CA2721858C - Pyridazinone derivatives - Google Patents

Pyridazinone derivatives Download PDF

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Publication number
CA2721858C
CA2721858C CA2721858A CA2721858A CA2721858C CA 2721858 C CA2721858 C CA 2721858C CA 2721858 A CA2721858 A CA 2721858A CA 2721858 A CA2721858 A CA 2721858A CA 2721858 C CA2721858 C CA 2721858C
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CA
Canada
Prior art keywords
denotes
formula
leukaemia
compound
compounds
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2721858A
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English (en)
French (fr)
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CA2721858A1 (en
Inventor
Dieter Dorsch
Oliver Schadt
Frank Stieber
Andree Blaukat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
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Merck Patent GmbH
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Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CA2721858A1 publication Critical patent/CA2721858A1/en
Application granted granted Critical
Publication of CA2721858C publication Critical patent/CA2721858C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2721858A 2008-04-21 2009-03-24 Pyridazinone derivatives Active CA2721858C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008019907A DE102008019907A1 (de) 2008-04-21 2008-04-21 Pyridazinonderivate
DE102008019907.9 2008-04-21
PCT/EP2009/002137 WO2009129905A1 (de) 2008-04-21 2009-03-24 Pyridazinonderivate

Publications (2)

Publication Number Publication Date
CA2721858A1 CA2721858A1 (en) 2009-10-29
CA2721858C true CA2721858C (en) 2016-07-19

Family

ID=40639931

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2721858A Active CA2721858C (en) 2008-04-21 2009-03-24 Pyridazinone derivatives

Country Status (22)

Country Link
US (1) US8604036B2 (https=)
EP (1) EP2280962B1 (https=)
JP (1) JP5576358B2 (https=)
KR (1) KR20100137564A (https=)
CN (1) CN102015694A (https=)
AR (1) AR071208A1 (https=)
AU (1) AU2009240346B2 (https=)
BR (1) BRPI0911161B8 (https=)
CA (1) CA2721858C (https=)
CY (1) CY1113443T1 (https=)
DE (1) DE102008019907A1 (https=)
DK (1) DK2280962T5 (https=)
EA (1) EA018362B1 (https=)
ES (1) ES2394147T3 (https=)
HR (1) HRP20120884T1 (https=)
IL (1) IL208336A (https=)
MX (1) MX2010011454A (https=)
PL (1) PL2280962T3 (https=)
PT (1) PT2280962E (https=)
SI (1) SI2280962T1 (https=)
WO (1) WO2009129905A1 (https=)
ZA (1) ZA201008330B (https=)

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CN102532126B (zh) * 2012-02-10 2014-06-18 贵州大学 2-取代-4-氯-5-[5-取代胺基-2-(1,3,4-噻二唑基)-巯基]-3(2h)-哒嗪酮类衍生物及其制备方法和用途
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CN108752322A (zh) * 2018-09-12 2018-11-06 广州新民培林医药科技有限公司 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用
ES2958954T3 (es) 2018-11-06 2024-02-16 Edgewise Therapeutics Inc Compuestos de piridazinona y usos de los mismos
WO2020097258A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
EP3877052B1 (en) 2018-11-06 2023-08-16 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
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CN114502551B (zh) 2019-11-01 2023-08-22 优迈特株式会社 含氟嘧啶化合物及其制备方法

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Also Published As

Publication number Publication date
MX2010011454A (es) 2010-12-21
IL208336A (en) 2016-07-31
IL208336A0 (en) 2010-12-30
BRPI0911161A2 (pt) 2015-10-06
EP2280962B1 (de) 2012-10-03
DK2280962T3 (da) 2012-11-19
BRPI0911161B8 (pt) 2021-05-25
US20110034474A1 (en) 2011-02-10
CY1113443T1 (el) 2016-06-22
WO2009129905A1 (de) 2009-10-29
ES2394147T3 (es) 2013-01-22
EA201001648A1 (ru) 2011-06-30
PT2280962E (pt) 2012-12-17
SI2280962T1 (sl) 2013-01-31
EA018362B1 (ru) 2013-07-30
CN102015694A (zh) 2011-04-13
KR20100137564A (ko) 2010-12-30
HRP20120884T1 (hr) 2012-11-30
AR071208A1 (es) 2010-06-02
DK2280962T5 (da) 2013-09-16
EP2280962A1 (de) 2011-02-09
US8604036B2 (en) 2013-12-10
CA2721858A1 (en) 2009-10-29
DE102008019907A1 (de) 2009-10-22
AU2009240346A1 (en) 2009-10-29
PL2280962T3 (pl) 2013-02-28
JP5576358B2 (ja) 2014-08-20
JP2011518202A (ja) 2011-06-23
AU2009240346B2 (en) 2013-10-10
BRPI0911161B1 (pt) 2020-02-11
ZA201008330B (en) 2011-09-28

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