CA2768727C - Particulate tissue graft with components of differing density and methods of making and using the same - Google Patents
Particulate tissue graft with components of differing density and methods of making and using the same Download PDFInfo
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- CA2768727C CA2768727C CA2768727A CA2768727A CA2768727C CA 2768727 C CA2768727 C CA 2768727C CA 2768727 A CA2768727 A CA 2768727A CA 2768727 A CA2768727 A CA 2768727A CA 2768727 C CA2768727 C CA 2768727C
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/26—Materials or treatment for tissue regeneration for kidney reconstruction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
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Priority Applications (1)
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|---|---|---|---|
| CA2986673A CA2986673C (en) | 2009-07-22 | 2010-07-21 | Particulate tissue graft with components of differing density and methods of making and using the same |
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| US12/507,311 | 2009-07-22 | ||
| US12/507,311 US8652500B2 (en) | 2009-07-22 | 2009-07-22 | Particulate tissue graft with components of differing density and methods of making and using the same |
| PCT/US2010/042701 WO2011011484A2 (en) | 2009-07-22 | 2010-07-21 | Particulate tissue graft with components of differing density and methods of making and using the same |
Related Child Applications (1)
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| CA2986673A Division CA2986673C (en) | 2009-07-22 | 2010-07-21 | Particulate tissue graft with components of differing density and methods of making and using the same |
Publications (2)
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| CA2768727A1 CA2768727A1 (en) | 2011-01-27 |
| CA2768727C true CA2768727C (en) | 2018-01-16 |
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| CA2986673A Active CA2986673C (en) | 2009-07-22 | 2010-07-21 | Particulate tissue graft with components of differing density and methods of making and using the same |
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| CA2986673A Active CA2986673C (en) | 2009-07-22 | 2010-07-21 | Particulate tissue graft with components of differing density and methods of making and using the same |
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Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7393339B2 (en) | 2003-02-21 | 2008-07-01 | C. R. Bard, Inc. | Multi-lumen catheter with separate distal tips |
| US20040243095A1 (en) | 2003-05-27 | 2004-12-02 | Shekhar Nimkar | Methods and apparatus for inserting multi-lumen spit-tip catheters into a blood vessel |
| US8992454B2 (en) | 2004-06-09 | 2015-03-31 | Bard Access Systems, Inc. | Splitable tip catheter with bioresorbable adhesive |
| EP1765981A4 (en) * | 2004-06-11 | 2007-09-12 | Victorian Tissue Engineering C | WOVEN MATERIAL AND MUSCLE MATRIX |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20150359934A1 (en) * | 2007-05-10 | 2015-12-17 | CorMartix Cardiovascular, Inc. | Articles for Tissue Regeneration with Biodegradable Polymer |
| US8500939B2 (en) | 2007-10-17 | 2013-08-06 | Bard Access Systems, Inc. | Manufacture of split tip catheters |
| US8066660B2 (en) | 2007-10-26 | 2011-11-29 | C. R. Bard, Inc. | Split-tip catheter including lateral distal openings |
| US8292841B2 (en) | 2007-10-26 | 2012-10-23 | C. R. Bard, Inc. | Solid-body catheter including lateral distal openings |
| WO2009059220A1 (en) | 2007-11-01 | 2009-05-07 | C.R. Bard, Inc. | Catheter assembly including triple lumen tip |
| US9579485B2 (en) | 2007-11-01 | 2017-02-28 | C. R. Bard, Inc. | Catheter assembly including a multi-lumen configuration |
| WO2009111069A1 (en) * | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9549805B2 (en) * | 2011-12-20 | 2017-01-24 | Lifecell Corporation | Flowable tissue products |
| EP3549615B1 (en) * | 2011-12-20 | 2020-12-16 | LifeCell Corporation | Sheet tissue products |
| KR102223440B1 (ko) | 2013-02-08 | 2021-03-05 | 아셀, 인크. | 세포외 기질 재료로부터의 생리활성 겔의 제조 방법 |
| USD748252S1 (en) | 2013-02-08 | 2016-01-26 | C. R. Bard, Inc. | Multi-lumen catheter tip |
| AU2014218734B2 (en) * | 2013-02-22 | 2018-03-15 | Allosource | Cartilage mosaic compositions and methods |
| US9878071B2 (en) | 2013-10-16 | 2018-01-30 | Purdue Research Foundation | Collagen compositions and methods of use |
