CA2861722C - Method and device for fast dissolution of solid protein composition - Google Patents

Method and device for fast dissolution of solid protein composition Download PDF

Info

Publication number
CA2861722C
CA2861722C CA2861722A CA2861722A CA2861722C CA 2861722 C CA2861722 C CA 2861722C CA 2861722 A CA2861722 A CA 2861722A CA 2861722 A CA2861722 A CA 2861722A CA 2861722 C CA2861722 C CA 2861722C
Authority
CA
Canada
Prior art keywords
fibrinogen
solid
syringe
container
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2861722A
Other languages
English (en)
French (fr)
Other versions
CA2861722A1 (en
Inventor
Erez Ilan
Kfir Regev
Dana LEITMAN
Israel Nur
Moti Meron
John Goodman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals Ltd
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL217273A external-priority patent/IL217273A0/en
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Priority to CA3078563A priority Critical patent/CA3078563A1/en
Publication of CA2861722A1 publication Critical patent/CA2861722A1/en
Application granted granted Critical
Publication of CA2861722C publication Critical patent/CA2861722C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2861722A 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition Expired - Fee Related CA2861722C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3078563A CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IL217273 2011-12-29
IL217273A IL217273A0 (en) 2011-12-29 2011-12-29 Fast dissolution of solid fibrinogen
US201261582524P 2012-01-03 2012-01-03
US61/582,524 2012-01-03
US201261677048P 2012-07-30 2012-07-30
IL221180 2012-07-30
US61/677,048 2012-07-30
IL22118012 2012-07-30
PCT/IL2012/000393 WO2013098805A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3078563A Division CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Publications (2)

Publication Number Publication Date
CA2861722A1 CA2861722A1 (en) 2013-07-04
CA2861722C true CA2861722C (en) 2020-06-30

Family

ID=48696437

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2861722A Expired - Fee Related CA2861722C (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition
CA3078563A Abandoned CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3078563A Abandoned CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Country Status (13)

Country Link
US (2) US10618950B2 (forum.php)
EP (1) EP2797681B1 (forum.php)
JP (1) JP6223999B2 (forum.php)
KR (1) KR102109317B1 (forum.php)
AU (1) AU2012360048B2 (forum.php)
BR (1) BR112014016193A8 (forum.php)
CA (2) CA2861722C (forum.php)
ES (1) ES2621363T3 (forum.php)
IL (1) IL233361B (forum.php)
IN (1) IN2014DN05901A (forum.php)
MX (1) MX351980B (forum.php)
RU (1) RU2605710C2 (forum.php)
WO (1) WO2013098805A1 (forum.php)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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AU2012360048B2 (en) 2011-12-29 2017-05-25 Omrix Biopharmaceuticals Ltd. Method and device for fast dissolution of solid protein composition
CA2936721C (en) 2014-01-20 2021-12-14 Eveon Process for reconstitution of a solid form of a pharmaceutical composition
US20170274012A1 (en) * 2014-09-03 2017-09-28 Entegrion, Inc. Acceleration of Reconstitution of Plasma Powder by Mixing with Small Beads
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
USD877891S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
USD829888S1 (en) * 2015-12-22 2018-10-02 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
US10918790B2 (en) * 2015-12-22 2021-02-16 Guangzhou Bioseal Biotech Co., Ltd. Dual syringe with funnel feeding kit
USD877890S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution device
IL244922A0 (en) * 2016-04-05 2016-07-31 Omrix Biopharmaceuticals Ltd Device and method for sample preparation
WO2017184880A1 (en) * 2016-04-20 2017-10-26 Coherus Biosciences, Inc. A method of filling a container with no headspace
US10150115B2 (en) * 2016-07-21 2018-12-11 Spacepharma SA System and method for rehydrating powder and delivering the rehydrated powder to a reactor
WO2018150375A1 (en) * 2017-02-17 2018-08-23 Baxter International Inc. Devices and methods for forming and delivering a tissue sealant
NZ744155A (en) 2017-07-06 2025-06-27 Plas Tech Eng Inc Systems and methods related to fluid pumping
EP4452233A1 (en) 2021-12-21 2024-10-30 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions

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AU2012360048B2 (en) 2011-12-29 2017-05-25 Omrix Biopharmaceuticals Ltd. Method and device for fast dissolution of solid protein composition

Also Published As

Publication number Publication date
MX2014008033A (es) 2014-12-08
IL233361B (en) 2018-06-28
AU2012360048B2 (en) 2017-05-25
US20130312868A1 (en) 2013-11-28
WO2013098805A1 (en) 2013-07-04
US20200262892A1 (en) 2020-08-20
RU2014131276A (ru) 2016-02-20
CA2861722A1 (en) 2013-07-04
JP2015509084A (ja) 2015-03-26
IL233361A0 (en) 2014-08-31
IN2014DN05901A (forum.php) 2015-06-05
CN104144742A (zh) 2014-11-12
AU2012360048A1 (en) 2014-08-14
BR112014016193A2 (pt) 2017-06-13
US11634473B2 (en) 2023-04-25
BR112014016193A8 (pt) 2017-07-04
EP2797681B1 (en) 2017-02-01
ES2621363T3 (es) 2017-07-03
CA3078563A1 (en) 2013-07-04
RU2605710C2 (ru) 2016-12-27
MX351980B (es) 2017-11-03
KR20140108709A (ko) 2014-09-12
US10618950B2 (en) 2020-04-14
HK1203438A1 (en) 2015-10-30
KR102109317B1 (ko) 2020-05-29
JP6223999B2 (ja) 2017-11-01
EP2797681A1 (en) 2014-11-05

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Effective date: 20201221