CA2835438A1 - Pirfenidone et traitement antifibrotique chez des patients selectionnes - Google Patents

Pirfenidone et traitement antifibrotique chez des patients selectionnes Download PDF

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Publication number
CA2835438A1
CA2835438A1 CA2835438A CA2835438A CA2835438A1 CA 2835438 A1 CA2835438 A1 CA 2835438A1 CA 2835438 A CA2835438 A CA 2835438A CA 2835438 A CA2835438 A CA 2835438A CA 2835438 A1 CA2835438 A1 CA 2835438A1
Authority
CA
Canada
Prior art keywords
pirfenidone
receptor
inhibitor
agent
fvc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2835438A
Other languages
English (en)
Inventor
Williamson Ziegler Bradford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intermune Inc
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of CA2835438A1 publication Critical patent/CA2835438A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2835438A 2011-05-25 2012-05-25 Pirfenidone et traitement antifibrotique chez des patients selectionnes Abandoned CA2835438A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161489936P 2011-05-25 2011-05-25
US61/489,936 2011-05-25
US201161490057P 2011-05-26 2011-05-26
US61/490,057 2011-05-26
US201161523047P 2011-08-12 2011-08-12
US61/523,047 2011-08-12
US201161524961P 2011-08-18 2011-08-18
US61/524,961 2011-08-18
PCT/US2012/039538 WO2012162592A1 (fr) 2011-05-25 2012-05-25 Pirfénidone et traitement antifibrotique chez des patients sélectionnés

Publications (1)

Publication Number Publication Date
CA2835438A1 true CA2835438A1 (fr) 2012-11-29

Family

ID=47217770

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2835438A Abandoned CA2835438A1 (fr) 2011-05-25 2012-05-25 Pirfenidone et traitement antifibrotique chez des patients selectionnes

Country Status (11)

Country Link
US (1) US20150164874A1 (fr)
EP (1) EP2713732A4 (fr)
JP (1) JP6170040B2 (fr)
KR (1) KR20140022048A (fr)
AU (1) AU2012258575B2 (fr)
CA (1) CA2835438A1 (fr)
HK (1) HK1197159A1 (fr)
IL (1) IL229226A0 (fr)
MX (1) MX2013013752A (fr)
SG (1) SG195110A1 (fr)
WO (1) WO2012162592A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101583737B1 (ko) 2007-06-20 2016-01-11 오스펙스 파마슈티칼스, 인코포레이티드 섬유증 저해제로서의 치환된 ｎ-아릴 피리디논
KR20140011355A (ko) * 2011-03-08 2014-01-28 오스펙스 파마슈티칼스, 인코포레이티드 치환된 ｎ­아릴 피리디논
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP3027026A4 (fr) * 2013-07-31 2017-05-03 Windward Pharma, Inc. Composés inhibiteurs de tyrosine kinase en aérosol et leurs utilisations
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
EP3194446B1 (fr) * 2014-09-18 2022-10-26 Cedars-Sinai Medical Center Compositions et procédés de traitement de la fibrose
DK3050574T3 (da) * 2015-01-28 2020-01-20 Univ Bordeaux Anvendelse af plerixafor til behandling og/eller forebyggelse af akutte forværringer af kronisk obstruktiv lungesygdom
US20180064662A1 (en) * 2015-03-05 2018-03-08 The General Hospital Corporation Novel compositions and uses of metformin agents
EP3595656A1 (fr) * 2017-03-13 2020-01-22 Genfit Compositions pharmaceutiques pour polythérapie
JP2020531521A (ja) * 2017-08-22 2020-11-05 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． 抗アルファ（ｖ）ベータ（６）抗体を含有する医薬組成物及び投薬計画
WO2020236615A1 (fr) * 2019-05-17 2020-11-26 The Regents Of The University Of California Peptides modifiés par mps et leur utilisation
CN112239507A (zh) * 2019-07-17 2021-01-19 鸿运华宁（杭州）生物医药有限公司 ETA抗体与TGF-β Trap的融合蛋白质，以及其药物组合物和应用
EP3821946A1 (fr) * 2019-11-12 2021-05-19 Université de Strasbourg Anticorps monoclonaux anti-claudine-1 pour la prévention et le traitement de maladies fibrotiques
KR20220109439A (ko) 2019-12-04 2022-08-04 이도르시아 파마슈티컬스 리미티드 섬유증 질환의 치료에서 사용하기 위한 아제티딘 lpa1 수용체 길항제와 피르페니돈 및/또는 닌테다닙의 조합
EP4117659A4 (fr) * 2020-03-13 2024-04-03 Puretech Lyt 100 Inc Méthodes de traitement d'une maladie respiratoire avec de la pirfénidone deutérée
CN114617890A (zh) * 2020-12-08 2022-06-14 四川夏派森医药科技有限公司 DH404在治疗SARS-CoV-2感染中的应用
CN112640887B (zh) * 2020-12-25 2022-05-13 武汉睿健医药科技有限公司 一种神经干细胞冻存液及其应用
WO2022266370A1 (fr) * 2021-06-17 2022-12-22 Aria Pharmaceuticals, Inc. Sparsentan pour le traitement de la fibrose pulmonaire idiopathique
CN114097807B (zh) * 2021-11-25 2023-05-05 兰州大学 巴多索隆类化合物在抗农业病原真菌中的用途
WO2023192646A1 (fr) * 2022-03-31 2023-10-05 Puretech Lyt 100, Inc. Méthodes de traitement de maladies et de troubles médiés par la fibrose et le collagène avec de la deupirfénidone

