CA2772372C - Methods of treating chronic neurogenic inflammation using a modified clostridial toxin - Google Patents
Methods of treating chronic neurogenic inflammation using a modified clostridial toxin Download PDFInfo
- Publication number
- CA2772372C CA2772372C CA2772372A CA2772372A CA2772372C CA 2772372 C CA2772372 C CA 2772372C CA 2772372 A CA2772372 A CA 2772372A CA 2772372 A CA2772372 A CA 2772372A CA 2772372 C CA2772372 C CA 2772372C
- Authority
- CA
- Canada
- Prior art keywords
- botulinum
- neurotoxin
- patient
- botulinum toxin
- toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000007920 Neurogenic Inflammation Diseases 0.000 title 1
- 230000001684 chronic effect Effects 0.000 title 1
- 231100001102 clostridial toxin Toxicity 0.000 title 1
- 108010055044 Tetanus Toxin Proteins 0.000 claims abstract 22
- 108030001720 Bontoxilysin Proteins 0.000 claims abstract 9
- 231100001103 botulinum neurotoxin Toxicity 0.000 claims abstract 9
- 206010036596 premature ejaculation Diseases 0.000 claims abstract 2
- 108010057266 Type A Botulinum Toxins Proteins 0.000 claims 7
- 210000003899 penis Anatomy 0.000 claims 6
- 101710117524 Botulinum neurotoxin type B Proteins 0.000 claims 3
- 206010049244 Ankyloglossia congenital Diseases 0.000 claims 2
- 101710117523 Botulinum neurotoxin type C Proteins 0.000 claims 1
- 101710117518 Botulinum neurotoxin type D Proteins 0.000 claims 1
- 101710117520 Botulinum neurotoxin type F Proteins 0.000 claims 1
- 101710117519 Botulinum neurotoxin type G Proteins 0.000 claims 1
- 101710138657 Neurotoxin Proteins 0.000 claims 1
- 108010069023 botulinum toxin type E Proteins 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 239000002581 neurotoxin Substances 0.000 claims 1
- 231100000618 neurotoxin Toxicity 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/548,073 | 2009-08-26 | ||
| US12/548,073 US8147848B2 (en) | 2009-08-26 | 2009-08-26 | Method for treating premature ejaculation with a botulinum neurotoxin |
| PCT/US2010/044959 WO2011028371A1 (en) | 2009-08-26 | 2010-08-10 | Methods of treating chronic neurogenic inflammation using a modified clostridial toxin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2772372A1 CA2772372A1 (en) | 2011-03-10 |
| CA2772372C true CA2772372C (en) | 2016-07-12 |
Family
ID=43127150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2772372A Expired - Fee Related CA2772372C (en) | 2009-08-26 | 2010-08-10 | Methods of treating chronic neurogenic inflammation using a modified clostridial toxin |
Country Status (18)
| Country | Link |
|---|---|
| US (8) | US8147848B2 (enExample) |
| EP (2) | EP2470202B1 (enExample) |
| JP (2) | JP5766699B2 (enExample) |
| KR (1) | KR101612988B1 (enExample) |
| CN (2) | CN103816530B (enExample) |
| AU (2) | AU2010289969B2 (enExample) |
| BR (1) | BR112012004246A2 (enExample) |
| CA (1) | CA2772372C (enExample) |
| CY (1) | CY1114792T1 (enExample) |
| DK (2) | DK2470202T3 (enExample) |
| ES (2) | ES2564677T3 (enExample) |
| IN (1) | IN2012DN02210A (enExample) |
| MX (2) | MX349947B (enExample) |
| PL (1) | PL2470202T3 (enExample) |
| PT (1) | PT2470202E (enExample) |
| RU (1) | RU2568844C2 (enExample) |
| SI (1) | SI2470202T1 (enExample) |
| WO (1) | WO2011028371A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8147848B2 (en) | 2009-08-26 | 2012-04-03 | Allergan, Inc. | Method for treating premature ejaculation with a botulinum neurotoxin |
| US20120251518A1 (en) * | 2011-03-29 | 2012-10-04 | Allergan, Inc. | Endopeptidase Treatment of Sexual Dysfunction Disorders |
| US20130066148A1 (en) * | 2011-09-12 | 2013-03-14 | Kang Seon Cho | Method of augmenting glans |
| EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
| EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
| ES2660901T3 (es) | 2012-04-13 | 2018-03-26 | Lubrizol Advanced Materials, Inc. | Compuestos que inhiben la exocitosis neuronal (II) |
| US9764010B2 (en) * | 2012-08-24 | 2017-09-19 | Allergan, Inc. | Method for treating premature ejaculation with a neurotoxin |
