CA2792093C - Inhibitors of intestinal apical membrane sodium/phosphate co-transport - Google Patents

Inhibitors of intestinal apical membrane sodium/phosphate co-transport Download PDF

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Publication number
CA2792093C
CA2792093C CA2792093A CA2792093A CA2792093C CA 2792093 C CA2792093 C CA 2792093C CA 2792093 A CA2792093 A CA 2792093A CA 2792093 A CA2792093 A CA 2792093A CA 2792093 C CA2792093 C CA 2792093C
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CA
Canada
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
formula
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2792093A
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English (en)
French (fr)
Other versions
CA2792093A1 (en
Inventor
Brian Peerce
Larry Slomowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DUOPHOS
Original Assignee
DUOPHOS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DUOPHOS filed Critical DUOPHOS
Publication of CA2792093A1 publication Critical patent/CA2792093A1/en
Application granted granted Critical
Publication of CA2792093C publication Critical patent/CA2792093C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C07F9/146—Esters of phosphorous acids containing P-halide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
    • C07F9/1406—Esters of phosphoric acids containing P(=O)-halide groups containing the structure Hal-P(=O)-O-aryl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2792093A 2010-03-05 2011-03-04 Inhibitors of intestinal apical membrane sodium/phosphate co-transport Active CA2792093C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31090210P 2010-03-05 2010-03-05
US61/310,902 2010-03-05
PCT/US2011/027232 WO2011109731A2 (en) 2010-03-05 2011-03-04 Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport

Publications (2)

Publication Number Publication Date
CA2792093A1 CA2792093A1 (en) 2011-09-09
CA2792093C true CA2792093C (en) 2018-05-22

Family

ID=44542860

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2792093A Active CA2792093C (en) 2010-03-05 2011-03-04 Inhibitors of intestinal apical membrane sodium/phosphate co-transport

Country Status (13)

Country Link
US (2) US8921343B2 (https=)
EP (1) EP2542560B8 (https=)
JP (1) JP5819865B2 (https=)
CN (1) CN102918050B (https=)
AU (1) AU2011222551B2 (https=)
BR (1) BR112012022349B1 (https=)
CA (1) CA2792093C (https=)
ES (1) ES2561672T3 (https=)
IL (1) IL221747A (https=)
MX (1) MX2012010288A (https=)
NZ (1) NZ602703A (https=)
RU (1) RU2566757C2 (https=)
WO (1) WO2011109731A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011222551B2 (en) * 2010-03-05 2016-10-06 Duophos Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport
WO2017111087A1 (ja) * 2015-12-25 2017-06-29 ステラケミファ株式会社 モノフルオロリン酸エステル塩、その製造方法及びフッ素イオン放出性組成物
CN119431437B (zh) * 2024-11-04 2025-09-30 山东花物堂生物科技有限公司 丹皮酚磷酸酯及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2371910A1 (en) * 1999-01-21 2000-07-27 Brian E. Peerce Inhibitors of intestinal apical membrane na/phosphate co-transportation
US7119120B2 (en) * 2001-12-26 2006-10-10 Genzyme Corporation Phosphate transport inhibitors
ATE337326T1 (de) * 2002-03-19 2006-09-15 Genzyme Corp Hemmer des phosphattransports
RU2279676C2 (ru) * 2003-06-16 2006-07-10 Уральская государственная академия ветеринарной медицины Способ контроля над репаративным остеогенезом у животных
ES2633689T3 (es) * 2009-01-26 2017-09-22 Opko Ireland Global Holdings, Limited Regulación de fosfato con moléculas pequeñas
AU2011222551B2 (en) * 2010-03-05 2016-10-06 Duophos Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport

Also Published As

Publication number Publication date
US20130059822A1 (en) 2013-03-07
EP2542560A4 (en) 2014-10-15
HK1180692A1 (zh) 2013-10-25
AU2011222551A1 (en) 2012-09-27
BR112012022349A2 (pt) 2016-07-05
EP2542560B8 (en) 2015-12-30
NZ602703A (en) 2015-01-30
WO2011109731A2 (en) 2011-09-09
US8921343B2 (en) 2014-12-30
MX2012010288A (es) 2013-02-27
AU2011222551B2 (en) 2016-10-06
BR112012022349B1 (pt) 2019-09-24
US9328128B2 (en) 2016-05-03
US20150080597A1 (en) 2015-03-19
ES2561672T8 (es) 2016-03-11
RU2012142336A (ru) 2014-04-10
JP5819865B2 (ja) 2015-11-24
EP2542560A2 (en) 2013-01-09
CN102918050A (zh) 2013-02-06
CA2792093A1 (en) 2011-09-09
IL221747A (en) 2016-02-29
ES2561672T3 (es) 2016-02-29
JP2013521337A (ja) 2013-06-10
RU2566757C2 (ru) 2015-10-27
CN102918050B (zh) 2015-07-01
WO2011109731A3 (en) 2012-03-01
EP2542560B1 (en) 2015-11-11

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