CA2743753A1 - Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus - Google Patents
Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus Download PDFInfo
- Publication number
- CA2743753A1 CA2743753A1 CA2743753A CA2743753A CA2743753A1 CA 2743753 A1 CA2743753 A1 CA 2743753A1 CA 2743753 A CA2743753 A CA 2743753A CA 2743753 A CA2743753 A CA 2743753A CA 2743753 A1 CA2743753 A1 CA 2743753A1
- Authority
- CA
- Canada
- Prior art keywords
- granule
- active ingredients
- sucrose
- group
- macrogolglycerides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008187 granular material Substances 0.000 title claims abstract 13
- 238000000034 method Methods 0.000 title claims 6
- 239000004480 active ingredient Substances 0.000 claims abstract 9
- 239000011248 coating agent Substances 0.000 claims abstract 5
- 239000007787 solid Substances 0.000 claims abstract 4
- 238000000576 coating method Methods 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 239000000419 plant extract Substances 0.000 claims abstract 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 5
- 229930006000 Sucrose Natural products 0.000 claims 5
- 239000005720 sucrose Substances 0.000 claims 5
- 229920005862 polyol Polymers 0.000 claims 4
- 150000003077 polyols Chemical group 0.000 claims 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 3
- 229920001800 Shellac Polymers 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 235000010443 alginic acid Nutrition 0.000 claims 3
- 229920000615 alginic acid Polymers 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 235000010980 cellulose Nutrition 0.000 claims 3
- 238000010410 dusting Methods 0.000 claims 3
- 125000005456 glyceride group Chemical group 0.000 claims 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 239000004208 shellac Substances 0.000 claims 3
- 235000013874 shellac Nutrition 0.000 claims 3
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 3
- 229940113147 shellac Drugs 0.000 claims 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 2
- 239000001506 calcium phosphate Substances 0.000 claims 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 2
- 229940038472 dicalcium phosphate Drugs 0.000 claims 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 229960001375 lactose Drugs 0.000 claims 2
- 239000000845 maltitol Substances 0.000 claims 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 2
- 235000010449 maltitol Nutrition 0.000 claims 2
- 229940035436 maltitol Drugs 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 150000004760 silicates Chemical class 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 235000010356 sorbitol Nutrition 0.000 claims 2
- 229960002920 sorbitol Drugs 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 239000000811 xylitol Substances 0.000 claims 2
- 235000010447 xylitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 2
- 229960002675 xylitol Drugs 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Chemical class 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 241000978776 Senegalia senegal Species 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 235000015778 magnesium gluconate Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- 125000005395 methacrylic acid group Chemical group 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 229920001223 polyethylene glycol Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 239000005060 rubber Substances 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
- Glanulating (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Seasonings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0857764 | 2008-11-14 | ||
| FR0857764A FR2938432B1 (fr) | 2008-11-14 | 2008-11-14 | Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus |
| PCT/FR2009/052180 WO2010055268A1 (fr) | 2008-11-14 | 2009-11-13 | Nouveau procédé de préparation de granulés de principes actifs, et granulés tels qu'obtenus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2743753A1 true CA2743753A1 (fr) | 2010-05-20 |
Family
ID=40348849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2743753A Abandoned CA2743753A1 (fr) | 2008-11-14 | 2009-11-13 | Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20110280945A1 (enExample) |
