CA2735921C - Process for the synthesis of halogenated cyclic compounds - Google Patents

Process for the synthesis of halogenated cyclic compounds Download PDF

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Publication number
CA2735921C
CA2735921C CA2735921A CA2735921A CA2735921C CA 2735921 C CA2735921 C CA 2735921C CA 2735921 A CA2735921 A CA 2735921A CA 2735921 A CA2735921 A CA 2735921A CA 2735921 C CA2735921 C CA 2735921C
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CA
Canada
Prior art keywords
process according
formula
compound
alkyl group
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2735921A
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English (en)
French (fr)
Other versions
CA2735921A1 (en
Inventor
Max Braun
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Solvay SA
Original Assignee
Solvay SA
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Filing date
Publication date
Application filed by Solvay SA filed Critical Solvay SA
Publication of CA2735921A1 publication Critical patent/CA2735921A1/en
Application granted granted Critical
Publication of CA2735921C publication Critical patent/CA2735921C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
CA2735921A 2008-09-30 2009-09-25 Process for the synthesis of halogenated cyclic compounds Expired - Fee Related CA2735921C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08165547 2008-09-30
EP08165547.4 2008-09-30
PCT/EP2009/062462 WO2010037688A1 (en) 2008-09-30 2009-09-25 Process for the synthesis of halogenated cyclic compounds

Publications (2)

Publication Number Publication Date
CA2735921A1 CA2735921A1 (en) 2010-04-08
CA2735921C true CA2735921C (en) 2017-03-21

Family

ID=40351699

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2735921A Expired - Fee Related CA2735921C (en) 2008-09-30 2009-09-25 Process for the synthesis of halogenated cyclic compounds

Country Status (7)

Country Link
US (2) US8431710B2 (enExample)
EP (1) EP2334645B1 (enExample)
JP (5) JP6180705B2 (enExample)
KR (3) KR20190080972A (enExample)
CN (2) CN102164898A (enExample)
CA (1) CA2735921C (enExample)
WO (1) WO2010037688A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102112428B (zh) 2008-07-04 2015-09-09 索尔维公司 制备烯酮的方法
WO2010037688A1 (en) 2008-09-30 2010-04-08 Solvay Sa Process for the synthesis of halogenated cyclic compounds
GB0903749D0 (en) * 2009-03-04 2009-04-15 Syngenta Participations Ag Chemical process
ES2537676T3 (es) 2009-07-06 2015-06-10 Solvay Sa Proceso para la fabricación de precursores halogenados de alquenonas en presencia de un disolvente
US8957254B2 (en) 2009-07-06 2015-02-17 Solvay Sa Process for chemical synthesis from an alkenone made from a halogenated precursor
EP2662359A1 (en) 2012-05-08 2013-11-13 Solvay Sa Ionic Liquids, Method for manufacturing thereof, and Electrochemical Devices Comprising the Same
DK2888219T3 (da) * 2012-08-22 2019-05-13 Solvay Fremgangsmåde til fremstilling af alkenoner
JP6449169B2 (ja) * 2012-12-20 2019-01-09 ソルヴェイ（ソシエテ アノニム） 電解質中の成分としての窒素含有複素環式アニオンの塩
MX2015017640A (es) * 2013-06-20 2016-09-07 Basf Se Proceso para preparar compuestos de piridilpirazol y sus derivados de piridilhidrazina.
EP2987782A1 (en) 2014-08-22 2016-02-24 Solvay SA Distillation process comprising at least two distillation steps to obtain purified halogenated carboxylic acid halide, and use of the purified halogenated carboxylic acid halide
US20170340986A1 (en) 2014-11-17 2017-11-30 Solvay Sa Distillation process comprising at least two distillation steps to obtain purified halogenated carboxylic acid halide, and use of the purified halogenated carboxylic acid halide
WO2016079122A1 (en) 2014-11-17 2016-05-26 Solvay Sa A method for producing a chemical compound and apparatus therefor
EP3031791A1 (en) 2014-12-10 2016-06-15 Solvay SA Halogenation process of 1,1-dihaloethene
EP3199522A1 (en) 2016-02-01 2017-08-02 Solvay SA Aminothioate derivatives, production thereof and use
WO2019043238A1 (en) 2017-09-04 2019-03-07 Solvay Sa PROCESS AND INTERMEDIARY FOR MANUFACTURING DIFLUOROACETYL CHLORIDE
JP6911143B2 (ja) 2018-11-07 2021-07-28 福建永晶科技股▲ふん▼有限公司Ｆｕｊｉａｎ Ｙｏｎｇｊｉｎｇ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ ピラゾール又はピリミジノンの新しい製造方法
CN113227052B (zh) * 2018-12-27 2025-05-06 科迪华农业科技有限责任公司 磺酰胺除草剂方法中间体的制备
JP2023512000A (ja) 2020-01-31 2023-03-23 ソルヴェイ（ソシエテ アノニム） ハロアルキル置換ピリジン化合物の製造のプロセス
JP2021079146A (ja) * 2021-02-22 2021-05-27 株式会社三洋物産 遊技機
JP7315071B2 (ja) * 2021-03-03 2023-07-26 株式会社三洋物産 遊技機

