CA2841890C - Hbv polymerase mutants - Google Patents

Hbv polymerase mutants Download PDF

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Publication number
CA2841890C
CA2841890C CA2841890A CA2841890A CA2841890C CA 2841890 C CA2841890 C CA 2841890C CA 2841890 A CA2841890 A CA 2841890A CA 2841890 A CA2841890 A CA 2841890A CA 2841890 C CA2841890 C CA 2841890C
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residue
seq
hbv
vector
amino acid
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CA2841890A1 (en
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Perrine Martin
Nathalie Silvestre
Jean-Baptiste Marchand
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Transgene SA
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Transgene SA
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/1252DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/292Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/1276RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
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    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/26Endoribonucleases producing 5'-phosphomonoesters (3.1.26)
    • C12Y301/26004Ribonuclease H (3.1.26.4)
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    • A61K2039/53DNA (RNA) vaccination
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
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    • C07ORGANIC CHEMISTRY
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    • C12N2730/00Reverse transcribing DNA viruses
    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
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    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus

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  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
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CA2841890A 2011-07-12 2012-07-12 Hbv polymerase mutants Active CA2841890C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11305909 2011-07-12
EP11305909.1 2011-07-12
EP12305450.4 2012-04-18
EP12305450 2012-04-18
PCT/EP2012/063640 WO2013007772A1 (en) 2011-07-12 2012-07-12 Hbv polymerase mutants

Publications (2)

Publication Number Publication Date
CA2841890A1 CA2841890A1 (en) 2013-01-17
CA2841890C true CA2841890C (en) 2020-08-04

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CA2841890A Active CA2841890C (en) 2011-07-12 2012-07-12 Hbv polymerase mutants

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US (3) US9512412B2 (OSRAM)
EP (1) EP2732034B1 (OSRAM)
JP (1) JP6189293B2 (OSRAM)
KR (1) KR102061357B1 (OSRAM)
CN (1) CN103998604B (OSRAM)
AU (1) AU2012282506C1 (OSRAM)
BR (1) BR112014000627B1 (OSRAM)
CA (1) CA2841890C (OSRAM)
DK (1) DK2732034T3 (OSRAM)
ES (1) ES2632497T3 (OSRAM)
HU (1) HUE033789T2 (OSRAM)
IL (1) IL230402B (OSRAM)
MX (1) MX346835B (OSRAM)
PE (2) PE20190660A1 (OSRAM)
RU (1) RU2625021C2 (OSRAM)
TW (2) TWI575070B (OSRAM)
WO (1) WO2013007772A1 (OSRAM)

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