CA2823812C - Molecules d'anticorps se liant a il-17a et il-17f - Google Patents

Molecules d'anticorps se liant a il-17a et il-17f Download PDF

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CA2823812C
CA2823812C CA2823812A CA2823812A CA2823812C CA 2823812 C CA2823812 C CA 2823812C CA 2823812 A CA2823812 A CA 2823812A CA 2823812 A CA2823812 A CA 2823812A CA 2823812 C CA2823812 C CA 2823812C
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antibody
seq
disease
pharmaceutical composition
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CA2823812A1 (fr
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Ralph Adams
Terence Seward Baker
Alastair David Griffiths Lawson
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UCB Biopharma SRL
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UCB Biopharma SRL
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Neurosurgery (AREA)
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  • Biomedical Technology (AREA)
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  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
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Abstract

Molécules d'anticorps ayant une spécificité pour des déterminants antigéniques à la fois de IL-17A et IL-17F, les utilisations thérapeutiques de ces molécules d'anticorps et des procédés d'obtention des dites molécules.
CA2823812A 2011-01-14 2012-01-11 Molecules d'anticorps se liant a il-17a et il-17f Active CA2823812C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161432814P 2011-01-14 2011-01-14
US61/432,814 2011-01-14
PCT/GB2012/050050 WO2012095662A1 (fr) 2011-01-14 2012-01-11 Molécules d'anticorps se liant à il-17a et il-17f

Publications (2)

Publication Number Publication Date
CA2823812A1 CA2823812A1 (fr) 2012-07-19
CA2823812C true CA2823812C (fr) 2017-02-14

Family

ID=45496193

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2823812A Active CA2823812C (fr) 2011-01-14 2012-01-11 Molecules d'anticorps se liant a il-17a et il-17f

Country Status (36)

Country Link
US (5) US8580265B2 (fr)
EP (2) EP3219728A1 (fr)
JP (2) JP6028737B2 (fr)
KR (1) KR101950306B1 (fr)
CN (1) CN103384682B (fr)
AR (2) AR084845A1 (fr)
AU (1) AU2012206431B2 (fr)
BR (1) BR112013017951B1 (fr)
CA (1) CA2823812C (fr)
CL (1) CL2013002044A1 (fr)
CO (1) CO6781516A2 (fr)
CY (1) CY1119055T1 (fr)
DK (1) DK2663577T3 (fr)
EA (1) EA037071B1 (fr)
ES (1) ES2632583T3 (fr)
FI (1) FIC20220002I1 (fr)
FR (1) FR22C1000I2 (fr)
HR (1) HRP20171034T1 (fr)
HU (1) HUS2200001I1 (fr)
IL (1) IL227347B (fr)
LT (2) LT2663577T (fr)
MA (1) MA34907B1 (fr)
ME (1) ME02734B (fr)
MX (1) MX341489B (fr)
MY (1) MY162790A (fr)
NL (1) NL301159I2 (fr)
PL (1) PL2663577T3 (fr)
PT (1) PT2663577T (fr)
RS (1) RS56298B1 (fr)
SG (2) SG10201510762YA (fr)
SI (1) SI2663577T1 (fr)
TN (1) TN2013000292A1 (fr)
TW (1) TWI511978B (fr)
UA (1) UA110358C2 (fr)
WO (1) WO2012095662A1 (fr)
ZA (1) ZA201306080B (fr)

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GB0620729D0 (en) * 2006-10-18 2006-11-29 Ucb Sa Biological products
GB0807413D0 (en) * 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
KR20130080790A (ko) 2010-05-20 2013-07-15 아블린쓰 엔.브이. Ｈｅｒ３와 관련된 생물학적 물질들
CA2823812C (fr) 2011-01-14 2017-02-14 Ucb Pharma S.A. Molecules d'anticorps se liant a il-17a et il-17f
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
KR102023401B1 (ko) 2012-05-10 2019-11-04 바이오아트라, 엘엘씨 다중-특이적 모노클로날 항체
GB201310544D0 (en) 2013-06-13 2013-07-31 Ucb Pharma Sa Obtaining an improved therapeutic ligand
EP3072905B1 (fr) * 2013-11-18 2020-08-19 Shanghai Hengrui Pharmaceutical Co., Ltd. Agent de liaison il-17a et utilisations associees
CA2937556A1 (fr) 2014-02-21 2015-08-27 Genentech, Inc. Anticorps bispecifiques anti-il-13/il-17 et leurs utilisations
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
EP3250927B1 (fr) 2015-01-28 2020-02-19 H. Hoffnabb-La Roche Ag Marqueurs d'expression génique et traitement de la sclérose en plaques
CN116059350A (zh) * 2015-10-27 2023-05-05 Ucb生物制药有限责任公司 使用抗-il-17a/f抗体的治疗方法
RU2680011C2 (ru) * 2016-04-29 2019-02-14 Закрытое Акционерное Общество "Биокад" Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы
ES2905917T3 (es) 2016-09-14 2022-04-12 Beijing Hanmi Pharmaceutical Co Ltd Anticuerpo que se une específicamente a IL-17A y fragmento funcional del mismo
WO2018161340A1 (fr) * 2017-03-10 2018-09-13 X-Kang United Biopharmaceutical Science & Technology Co., Ltd. Anticorps monoclonal dirigé contre l'il-17a et l'il-17f et utilisation associée
GB201719447D0 (en) * 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
WO2020024931A1 (fr) * 2018-07-31 2020-02-06 Shen Weiqun Anticorps anti-il-17 a et leur utilisation
CN110151999A (zh) * 2019-05-22 2019-08-23 中国人民解放军第四军医大学 用于抑制恶性黑色素瘤进展的靶向药物
EP3998286A4 (fr) * 2019-07-11 2023-04-26 Wuhan Yzy Biopharma Co., Ltd. Anticorps bispécifique symétrique tétravalent
GB201919061D0 (en) * 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibody
EP4393948A1 (fr) * 2022-12-28 2024-07-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Anticorps vhh thérapeutiques neutralisant de manière croisée les homodimères il-17a et il-17f et l'hétérodimère il-17af

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