CA2766855A1 - Substituted 2-carboxamide cycloamino ureas - Google Patents
Substituted 2-carboxamide cycloamino ureas Download PDFInfo
- Publication number
- CA2766855A1 CA2766855A1 CA2766855A CA2766855A CA2766855A1 CA 2766855 A1 CA2766855 A1 CA 2766855A1 CA 2766855 A CA2766855 A CA 2766855A CA 2766855 A CA2766855 A CA 2766855A CA 2766855 A1 CA2766855 A1 CA 2766855A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- methyl
- amide
- pyrrolidine
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000003672 ureas Chemical class 0.000 title description 4
- 235000013877 carbamide Nutrition 0.000 title description 3
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- 238000000034 method Methods 0.000 claims description 110
- -1 pyrrolidino, oxo-pyrrolidino, piperidino, piperazin-1-yl Chemical group 0.000 claims description 89
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- 125000001424 substituent group Chemical group 0.000 claims description 37
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- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 125000000623 heterocyclic group Chemical group 0.000 claims description 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 14
- LFEUADMCDRWDRA-UHNVWZDZSA-N (2s,3r)-3-methylpyrrolidine-1,2-dicarboxylic acid Chemical compound C[C@@H]1CCN(C(O)=O)[C@@H]1C(O)=O LFEUADMCDRWDRA-UHNVWZDZSA-N 0.000 claims description 13
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- TVWSZMXMMPFCMN-IUCAKERBSA-N (2S,3S)-3-(morpholin-4-ylmethyl)pyrrolidine-1,2-dicarboxylic acid Chemical compound N1(CCOCC1)C[C@H]1[C@H](N(CC1)C(=O)O)C(=O)O TVWSZMXMMPFCMN-IUCAKERBSA-N 0.000 claims description 4
- NMKJZOUSNLUCPS-UHFFFAOYSA-N 3,3-dimethylpyrrolidine-1,2-dicarboxylic acid Chemical compound CC1(C(N(CC1)C(=O)O)C(=O)O)C NMKJZOUSNLUCPS-UHFFFAOYSA-N 0.000 claims description 4
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- 150000003584 thiosemicarbazones Chemical class 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 229960003087 tioguanine Drugs 0.000 description 1
- 229960000257 tiotropium bromide Drugs 0.000 description 1
- PLHJCIYEEKOWNM-HHHXNRCGSA-N tipifarnib Chemical compound CN1C=NC=C1[C@](N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-HHHXNRCGSA-N 0.000 description 1
- 229950009158 tipifarnib Drugs 0.000 description 1
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- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
- 229960002190 topotecan hydrochloride Drugs 0.000 description 1
- 229960005026 toremifene Drugs 0.000 description 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 description 1
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 description 1
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
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- 229960000241 vandetanib Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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- GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27002909P | 2009-07-02 | 2009-07-02 | |
| US61/270,029 | 2009-07-02 | ||
| PCT/EP2010/059352 WO2011000905A1 (en) | 2009-07-02 | 2010-07-01 | Substituted 2-carboxamide cycloamino ureas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2766855A1 true CA2766855A1 (en) | 2011-01-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2766855A Abandoned CA2766855A1 (en) | 2009-07-02 | 2010-07-01 | Substituted 2-carboxamide cycloamino ureas |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8293753B2 (OSRAM) |
| EP (1) | EP2448935B1 (OSRAM) |
| JP (1) | JP2012531456A (OSRAM) |
