CA2757998A1 - Methods of treating edema related to ischemia-reperfusion - Google Patents
Methods of treating edema related to ischemia-reperfusion Download PDFInfo
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- CA2757998A1 CA2757998A1 CA2757998A CA2757998A CA2757998A1 CA 2757998 A1 CA2757998 A1 CA 2757998A1 CA 2757998 A CA2757998 A CA 2757998A CA 2757998 A CA2757998 A CA 2757998A CA 2757998 A1 CA2757998 A1 CA 2757998A1
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- Prior art keywords
- tissue
- compound
- ischemia
- transplant
- reperfusion
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- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000010814 radioimmunoprecipitation assay Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
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- 230000036387 respiratory rate Effects 0.000 description 1
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- 210000001525 retina Anatomy 0.000 description 1
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- 230000028327 secretion Effects 0.000 description 1
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- 150000004760 silicates Chemical class 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- RWVGQQGBQSJDQV-UHFFFAOYSA-M sodium;3-[[4-[(e)-[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]-2-methylcyclohexa-2,5-dien-1-ylidene]methyl]-n-ethyl-3-methylanilino]methyl]benzenesulfonate Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C(=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C)C=2C(=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C)C=C1 RWVGQQGBQSJDQV-UHFFFAOYSA-M 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
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- 239000000375 suspending agent Substances 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
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- 210000002435 tendon Anatomy 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003538 tetroses Chemical class 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
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- 230000002537 thrombolytic effect Effects 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
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- 230000008733 trauma Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 150000003641 trioses Chemical class 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
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- 241000701161 unidentified adenovirus Species 0.000 description 1
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- 238000002689 xenotransplantation Methods 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16808909P | 2009-04-09 | 2009-04-09 | |
| US61/168,089 | 2009-04-09 | ||
| PCT/US2010/030556 WO2010118334A1 (en) | 2009-04-09 | 2010-04-09 | Methods of treating edema related to ischemia-reperfusion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2757998A1 true CA2757998A1 (en) | 2010-10-14 |
Family
ID=42936599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2757998A Abandoned CA2757998A1 (en) | 2009-04-09 | 2010-04-09 | Methods of treating edema related to ischemia-reperfusion |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120064044A1 (https=) |
| EP (1) | EP2416651A4 (https=) |
| JP (1) | JP2012523432A (https=) |
| KR (1) | KR20120005025A (https=) |
| CN (1) | CN102458113A (https=) |
| AU (1) | AU2010233151A1 (https=) |
| BR (1) | BRPI1010516A2 (https=) |
| CA (1) | CA2757998A1 (https=) |
| EA (1) | EA201101349A1 (https=) |
| IL (1) | IL215604A0 (https=) |
| MX (1) | MX2011010616A (https=) |
| SG (1) | SG175133A1 (https=) |
| WO (1) | WO2010118334A1 (https=) |
| ZA (1) | ZA201107815B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0911195A2 (pt) * | 2008-04-09 | 2017-06-20 | The Univ Of North Caroline At Chapel Hill | métodos de regulação de arranjo de citoesqueleto de actina e formação de gap intracelular |
| CN103492572A (zh) | 2011-03-03 | 2014-01-01 | 夸克医药公司 | 用于治疗肺疾病和损伤的组合物和方法 |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| CN110446511B (zh) | 2017-03-10 | 2024-04-02 | 北卡罗来纳大学查珀尔希尔分校 | 短效的基于肝素的抗凝血剂化合物和方法 |
| WO2019010216A1 (en) | 2017-07-03 | 2019-01-10 | The University Of North Carolina At Chapel Hill | ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES |
| JP7495061B2 (ja) | 2017-11-03 | 2024-06-04 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 抗炎症作用を有する硫酸化オリゴ糖 |
| ES2985591T3 (es) | 2018-02-12 | 2024-11-06 | Inimmune Corp | Ligandos de receptores tipo Toll |
| CN112437667B (zh) | 2018-06-20 | 2024-05-28 | 北卡罗来纳大学查珀尔希尔分校 | 细胞保护方法和组合物 |
| WO2021097345A1 (en) * | 2019-11-13 | 2021-05-20 | The University Of North Carolina At Chapel Hill | Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05139992A (ja) * | 1991-11-13 | 1993-06-08 | Ajinomoto Co Inc | ヒトａｄｆを含有する臓器保護剤 |
| US6113918A (en) * | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US7960522B2 (en) * | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| JPWO2004085396A1 (ja) * | 2003-03-26 | 2006-06-29 | 三菱ウェルファーマ株式会社 | 虚血再灌流障害の予防または治療剤、臓器保存剤およびスクリーニング方法 |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| US7928132B2 (en) * | 2004-08-06 | 2011-04-19 | Ohio University | Methods for the amelioration of episodes of acute or chronic ulcerative colitis |
| US8734788B2 (en) * | 2007-08-03 | 2014-05-27 | Opsona Therapeutics Ltd | Composition and method for treatment of reperfusion injury and tissue damage |
| BRPI0911195A2 (pt) * | 2008-04-09 | 2017-06-20 | The Univ Of North Caroline At Chapel Hill | métodos de regulação de arranjo de citoesqueleto de actina e formação de gap intracelular |
-
2010
- 2010-04-09 BR BRPI1010516-6A patent/BRPI1010516A2/pt not_active IP Right Cessation
- 2010-04-09 KR KR1020117026569A patent/KR20120005025A/ko not_active Withdrawn
- 2010-04-09 AU AU2010233151A patent/AU2010233151A1/en not_active Abandoned
- 2010-04-09 US US13/263,435 patent/US20120064044A1/en not_active Abandoned
- 2010-04-09 JP JP2012504890A patent/JP2012523432A/ja active Pending
- 2010-04-09 EP EP10762505.5A patent/EP2416651A4/en not_active Withdrawn
- 2010-04-09 EA EA201101349A patent/EA201101349A1/ru unknown
- 2010-04-09 SG SG2011073475A patent/SG175133A1/en unknown
- 2010-04-09 CA CA2757998A patent/CA2757998A1/en not_active Abandoned
- 2010-04-09 WO PCT/US2010/030556 patent/WO2010118334A1/en not_active Ceased
- 2010-04-09 MX MX2011010616A patent/MX2011010616A/es not_active Application Discontinuation
- 2010-04-09 CN CN2010800259139A patent/CN102458113A/zh active Pending
-
2011
- 2011-10-06 IL IL215604A patent/IL215604A0/en unknown
- 2011-10-25 ZA ZA2011/07815A patent/ZA201107815B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010233151A1 (en) | 2011-11-17 |
| JP2012523432A (ja) | 2012-10-04 |
| EP2416651A1 (en) | 2012-02-15 |
| US20120064044A1 (en) | 2012-03-15 |
| MX2011010616A (es) | 2012-03-14 |
| SG175133A1 (en) | 2011-12-29 |
| WO2010118334A1 (en) | 2010-10-14 |
| KR20120005025A (ko) | 2012-01-13 |
| BRPI1010516A2 (pt) | 2015-08-25 |
| CN102458113A (zh) | 2012-05-16 |
| EP2416651A4 (en) | 2014-03-26 |
| ZA201107815B (en) | 2013-04-24 |
| IL215604A0 (en) | 2011-12-29 |
| EA201101349A1 (ru) | 2012-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150408 |
|
| FZDE | Discontinued |
Effective date: 20171108 |