CA2785736A1 - Method for recovering bowman-birk inhibitor proteins from a soy processing stream - Google Patents
Method for recovering bowman-birk inhibitor proteins from a soy processing stream Download PDFInfo
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- CA2785736A1 CA2785736A1 CA2785736A CA2785736A CA2785736A1 CA 2785736 A1 CA2785736 A1 CA 2785736A1 CA 2785736 A CA2785736 A CA 2785736A CA 2785736 A CA2785736 A CA 2785736A CA 2785736 A1 CA2785736 A1 CA 2785736A1
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Classifications
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
- A23J3/16—Vegetable proteins from soybean
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Dairy Products (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29131209P | 2009-12-30 | 2009-12-30 | |
| US61/291,312 | 2009-12-30 | ||
| PCT/US2010/062556 WO2011082338A1 (en) | 2009-12-30 | 2010-12-30 | Method for recovering bowman-birk inhibitor proteins from a soy processing stream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2785736A1 true CA2785736A1 (en) | 2011-07-07 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2785736A Abandoned CA2785736A1 (en) | 2009-12-30 | 2010-12-30 | Method for recovering bowman-birk inhibitor proteins from a soy processing stream |
| CA2785599A Abandoned CA2785599A1 (en) | 2009-12-30 | 2010-12-30 | Purified bowman-birk protease inhibitor proteins isolated from a soy processing stream |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2785599A Abandoned CA2785599A1 (en) | 2009-12-30 | 2010-12-30 | Purified bowman-birk protease inhibitor proteins isolated from a soy processing stream |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US20120289683A1 (enExample) |
| EP (5) | EP2519117A4 (enExample) |
| JP (5) | JP2013516429A (enExample) |
| CN (6) | CN102781459A (enExample) |
| BR (2) | BR112012016225A2 (enExample) |
| CA (2) | CA2785736A1 (enExample) |
| WO (5) | WO2011082360A1 (enExample) |
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| JP5395160B2 (ja) | 2008-03-26 | 2014-01-22 | オラムド エルティーディー． | タンパク質の経口投与方法及び組成物 |
| WO2013002786A1 (en) * | 2011-06-29 | 2013-01-03 | Solae | Baked food compositions comprising soy whey proteins that have been isolated from processing streams |
| HUE066433T2 (hu) | 2012-02-01 | 2024-08-28 | Oramed Ltd | Proteáz inhibitort tartalmazó készítmények, azokat tartalmazó összetevõk, valamint eljárások azok elõállítására és felhasználására |
| WO2014018923A2 (en) * | 2012-07-26 | 2014-01-30 | Solae, Llc | Emulsifying agent for use in personal care products and industrial products |
| CN104736001A (zh) * | 2012-07-26 | 2015-06-24 | 索莱有限责任公司 | 用于食品组合物中的发泡剂 |
| US20150223498A1 (en) * | 2012-07-26 | 2015-08-13 | Solae, Llc | Emulsifying agent for use in food compositions |
| EP2877063A2 (en) * | 2012-07-26 | 2015-06-03 | Solae, LLC | Foaming agent for use in personal care products and industrial products |
| US9765111B2 (en) | 2012-10-23 | 2017-09-19 | Upfront Chromatography A/S | Separation processes for soy protein |