| DK3188706T3 (da) * | 2014-09-02 | 2020-01-20 | American Silver Llc | Botulinumtoksin og kolloide sølvpartikler |
| RU2565104C1 (ru) * | 2014-10-24 | 2015-10-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России) | Способ лечения преждевременной эякуляции |
| AU2018270092C1 (en) * | 2017-05-18 | 2026-01-08 | Revance Therapeutics, Inc. | Methods of treatment for cervical dystonia |
| WO2018220232A1 (en) * | 2017-06-02 | 2018-12-06 | Universite De Versailles-St Quentin En Yvelines | Pharmaceutical combination product comprising botulinum toxin for the treatment of erectile dysfunction |
| US12102556B2 (en) | 2022-05-31 | 2024-10-01 | Max Azevedo | System and method for fallopian birth control |
| US12337014B1 (en) | 2024-06-17 | 2025-06-24 | Enrico Guarino | Intracavernosal gel infusion system with neurotoxin modulation for erectile function |
| WO2026118698A1 (en) * | 2024-12-03 | 2026-06-11 | Obigen Pharma, Inc. | Novel use of clostridium botulinum toxin type a for treatment of glabellar lines |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9120306D0 (en) | 1991-09-24 | 1991-11-06 | Graham Herbert K | Method and compositions for the treatment of cerebral palsy |
| US5437291A (en) | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| US5427291A (en) | 1993-09-21 | 1995-06-27 | Smith; David S. | Ski carrier and method employing same |
| DE69434535T2 (de) | 1993-12-28 | 2006-07-20 | Allergan, Inc., Irvine | Toxische Komponente der Botulinumtoxine zur Modulation cholinergisch kontrollierter Sekretionen |
| US5766605A (en) | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| CN1123680A (zh) * | 1994-11-18 | 1996-06-05 | 吕建京 | 一种对于肺脾肾虚有良好功效的保健品及其制造方法 |
| ATE320815T1 (de) | 1997-07-15 | 2006-04-15 | Univ Colorado | Verwendung einer neurotoxintherapie zur behandlung von prostata erkrankungen |
| US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| US6593335B1 (en) | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| US6727283B2 (en) | 1998-10-13 | 2004-04-27 | Pfizer Inc. | Sertraline oral concentrate |
| CN1146866C (zh) * | 1998-11-17 | 2004-04-21 | 阿尔卑斯电气株式会社 | 浮起式磁头的冠顶形成方法及冠顶形成装置 |
| FR2793689B1 (fr) | 1999-05-19 | 2001-08-24 | Pf Medicament | Dispositif transdermique pour l'administration de testosterone ou d'un de ses derives |
| US20060216313A1 (en) * | 1999-08-10 | 2006-09-28 | Allergan, Inc. | Methods for treating a stricture with a botulinum toxin |
| RU2180591C2 (ru) * | 1999-12-24 | 2002-03-20 | Государственное научное предприятие Московский научно-исследовательский институт психиатрии МЗ РФ | Средство для лечения сексуальных дисфункций у мужчин |
| US6495154B1 (en) | 2000-11-21 | 2002-12-17 | Vivus Inc. | On demand administration of clomipramine and salts thereof to treat premature ejaculation |
| US20020086036A1 (en) | 2000-12-05 | 2002-07-04 | Allergan Sales, Inc. | Methods for treating hyperhidrosis |
| NZ528935A (en) | 2001-03-16 | 2004-10-29 | Dmi Biosciences Inc | Method of delaying ejaculation |
| CZ20032644A3 (en) | 2001-03-29 | 2004-06-16 | Bristol-Myers Squibb Company | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors |
| US20030113349A1 (en) | 2001-12-18 | 2003-06-19 | Coleman William P. | Topically applied clostridium botulinum toxin compositions and treatment methods |
| DK1474143T3 (da) * | 2002-01-25 | 2009-01-26 | Modular Properties Ltd | Fremgangsmåder og sammensætninger til bahandling af mandlig erektil dysfunktion |
| US6776991B2 (en) * | 2002-06-26 | 2004-08-17 | Allergan, Inc. | Methods for treating priapism |
| US20040009180A1 (en) | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
| TW200418838A (en) * | 2002-09-18 | 2004-10-01 | Bristol Myers Squibb Co | Compounds for the treatment of premature ejaculation |
| WO2005072433A2 (en) * | 2004-01-26 | 2005-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Toxin induced sympathectomy |
| US20060100584A1 (en) | 2004-08-10 | 2006-05-11 | Orest Olejnik | Needleless microprotrusion elastoplast system |