| KR (1) | KR20120092552A (OSRAM) |
| CN (1) | CN102471332A (OSRAM) |
| AR (1) | AR077367A1 (OSRAM) |
| AU (1) | AU2010268019A1 (OSRAM) |
| BR (1) | BRPI1015909A2 (OSRAM) |
| CA (1) | CA2766855A1 (OSRAM) |
| EA (1) | EA201200086A1 (OSRAM) |
| MX (1) | MX2012000177A (OSRAM) |
| TW (1) | TW201105666A (OSRAM) |
| UY (1) | UY32747A (OSRAM) |
| WO (1) | WO2011000905A1 (OSRAM) |
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| TW200519106A (en) * | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| WO2009080694A1 (en) * | 2007-12-20 | 2009-07-02 | Novartis Ag | Thiazole derivatives used as pi 3 kinase inhibitors |
| RU2014149145A (ru) | 2012-05-23 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Композиции и способы получения и применения эндодермальных клеток и гепатоцитов |
| ES2686689T3 (es) * | 2012-09-20 | 2018-10-19 | Novartis Ag | Combinación farmacéutica que comprende un inhibidor de fosfatidilinositol 3-quinasa y un inhibidor de aromatasa |
| EP2948447B1 (en) | 2013-01-23 | 2016-09-21 | Astrazeneca AB | Chemical compounds |
| TW202214254A (zh) | 2013-03-01 | 2022-04-16 | 美商英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途 |
| TW201726140A (zh) | 2015-09-17 | 2017-08-01 | 瑞典商阿斯特捷利康公司 | 治療癌症之新型生物標記及方法 |
| WO2020072892A1 (en) | 2018-10-05 | 2020-04-09 | Sloan-Kettering Institute For Cancer Research | Pi3k inhibitors and uses thereof |
| AU2023366352A1 (en) * | 2022-10-28 | 2025-05-08 | Assistance Publique – Hopitaux De Paris (Aphp) | New inhibitors of phosphatidylinositol 3-kinase |
| CN116239591B (zh) * | 2023-02-14 | 2025-09-23 | 嘉兴大学 | 一种(4r)-磺酰氨基-l-脯氨酰胺类化合物、制备方法、应用及其药物组合 |
| CN116987072A (zh) * | 2023-07-27 | 2023-11-03 | 武汉呈瑞生物医药科技有限公司 | 化合物及其应用 |
| EP4643858A1 (en) * | 2024-04-29 | 2025-11-05 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical composition for the treatment of uterine disease |
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-
2010
- 2010-06-28 US US12/824,461 patent/US8293753B2/en active Active
- 2010-06-30 UY UY0001032747A patent/UY32747A/es not_active Application Discontinuation
- 2010-07-01 JP JP2012518092A patent/JP2012531456A/ja active Pending
- 2010-07-01 KR KR1020127002827A patent/KR20120092552A/ko not_active Withdrawn
- 2010-07-01 TW TW099121705A patent/TW201105666A/zh unknown
- 2010-07-01 WO PCT/EP2010/059352 patent/WO2011000905A1/en not_active Ceased
- 2010-07-01 CA CA2766855A patent/CA2766855A1/en not_active Abandoned
- 2010-07-01 MX MX2012000177A patent/MX2012000177A/es not_active Application Discontinuation
- 2010-07-01 AR ARP100102354A patent/AR077367A1/es unknown
- 2010-07-01 CN CN2010800300379A patent/CN102471332A/zh active Pending
- 2010-07-01 EA EA201200086A patent/EA201200086A1/ru unknown
- 2010-07-01 EP EP10730435.4A patent/EP2448935B1/en not_active Not-in-force
- 2010-07-01 BR BRPI1015909A patent/BRPI1015909A2/pt not_active IP Right Cessation
- 2010-07-01 AU AU2010268019A patent/AU2010268019A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR077367A1 (es) | 2011-08-24 |
| US20110003818A1 (en) | 2011-01-06 |
| AU2010268019A1 (en) | 2012-01-19 |
| EA201200086A1 (ru) | 2012-07-30 |
| JP2012531456A (ja) | 2012-12-10 |
| MX2012000177A (es) | 2012-02-28 |
| CN102471332A (zh) | 2012-05-23 |
| WO2011000905A1 (en) | 2011-01-06 |
| EP2448935B1 (en) | 2015-06-24 |
| BRPI1015909A2 (pt) | 2019-09-24 |
| KR20120092552A (ko) | 2012-08-21 |
| UY32747A (es) | 2011-01-31 |
| US8293753B2 (en) | 2012-10-23 |
| TW201105666A (en) | 2011-02-16 |
| EP2448935A1 (en) | 2012-05-09 |
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