CA2718791C - Lyophilized nanoemulsion - Google Patents

Lyophilized nanoemulsion Download PDF

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Publication number
CA2718791C
CA2718791C CA2718791A CA2718791A CA2718791C CA 2718791 C CA2718791 C CA 2718791C CA 2718791 A CA2718791 A CA 2718791A CA 2718791 A CA2718791 A CA 2718791A CA 2718791 C CA2718791 C CA 2718791C
Authority
CA
Canada
Prior art keywords
nanoemulsion
lyophilised
lipid
prepared
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2718791A
Other languages
English (en)
French (fr)
Other versions
CA2718791A1 (en
Inventor
Andrea Hanefeld
Martina Victoria Schmidt
Simon Geissler
Peter Langguth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CA2718791A1 publication Critical patent/CA2718791A1/en
Application granted granted Critical
Publication of CA2718791C publication Critical patent/CA2718791C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2718791A 2008-03-20 2009-02-26 Lyophilized nanoemulsion Active CA2718791C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008015366A DE102008015366A1 (de) 2008-03-20 2008-03-20 Lyophilisierte Nanoemulsion
DE102008015366.4 2008-03-20
PCT/EP2009/001355 WO2009115175A2 (de) 2008-03-20 2009-02-26 Lyophilisierte nanoemulsion

Publications (2)

Publication Number Publication Date
CA2718791A1 CA2718791A1 (en) 2009-09-24
CA2718791C true CA2718791C (en) 2016-03-29

Family

ID=40984061

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2718791A Active CA2718791C (en) 2008-03-20 2009-02-26 Lyophilized nanoemulsion

Country Status (9)

Country Link
US (1) US8211948B2 (https=)
EP (1) EP2252267B1 (https=)
JP (1) JP5603852B2 (https=)
AU (1) AU2009226618B2 (https=)
CA (1) CA2718791C (https=)
DE (1) DE102008015366A1 (https=)
ES (1) ES2608062T3 (https=)
IL (1) IL207913A (https=)
WO (1) WO2009115175A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8357639B2 (en) * 2007-07-03 2013-01-22 Baker Hughes Incorporated Nanoemulsions
MX2010010050A (es) 2008-03-20 2011-03-15 Virun Inc Star Emulsiones que incluyen un derivado de polietilen glicol de tocoferol.
WO2009117151A2 (en) 2008-03-20 2009-09-24 Virun, Inc. Compositions containing non-polar compounds
CN103037708B (zh) * 2010-03-23 2015-05-20 维尔恩公司 含有蔗糖脂肪酸酯的纳米乳液
WO2011162802A1 (en) 2010-06-21 2011-12-29 Virun, Inc. Compositions containing non-polar compounds
US8586527B2 (en) 2011-10-20 2013-11-19 Jaipal Singh Cerivastatin to treat pulmonary disorders
SG10201606063RA (en) 2012-01-23 2016-09-29 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
EP2811847B1 (en) 2012-02-10 2017-12-13 Virun, Inc. Beverage compositions containing non-polar compounds
MX2015002252A (es) 2012-08-21 2015-07-21 Sage Therapeutics Inc Metodos para tratar epilepsia o estado de epilepsia.
US9351517B2 (en) 2013-03-15 2016-05-31 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and compositions containing same
US9693574B2 (en) 2013-08-08 2017-07-04 Virun, Inc. Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch
US9861611B2 (en) 2014-09-18 2018-01-09 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same
US10016363B2 (en) 2014-09-18 2018-07-10 Virun, Inc. Pre-spray emulsions and powders containing non-polar compounds
CA3122359A1 (en) * 2018-12-06 2020-06-11 Lipicare Life Sciences Ltd. Vitamin d micro-emulsions and uses thereof
JP7756548B2 (ja) * 2021-11-30 2025-10-20 株式会社ダイセル ガス発生器
CN116650425B (zh) * 2023-07-13 2025-06-27 晟迪生物医药(苏州)有限公司 糖酯化合物或其盐在冷冻保护、冷冻干燥保护中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5296724A (en) 1976-02-10 1977-08-13 Kyowa Hakko Kogyo Co Ltd Preparation of powdery products
FR2561916B1 (fr) * 1984-03-30 1987-12-11 Lafon Labor Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
JPH04275216A (ja) * 1991-03-04 1992-09-30 Eisai Co Ltd 脂溶性薬物を含有した凍結乾燥組成物
DE4244122C1 (de) 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US5646082A (en) 1993-06-24 1997-07-08 Cosmo Research Institute Crystalline aluminosilicate, process for producing the same, and catalyst employing the same for catalytic cracking of hydrocarbon oil
US5948002A (en) * 1996-11-15 1999-09-07 Bonutti; Peter M. Apparatus and method for use in positioning a suture anchor
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
JPH11171796A (ja) 1997-12-08 1999-06-29 Ohta Pharmaceut Co Ltd テプレノン経口投与用製剤およびその製造方法
FR2800611B1 (fr) * 1999-11-08 2002-10-11 Oreal Composition a application topique contenant un sucre, et ses utilisations cosmetiques
WO2002087692A1 (en) * 2001-04-26 2002-11-07 The Procter & Gamble Company A method and apparatus for the treatment of cosmetic skin conditioins
JP2004161650A (ja) 2002-11-12 2004-06-10 Taisho Pharmaceut Co Ltd Ｗ／ｏ／ｗ型ドライエマルション
EP1598060A1 (en) * 2004-05-18 2005-11-23 Nestec S.A. Oil-in-water emulsion for delivery
WO2006134970A1 (ja) * 2005-06-15 2006-12-21 Kaneka Corporation コエンザイムｑ１０含有水溶性組成物及びその製法
FR2901124B1 (fr) * 2006-05-17 2008-06-27 Oreal Emulsion huile dans eau fine
JP2008142588A (ja) * 2006-12-06 2008-06-26 Fujifilm Corp 水中油滴型エマルション及びその製造方法、並びに機能性粉末及びその製造方法
CN101428002A (zh) * 2008-11-20 2009-05-13 沈阳万爱普利德医药科技有限公司 注射用紫杉醇冻干微乳剂及其制备方法

Also Published As

Publication number Publication date
ES2608062T3 (es) 2017-04-05
JP2011519349A (ja) 2011-07-07
WO2009115175A3 (de) 2010-01-07
AU2009226618B2 (en) 2014-04-10
DE102008015366A1 (de) 2009-09-24
AU2009226618A1 (en) 2009-09-24
WO2009115175A2 (de) 2009-09-24
US20110015266A1 (en) 2011-01-20
EP2252267B1 (de) 2016-09-28
JP5603852B2 (ja) 2014-10-08
IL207913A0 (en) 2010-12-30
CA2718791A1 (en) 2009-09-24
IL207913A (en) 2015-05-31
US8211948B2 (en) 2012-07-03
EP2252267A2 (de) 2010-11-24

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