CA2768940C - Isoform selective phospholipase d inhibitors - Google Patents
Isoform selective phospholipase d inhibitors Download PDFInfo
- Publication number
- CA2768940C CA2768940C CA2768940A CA2768940A CA2768940C CA 2768940 C CA2768940 C CA 2768940C CA 2768940 A CA2768940 A CA 2768940A CA 2768940 A CA2768940 A CA 2768940A CA 2768940 C CA2768940 C CA 2768940C
- Authority
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- Canada
- Prior art keywords
- optionally substituted
- cycloalkyl
- alkyl
- compound
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000009750 upstream signaling Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22849209P | 2009-07-24 | 2009-07-24 | |
| US61/228,492 | 2009-07-24 | ||
| PCT/US2010/043045 WO2011011680A1 (en) | 2009-07-24 | 2010-07-23 | Isoform selective phospholipase d inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2768940A1 CA2768940A1 (en) | 2011-01-27 |
| CA2768940C true CA2768940C (en) | 2018-03-13 |
Family
ID=43499428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2768940A Expired - Fee Related CA2768940C (en) | 2009-07-24 | 2010-07-23 | Isoform selective phospholipase d inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9127005B2 (enExample) |
| EP (1) | EP2456307B1 (enExample) |
| JP (1) | JP2013500260A (enExample) |
| KR (1) | KR20120090034A (enExample) |
| CN (1) | CN102573474A (enExample) |
| AU (1) | AU2010275526A1 (enExample) |
| BR (1) | BR112012001586A2 (enExample) |
| CA (1) | CA2768940C (enExample) |
| IL (1) | IL217720A0 (enExample) |
| IN (1) | IN2012DN01661A (enExample) |
| MX (1) | MX2012001064A (enExample) |
| RU (1) | RU2012106657A (enExample) |
| SG (1) | SG178102A1 (enExample) |
| WO (1) | WO2011011680A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2012106657A (ru) | 2009-07-24 | 2013-08-27 | Вандербилт Юниверсити | Изоформы избирательного ингибитора фосфолипазы d |
| US9453017B2 (en) | 2011-09-30 | 2016-09-27 | Vanderbilt University | Antiviral therapies with phospholipase D inhibitors |
| US20140163055A1 (en) * | 2012-12-11 | 2014-06-12 | Vanderbilt University | Methods and compositions of treating hiv infection |
| EP2931277A4 (en) * | 2012-12-11 | 2016-07-27 | Univ Vanderbilt | PROCEDURE AND COMPOSITIONS WITH ACTIVE INHIBITORS AND / OR PHOSPHOLIPASE D INHIBITORS |
| CN114778844A (zh) * | 2022-03-07 | 2022-07-22 | 天津市肿瘤医院（天津医科大学肿瘤医院） | Pld1作为评估肿瘤患者对于化疗药物敏感性的分子标志物的用途 |
| EP4541791A4 (en) * | 2022-06-16 | 2026-06-24 | Shionogi & Co | Dihydrooxadiazinone compound and pharmaceutical use thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1281502B1 (it) | 1995-06-13 | 1998-02-18 | Sardinian Antiviral Research C | Impiego di un inibitore non nucleosidico della trascrittasi inversa in associazione con inibitori nucleosidici per il trattamento della |
| US6187559B1 (en) | 1997-08-28 | 2001-02-13 | Novartis Ag | Phospholipase D gene |
| AU6262601A (en) | 2000-05-25 | 2001-12-03 | Ben Williger | Phospholipase d effectors for therapy and screening |
| US6482829B2 (en) * | 2000-06-08 | 2002-11-19 | Hoffmann-La Roche Inc. | Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor |
| US20060172363A1 (en) | 2002-09-18 | 2006-08-03 | Postech Foundation | Peptide complexes containing phospholipase d |
| BRPI0517423A (pt) * | 2004-12-27 | 2008-10-07 | Astrazeneca Ab | composto, composição farmacêutica, método para o tratamento ou prevenção de distúrbios neurológicos e psiquiátricos associados com disfunção do glutamato em um animal, e, uso em um composto |