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001232340A1 (en) * 2000-02-18 2001-08-27 Kirin Beer Kabushiki Kaisha Novel isoxazole and thiazole compounds and use thereof as drugs
CN1307997C (zh) * 2002-06-28 2007-04-04 图兰恩教育基金管理人 用于治疗肺纤维化的4－(4－甲基哌嗪－1－基甲基)－n－[4－甲基－3－(4－(吡啶－3－基)嘧啶－2－基氨基)苯基]－苯甲酰胺
US20070092488A1 (en) * 2003-05-16 2007-04-26 Intermune Inc. Methods of treating idiopathic pulmonary fibrosis
WO2005110478A2 (fr) * 2004-04-13 2005-11-24 Intermune, Inc. Polytherapie destinee a traiter des troubles fibreux
BRPI0709950A2 (pt) * 2006-04-13 2011-08-02 Actelion Pharmaceuticals Ltd uso de bosentan na preparação de um medicamento para o tratamento de fibrose pulmonar idiopática em estágio precoce e uso de antagonista do receptor endotelin
MX349810B (es) * 2006-09-08 2017-08-14 Abbvie Bahamas Ltd Proteinas de enlace de interleucina-13.
KR101583737B1 (ko) * 2007-06-20 2016-01-11 오스펙스 파마슈티칼스, 인코포레이티드 섬유증 저해제로서의 치환된 ｎ-아릴 피리디논
AU2010206543A1 (en) * 2009-01-26 2011-07-07 Intermune, Inc. Methods for treating acute myocardial infarctions and associated disorders
GB2474748B (en) * 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists

Also Published As

Publication number Publication date
SG195110A1 (en) 2013-12-30
JP6170040B2 (ja) 2017-07-26
WO2012162592A1 (fr) 2012-11-29
NZ617415A (en) 2017-07-28
AU2012258575B2 (en) 2017-03-02
US20150164874A1 (en) 2015-06-18
KR20140022048A (ko) 2014-02-21
AU2012258575A1 (en) 2013-11-21
MX2013013752A (es) 2014-08-01
HK1197159A1 (en) 2015-01-09
EP2713732A4 (fr) 2014-12-03
JP2014518880A (ja) 2014-08-07
IL229226A0 (en) 2014-01-30
EP2713732A1 (fr) 2014-04-09

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170524

FZDE Discontinued

Effective date: 20191024