EP2542560B8 - Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport - Google Patents

Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport Download PDF

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Publication number
EP2542560B8
EP2542560B8 EP11751437.2A EP11751437A EP2542560B8 EP 2542560 B8 EP2542560 B8 EP 2542560B8 EP 11751437 A EP11751437 A EP 11751437A EP 2542560 B8 EP2542560 B8 EP 2542560B8
Authority
EP
European Patent Office
Prior art keywords
arylfluorophosphate
inhibitors
phosphate
transport
apical membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP11751437.2A
Other languages
German (de)
French (fr)
Other versions
EP2542560A2 (en
EP2542560B1 (en
EP2542560A4 (en
Inventor
Brian Peerce
Larry Slomowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DUOPHOS
Original Assignee
DUOPHOS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DUOPHOS filed Critical DUOPHOS
Publication of EP2542560A2 publication Critical patent/EP2542560A2/en
Publication of EP2542560A4 publication Critical patent/EP2542560A4/en
Publication of EP2542560B1 publication Critical patent/EP2542560B1/en
Application granted granted Critical
Publication of EP2542560B8 publication Critical patent/EP2542560B8/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C07F9/146—Esters of phosphorous acids containing P-halide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
    • C07F9/1406—Esters of phosphoric acids containing P(=O)-halide groups containing the structure Hal-P(=O)-O-aryl
EP11751437.2A 2010-03-05 2011-03-04 Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport Active EP2542560B8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31090210P 2010-03-05 2010-03-05
PCT/US2011/027232 WO2011109731A2 (en) 2010-03-05 2011-03-04 Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport

Publications (4)

Publication Number Publication Date
EP2542560A2 EP2542560A2 (en) 2013-01-09
EP2542560A4 EP2542560A4 (en) 2014-10-15
EP2542560B1 EP2542560B1 (en) 2015-11-11
EP2542560B8 true EP2542560B8 (en) 2015-12-30

Family

ID=44542860

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11751437.2A Active EP2542560B8 (en) 2010-03-05 2011-03-04 Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport

Country Status (14)

Country Link
US (2) US8921343B2 (en)
EP (1) EP2542560B8 (en)
JP (1) JP5819865B2 (en)
CN (1) CN102918050B (en)
AU (1) AU2011222551B2 (en)
BR (1) BR112012022349B1 (en)
CA (1) CA2792093C (en)
ES (1) ES2561672T3 (en)
HK (1) HK1180692A1 (en)
IL (1) IL221747A (en)
MX (1) MX2012010288A (en)
NZ (1) NZ602703A (en)
RU (1) RU2566757C2 (en)
WO (1) WO2011109731A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5819865B2 (en) * 2010-03-05 2015-11-24 デュオフォス Intestinal brush border membrane sodium / phosphate co-transport arylfluorophosphate inhibitors
WO2017111087A1 (en) * 2015-12-25 2017-06-29 ステラケミファ株式会社 Monofluorophosphate ester salt, method for producing same, and fluorine ion-releasing composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355823B1 (en) * 1999-01-21 2002-03-12 Board Of Regents, The University Of Texas System Inhibitors of intestinal apical membrane na/phoshate co-transportation
US7119120B2 (en) * 2001-12-26 2006-10-10 Genzyme Corporation Phosphate transport inhibitors
JP4465193B2 (en) * 2002-03-19 2010-05-19 ジェンザイム コーポレーション Phosphate transport inhibitor
RU2279676C2 (en) * 2003-06-16 2006-07-10 Уральская государственная академия ветеринарной медицины Method for controlling reparative osteogenesis in animals
JP5783910B2 (en) * 2009-01-26 2015-09-24 シトクロマ インコーポレイテッド Phosphate management using small molecules
JP5819865B2 (en) * 2010-03-05 2015-11-24 デュオフォス Intestinal brush border membrane sodium / phosphate co-transport arylfluorophosphate inhibitors

Also Published As

Publication number Publication date
ES2561672T3 (en) 2016-02-29
BR112012022349B1 (en) 2019-09-24
BR112012022349A2 (en) 2016-07-05
ES2561672T8 (en) 2016-03-11
JP2013521337A (en) 2013-06-10
EP2542560A2 (en) 2013-01-09
US20130059822A1 (en) 2013-03-07
EP2542560B1 (en) 2015-11-11
IL221747A (en) 2016-02-29
CA2792093C (en) 2018-05-22
CN102918050B (en) 2015-07-01
NZ602703A (en) 2015-01-30
WO2011109731A3 (en) 2012-03-01
RU2566757C2 (en) 2015-10-27
CA2792093A1 (en) 2011-09-09
AU2011222551B2 (en) 2016-10-06
JP5819865B2 (en) 2015-11-24
US9328128B2 (en) 2016-05-03
EP2542560A4 (en) 2014-10-15
CN102918050A (en) 2013-02-06
US8921343B2 (en) 2014-12-30
MX2012010288A (en) 2013-02-27
AU2011222551A1 (en) 2012-09-27
WO2011109731A2 (en) 2011-09-09
RU2012142336A (en) 2014-04-10
HK1180692A1 (en) 2013-10-25
US20150080597A1 (en) 2015-03-19

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