| JP6618898B2 (ja) * | 2013-11-19 | 2019-12-11 | コーネル ユニヴァーシティー | 組織再生のための組織スキャフォールド材料および作製方法 |
| US20150283308A1 (en) * | 2014-04-03 | 2015-10-08 | Cook Biotech, Incorporated | Endoluminal device and method of implanting same |
| US10258768B2 (en) | 2014-07-14 | 2019-04-16 | C. R. Bard, Inc. | Apparatuses, systems, and methods for inserting catheters having enhanced stiffening and guiding features |
| KR20170040809A (ko) * | 2014-08-25 | 2017-04-13 | 에이치엘아이 셀룰러 테라퓨틱스, 엘엘씨 | 세포외 기질 조성물 |
| EP3185922B1 (en) | 2014-08-27 | 2025-04-02 | Purdue Research Foundation | Collagen-based therapeutic delivery systems |
| US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
| WO2016172365A1 (en) | 2015-04-21 | 2016-10-27 | Purdue Research Foundation Office Of Technology Commercialization | Cell-collagen-silica composites and methods of making and using the same |
| WO2016187413A1 (en) | 2015-05-21 | 2016-11-24 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| CN109152635A (zh) * | 2016-03-14 | 2019-01-04 | 雷金蒂斯公司 | 治疗炎性肠病的方法和组合物 |
| US10881555B2 (en) * | 2016-03-30 | 2021-01-05 | Basf Se | Fluid-absorbent article |
| US10537417B2 (en) | 2016-07-07 | 2020-01-21 | Collagen Matrix, Inc. | Density gradient biopolymeric matrix implants |
| JP7242553B2 (ja) | 2017-01-31 | 2023-03-20 | ジェニフィス,インコーポレイテッド | 基質の調製のための方法及び組成物 |
| WO2018200750A1 (en) | 2017-04-25 | 2018-11-01 | Purdue Research Foundation | 3-dimensional (3d) tissue-engineered muscle for tissue restoration |
| AU2019263122B2 (en) | 2018-05-03 | 2022-09-29 | Collplant Ltd. | Dermal fillers and applications thereof |
| CN109513044B (zh) * | 2019-01-29 | 2022-02-18 | 北京颢美细胞基因生物技术有限公司 | 用于微整形的再生组织基质微粒植入剂、制备方法及应用 |
| JP7256395B2 (ja) * | 2019-10-24 | 2023-04-12 | サミー株式会社 | 遊技機 |
| CA3168904A1 (en) | 2020-01-27 | 2021-08-05 | Geniphys, Inc. | Biologic filler for restoring and regenerating tissue |
| US11826490B1 (en) | 2020-12-29 | 2023-11-28 | Acell, Inc. | Extracellular matrix sheet devices with improved mechanical properties and method of making |
| JP2023110424A (ja) * | 2022-01-28 | 2023-08-09 | 国立大学法人信州大学 | 細胞外マトリクス由来の成形体及びその成型体 |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT261800B (de) * | 1966-08-22 | 1968-05-10 | Braun Internat Gmbh B | Verfahren zur Herstellung von röhrenförmigen, glatten bzw. mit einem Gewinde versehenen Gewebe-Blutgefäß-Prothesen |
| US4439521A (en) * | 1981-10-21 | 1984-03-27 | Ontario Cancer Institute | Method for producing self-reproducing mammalian pancreatic islet-like structures |
| US4801299A (en) * | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
| IL74715A0 (en) * | 1984-03-27 | 1985-06-30 | Univ New Jersey Med | Biodegradable matrix and methods for producing same |
| US4829000A (en) * | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
| US4780450A (en) * | 1985-12-20 | 1988-10-25 | The University Of Maryland At Baltimore | Physically stable composition and method of use thereof for osseous repair |
| GB8618374D0 (en) * | 1986-07-28 | 1986-09-03 | Hsc Res Dev Corp | Biological vascular prostheses |
| US4902528A (en) * | 1987-08-12 | 1990-02-20 | Nestec S.A. | Preparation of dried precooked rice product |
| US4776653A (en) | 1987-10-16 | 1988-10-11 | The Merton Company, Ltd. | Amusement device with kaleidoscope viewer |
| US4902508A (en) | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
| US4956178A (en) * | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
| JPH02249556A (ja) * | 1988-10-25 | 1990-10-05 | Takao Yamamuro | 骨修復材および人工骨固定化剤 |
| US5425769A (en) * | 1990-04-23 | 1995-06-20 | Snyders, Jr.; Robert V. | Composition of material for osseous repair |
| US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
| ES2179821T3 (es) | 1991-06-24 | 2003-02-01 | Hcell Technology Inc | Celulas pancreaticas secretoras de hormonas y mantenimiento en cultivo a largo plazo. |
| US5281422A (en) * | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
| US5800537A (en) * | 1992-08-07 | 1998-09-01 | Tissue Engineering, Inc. | Method and construct for producing graft tissue from an extracellular matrix |
| US5275826A (en) * | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
| US5641518A (en) * | 1992-11-13 | 1997-06-24 | Purdue Research Foundation | Method of repairing bone tissue |
