CA2764553A1 - Drug delivery device having mechanical display adjustable by mounting a drug cartridge - Google Patents
Drug delivery device having mechanical display adjustable by mounting a drug cartridge Download PDFInfo
- Publication number
- CA2764553A1 CA2764553A1 CA2764553A CA2764553A CA2764553A1 CA 2764553 A1 CA2764553 A1 CA 2764553A1 CA 2764553 A CA2764553 A CA 2764553A CA 2764553 A CA2764553 A CA 2764553A CA 2764553 A1 CA2764553 A1 CA 2764553A1
- Authority
- CA
- Canada
- Prior art keywords
- delivery device
- cartridge
- drug delivery
- display
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 229940079593 drug Drugs 0.000 title claims abstract description 135
- 238000012377 drug delivery Methods 0.000 title claims abstract description 125
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
- A61M5/003—Kits for diabetics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09008852.7 | 2009-07-07 | ||
| EP09008852 | 2009-07-07 | ||
| PCT/EP2010/059425 WO2011003817A1 (en) | 2009-07-07 | 2010-07-02 | Drug delivery device having mechanical display adjustable by mounting a drug cartridge |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2764553A1 true CA2764553A1 (en) | 2011-01-13 |
Family
ID=41112559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2764553A Abandoned CA2764553A1 (en) | 2009-07-07 | 2010-07-02 | Drug delivery device having mechanical display adjustable by mounting a drug cartridge |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9669202B2 (https=) |
| EP (1) | EP2451507B1 (https=) |
| JP (2) | JP5781068B2 (https=) |
| CA (1) | CA2764553A1 (https=) |
| DK (1) | DK2451507T3 (https=) |
| WO (1) | WO2011003817A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL160044A0 (en) * | 2001-08-27 | 2004-06-20 | Novo Nordisk As | A cartridge and a medical delivery system accommodating such cartridge |
| WO2006083876A2 (en) | 2005-02-01 | 2006-08-10 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
| US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
| US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
| US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
| USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
| BR112013003376A2 (pt) * | 2010-08-13 | 2016-07-12 | Sanofi Aventis Deutschland | sistema de codificação para um dispositivo de administração de fármaco e sistema de administração de fármaco |
| US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| DK2758101T3 (en) * | 2011-09-22 | 2015-12-21 | Abbvie Inc | Automatic injection device |
| MX2014003527A (es) | 2011-09-22 | 2014-12-05 | Abbvie Inc | Dispositivo de inyeccion automatico. |
| US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
| CA2896708A1 (en) | 2012-12-27 | 2014-07-03 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| CA3056099C (en) * | 2015-01-16 | 2021-10-19 | Becton Dickinson France | Drug storage and dispensing system for pre-filled containers |
| EP3274021B1 (en) | 2015-03-24 | 2024-02-14 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
| JP6830067B2 (ja) | 2015-06-30 | 2021-02-17 | カレオ，インコーポレイテッド | プレフィルドシリンジ内の医薬を投与する自動注射器 |
| WO2017110590A1 (ja) * | 2015-12-24 | 2017-06-29 | パナソニックヘルスケアホールディングス株式会社 | 薬剤注入装置、カートリッジアダプタおよび薬剤注入システム |
| US10722658B2 (en) | 2016-02-26 | 2020-07-28 | Eli Lilly And Company | Reusable medication delivery device with remaining medication determination capability |
| EP3432949B1 (en) | 2016-03-25 | 2024-05-01 | Eli Lilly and Company | Determination of a dose set and delivered in a medication delivery device |
| US11266788B2 (en) | 2016-04-19 | 2022-03-08 | Eli Lilly And Company | Determination of a dose in a medication delivery device using two moving arrays with teeth and a sensor |
