MX349947B - Metodos de tratamiento de inflamacion neurogenica cronica usando una toxina clostridial modificada. - Google Patents
Metodos de tratamiento de inflamacion neurogenica cronica usando una toxina clostridial modificada.Info
- Publication number
- MX349947B MX349947B MX2014001306A MX2014001306A MX349947B MX 349947 B MX349947 B MX 349947B MX 2014001306 A MX2014001306 A MX 2014001306A MX 2014001306 A MX2014001306 A MX 2014001306A MX 349947 B MX349947 B MX 349947B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- clostridial toxin
- treating chronic
- modified clostridial
- neurogenic inflammation
- Prior art date
Links
- 208000007920 Neurogenic Inflammation Diseases 0.000 title 1
- 230000001684 chronic effect Effects 0.000 title 1
- 231100001102 clostridial toxin Toxicity 0.000 title 1
- 108030001720 Bontoxilysin Proteins 0.000 abstract 1
- 108010055044 Tetanus Toxin Proteins 0.000 abstract 1
- 231100001103 botulinum neurotoxin Toxicity 0.000 abstract 1
- 206010036596 premature ejaculation Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a método para prolongar el tiempo de clímax en un paciente con necesidad del mismo, como son los métodos para tratar la eyaculación precoz mediante la administración local de una neurotoxina clostridial, tal como una neurotoxina botulínica, al paciente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/548,073 US8147848B2 (en) | 2009-08-26 | 2009-08-26 | Method for treating premature ejaculation with a botulinum neurotoxin |
| PCT/US2010/044959 WO2011028371A1 (en) | 2009-08-26 | 2010-08-10 | Methods of treating chronic neurogenic inflammation using a modified clostridial toxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX349947B true MX349947B (es) | 2017-08-22 |
Family
ID=43127150
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012002378A MX2012002378A (es) | 2009-08-26 | 2010-08-10 | Metodos de tratamiento de inflamacion neurogenica cronica usando una toxina clostridial modificada. |
| MX2014001306A MX349947B (es) | 2009-08-26 | 2010-08-10 | Metodos de tratamiento de inflamacion neurogenica cronica usando una toxina clostridial modificada. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012002378A MX2012002378A (es) | 2009-08-26 | 2010-08-10 | Metodos de tratamiento de inflamacion neurogenica cronica usando una toxina clostridial modificada. |
Country Status (18)
| Country | Link |
|---|---|
| US (8) | US8147848B2 (es) |
| EP (2) | EP2470202B1 (es) |
| JP (2) | JP5766699B2 (es) |
| KR (1) | KR101612988B1 (es) |
| CN (2) | CN102802663B (es) |
| AU (2) | AU2010289969B2 (es) |
| BR (1) | BR112012004246A2 (es) |
| CA (1) | CA2772372C (es) |
| CY (1) | CY1114792T1 (es) |
| DK (2) | DK2470202T3 (es) |
| ES (2) | ES2446969T3 (es) |
| IN (1) | IN2012DN02210A (es) |
| MX (2) | MX2012002378A (es) |
| PL (1) | PL2470202T3 (es) |
| PT (1) | PT2470202E (es) |
| RU (1) | RU2568844C2 (es) |
| SI (1) | SI2470202T1 (es) |
| WO (1) | WO2011028371A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8147848B2 (en) | 2009-08-26 | 2012-04-03 | Allergan, Inc. | Method for treating premature ejaculation with a botulinum neurotoxin |
| US20120251518A1 (en) * | 2011-03-29 | 2012-10-04 | Allergan, Inc. | Endopeptidase Treatment of Sexual Dysfunction Disorders |
| US20130066148A1 (en) * | 2011-09-12 | 2013-03-14 | Kang Seon Cho | Method of augmenting glans |
| EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
| EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
| AU2013246882B2 (en) | 2012-04-13 | 2017-10-19 | Lubrizol Advanced Materials, Inc. | Compounds which inhibit neuronal exocytosis (II) |
| EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| US9764010B2 (en) | 2012-08-24 | 2017-09-19 | Allergan, Inc. | Method for treating premature ejaculation with a neurotoxin |
| EP3188706B1 (en) * | 2014-09-02 | 2019-10-09 | American Silver, LLC | Botulinum toxin and colloidal silver particles |
