CA2764729C - Expression of surrogate light chains - Google Patents

Expression of surrogate light chains Download PDF

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Publication number
CA2764729C
CA2764729C CA2764729A CA2764729A CA2764729C CA 2764729 C CA2764729 C CA 2764729C CA 2764729 A CA2764729 A CA 2764729A CA 2764729 A CA2764729 A CA 2764729A CA 2764729 C CA2764729 C CA 2764729C
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Prior art keywords
sequence
polypeptide
slc
vpreb
nucleic acid
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Expired - Fee Related
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CA2764729A
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English (en)
French (fr)
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CA2764729A1 (en
Inventor
Lawrence Horowitz
Ramesh Bhatt
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I2 Pharmaceuticals Inc
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I2 Pharmaceuticals Inc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Holo Graphy (AREA)
CA2764729A 2009-06-26 2010-06-25 Expression of surrogate light chains Expired - Fee Related CA2764729C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22087809P 2009-06-26 2009-06-26
US61/220,878 2009-06-26
PCT/US2010/040052 WO2010151808A1 (en) 2009-06-26 2010-06-25 Expression of surrogate light chains

Publications (2)

Publication Number Publication Date
CA2764729A1 CA2764729A1 (en) 2010-12-29
CA2764729C true CA2764729C (en) 2019-04-02

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Family Applications (1)

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CA2764729A Expired - Fee Related CA2764729C (en) 2009-06-26 2010-06-25 Expression of surrogate light chains

Country Status (12)

Country Link
US (1) US8969082B2 (OSRAM)
EP (2) EP2446032B8 (OSRAM)
JP (2) JP2012531208A (OSRAM)
KR (2) KR20180017231A (OSRAM)
CN (1) CN102498210B (OSRAM)
AU (1) AU2010265949B2 (OSRAM)
BR (1) BRPI1015916A2 (OSRAM)
CA (1) CA2764729C (OSRAM)
IL (1) IL216796A (OSRAM)
MX (1) MX2012000129A (OSRAM)
TW (1) TWI560271B (OSRAM)
WO (1) WO2010151808A1 (OSRAM)

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US10106624B2 (en) 2013-03-15 2018-10-23 Xencor, Inc. Heterodimeric proteins
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
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US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
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US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
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Also Published As

Publication number Publication date
CN102498210A (zh) 2012-06-13
TWI560271B (en) 2016-12-01
IL216796A0 (en) 2012-02-29
KR20120095343A (ko) 2012-08-28
KR101829073B1 (ko) 2018-02-13
JP2016105714A (ja) 2016-06-16
EP2446032B8 (en) 2017-03-15
JP2012531208A (ja) 2012-12-10
CN102498210B (zh) 2015-07-29
US20100330676A1 (en) 2010-12-30
EP2446032B1 (en) 2016-12-21
EP3205723A1 (en) 2017-08-16
TW201107468A (en) 2011-03-01
EP2446032A1 (en) 2012-05-02
AU2010265949A1 (en) 2011-12-22
AU2010265949B2 (en) 2016-05-05
WO2010151808A1 (en) 2010-12-29
CA2764729A1 (en) 2010-12-29
KR20180017231A (ko) 2018-02-20
IL216796A (en) 2015-09-24
US8969082B2 (en) 2015-03-03
BRPI1015916A2 (pt) 2015-09-01
MX2012000129A (es) 2012-02-01

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