CA2800203C - Morpholinopyrimidines et leur utilisation en therapie - Google Patents

Morpholinopyrimidines et leur utilisation en therapie Download PDF

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Publication number
CA2800203C
CA2800203C CA2800203A CA2800203A CA2800203C CA 2800203 C CA2800203 C CA 2800203C CA 2800203 A CA2800203 A CA 2800203A CA 2800203 A CA2800203 A CA 2800203A CA 2800203 C CA2800203 C CA 2800203C
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CA
Canada
Prior art keywords
methyl
pyrimidin
methylmorpholin
methylsulfonimidoyl
mmol
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Active
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CA2800203A
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English (en)
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CA2800203A1 (fr
Inventor
Kevin Michael Foote
Johannes Wilhelmus Maria Nissink
Paul Turner
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AstraZeneca AB
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AstraZeneca AB
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Publication of CA2800203A1 publication Critical patent/CA2800203A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne les composés pyrimidinyle de formule (I), où R2 est (1) ou des sels pharmaceutiquement acceptables de ceux-ci, des processus pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en thérapie. .
CA2800203A 2010-06-11 2011-06-09 Morpholinopyrimidines et leur utilisation en therapie Active CA2800203C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35371310P 2010-06-11 2010-06-11
US61/353,713 2010-06-11
PCT/GB2011/051074 WO2011154737A1 (fr) 2010-06-11 2011-06-09 Morpholinopyrimidines et leur utilisation en thérapie

Publications (2)

Publication Number Publication Date
CA2800203A1 CA2800203A1 (fr) 2011-12-15
CA2800203C true CA2800203C (fr) 2019-01-22

Family

ID=44168987

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2800203A Active CA2800203C (fr) 2010-06-11 2011-06-09 Morpholinopyrimidines et leur utilisation en therapie

Country Status (38)

Country Link
US (5) US8252802B2 (fr)
EP (1) EP2579877B1 (fr)
JP (1) JP5721821B2 (fr)
KR (1) KR101820996B1 (fr)
CN (1) CN103068391B (fr)
AR (1) AR081859A1 (fr)
AU (1) AU2011263491B2 (fr)
BR (1) BR112012031561B1 (fr)
CA (1) CA2800203C (fr)
CL (1) CL2012003503A1 (fr)
CO (1) CO6640270A2 (fr)
CR (1) CR20120628A (fr)
CU (1) CU24109B1 (fr)
DK (1) DK2579877T3 (fr)
DO (1) DOP2012000310A (fr)
EA (1) EA022087B1 (fr)
EC (1) ECSP12012334A (fr)
ES (1) ES2514325T3 (fr)
GT (1) GT201200334A (fr)
HK (1) HK1182019A1 (fr)
HR (1) HRP20140953T1 (fr)
MX (1) MX2012014477A (fr)
MY (1) MY158193A (fr)
NI (1) NI201200184A (fr)
NZ (1) NZ604480A (fr)
PE (1) PE20130306A1 (fr)
PL (1) PL2579877T3 (fr)
PT (1) PT2579877E (fr)
RS (1) RS53566B1 (fr)
SA (1) SA111320519B1 (fr)
SG (1) SG185711A1 (fr)
SI (1) SI2579877T1 (fr)
SM (1) SMT201400146B (fr)
TW (1) TWI526208B (fr)
UA (1) UA109010C2 (fr)
UY (1) UY33440A (fr)
WO (1) WO2011154737A1 (fr)
ZA (1) ZA201300255B (fr)

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