| RU2565104C1 (ru) * | 2014-10-24 | 2015-10-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России) | Способ лечения преждевременной эякуляции |
| WO2018213710A1 (en) * | 2017-05-18 | 2018-11-22 | Revance Therapeutics, Inc. | Methods of treatment for cervical dystonia |
| WO2018220232A1 (en) * | 2017-06-02 | 2018-12-06 | Universite De Versailles-St Quentin En Yvelines | Pharmaceutical combination product comprising botulinum toxin for the treatment of erectile dysfunction |
| US12102556B2 (en) | 2022-05-31 | 2024-10-01 | Max Azevedo | System and method for fallopian birth control |
| US12337014B1 (en) | 2024-06-17 | 2025-06-24 | Enrico Guarino | Intracavernosal gel infusion system with neurotoxin modulation for erectile function |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9120306D0 (en) | 1991-09-24 | 1991-11-06 | Graham Herbert K | Method and compositions for the treatment of cerebral palsy |
| US5437291A (en) | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| US5427291A (en) | 1993-09-21 | 1995-06-27 | Smith; David S. | Ski carrier and method employing same |
| ES2159624T3 (es) | 1993-12-28 | 2001-10-16 | Allergan Sales Inc | Toxinas botulinicas para el tratamiento de la hiperhidrosis. |
| US5766605A (en) | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| CN1123680A (zh) * | 1994-11-18 | 1996-06-05 | 吕建京 | 一种对于肺脾肾虚有良好功效的保健品及其制造方法 |
| EP1658858B2 (en) | 1997-07-15 | 2014-03-26 | The Regents of the University of Colorado | Use of botulinum toxin for the treatment of recalcitrant voiding dysfunction |
| US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| US6593335B1 (en) | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| US6727283B2 (en) | 1998-10-13 | 2004-04-27 | Pfizer Inc. | Sertraline oral concentrate |
| CN1146866C (zh) * | 1998-11-17 | 2004-04-21 | 阿尔卑斯电气株式会社 | 浮起式磁头的冠顶形成方法及冠顶形成装置 |
| FR2793689B1 (fr) | 1999-05-19 | 2001-08-24 | Pf Medicament | Dispositif transdermique pour l'administration de testosterone ou d'un de ses derives |
| US20060216313A1 (en) * | 1999-08-10 | 2006-09-28 | Allergan, Inc. | Methods for treating a stricture with a botulinum toxin |
| RU2180591C2 (ru) * | 1999-12-24 | 2002-03-20 | Государственное научное предприятие Московский научно-исследовательский институт психиатрии МЗ РФ | Средство для лечения сексуальных дисфункций у мужчин |
| US6495154B1 (en) | 2000-11-21 | 2002-12-17 | Vivus Inc. | On demand administration of clomipramine and salts thereof to treat premature ejaculation |
| US20020086036A1 (en) | 2000-12-05 | 2002-07-04 | Allergan Sales, Inc. | Methods for treating hyperhidrosis |
| CA2758923A1 (en) | 2001-03-16 | 2002-09-26 | Dmi Biosciences, Inc. | Use of tramadol to delay ejaculation |
| JP2004531506A (ja) | 2001-03-29 | 2004-10-14 | ブリストル−マイヤーズ スクイブ カンパニー | 選択的なセロトニン再取り込みインヒビターとしてのシクロプロピルインドール誘導体 |
| US20030113349A1 (en) | 2001-12-18 | 2003-06-19 | Coleman William P. | Topically applied clostridium botulinum toxin compositions and treatment methods |
| DE60323332D1 (de) * | 2002-01-25 | 2008-10-16 | Modular Properties Ltd | Verfahren und zusammensetzungen zur behandlung der männlichen erektionsstörung |
| US6776991B2 (en) * | 2002-06-26 | 2004-08-17 | Allergan, Inc. | Methods for treating priapism |
| US20040009180A1 (en) | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
| TW200418838A (en) * | 2002-09-18 | 2004-10-01 | Bristol Myers Squibb Co | Compounds for the treatment of premature ejaculation |
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| ZA200707352B (en) | 2005-03-03 | 2009-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| EP1948230A4 (en) | 2005-11-17 | 2010-03-10 | Revance Therapeutics Inc | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF BOTULIN TOXINES WITH A REDUCED NUMBER OF NON-TOXIC PROTEINS |
| US7445783B2 (en) | 2006-10-30 | 2008-11-04 | Cappellos, Inc. | Topical and transdermal treatments using urea formulations |