| EP (1) | EP2349226A1 (enExample) |
| JP (1) | JP5608681B2 (enExample) |
| KR (1) | KR101585705B1 (enExample) |
| CN (1) | CN102223879A (enExample) |
| AR (1) | AR074330A1 (enExample) |
| AU (1) | AU2009315449B2 (enExample) |
| BR (1) | BRPI0916019A2 (enExample) |
| CA (1) | CA2743753A1 (enExample) |
| CL (1) | CL2011001115A1 (enExample) |
| CO (1) | CO6382108A2 (enExample) |
| CU (1) | CU20110107A7 (enExample) |
| EA (1) | EA201100757A1 (enExample) |
| FR (1) | FR2938432B1 (enExample) |
| IL (1) | IL212850A0 (enExample) |
| MA (1) | MA32789B1 (enExample) |
| MX (1) | MX2011005072A (enExample) |
| NZ (1) | NZ592857A (enExample) |
| PE (1) | PE20110945A1 (enExample) |
| SG (1) | SG195651A1 (enExample) |
| TN (1) | TN2011000235A1 (enExample) |
| TW (1) | TWI522113B (enExample) |
| UA (1) | UA103781C2 (enExample) |
| WO (1) | WO2010055268A1 (enExample) |
| ZA (1) | ZA201103543B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2971422B1 (fr) * | 2011-02-11 | 2016-05-20 | Debregeas Et Associes Pharma | Granules d'acide gamma-hydroxybutyrique |
| US20140127296A1 (en) * | 2012-11-05 | 2014-05-08 | Kenneth John Tibbs | Pharmaceutical preparation and method for treatment of diabetes |
| US9241956B2 (en) * | 2012-11-05 | 2016-01-26 | Kenneth John Tibbs | Pharmaceutical preparation and method for treatment of diabetes |
| US11058635B1 (en) * | 2020-10-15 | 2021-07-13 | King Abdulaziz University | Oral administration of 5-FU in a gelling nanosuspension for targeted delivery to treat colorectal cancers |
| KR20240157168A (ko) * | 2023-04-24 | 2024-11-01 | 주식회사 케이티앤지 | 바인더를 사용하는 파우치 충진 물질의 제조 방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6327424A (ja) * | 1986-07-17 | 1988-02-05 | Shionogi & Co Ltd | 徐放性製剤およびその製造法 |
| JP2820829B2 (ja) * | 1991-03-07 | 1998-11-05 | 武田薬品工業株式会社 | 有核散剤およびその製造方法 |
| JPH08310969A (ja) * | 1995-05-22 | 1996-11-26 | Lion Corp | 固形薬品組成物及びその製造方法 |
| FR2790668B1 (fr) * | 1999-03-12 | 2002-07-26 | D B F | Granules contenant une substance vegetale et leur procede de preparation |
| PT1178778E (pt) * | 1999-05-17 | 2006-06-30 | D B F | Granulos que contem uma substancia vegetal e o seu procedimento de preparacao |
| MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| US9247765B2 (en) * | 2004-01-14 | 2016-02-02 | Omniactive Health Technologies Limited | Stable beadlets of lipophilic nutrients |
| FR2880541B1 (fr) * | 2005-01-10 | 2008-02-22 | Amalric Veret | Une nouvelle formule de plantes sous forme de micro-granules de xilitol pour renforcer les effets des plantes et leurs proprietes par une meilleure assimilation |
| US20060182796A1 (en) * | 2005-02-03 | 2006-08-17 | Abrika Pharmaceuticals, Inc. | Taste masked pharmaceutical compositions |
| KR101468053B1 (ko) * | 2006-08-31 | 2014-12-02 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 약물의 고용체를 포함하는 약물 전달 시스템 |
| EP2110413B1 (en) * | 2007-02-14 | 2013-03-20 | Dainichiseika Color & Chemicals Mfg. Co., Ltd. | Dispersing agent for organic pigment and use thereof |
| US20090004281A1 (en) * | 2007-06-26 | 2009-01-01 | Biovail Laboratories International S.R.L. | Multiparticulate osmotic delivery system |
-
2008
- 2008-11-14 FR FR0857764A patent/FR2938432B1/fr not_active Expired - Fee Related
-
2009
- 2009-11-13 US US13/129,028 patent/US20110280945A1/en not_active Abandoned
- 2009-11-13 AR ARP090104388A patent/AR074330A1/es unknown
- 2009-11-13 KR KR1020117013588A patent/KR101585705B1/ko not_active Expired - Fee Related
- 2009-11-13 CA CA2743753A patent/CA2743753A1/fr not_active Abandoned
- 2009-11-13 WO PCT/FR2009/052180 patent/WO2010055268A1/fr not_active Ceased
- 2009-11-13 JP JP2011543800A patent/JP5608681B2/ja not_active Expired - Fee Related
- 2009-11-13 SG SG2013082482A patent/SG195651A1/en unknown
- 2009-11-13 NZ NZ592857A patent/NZ592857A/xx not_active IP Right Cessation
- 2009-11-13 MX MX2011005072A patent/MX2011005072A/es active IP Right Grant
- 2009-11-13 EA EA201100757A patent/EA201100757A1/ru unknown
- 2009-11-13 AU AU2009315449A patent/AU2009315449B2/en not_active Ceased
- 2009-11-13 CN CN2009801457596A patent/CN102223879A/zh active Pending