| EP4215205A1 (en) | 2013-01-03 | 2023-07-26 | Oramed Ltd. | Methods and compositions for treating nafld, hepatic steatosis, and sequelae thereof |
| FR3001362B1 (fr) | 2013-01-31 | 2015-07-10 | Roquette Freres | Procede de fractionnement des solubles de pois, fractions obtenues et leur valorisation |
| CN103392907B (zh) * | 2013-06-08 | 2014-12-17 | 东北农业大学 | 酶法修饰改善乳清蛋白纳米纤维聚合量的方法 |
| WO2015101435A1 (en) * | 2013-12-30 | 2015-07-09 | Koninklijke Philips N.V. | A method of making soymilk |
| CA2937598A1 (en) * | 2014-01-29 | 2015-08-06 | Upfront Chromatography A/S | Novel separation processes for pea protein |
| CN103933548A (zh) * | 2014-04-17 | 2014-07-23 | 中国药科大学 | 露那辛多肽在防治白内障药物中的应用 |
| WO2017075456A1 (en) * | 2015-10-30 | 2017-05-04 | Beth Israel Deaconess Medical Center, Inc. | Methods for determination of bioactivity, quantity, removal, or inactivation of cereal amylase trypsin inhibitors in cereals, flours, plants, and complex foods |
| US10858390B2 (en) * | 2016-09-02 | 2020-12-08 | Cem Corporation | Use of excess carbodiimide for peptide synthesis at elevated temperatures |
| CA3237785A1 (en) | 2017-03-31 | 2018-10-04 | J.R. Simplot Company | Potato protein powders |
| CN107488226A (zh) * | 2017-09-06 | 2017-12-19 | 成都晟博源生物工程有限公司 | 一种大豆胰蛋白酶抑制剂的提取方法 |
| CN110872140B (zh) * | 2018-09-03 | 2022-06-21 | 中国石油化工股份有限公司 | 危化品分离回收系统 |
| CN110104754B (zh) * | 2019-04-03 | 2022-03-29 | 江苏农林职业技术学院 | 一种豆制品废水废渣处理甲基橙染料废水的方法 |
| CN114560928A (zh) * | 2019-08-27 | 2022-05-31 | 合肥天汇孵化科技有限公司 | 一种基于大豆深加工废液以豆清水为原料粗提sbti蛋白工艺 |
| IL293121A (en) * | 2019-11-20 | 2022-07-01 | Csl Behring Ag | Method for extracting a protein from a precipitate and method for precipitating impurities |
| AU2021227964A1 (en) * | 2020-02-26 | 2022-09-22 | Eat Just, Inc. | Pulse protein isolation by ultrafiltration |
| WO2021250191A1 (en) * | 2020-06-12 | 2021-12-16 | Basf Se | Improved demineralization of fermentation broths and purification of fine chemicals such as oligosaccharides |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4368151A (en) * | 1981-08-10 | 1983-01-11 | A. E. Staley Manufacturing Company | 7S And 11S vegetable protein fractionation and isolation |
| US5288856A (en) * | 1986-11-20 | 1994-02-22 | Pierre Amiguet | Method of isolating acid-stable, biologically active proteins |
| US4808314A (en) * | 1987-09-18 | 1989-02-28 | Scripps Clinic And Research Foundation | Method for reducing bacterial endotoxin contamination in solutions of macromolecules |
| TR24186A (tr) * | 1988-04-11 | 1991-05-30 | Monsanto Co | Hasere zehirlerinin etkinligini arttirmak icin yoentem |
| US5250515A (en) * | 1988-04-11 | 1993-10-05 | Monsanto Company | Method for improving the efficacy of insect toxins |
| JPH06145198A (ja) * | 1992-03-30 | 1994-05-24 | Shokuhin Sangyo High Separeeshiyon Syst Gijutsu Kenkyu Kumiai | 大豆トリプシンインヒビターの製造方法 |
| DK46793D0 (da) * | 1993-04-26 | 1993-04-26 | Novo Nordisk As | Enzym |
| JPH1066572A (ja) * | 1996-08-29 | 1998-03-10 | Showa Sangyo Co Ltd | 高純度の大豆トリプシンインヒビターの製造方法 |
| US6313273B1 (en) * | 1999-08-25 | 2001-11-06 | Abbott Laboratories | Soy proteins and methods for their production |