| WO2008070538A2 (en) | 2006-12-01 | 2008-06-12 | Anterios, Inc. | Micellar nanoparticles comprising botulinum toxin |
| US20090005319A1 (en) * | 2007-07-01 | 2009-01-01 | Barone Jr Frank V | Topical compositions for delaying ejaculation and methods of using the same |
| US20090093547A1 (en) * | 2007-10-09 | 2009-04-09 | Sciele Pharma, Inc. | Compositions and Methods for Treating Premature Ejaculation |
| AU2008316989A1 (en) | 2007-10-23 | 2009-04-30 | Allergan, Inc. | Methods of treating urogenital-neurological disorders using modified clostridial toxins |
| US8147848B2 (en) | 2009-08-26 | 2012-04-03 | Allergan, Inc. | Method for treating premature ejaculation with a botulinum neurotoxin |
| US9049616B2 (en) | 2012-03-29 | 2015-06-02 | Broadcom Corporation | Session recovery after network coordinator or AP restart for single user, multiple user, multiple access, and/or MIMO wireless communications |
| US9764010B2 (en) | 2012-08-24 | 2017-09-19 | Allergan, Inc. | Method for treating premature ejaculation with a neurotoxin |
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2009
- 2009-08-26 US US12/548,073 patent/US8147848B2/en not_active Expired - Fee Related
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2010
- 2010-08-10 EP EP10742993.8A patent/EP2470202B1/en not_active Not-in-force
- 2010-08-10 MX MX2012002378A patent/MX2012002378A/es active IP Right Grant
- 2010-08-10 CN CN201080048073.8A patent/CN102802663B/zh not_active Expired - Fee Related
- 2010-08-10 ES ES10742993.8T patent/ES2446969T3/es active Active
- 2010-08-10 CN CN201410067182.4A patent/CN103816530B/zh not_active Expired - Fee Related
- 2010-08-10 IN IN2210DEN2012 patent/IN2012DN02210A/en unknown
- 2010-08-10 PT PT107429938T patent/PT2470202E/pt unknown
- 2010-08-10 RU RU2012110324/15A patent/RU2568844C2/ru active
- 2010-08-10 SI SI201030508T patent/SI2470202T1/sl unknown
- 2010-08-10 AU AU2010289969A patent/AU2010289969B2/en not_active Ceased
- 2010-08-10 MX MX2014001306A patent/MX349947B/es unknown
- 2010-08-10 DK DK10742993.8T patent/DK2470202T3/da active
- 2010-08-10 PL PL10742993T patent/PL2470202T3/pl unknown
- 2010-08-10 JP JP2012526812A patent/JP5766699B2/ja not_active Expired - Fee Related
- 2010-08-10 EP EP13188887.7A patent/EP2708239B1/en active Active
- 2010-08-10 ES ES13188887.7T patent/ES2564677T3/es active Active
- 2010-08-10 CA CA2772372A patent/CA2772372C/en not_active Expired - Fee Related
- 2010-08-10 WO PCT/US2010/044959 patent/WO2011028371A1/en not_active Ceased
- 2010-08-10 BR BR112012004246A patent/BR112012004246A2/pt not_active Application Discontinuation
- 2010-08-10 KR KR1020127007553A patent/KR101612988B1/ko not_active Expired - Fee Related
- 2010-08-10 DK DK13188887.7T patent/DK2708239T3/en active
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2012
- 2012-02-22 US US13/402,755 patent/US8329193B2/en not_active Expired - Fee Related
- 2012-10-18 US US13/654,808 patent/US8617570B2/en not_active Expired - Fee Related
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2013
- 2013-11-15 US US14/081,993 patent/US8916177B2/en not_active Expired - Fee Related
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2014
- 2014-01-29 CY CY20141100075T patent/CY1114792T1/el unknown
- 2014-11-06 US US14/534,913 patent/US9186395B2/en not_active Expired - Fee Related
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2015
- 2015-06-17 JP JP2015122108A patent/JP6078108B2/ja not_active Expired - Fee Related
- 2015-08-14 AU AU2015213381A patent/AU2015213381B2/en not_active Ceased
- 2015-11-16 US US14/942,424 patent/US9457069B2/en not_active Expired - Fee Related
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2016
- 2016-10-03 US US15/283,734 patent/US9907841B2/en not_active Expired - Fee Related
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2018
- 2018-03-02 US US15/910,417 patent/US10420823B2/en not_active Expired - Fee Related
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