CA2786950C - Fused heteroaromatic pyrrolidinones as syk inhibitors - Google Patents

Fused heteroaromatic pyrrolidinones as syk inhibitors Download PDF

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Publication number
CA2786950C
CA2786950C CA2786950A CA2786950A CA2786950C CA 2786950 C CA2786950 C CA 2786950C CA 2786950 A CA2786950 A CA 2786950A CA 2786950 A CA2786950 A CA 2786950A CA 2786950 C CA2786950 C CA 2786950C
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Canada
Prior art keywords
pyrrolo
pyridin
fluoro
pyrazol
methyl
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CA2786950A
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English (en)
French (fr)
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CA2786950A1 (en
Inventor
Yasuyoshi Arikawa
Benjamin Jones
Betty Lam
Zhe Nie
Christopher Smith
Masashi Takahashi
Qing Dong
Victoria Feher
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of CA2786950A1 publication Critical patent/CA2786950A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Diabetes (AREA)
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  • Neurology (AREA)
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CA2786950A 2009-12-23 2010-12-17 Fused heteroaromatic pyrrolidinones as syk inhibitors Active CA2786950C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28996909P 2009-12-23 2009-12-23
US61/289,969 2009-12-23
US38696410P 2010-09-27 2010-09-27
US61/386,964 2010-09-27
PCT/US2010/061146 WO2011079051A1 (en) 2009-12-23 2010-12-17 Fused heteroaromatic pyrrolidinones as syk inhibitors

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Publication Number Publication Date
CA2786950A1 CA2786950A1 (en) 2011-06-30
CA2786950C true CA2786950C (en) 2019-01-15

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CA2786950A Active CA2786950C (en) 2009-12-23 2010-12-17 Fused heteroaromatic pyrrolidinones as syk inhibitors

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EP (4) EP2516434B1 (https=)
JP (7) JP5658274B2 (https=)
KR (1) KR101790255B1 (https=)
CN (1) CN102753548B (https=)
AR (1) AR081797A1 (https=)
AU (1) AU2010333804B2 (https=)
BR (1) BR112012015651B1 (https=)
CA (1) CA2786950C (https=)
CL (1) CL2012001745A1 (https=)
CO (1) CO6592058A2 (https=)
CR (1) CR20120392A (https=)
CY (1) CY1116736T1 (https=)
DK (1) DK2516434T3 (https=)
DO (1) DOP2012000180A (https=)
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SI (1) SI2516434T1 (https=)
SM (1) SMT201500199B (https=)
TN (1) TN2012000316A1 (https=)
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UA (1) UA107100C2 (https=)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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