CA2754283A1 - Derives indoliques pour le traitement de maladies neurodegeneratives - Google Patents

Derives indoliques pour le traitement de maladies neurodegeneratives Download PDF

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Publication number
CA2754283A1
CA2754283A1 CA2754283A CA2754283A CA2754283A1 CA 2754283 A1 CA2754283 A1 CA 2754283A1 CA 2754283 A CA2754283 A CA 2754283A CA 2754283 A CA2754283 A CA 2754283A CA 2754283 A1 CA2754283 A1 CA 2754283A1
Authority
CA
Canada
Prior art keywords
compound
formula
alkyl
group
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2754283A
Other languages
English (en)
French (fr)
Inventor
Fanny Schmidt
Bruno Figadere
Rita Raisman-Vozari
Pierre Champy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Original Assignee
Centre National de la Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique filed Critical Centre National de la Recherche Scientifique
Publication of CA2754283A1 publication Critical patent/CA2754283A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CA2754283A 2009-03-02 2010-03-02 Derives indoliques pour le traitement de maladies neurodegeneratives Abandoned CA2754283A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0951303A FR2942625B1 (fr) 2009-03-02 2009-03-02 Derives indoliques pour le traitement de maladies neurodegeneratives
FR0951303 2009-03-02
PCT/EP2010/052596 WO2010100133A2 (fr) 2009-03-02 2010-03-02 Derives indoliques pour le traitement de maladies neurodegeneratives

Publications (1)

Publication Number Publication Date
CA2754283A1 true CA2754283A1 (fr) 2010-09-10

Family

ID=40688413

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2754283A Abandoned CA2754283A1 (fr) 2009-03-02 2010-03-02 Derives indoliques pour le traitement de maladies neurodegeneratives

Country Status (7)

Country Link
US (1) US8614246B2 (cg-RX-API-DMAC7.html)
EP (1) EP2403830A2 (cg-RX-API-DMAC7.html)
JP (1) JP2012519202A (cg-RX-API-DMAC7.html)
CN (1) CN102369185A (cg-RX-API-DMAC7.html)
CA (1) CA2754283A1 (cg-RX-API-DMAC7.html)
FR (1) FR2942625B1 (cg-RX-API-DMAC7.html)
WO (1) WO2010100133A2 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
CN106309436A (zh) * 2016-07-25 2017-01-11 宁波大学 可用作乙酰胆碱酯酶抑制剂的色胺衍生物及其用途
CN106565588A (zh) * 2016-11-10 2017-04-19 徐州工程学院 一种从坚果中提取食物源二十烷酸‑5‑羟色胺的方法
KR101874594B1 (ko) * 2016-12-07 2018-07-05 한국한의학연구원 아떼모야 잎 추출물 또는 이의 분획물을 포함하는 인지기능 장애의 예방 또는 치료용 조성물
CN107118146B (zh) * 2017-04-13 2019-09-03 宁波大学 一种6-溴色胺衍生物及其制备方法和用途
CN107814787A (zh) * 2017-11-13 2018-03-20 济南大学 一种他克林‑吲哚乙酸杂联体化合物及其制备方法和应用
US11041847B1 (en) 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
KR20230005367A (ko) * 2020-05-04 2023-01-09 트러스티즈 오브 터프츠 칼리지 뇌 전달을 위한 합성 지질-유사 물질
CA3229361A1 (en) * 2021-08-20 2023-02-23 Abdelmalik Slassi 3-cycloamino-indole compounds as serotonergic agents useful for the treatment of disorders related thereto
WO2025137730A1 (en) * 2023-12-22 2025-06-26 Alexander Shulgin Research Institute, Inc. N-substituted tryptamines and n-substituted lysergamides and their use as therapeutic agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08239362A (ja) * 1994-12-28 1996-09-17 Sankyo Co Ltd インドール誘導体
FR2729147A1 (fr) * 1995-01-11 1996-07-12 Adir Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JPH1077267A (ja) * 1996-09-03 1998-03-24 Sagami Chem Res Center ５−メトキシトリプタミン誘導体
RU2141483C1 (ru) * 1997-07-04 1999-11-20 Небольсин Владимир Евгеньевич Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция
JP4156825B2 (ja) * 2001-11-01 2008-09-24 株式会社ロッテ 抗鬱・抗ストレス剤及びそれを含有する組成物
CN102014897B (zh) * 2008-04-21 2015-08-05 西格纳姆生物科学公司 化合物、组合物和其制备方法

Also Published As

Publication number Publication date
JP2012519202A (ja) 2012-08-23
WO2010100133A3 (fr) 2010-11-18
EP2403830A2 (fr) 2012-01-11
FR2942625A1 (fr) 2010-09-03
WO2010100133A2 (fr) 2010-09-10
CN102369185A (zh) 2012-03-07
FR2942625B1 (fr) 2013-11-22
US20110319387A1 (en) 2011-12-29
US8614246B2 (en) 2013-12-24

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20150303