| WO2018031390A1 (en) | 2016-08-12 | 2018-02-15 | Eli Lilly And Company | Dose sensing mechanism in a medication delivery device |
| CA3046804C (en) | 2016-12-15 | 2022-07-19 | Eli Lilly And Company | Medication delivery device with sensing system |
| WO2018119218A1 (en) | 2016-12-23 | 2018-06-28 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
| JP2020507841A (ja) | 2017-01-17 | 2020-03-12 | カレオ，インコーポレイテッド | 無線接続及び事象検出を伴う薬剤送達デバイス |
| WO2020018433A1 (en) | 2018-07-16 | 2020-01-23 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
| US12478739B2 (en) | 2018-12-29 | 2025-11-25 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| WO2021030210A1 (en) | 2019-08-09 | 2021-02-18 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| US12268847B1 (en) | 2021-02-10 | 2025-04-08 | Kaleo, Inc. | Devices and methods for delivery of substances within a medicament container |
| US20240226446A1 (en) * | 2021-04-07 | 2024-07-11 | Medmix Switzerland Ag | Drug delivery device with keyed connectors |
| EP4702998A1 (en) | 2024-08-27 | 2026-03-04 | Ypsomed AG | Lock mechanism for a reservoir holder of a drug delivery device |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959056A (en) * | 1988-06-14 | 1990-09-25 | Wayne State University | Digital dispenser |
| DE3833821A1 (de) | 1988-10-05 | 1990-04-12 | Braun Melsungen Ag | Injektionsvorrichtung |
| ES2073173T3 (es) * | 1990-09-21 | 1995-08-01 | Novo Nordisk As | Cubierta adaptadora. |
| US5279585A (en) * | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Medication delivery pen having improved dose delivery features |
| US5431627A (en) | 1993-11-12 | 1995-07-11 | Abbott Laboratories | Cassette identification system for use with a multi-program drug infusion pump |
| US5531697A (en) * | 1994-04-15 | 1996-07-02 | Sims Deltec, Inc. | Systems and methods for cassette identification for drug pumps |
| JP2529819B2 (ja) | 1994-01-27 | 1996-09-04 | 日本イーライリリー株式会社 | 注射装置 |
| US5536249A (en) * | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
| ES2180642T3 (es) | 1994-05-30 | 2003-02-16 | B D Medico S A R L | Aparato de inyeccion. |
| JPH11202400A (ja) * | 1998-01-20 | 1999-07-30 | Sigma Corp | オートフォーカス・マニュアルフォーカス切換可能なレンズ鏡筒の撮影倍率表示装置 |
| JPH11276583A (ja) * | 1998-03-31 | 1999-10-12 | Miyota Kk | 注射器及び注射液充填用カートリッジ |
| US6669090B2 (en) * | 2000-08-10 | 2003-12-30 | Novo Nordick A/S | Electronic marking of a medication cartridge |
| JP2002229101A (ja) * | 2001-02-01 | 2002-08-14 | Konica Corp | カメラ販売システム、カメラ販売方法、フォトサービスシステム及びカメラ |
| DK2258424T3 (da) | 2001-05-16 | 2013-02-18 | Lilly Co Eli | Indretning til injektion af lægemidler |
| DE20110690U1 (de) * | 2001-06-27 | 2001-09-13 | Spyra, Heinrich, 91056 Erlangen | Verwechslungsschutz zur Verhinderung von Bestückung einer Injektionshilfe mit einer falschen Medikamentenampulle |
| IL160044A0 (en) | 2001-08-27 | 2004-06-20 | Novo Nordisk As | A cartridge and a medical delivery system accommodating such cartridge |
| DE10147973A1 (de) | 2001-09-28 | 2003-04-17 | Disetronic Licensing Ag | Ampullenerkennung |
| GB0129187D0 (en) | 2001-12-06 | 2002-01-23 | Dca Design Int Ltd | Improvements in and relating to a medicament cartridge |
| JP3951724B2 (ja) * | 2002-02-04 | 2007-08-01 | 東レ株式会社 | 浄水器 |
| SE0201142D0 (sv) * | 2002-04-16 | 2002-04-16 | Pharmacia Ab | A system and method for modification of a device and a device suitable for modification |
| DE10351732B4 (de) | 2003-07-10 | 2010-10-21 | Tecpharma Licensing Ag | Konfiguration einer Injektionsvorrichtung |
| WO2005023335A2 (en) * | 2003-09-05 | 2005-03-17 | Kurve Technology, Inc. | Integrated nebulizer and particle dispersing chamber for delivery of medicament |
| DE102004005311A1 (de) | 2004-02-03 | 2005-08-18 | Tecpharma Licensing Ag | Ampullenerkennung |
| JP4654180B2 (ja) * | 2004-04-05 | 2011-03-16 | 株式会社根本杏林堂 | 薬液注入システム |
