CA2769349A1 - Antitumor 1,2-diphenylpyrrole compounds and their preparation process - Google Patents
Antitumor 1,2-diphenylpyrrole compounds and their preparation process Download PDFInfo
- Publication number
- CA2769349A1 CA2769349A1 CA2769349A CA2769349A CA2769349A1 CA 2769349 A1 CA2769349 A1 CA 2769349A1 CA 2769349 A CA2769349 A CA 2769349A CA 2769349 A CA2769349 A CA 2769349A CA 2769349 A1 CA2769349 A1 CA 2769349A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- group
- halogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22964309P | 2009-07-29 | 2009-07-29 | |
EP09166668.5 | 2009-07-29 | ||
US61/229,643 | 2009-07-29 | ||
EP09166668A EP2284154A1 (en) | 2009-07-29 | 2009-07-29 | Antitumor 1,2-diphenylpyrrole compounds and their preparation process |
PCT/EP2010/060983 WO2011012660A1 (en) | 2009-07-29 | 2010-07-28 | Antitumor 1,2-diphenylpyrrole compounds and their preparation process |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2769349A1 true CA2769349A1 (en) | 2011-02-03 |
Family
ID=41130615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2769349A Abandoned CA2769349A1 (en) | 2009-07-29 | 2010-07-28 | Antitumor 1,2-diphenylpyrrole compounds and their preparation process |
Country Status (5)
Country | Link |
---|---|
US (1) | US20120196915A1 (ja) |
EP (2) | EP2284154A1 (ja) |
JP (1) | JP2013500310A (ja) |
CA (1) | CA2769349A1 (ja) |
WO (1) | WO2011012660A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1799212A2 (en) * | 2004-10-13 | 2007-06-27 | PTC Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
JPH11246403A (ja) * | 1997-12-24 | 1999-09-14 | Sankyo Co Ltd | 腫瘍増殖の予防又は抑制剤 |
NZ333399A (en) | 1997-12-24 | 2000-05-26 | Sankyo Co | Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis |
JP2010522763A (ja) * | 2007-03-26 | 2010-07-08 | ユニヴァーシティー オブ サザン カリフォルニア | Erストレスを刺激することによりアポトーシスを誘導するための方法および化合物 |
-
2009
- 2009-07-29 EP EP09166668A patent/EP2284154A1/en not_active Withdrawn
-
2010
- 2010-07-28 US US13/387,634 patent/US20120196915A1/en not_active Abandoned
- 2010-07-28 EP EP10739347.2A patent/EP2459532B1/en not_active Not-in-force
- 2010-07-28 WO PCT/EP2010/060983 patent/WO2011012660A1/en active Application Filing
- 2010-07-28 JP JP2012522167A patent/JP2013500310A/ja active Pending
- 2010-07-28 CA CA2769349A patent/CA2769349A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2013500310A (ja) | 2013-01-07 |
WO2011012660A1 (en) | 2011-02-03 |
EP2284154A1 (en) | 2011-02-16 |
US20120196915A1 (en) | 2012-08-02 |
EP2459532B1 (en) | 2014-04-09 |
EP2459532A1 (en) | 2012-06-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |
Effective date: 20150728 |