| US5352463A (en) | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
| ES2219660T3 (es) * | 1994-03-14 | 2004-12-01 | Cryolife, Inc | Metodos de preparacion de tejidos para implantacion. |
| US5891558A (en) * | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
| US5695998A (en) * | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US6485723B1 (en) * | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
| US5554389A (en) * | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
| WO1996031232A1 (en) * | 1995-04-07 | 1996-10-10 | Purdue Research Foundation | Tissue graft and method for urinary bladder reconstruction |
| US5711969A (en) * | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
| CA2172917A1 (en) * | 1995-06-07 | 1996-12-08 | Hugh R. Mcmullin | Moldable collagen compositions for hard tissue repair and augmentation |
| JPH09122227A (ja) * | 1995-10-31 | 1997-05-13 | Bio Eng Lab:Kk | 医用材料およびその製造方法 |
| JPH09122225A (ja) * | 1995-10-31 | 1997-05-13 | Bio Eng Lab:Kk | 医用材料の原料膜材およびその製造方法 |
| ATE258810T1 (de) | 1995-11-09 | 2004-02-15 | Univ Massachusetts | Wiederherstellung der gewebeoberfläche mit zusammensetzungen aus hydrogel-zellen |
| US5869041A (en) * | 1996-01-12 | 1999-02-09 | The Miriam Hospital | Delivery of bioactive compounds to an organism |
| US5755791A (en) * | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
| US6171344B1 (en) * | 1996-08-16 | 2001-01-09 | Children's Medical Center Corporation | Bladder submucosa seeded with cells for tissue reconstruction |
| EP1955721B1 (en) * | 1996-08-23 | 2014-10-29 | Cook Biotech, Inc. | Collagen-based graft prosthesis |
| WO1998019719A1 (en) * | 1996-11-05 | 1998-05-14 | Purdue Research Foundation | Myocardial graft constructs |
| WO1998025546A1 (en) | 1996-12-10 | 1998-06-18 | Cook Biotech, Inc. | Tubular grafts from purified submucosa |
| CA2272097C (en) * | 1996-12-10 | 2007-02-20 | Purdue Research Foundation | Artificial vascular valves |
| CA2274033C (en) | 1996-12-10 | 2010-05-11 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
| WO1998025545A1 (en) | 1996-12-10 | 1998-06-18 | Cook Biotech, Inc. | Stent grafts containing purified submucosa |
| US5866415A (en) * | 1997-03-25 | 1999-02-02 | Villeneuve; Peter E. | Materials for healing cartilage and bone defects |
| WO1998046165A1 (en) | 1997-04-11 | 1998-10-22 | Cryolife, Inc. | Tissue decellularization |
| ES2175753T3 (es) | 1997-06-27 | 2002-11-16 | Augustinus Bader | Injerto biosintetico y metodo para su produccion. |
| WO1999032607A1 (en) * | 1997-12-23 | 1999-07-01 | Purdue Research Foundation | Biomaterial derived from follicle basement membranes |
| WO1999062427A1 (en) * | 1998-06-05 | 1999-12-09 | Organogenesis Inc. | Bioengineered vascular graft support prostheses |
| CA2342589A1 (en) | 1998-09-11 | 2000-03-23 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
| ES2402739T3 (es) * | 1998-11-19 | 2013-05-08 | Organogenesis Inc. | Constructos tisulares modificados por bioingeniería y métodos para producirlos y utilizarlos |
| JP2000223701A (ja) * | 1999-01-28 | 2000-08-11 | Mitsubishi Electric Corp | 半導体装置およびその製造方法 |
| US6322593B1 (en) * | 1999-04-09 | 2001-11-27 | Sulzer Carbomedics Inc. | Method for treating cross-linked biological tissues |
| EP1187909B1 (en) * | 1999-04-30 | 2005-02-02 | Massachusetts General Hospital | Fabrication of threedimensional vascularized tissue using microfabricated two-dimensional molds |
| AU782297B2 (en) * | 1999-06-30 | 2005-07-14 | Ethicon Inc. | Porous tissue scaffoldings for the repair or regeneration of tissue |
| US6454804B1 (en) * | 1999-10-08 | 2002-09-24 | Bret A. Ferree | Engineered tissue annulus fibrosis augmentation methods and apparatus |
| US6432712B1 (en) | 1999-11-22 | 2002-08-13 | Bioscience Consultants, Llc | Transplantable recellularized and reendothelialized vascular tissue graft |
| US6579538B1 (en) * | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
| US6576265B1 (en) * | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| US20040043006A1 (en) * | 2002-08-27 | 2004-03-04 | Badylak Stephen F. | Tissue regenerative composition |
| DE60009339T2 (de) | 1999-12-22 | 2004-08-19 | Acell, Inc., Cambridge | Zusammensetzung zur gewebsregeneration |
| US20090053279A1 (en) | 1999-12-22 | 2009-02-26 | Badylak Stephen F | Tissue regenerative composition |