| EP1642607A1 (en) * | 2004-10-04 | 2006-04-05 | Sanofi-Aventis Deutschland GmbH | Dose display mechanism for a drug delivery device |
| WO2006084464A1 (en) | 2005-02-08 | 2006-08-17 | Novo Nordisk A/S | A medical apparatus with a code reader and a method for operating such apparatus |
| US20080051692A1 (en) * | 2005-11-30 | 2008-02-28 | Transport Pharmaceuticals, Inc. | Applicator cartridge for an electrokinetic delivery system for self administration of medicaments |
| JP2007159717A (ja) | 2005-12-12 | 2007-06-28 | Maeda Sangyo Kk | 注射器 |
| US20070197978A1 (en) * | 2006-02-17 | 2007-08-23 | Leon Wortham | Drug Delivery Device |
| WO2007104636A1 (en) * | 2006-03-10 | 2007-09-20 | Novo Nordisk A/S | An injection device and a method of changing a cartridge in the device |
| US7976506B2 (en) * | 2006-09-29 | 2011-07-12 | Arrow International, Inc. | Syringe with selectable indicia of contents |
| ATE507863T1 (de) | 2006-11-21 | 2011-05-15 | Novo Nordisk As | Medizinisches abgabesystem mit einem arretierungsring mit l-förmigen nuten |
| CN101641127B (zh) * | 2007-03-21 | 2012-11-28 | 诺沃-诺迪斯克有限公司 | 具有容器识别的医药输送系统和用于医药输送系统的容器 |
| US20090053085A1 (en) * | 2007-08-24 | 2009-02-26 | Thompson Loren M | Peristalitic pump assembly and method for attaching a cassette thereto |
| US20090062730A1 (en) * | 2007-09-01 | 2009-03-05 | San Hoon Woo | Control of body fluid condition using diuretics, based on biological parameters |
| EP2201970A1 (en) * | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Drug delivery device |
| AU2010206179B2 (en) * | 2009-01-23 | 2014-10-02 | Sanofi-Aventis Deutschland Gmbh | Medicament identification system for multi-dose injection devices |
| EP2415041B1 (en) * | 2009-03-31 | 2018-11-21 | Sanofi-Aventis Deutschland GmbH | Method for manufacturing a drug delivery device body using an adhesive and drug delivery device body |
| CA2771373A1 (en) * | 2009-08-27 | 2011-03-03 | Sanofi-Aventis Deutschland Gmbh | Reminder device for drug delivery devices |
| US20120310172A1 (en) * | 2009-09-30 | 2012-12-06 | Sanofi-Aventis Deutschland Gmbh | Drug Delivery Device |
| EP2335755A1 (en) * | 2009-12-17 | 2011-06-22 | Sanofi-Aventis Deutschland GmbH | Device and method for delivery of two or more drug agents |
| JP6085479B2 (ja) * | 2010-01-22 | 2017-02-22 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物リザーバに関する情報を特定する方法及びシステム |
| TW201200190A (en) * | 2010-03-26 | 2012-01-01 | Sanofi Aventis Deutschland | Electro-mechanical drug delivery device |
| EP2555816A1 (en) * | 2010-04-09 | 2013-02-13 | Sanofi-Aventis Deutschland GmbH | Method and system for differentiating drug delivery devices |
| CA2798118A1 (en) * | 2010-05-04 | 2011-11-10 | Sanofi-Aventis Deutschland Gmbh | Tactile identification of drug filled cartridge |
-
2010
- 2010-07-02 JP JP2012518917A patent/JP5781068B2/ja active Active
- 2010-07-02 CA CA2764553A patent/CA2764553A1/en not_active Abandoned
- 2010-07-02 DK DK10727441.7T patent/DK2451507T3/en active
- 2010-07-02 WO PCT/EP2010/059425 patent/WO2011003817A1/en not_active Ceased
- 2010-07-02 US US13/382,497 patent/US9669202B2/en active Active
- 2010-07-02 EP EP10727441.7A patent/EP2451507B1/en active Active
-
2015
- 2015-04-13 JP JP2015081367A patent/JP5986256B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2451507A1 (en) | 2012-05-16 |
| DK2451507T3 (en) | 2018-04-30 |
| JP2012532634A (ja) | 2012-12-20 |
| JP5781068B2 (ja) | 2015-09-16 |
| EP2451507B1 (en) | 2018-01-17 |
| US20120238960A1 (en) | 2012-09-20 |
| JP2015154950A (ja) | 2015-08-27 |
| WO2011003817A1 (en) | 2011-01-13 |
| JP5986256B2 (ja) | 2016-09-06 |
| US9669202B2 (en) | 2017-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150622 |
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| FZDE | Dead |
Effective date: 20180704 |