CA2747999A1 - Reactifs de sulfurisation et leur utilisation pour la synthese d'oligonucleotides - Google Patents

Reactifs de sulfurisation et leur utilisation pour la synthese d'oligonucleotides Download PDF

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Publication number
CA2747999A1
CA2747999A1 CA2747999A CA2747999A CA2747999A1 CA 2747999 A1 CA2747999 A1 CA 2747999A1 CA 2747999 A CA2747999 A CA 2747999A CA 2747999 A CA2747999 A CA 2747999A CA 2747999 A1 CA2747999 A1 CA 2747999A1
Authority
CA
Canada
Prior art keywords
group
oligonucleotide
mmol
mixture
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2747999A
Other languages
English (en)
Inventor
Wieslaw Adam Mazur
Yigang He
Victor Sorokin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Girindus America Inc
Original Assignee
Girindus America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Girindus America Inc filed Critical Girindus America Inc
Publication of CA2747999A1 publication Critical patent/CA2747999A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/08—Sulfenic acids; Derivatives thereof
    • C07C313/18—Sulfenamides
    • C07C313/36—Sulfenamides having nitrogen atoms of sulfenamide groups further bound to other hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2747999A 2008-12-23 2009-12-23 Reactifs de sulfurisation et leur utilisation pour la synthese d'oligonucleotides Abandoned CA2747999A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14039108P 2008-12-23 2008-12-23
US61/140,391 2008-12-23
PCT/EP2009/067902 WO2010072831A1 (fr) 2008-12-23 2009-12-23 Réactifs de sulfurisation et leur utilisation pour la synthèse d'oligonucléotides

Publications (1)

Publication Number Publication Date
CA2747999A1 true CA2747999A1 (fr) 2010-07-01

Family

ID=41665222

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2747999A Abandoned CA2747999A1 (fr) 2008-12-23 2009-12-23 Reactifs de sulfurisation et leur utilisation pour la synthese d'oligonucleotides

Country Status (6)

Country Link
EP (1) EP2382227A1 (fr)
JP (1) JP2012513450A (fr)
KR (1) KR20110099333A (fr)
CN (1) CN102307889A (fr)
CA (1) CA2747999A1 (fr)
WO (1) WO2010072831A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101927905B1 (ko) * 2008-04-03 2018-12-11 스프링 뱅크 파마슈티칼스, 인크. 바이러스 감염증을 치료하기 위한 조성물 및 방법
BRPI0923225A2 (pt) 2008-12-02 2016-10-04 Chiralgen Ltd metodo para sintese de acidos nucleicos modificados no atomo de fosforo
KR101885383B1 (ko) 2009-07-06 2018-08-03 웨이브 라이프 사이언시스 리미티드 신규한 핵산 프로드러그 및 그의 사용 방법
KR20130029108A (ko) 2010-06-30 2013-03-21 기린두스 아메리카 인코포레이티드 올리고뉴클레오타이드 합성을 위한 n-thio 화합물의 새로운 사용 방법
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
US20140179875A1 (en) * 2011-07-29 2014-06-26 Girindus America, Inc. Sulfurization reagents on solid supports
EP4219516A3 (fr) 2012-07-13 2024-01-10 Wave Life Sciences Ltd. Controle chiral
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
EP2873674B1 (fr) 2012-07-13 2020-05-06 Shin Nippon Biomedical Laboratories, Ltd. Adjuvant d'acide nucléique chiral
WO2015108047A1 (fr) 2014-01-15 2015-07-23 株式会社新日本科学 Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
CN107207555B (zh) 2015-01-21 2021-10-22 味之素株式会社 沉淀促进剂以及使用其的沉淀方法
CN106045887B (zh) * 2016-06-28 2018-08-31 江苏之江化工有限公司 一种n-乙基次磺酰胺类化合物的合成方法
WO2023011599A1 (fr) * 2021-08-05 2023-02-09 四川大学 Promédicament de persulfure d'hydrogène et son utilisation pharmaceutique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3034951A (en) * 1960-08-04 1962-05-15 Stauffer Chemical Co S-[o, o-dialkylphosphorothiomethyl]-s'-alkyltrithiocarbonates and their methods of preparation and use as pesticides
DE2206678A1 (de) * 1972-02-11 1973-08-16 Bayer Ag 0-alkyl-s- eckige klammer auf carbamoyloxymethyl eckige klammer zu -(thiono)thiolphosphor(phosphon)saeureester, verfahren zu ihrer herstellung sowie ihre verwendung als insektizide und akarizide
FR2705099B1 (fr) * 1993-05-12 1995-08-04 Centre Nat Rech Scient Oligonucléotides phosphorothioates triesters et procédé de préparation.
EP0779893B1 (fr) * 1994-09-07 2001-06-27 Hybridon, Inc. Promedicaments oligonucleotidiques
AU4156197A (en) * 1996-08-21 1998-03-06 Hybridon, Inc. Oligonucleotide prodrugs
AU4161997A (en) * 1996-08-30 1998-03-19 Hybridon, Inc. Novel sulfur transfer reagents for oligonucleotide synthesis
WO1998049181A1 (fr) * 1997-04-30 1998-11-05 Hybridon, Inc. Nouveaux reactifs de transfert de soufre pour la synthese d'oligonucleotides
GB9717158D0 (en) 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
US8076303B2 (en) * 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs

Also Published As

Publication number Publication date
KR20110099333A (ko) 2011-09-07
CN102307889A (zh) 2012-01-04
EP2382227A1 (fr) 2011-11-02
WO2010072831A1 (fr) 2010-07-01
JP2012513450A (ja) 2012-06-14

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20151223