- 2009-11-13 UA UAA201105988A patent/UA103781C2/uk unknown
- 2009-11-13 EP EP09768187A patent/EP2349226A1/fr not_active Withdrawn
- 2009-11-13 BR BRPI0916019A patent/BRPI0916019A2/pt not_active Application Discontinuation
- 2009-11-13 PE PE2011001032A patent/PE20110945A1/es not_active Application Discontinuation
- 2009-11-16 TW TW098138860A patent/TWI522113B/zh not_active IP Right Cessation
-
2011
- 2011-05-12 IL IL212850A patent/IL212850A0/en unknown
- 2011-05-12 TN TN2011000235A patent/TN2011000235A1/fr unknown
- 2011-05-13 CU CU20110107A patent/CU20110107A7/es unknown
- 2011-05-13 MA MA33837A patent/MA32789B1/fr unknown
- 2011-05-13 CL CL2011001115A patent/CL2011001115A1/es unknown
- 2011-05-13 CO CO11059023A patent/CO6382108A2/es not_active Application Discontinuation
- 2011-05-13 ZA ZA2011/03543A patent/ZA201103543B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO6382108A2 (es) | 2012-02-15 |
| CU20110107A7 (es) | 2012-01-31 |
| EA201100757A1 (ru) | 2011-12-30 |
| NZ592857A (en) | 2013-07-26 |
| CN102223879A (zh) | 2011-10-19 |
| ZA201103543B (en) | 2012-01-25 |
| BRPI0916019A2 (pt) | 2015-11-10 |
| CL2011001115A1 (es) | 2011-11-11 |
| TWI522113B (zh) | 2016-02-21 |
| AU2009315449B2 (en) | 2015-03-26 |
| UA103781C2 (uk) | 2013-11-25 |
| EP2349226A1 (fr) | 2011-08-03 |
| FR2938432B1 (fr) | 2011-05-20 |
| SG195651A1 (en) | 2013-12-30 |
| JP2012508786A (ja) | 2012-04-12 |
| AR074330A1 (es) | 2011-01-05 |
| MA32789B1 (fr) | 2011-11-01 |
| US20110280945A1 (en) | 2011-11-17 |
| TW201029667A (en) | 2010-08-16 |
| PE20110945A1 (es) | 2012-02-01 |
| JP5608681B2 (ja) | 2014-10-15 |
| AU2009315449A1 (en) | 2010-05-20 |
| IL212850A0 (en) | 2011-07-31 |
| KR101585705B1 (ko) | 2016-01-15 |
| WO2010055268A1 (fr) | 2010-05-20 |
| MX2011005072A (es) | 2011-10-03 |
| TN2011000235A1 (fr) | 2012-12-17 |
| KR20110095888A (ko) | 2011-08-25 |
| FR2938432A1 (fr) | 2010-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2743767A1 (fr) | Nouvelle composition a base d'acide gamma-hydroxybutyrique | |
| CA2743753A1 (fr) | Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus | |
| EP2568974B1 (fr) | Forme pharmaceutique orale alcoolo-resistante | |
| CA2771053C (fr) | Microgranules flottants | |
| EP1126829B1 (fr) | Particules enrobees d'ibuprofene cristallin granule | |
| CA2375600A1 (fr) | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif | |
| TWI268279B (en) | Dimeric anti-viral agents and methods for preparation and use thereof | |
| JP5954890B2 (ja) | ２−オキソ−１−ピロリジン誘導体を含む持続放出製剤 | |
| EP0937085A1 (fr) | Le (-)hydroxycitrate de magnesium, procede de preparation, applications, et compositions notamment pharmaceutiques le renfermant | |
| RS61239B1 (sr) | Inhibitori aldozne reduktaze i postupci korišćenja | |
| FR2557878A1 (fr) | Compose antibiotique, procede pour le preparer et compositions le contenant | |
| RS63383B1 (sr) | Sastavi prijatnog ukusa koji uključuju natrijum fenilbutirat i njihova primena | |
| MA29554B1 (fr) | Nouveaux derives d'amide d'acide piperidine carboxylique | |
| US5424301A (en) | Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents | |
| CN109415400A (zh) | (+)表儿茶素及其类似物的用途 | |
| WO2009007137A3 (en) | Pharmaceutical composition for topical application of poorly soluble compounds | |
| FR2821745A1 (fr) | Granules et granules enrobes au gout masque | |
| WO2005097763A3 (en) | 1,3,4-oxadiazol-2-ones as ppar delta | |
| JP2015143256A (ja) | ２−オキソ−１−ピロリジン誘導体を含む持続放出製剤 | |
| CN116178373B (zh) | 非甾体抗炎药和gs-441524的二联体化合物及其制备方法与用途 | |
| NO20081675L (no) | Cykliske N-[1,3,4]-tiadiazol-2-yl-benzensulfonamlder, fremgangsmate for fremstilling derav og deres anvendelse som farmasoytika | |
| RU2008117111A (ru) | Фармацевтическая композиция с контролируемым высвобождением венлафаксина гидрохлорида и способ ее получения | |
| CN119504753A (zh) | 一种芳香稠环亚胺类化合物及其制备方法和应用 | |
| EP1365775B1 (fr) | Suspension de telithromycine a gout masque | |
| US20070123568A1 (en) | Therapeutic methods using prostaglandin EP4 agonist components |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20141029 |
|
| FZDE | Discontinued |
Effective date: 20180419 |