| US6376244B1 (en) * | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
| US6479064B1 (en) * | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
| ATE332964T1 (de) | 2000-08-16 | 2006-08-15 | Univ Duke | Mittels gewebetechnologie hergestellte dezellularisierte gegenstände und gewebe |
| US6827966B2 (en) * | 2001-05-30 | 2004-12-07 | Novartis Ag | Diffusion-controllable coatings on medical device |
| CA2452040C (en) | 2001-06-29 | 2011-03-22 | Cook Biotech Incorporated | Porous sponge matrix medical devices and methods |
| US6613348B1 (en) * | 2001-07-31 | 2003-09-02 | Manoj K. Jain | Process of controlling absorbency in collagen flakes |
| EP1446015B1 (en) | 2001-10-18 | 2018-03-14 | Lifecell Corporation | Remodeling of tissues and organs |
| EP2292278B1 (en) | 2001-11-16 | 2013-04-24 | Children's Medical Center Corporation | Augmentation of organ function |
| US6849339B2 (en) * | 2001-11-27 | 2005-02-01 | Guardian Industries Corporation | Composite laminate structures especially useful for automotive trim components, and methods and tie layers employed to make the same |
| US7622299B2 (en) * | 2002-02-22 | 2009-11-24 | University Of Washington | Bioengineered tissue substitutes |
| US6651637B1 (en) * | 2002-10-29 | 2003-11-25 | Transpo Electronics, Inc. | Vehicle ignition system using ignition module with reduced heat generation |
| US20040175366A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
| US8741352B2 (en) * | 2003-08-25 | 2014-06-03 | Cook Biotech Incorporated | Graft materials containing ECM components, and methods for their manufacture |
| US20050175659A1 (en) * | 2004-02-09 | 2005-08-11 | Macomber Laurel R. | Collagen device and method of preparing the same |
| US20050283256A1 (en) * | 2004-02-09 | 2005-12-22 | Codman & Shurtleff, Inc. | Collagen device and method of preparing the same |
| GB2429162B (en) | 2004-03-29 | 2009-03-25 | Cook Biotech Inc | Methods for producing medical graft products with differing regions |
| EP2093256A3 (en) | 2005-07-28 | 2009-10-14 | Carnegie Mellon University | Biocompatible polymers and methods of use |
| WO2007048831A2 (en) | 2005-10-27 | 2007-05-03 | Coloplast A/S | Biodegradable scaffold with ecm material |
| US7838022B2 (en) * | 2006-05-01 | 2010-11-23 | Warsaw Orthopedic, Inc | Malleable implants containing demineralized bone matrix |
| US7771741B2 (en) * | 2006-05-01 | 2010-08-10 | Warsaw Orthopedic, Inc | Demineralized bone matrix devices |
| US20080005250A1 (en) * | 2006-06-30 | 2008-01-03 | Ragip Dogan Oksum | Messaging System and Related Methods |
| US8535719B2 (en) | 2006-07-07 | 2013-09-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biohybrid elastomeric scaffolds and methods of use thereof |
| US20080026032A1 (en) | 2006-07-27 | 2008-01-31 | Zubery Yuval | Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use |
| WO2008109407A2 (en) | 2007-03-02 | 2008-09-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Extracellular matrix-derived gels and related methods |
| US7799793B2 (en) | 2007-04-27 | 2010-09-21 | Medtronic, Inc. | N-alkylated rifampin |
| WO2009076391A2 (en) * | 2007-12-10 | 2009-06-18 | Cook Biotech Incorporated | Medical materials including modified extracellular matrix materials |
| ES2629613T3 (es) * | 2007-12-12 | 2017-08-11 | Mark K. Moser | Seguidor de fuente luminosa |
| CA2728513C (en) * | 2008-06-20 | 2016-03-15 | Cook Biotech Incorporated | Compressible/expandable medical graft products, and methods for applying hemostasis |
| US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
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2009
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2010
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2012
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2017
- 2017-09-28 JP JP2017188962A patent/JP6640808B2/ja not_active Expired - Fee Related
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2018
- 2018-10-12 US US16/158,805 patent/US10898610B2/en active Active
- 2018-11-20 US US16/196,272 patent/US11013829B2/en active Active
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2019
- 2019-07-19 JP JP2019134133A patent/JP2019193877A/ja active Pending
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2020
- 2020-01-21 JP JP2020007232A patent/JP2020058884A/ja active Pending
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