| AU2006233101B2 (en) | 2005-02-23 | 2011-09-01 | Arbiser, Jack | Honokiol derivatives for the treatment of proliferative disorders |
| KR101077295B1 (ko) * | 2006-05-18 | 2011-10-26 | 에프. 호프만-라 로슈 아게 | 아데노신 ａ2ｂ 수용체 길항물질로서의 티아졸로-피라미딘/피리딘 우레아 유도체 |
| US20100009970A1 (en) | 2008-03-19 | 2010-01-14 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| WO2010037081A1 (en) | 2008-09-29 | 2010-04-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific spiro-piperidine compounds |
| EP2413993B1 (en) | 2009-03-31 | 2020-07-15 | Sanofi-Aventis Deutschland GmbH | Drug delivery device body |
| WO2010138869A1 (en) | 2009-05-29 | 2010-12-02 | The Trustees Of Columbia University In The City Of New York | Modulation of phospholipase d for the treatment of neurodegenerative disorders |
| RU2012106657A (ru) | 2009-07-24 | 2013-08-27 | Вандербилт Юниверсити | Изоформы избирательного ингибитора фосфолипазы d |
| US9149445B2 (en) | 2009-07-27 | 2015-10-06 | The Trustees Of Princeton University | Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections |
| US9453017B2 (en) | 2011-09-30 | 2016-09-27 | Vanderbilt University | Antiviral therapies with phospholipase D inhibitors |
| US20140163055A1 (en) | 2012-12-11 | 2014-06-12 | Vanderbilt University | Methods and compositions of treating hiv infection |
| EP2931277A4 (en) | 2012-12-11 | 2016-07-27 | Univ Vanderbilt | PROCEDURE AND COMPOSITIONS WITH ACTIVE INHIBITORS AND / OR PHOSPHOLIPASE D INHIBITORS |
-
2010
- 2010-07-23 RU RU2012106657/04A patent/RU2012106657A/ru not_active Application Discontinuation
- 2010-07-23 IN IN1661DEN2012 patent/IN2012DN01661A/en unknown
- 2010-07-23 WO PCT/US2010/043045 patent/WO2011011680A1/en not_active Ceased
- 2010-07-23 BR BRBR112012001586-9A patent/BR112012001586A2/pt not_active IP Right Cessation
- 2010-07-23 CA CA2768940A patent/CA2768940C/en not_active Expired - Fee Related
- 2010-07-23 EP EP10802947.1A patent/EP2456307B1/en not_active Not-in-force
- 2010-07-23 SG SG2012005252A patent/SG178102A1/en unknown
- 2010-07-23 US US13/386,397 patent/US9127005B2/en not_active Expired - Fee Related
- 2010-07-23 AU AU2010275526A patent/AU2010275526A1/en not_active Abandoned
- 2010-07-23 JP JP2012521826A patent/JP2013500260A/ja active Pending
- 2010-07-23 MX MX2012001064A patent/MX2012001064A/es not_active Application Discontinuation
- 2010-07-23 KR KR1020127004698A patent/KR20120090034A/ko not_active Withdrawn
- 2010-07-23 CN CN2010800423044A patent/CN102573474A/zh active Pending
-
2012
- 2012-01-24 IL IL217720A patent/IL217720A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2456307A1 (en) | 2012-05-30 |
| US20120214832A1 (en) | 2012-08-23 |
| WO2011011680A1 (en) | 2011-01-27 |
| IL217720A0 (en) | 2012-03-29 |
| CN102573474A (zh) | 2012-07-11 |
| US9127005B2 (en) | 2015-09-08 |
| EP2456307B1 (en) | 2016-11-02 |
| MX2012001064A (es) | 2012-07-17 |
| EP2456307A4 (en) | 2013-01-16 |
| SG178102A1 (en) | 2012-03-29 |
| JP2013500260A (ja) | 2013-01-07 |
| IN2012DN01661A (enExample) | 2015-06-05 |
| CA2768940A1 (en) | 2011-01-27 |
| BR112012001586A2 (pt) | 2015-09-01 |
| KR20120090034A (ko) | 2012-08-16 |
| RU2012106657A (ru) | 2013-08-27 |
| AU2010275526A1 (en) | 2012-03-15 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20150722 |
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| MKLA | Lapsed |
Effective date: 20200831 |