KR20110099333A - 황화시약, 및 올리고뉴클레오타이드 합성을 위한 그 용도 - Google Patents

황화시약, 및 올리고뉴클레오타이드 합성을 위한 그 용도 Download PDF

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Publication number
KR20110099333A
KR20110099333A KR1020117017343A KR20117017343A KR20110099333A KR 20110099333 A KR20110099333 A KR 20110099333A KR 1020117017343 A KR1020117017343 A KR 1020117017343A KR 20117017343 A KR20117017343 A KR 20117017343A KR 20110099333 A KR20110099333 A KR 20110099333A
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KR
South Korea
Prior art keywords
group
oligonucleotide
mmol
mixture
solution
Prior art date
Application number
KR1020117017343A
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English (en)
Korean (ko)
Inventor
위슬로 아담 마주르
이강 허
빅터 소로킨
Original Assignee
기린두스 아메리카 인코포레이티드
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Application filed by 기린두스 아메리카 인코포레이티드 filed Critical 기린두스 아메리카 인코포레이티드
Publication of KR20110099333A publication Critical patent/KR20110099333A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/08—Sulfenic acids; Derivatives thereof
    • C07C313/18—Sulfenamides
    • C07C313/36—Sulfenamides having nitrogen atoms of sulfenamide groups further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
KR1020117017343A 2008-12-23 2009-12-23 황화시약, 및 올리고뉴클레오타이드 합성을 위한 그 용도 KR20110099333A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14039108P 2008-12-23 2008-12-23
US61/140,391 2008-12-23

Publications (1)

Publication Number Publication Date
KR20110099333A true KR20110099333A (ko) 2011-09-07

Family

ID=41665222

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117017343A KR20110099333A (ko) 2008-12-23 2009-12-23 황화시약, 및 올리고뉴클레오타이드 합성을 위한 그 용도

Country Status (6)

Country Link
EP (1) EP2382227A1 (fr)
JP (1) JP2012513450A (fr)
KR (1) KR20110099333A (fr)
CN (1) CN102307889A (fr)
CA (1) CA2747999A1 (fr)
WO (1) WO2010072831A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103816174B (zh) * 2008-04-03 2017-12-05 春堤制药公司 用于治疗病毒感染的化合物和方法
CA2744987C (fr) 2008-12-02 2018-01-16 Chiralgen, Ltd. Procede pour la synthese d'acides nucleiques modifies par des atomes de phosphore
CA2767253A1 (fr) 2009-07-06 2011-01-13 Ontorii, Inc. Nouveaux precurseurs d'acide nucleique et leurs methodes d'utilisation
CA2805546A1 (fr) 2010-06-30 2012-01-05 Girindus America, Inc. Nouveau procede d'utilisation des composes n-thio pour la synthese d'oligonucleotides
EP2620428B1 (fr) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Groupe auxiliaire asymétrique
EP3248982A1 (fr) 2011-07-19 2017-11-29 Wave Life Sciences Ltd. Reactifs de type thiosulfonate pour la synthèse d'acides nucléiques fonctionnalisés
WO2013017469A1 (fr) * 2011-07-29 2013-02-07 Girindus America, Inc. Réactifs de sulfuration sur des supports solides
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
EP4219516A3 (fr) 2012-07-13 2024-01-10 Wave Life Sciences Ltd. Controle chiral
WO2014010718A1 (fr) 2012-07-13 2014-01-16 株式会社新日本科学 Adjuvant d'acide nucléique chiral
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108046A1 (fr) 2014-01-15 2015-07-23 株式会社新日本科学 Adjuvant d'acide nucléique chiral ayant une activité anti-allergique, et agent anti-allergique
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
RU2016133035A (ru) 2014-01-16 2018-02-21 Уэйв Лайф Сайенсес Лтд. Хиральный дизайн
EP4049991A1 (fr) 2015-01-21 2022-08-31 Ajinomoto Co., Inc. Promoteur de précipitation et procédé de précipitation mettant en uvre celui-ci
CN106045887B (zh) * 2016-06-28 2018-08-31 江苏之江化工有限公司 一种n-乙基次磺酰胺类化合物的合成方法
WO2023011599A1 (fr) * 2021-08-05 2023-02-09 四川大学 Promédicament de persulfure d'hydrogène et son utilisation pharmaceutique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3034951A (en) * 1960-08-04 1962-05-15 Stauffer Chemical Co S-[o, o-dialkylphosphorothiomethyl]-s'-alkyltrithiocarbonates and their methods of preparation and use as pesticides
DE2206678A1 (de) * 1972-02-11 1973-08-16 Bayer Ag 0-alkyl-s- eckige klammer auf carbamoyloxymethyl eckige klammer zu -(thiono)thiolphosphor(phosphon)saeureester, verfahren zu ihrer herstellung sowie ihre verwendung als insektizide und akarizide
FR2705099B1 (fr) * 1993-05-12 1995-08-04 Centre Nat Rech Scient Oligonucléotides phosphorothioates triesters et procédé de préparation.
CA2199464A1 (fr) * 1994-09-07 1996-03-14 Radhakrishnan Iyer Promedicaments oligonucleotidiques
WO1998007734A1 (fr) * 1996-08-21 1998-02-26 Hybridon, Inc. Promedicaments oligonucleotidiques
WO1998008809A1 (fr) * 1996-08-30 1998-03-05 Hybridon, Inc. Nouveaux reactifs de transfert du soufre destines a la synthese d'oligonucleotides
WO1998049181A1 (fr) * 1997-04-30 1998-11-05 Hybridon, Inc. Nouveaux reactifs de transfert de soufre pour la synthese d'oligonucleotides
GB9717158D0 (en) 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
US8076303B2 (en) * 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs

Also Published As

Publication number Publication date
WO2010072831A1 (fr) 2010-07-01
CA2747999A1 (fr) 2010-07-01
CN102307889A (zh) 2012-01-04
JP2012513450A (ja) 2012-06-14
EP2382227A1 (fr) 2011-11-02

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