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3420166A1 (de) 1984-05-30 1985-12-05 Basf Ag, 6700 Ludwigshafen Pyrimidylphosphorsaeureester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen
US5393734A (en) 1991-03-07 1995-02-28 E. I. Du Pont De Nemours And Company Herbicidal pyridine sulfonamide
US5235060A (en) 1991-07-11 1993-08-10 E. I. Du Pont De Nemours And Company Certain three component ionic substituted pyridine compounds as intermediates for preparation as herbicides
DE4128828A1 (de) 1991-08-30 1993-03-04 Basf Ag Ammonium- oder harnstoffhaltige duengemittel und verfahren zu ihrer herstellung
US5708174A (en) 1992-03-12 1998-01-13 Smithkline Beecham P.L.C. Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists
EP0659729B1 (de) 1993-12-23 1998-06-24 Solvay Fluor und Derivate GmbH Verfahren zur Herstellung von Polyfluorchlor- und Perfluorcarbonsäurechloriden unter Chlorzusatz
JP3843152B2 (ja) * 1995-08-08 2006-11-08 石原産業株式会社 ４−アルコキシ−１，１，１−トリフルオロ−３−ブテン−２−オンの製造方法
GB2305174A (en) * 1995-09-15 1997-04-02 Zeneca Ltd Chemical process
GB9711114D0 (en) * 1997-05-29 1997-07-23 Merck Sharp & Dohme Therapeutic agents
DE19821088A1 (de) 1998-05-12 1999-11-18 Basf Ag Modifizierte Polykondensate der Asparaginsäure, Verfahren zu ihrer Herstellung und ihre Verwendung in Düngemitteln
AU2002235247A1 (en) 2000-12-29 2002-07-16 Honeywell International, Inc. Halogenated-alpha,beta-unsaturated-beta-(substituted-amino) carboxylate esters
ES2318275T3 (es) 2003-03-07 2009-05-01 Syngenta Participations Ag Procedimiento para la produccion de esteres del acido niocotinico sustituidos.
DE10325715A1 (de) * 2003-06-06 2004-12-23 Solvay Fluor Und Derivate Gmbh Vereinfachte Herstellung von Alkenonen
WO2006058201A2 (en) * 2004-11-23 2006-06-01 Reddy Us Therapeutics, Inc. Heterocyclic and bicyclic compounds, compositions and methods
DE102004061593A1 (de) 2004-12-21 2006-06-22 Abbott Gmbh & Co. Kg Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung
KR20080048502A (ko) 2005-09-29 2008-06-02 머크 앤드 캄파니 인코포레이티드 멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
US8076487B2 (en) * 2006-02-02 2011-12-13 Kumiai Chemical Industry Co., Ltd. Pyridone derivative and herbicide
WO2008098239A2 (en) * 2007-02-09 2008-08-14 Emory University Paramyxovirus family inhibitors and methods of use thereof
EP1987717A1 (de) 2007-04-30 2008-11-05 Bayer CropScience AG Pyridoncarboxamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung
EP2008996A1 (en) 2007-06-27 2008-12-31 Syngeta Participations AG Process for the production of pyrazoles
KR20110025869A (ko) 2008-07-01 2011-03-11 다우 아그로사이언시즈 엘엘씨 2-트리플루오로메틸-5-(1-치환된)알킬피리딘의 향상된 제조 방법
CN102112428B (zh) 2008-07-04 2015-09-09 索尔维公司 制备烯酮的方法
EP2154167A1 (de) * 2008-07-30 2010-02-17 Bayer MaterialScience AG Elektromechanischer Wandler mit einem Polymerelement auf Polyisocyanat-Basis
WO2010037688A1 (en) 2008-09-30 2010-04-08 Solvay Sa Process for the synthesis of halogenated cyclic compounds
ES2537676T3 (es) 2009-07-06 2015-06-10 Solvay Sa Proceso para la fabricación de precursores halogenados de alquenonas en presencia de un disolvente
MX2012000381A (es) 2009-07-06 2012-03-07 Solvay Proceso para la fabricacion de precursores halogenados de alquenonas bajo condiciones especificas.
WO2011003860A1 (en) 2009-07-06 2011-01-13 Solvay Sa Process for the manufacture of alkenones
JP6194245B2 (ja) * 2013-12-27 2017-09-06 株式会社Ｓｕｂａｒｕ 信号機認識装置

Also Published As

Publication number Publication date
KR20110066201A (ko) 2011-06-16
CA2735921A1 (en) 2010-04-08
JP2020023533A (ja) 2020-02-13
KR20160131129A (ko) 2016-11-15
JP6647268B2 (ja) 2020-02-14
CN106083710B (zh) 2021-03-12
JP6511346B2 (ja) 2019-05-15
JP6180705B2 (ja) 2017-08-16
US8431710B2 (en) 2013-04-30
CN106083710A (zh) 2016-11-09
KR20190080972A (ko) 2019-07-08
US20110178297A1 (en) 2011-07-21
JP2015227339A (ja) 2015-12-17
EP2334645A1 (en) 2011-06-22
US8981115B2 (en) 2015-03-17
JP2012504153A (ja) 2012-02-16
JP2022028792A (ja) 2022-02-16
EP2334645B1 (en) 2019-11-06
US20130237710A1 (en) 2013-09-12
JP2018058869A (ja) 2018-04-12
WO2010037688A1 (en) 2010-04-08
CN102164898A (zh) 2011-08-24

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