| US20080220021A1 (en) | 2005-02-14 | 2008-09-11 | Pankaj Modi | Topical Botulinum Toxin Compositions for the Treatment of Hyperhidrosis |
| CN1682810A (zh) * | 2005-02-22 | 2005-10-19 | 黄资源 | 一种治疗前列腺疾病的前列外敷散 |
| KR20070110402A (ko) | 2005-03-03 | 2007-11-16 | 레반스 테라퓨틱스 | 보툴리눔 독소의 국소 적용 및 경피 전달을 위한 조성물 및방법 |
| WO2007059528A2 (en) | 2005-11-17 | 2007-05-24 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins |
| US7445783B2 (en) | 2006-10-30 | 2008-11-04 | Cappellos, Inc. | Topical and transdermal treatments using urea formulations |
| CN101848702B (zh) | 2006-12-01 | 2013-07-17 | 安特里奥公司 | 两亲实体纳米粒子 |
| US20090005319A1 (en) * | 2007-07-01 | 2009-01-01 | Barone Jr Frank V | Topical compositions for delaying ejaculation and methods of using the same |
| US20090093547A1 (en) * | 2007-10-09 | 2009-04-09 | Sciele Pharma, Inc. | Compositions and Methods for Treating Premature Ejaculation |
| CA2703370A1 (en) | 2007-10-23 | 2009-04-30 | Allergan, Inc. | Methods of treating urogenital-neurological disorders using modified clostridial toxins |
| US8147848B2 (en) | 2009-08-26 | 2012-04-03 | Allergan, Inc. | Method for treating premature ejaculation with a botulinum neurotoxin |
| US9049616B2 (en) | 2012-03-29 | 2015-06-02 | Broadcom Corporation | Session recovery after network coordinator or AP restart for single user, multiple user, multiple access, and/or MIMO wireless communications |
| US9764010B2 (en) | 2012-08-24 | 2017-09-19 | Allergan, Inc. | Method for treating premature ejaculation with a neurotoxin |
-
2009
- 2009-08-26 US US12/548,073 patent/US8147848B2/en not_active Expired - Fee Related
-
2010
- 2010-08-10 PT PT107429938T patent/PT2470202E/pt unknown
- 2010-08-10 BR BR112012004246A patent/BR112012004246A2/pt not_active Application Discontinuation
- 2010-08-10 DK DK10742993.8T patent/DK2470202T3/da active
- 2010-08-10 KR KR1020127007553A patent/KR101612988B1/ko not_active Expired - Fee Related
- 2010-08-10 PL PL10742993T patent/PL2470202T3/pl unknown
- 2010-08-10 WO PCT/US2010/044959 patent/WO2011028371A1/en not_active Ceased
- 2010-08-10 EP EP10742993.8A patent/EP2470202B1/en not_active Not-in-force
- 2010-08-10 DK DK13188887.7T patent/DK2708239T3/en active
- 2010-08-10 IN IN2210DEN2012 patent/IN2012DN02210A/en unknown
- 2010-08-10 EP EP13188887.7A patent/EP2708239B1/en not_active Not-in-force
- 2010-08-10 ES ES13188887.7T patent/ES2564677T3/es active Active
- 2010-08-10 SI SI201030508T patent/SI2470202T1/sl unknown
- 2010-08-10 MX MX2014001306A patent/MX349947B/es unknown
- 2010-08-10 MX MX2012002378A patent/MX2012002378A/es active IP Right Grant
- 2010-08-10 ES ES10742993.8T patent/ES2446969T3/es active Active
- 2010-08-10 AU AU2010289969A patent/AU2010289969B2/en not_active Ceased
- 2010-08-10 CN CN201410067182.4A patent/CN103816530B/zh not_active Expired - Fee Related
- 2010-08-10 CA CA2772372A patent/CA2772372C/en not_active Expired - Fee Related
- 2010-08-10 RU RU2012110324/15A patent/RU2568844C2/ru active
- 2010-08-10 JP JP2012526812A patent/JP5766699B2/ja not_active Expired - Fee Related
- 2010-08-10 CN CN201080048073.8A patent/CN102802663B/zh not_active Expired - Fee Related
-
2012
- 2012-02-22 US US13/402,755 patent/US8329193B2/en not_active Expired - Fee Related
- 2012-10-18 US US13/654,808 patent/US8617570B2/en not_active Expired - Fee Related
-
2013
- 2013-11-15 US US14/081,993 patent/US8916177B2/en not_active Expired - Fee Related
-
2014
- 2014-01-29 CY CY20141100075T patent/CY1114792T1/el unknown
- 2014-11-06 US US14/534,913 patent/US9186395B2/en not_active Expired - Fee Related
-
2015
- 2015-06-17 JP JP2015122108A patent/JP6078108B2/ja not_active Expired - Fee Related
- 2015-08-14 AU AU2015213381A patent/AU2015213381B2/en not_active Ceased
- 2015-11-16 US US14/942,424 patent/US9457069B2/en not_active Expired - Fee Related
-
2016
- 2016-10-03 US US15/283,734 patent/US9907841B2/en not_active Expired - Fee Related
-
2018
- 2018-03-02 US US15/910,417 patent/US10420823B2/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150807 |
|
| MKLA | Lapsed |
Effective date: 20210810 |