (en) 2018-11-08
DK2827711T3 (da) 2019-09-23
US10357508B2 (en) 2019-07-23
CN104270945A (zh) 2015-01-07
EP2827711B1 (en) 2019-06-19
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