| US6787173B2 (en) * | 2000-11-30 | 2004-09-07 | Kraft Foods Holdings, Inc. | Method of deflavoring soy-derived materials |
| US7175869B2 (en) * | 2000-11-30 | 2007-02-13 | Kraft Foods Holdings, Inc. | Method of deflavoring soy-derived materials using electrodialysis |
| CN1150831C (zh) * | 2001-01-19 | 2004-05-26 | 北京中联捷思科技发展有限公司 | 超滤提取大豆乳清蛋白的方法 |
| US6927322B2 (en) * | 2001-03-30 | 2005-08-09 | Cornell Research Foundation, Inc. | Cabbage proteinase inhibitor gene confers resistance against plant pests |
| US7214394B2 (en) * | 2002-05-31 | 2007-05-08 | Archer-Daniels-Midland Company | Policosanol compositions, extraction from novel sources, and uses thereof |
| CN100506062C (zh) * | 2002-08-28 | 2009-07-01 | 不二制油株式会社 | 酸性大豆蛋白质凝胶食物及其生产方法 |
| JPWO2004104036A1 (ja) * | 2003-05-21 | 2006-10-26 | 不二製油株式会社 | 大豆ホエー蛋白及び大豆ホエー蛋白分解物の製造法 |
| US20070277269A1 (en) * | 2006-04-17 | 2007-11-29 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| BRPI0416231A (pt) * | 2003-11-05 | 2007-01-02 | Kerry Group Services Internati | proteìnas de soja estáveis em ácido solúveis na água, bebida acìdica, produto alimentìcio acìdico e métodos de fortalecimento de bebida acìdica com proteìna de soja, de preparação de proteìna de soja estável em ácido solúvel em água e de preparação de alimento ou bebida |
| US7279564B2 (en) * | 2003-11-06 | 2007-10-09 | Genencor International, Inc. | Expression in filamentous fungi of protease inhibitors and variants thereof |
| ATE530560T1 (de) * | 2003-11-06 | 2011-11-15 | Danisco Us Inc | Vegf bindende und geträgerte peptide zur behandlung von hautkrankheiten |
| CN1615722A (zh) * | 2003-11-14 | 2005-05-18 | 哈高科大豆食品有限责任公司 | 超滤膜分离技术制备大豆分离蛋白的方法 |
| WO2005082156A1 (ja) * | 2004-02-26 | 2005-09-09 | Fuji Oil Company, Limited | 大豆たん白含有溶液乃至ゲル |
| EP1731160B1 (en) * | 2004-02-27 | 2012-07-11 | Fuji Oil Company, Ltd. | Cancer metastasis inhibitory composition |
| US20060057275A1 (en) * | 2004-09-16 | 2006-03-16 | Shaowen Wu | Process for the preparation of glycinin-rich and beta-conglycinin-rich protein fractions |
| BRPI0613548A2 (pt) * | 2005-05-05 | 2011-01-18 | Genencor Int | composições de cuidado pessoal e métodos para seu uso |
| US20070054031A1 (en) * | 2005-09-02 | 2007-03-08 | Keshun Liu | Methods of extracting, concentrating and fractionating proteins and other chemical components |
| TWI257723B (en) * | 2005-09-15 | 2006-07-01 | Epitech Technology Corp | Vertical light-emitting diode and method for manufacturing the same |
| US20080182002A1 (en) * | 2007-01-26 | 2008-07-31 | Solae, Llc | Processes for Removing Bitter Components from Soy Protein Isolates |
| BRPI0811788A2 (pt) * | 2007-07-03 | 2014-10-07 | Solae Llc | Composição de proteína vegetal, processo para a fabricação de uma composição de proteína vegetal e produto alimentício |
| CN101367018A (zh) * | 2007-09-13 | 2009-02-18 | 中国海洋大学 | 壳聚糖树脂固定化酶纯化大豆乳清废水中胰蛋白酶抑制剂的工艺 |
| MX2011003803A (es) * | 2008-10-15 | 2011-07-04 | Danisco Inc | Inhibidores de proteasa de bowman birk, variantes, modificados. |
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