CA2716354C - Contrast agents for applications including perfusion imaging - Google Patents

Contrast agents for applications including perfusion imaging Download PDF

Info

Publication number
CA2716354C
CA2716354C CA2716354A CA2716354A CA2716354C CA 2716354 C CA2716354 C CA 2716354C CA 2716354 A CA2716354 A CA 2716354A CA 2716354 A CA2716354 A CA 2716354A CA 2716354 C CA2716354 C CA 2716354C
Authority
CA
Canada
Prior art keywords
imaging
mmol
brain
nervous system
central nervous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2716354A
Other languages
English (en)
French (fr)
Other versions
CA2716354A1 (en
Inventor
Simon P. Robinson
David S. Casebier
Ming Yu
Mikhail Kagan
Joel Lazewatsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
Lantheus Medical Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lantheus Medical Imaging Inc filed Critical Lantheus Medical Imaging Inc
Priority to CA2967254A priority Critical patent/CA2967254C/en
Publication of CA2716354A1 publication Critical patent/CA2716354A1/en
Application granted granted Critical
Publication of CA2716354C publication Critical patent/CA2716354C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2716354A 2008-02-29 2009-02-27 Contrast agents for applications including perfusion imaging Active CA2716354C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2967254A CA2967254C (en) 2008-02-29 2009-02-27 Contrast agents for applications including imaging cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6759308P 2008-02-29 2008-02-29
US61/067,593 2008-02-29
PCT/US2009/001247 WO2009110984A2 (en) 2008-02-29 2009-02-27 Contrast agents for applications including perfusion imaging

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2967254A Division CA2967254C (en) 2008-02-29 2009-02-27 Contrast agents for applications including imaging cancer

Publications (2)

Publication Number Publication Date
CA2716354A1 CA2716354A1 (en) 2009-09-11
CA2716354C true CA2716354C (en) 2017-06-13

Family

ID=41016660

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2716354A Active CA2716354C (en) 2008-02-29 2009-02-27 Contrast agents for applications including perfusion imaging
CA2967254A Active CA2967254C (en) 2008-02-29 2009-02-27 Contrast agents for applications including imaging cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2967254A Active CA2967254C (en) 2008-02-29 2009-02-27 Contrast agents for applications including imaging cancer

Country Status (12)

Country Link
US (2) US9408927B2 (enExample)
EP (1) EP2257315B1 (enExample)
JP (3) JP5946992B2 (enExample)
KR (1) KR101616139B1 (enExample)
CN (1) CN102014969B (enExample)
AU (1) AU2009220244B2 (enExample)
CA (2) CA2716354C (enExample)
DK (1) DK2257315T3 (enExample)
ES (1) ES2767973T3 (enExample)
IL (1) IL207853A (enExample)
PT (1) PT2257315T (enExample)
WO (2) WO2009108376A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) * 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
ES2767973T3 (es) 2008-02-29 2020-06-19 Lantheus Medical Imaging Inc Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión
US20100241001A1 (en) * 2009-03-20 2010-09-23 Palmeri Mark L Ultrasound Methods, Systems and Computer Program Products for Imaging Fluids
DK2419096T3 (da) * 2009-04-15 2020-02-03 Lantheus Medical Imaging Inc Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre
AU2011213568B2 (en) * 2010-02-08 2016-05-12 Lantheus Medical Imaging, Inc. Methods and apparatus for synthesizing imaging agents, and intermediates thereof
CA3123737A1 (en) 2011-09-09 2013-03-14 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CA2852395C (en) * 2011-10-21 2020-04-28 Lantheus Medical Imaging, Inc. Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods
CN103254140B (zh) * 2012-02-17 2016-02-17 北京师范大学 新型18f标记取代喹唑啉类化合物及其制备方法和肿瘤pet显像应用
SG10201608370TA (en) 2012-04-10 2016-11-29 Lantheus Medical Imaging Inc Radiopharmaceutical synthesis methods
AU2013203000B9 (en) * 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN104718299B (zh) * 2012-08-13 2024-02-06 通用医院公司 用于线粒体复合物i的定量定位的系统和方法
WO2014030709A1 (ja) 2012-08-24 2014-02-27 浜松ホトニクス株式会社 ミトコンドリアComplex-1の検出に適した化合物
EP4296364B1 (en) 2013-12-03 2025-12-03 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
WO2017139653A1 (en) * 2016-02-10 2017-08-17 The Charles Stark Draper Laboratory, Inc. Systems and methods for imaging
GB201805253D0 (en) 2018-03-29 2018-05-16 Ge Healthcare Ltd Ip Solid phase extraction
CN110305010B (zh) * 2019-07-17 2022-05-13 江苏中旗科技股份有限公司 一种2,5-二甲基苯乙酸的制备方法
WO2023013757A1 (ja) * 2021-08-05 2023-02-09 積水メディカル株式会社 アルキルシリルオキシ置換ベンジル化合物の製造方法
WO2024132895A1 (en) * 2022-12-19 2024-06-27 Syngenta Crop Protection Ag Microbiocidal dihydrooxadiazinyl pyridazinone compounds

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1073999A (en) 1965-01-29 1967-06-28 Ncr Co Process for forming stable images in photochromic material
US4510125A (en) 1982-12-08 1985-04-09 Mallinckrodt, Inc. Process for making lyophilized radiographic imaging kit
JPS604173A (ja) 1983-06-23 1985-01-10 Nissan Chem Ind Ltd ピリダジノン誘導体,その製造法および殺虫・殺ダニ・殺菌剤
EP0169375B1 (en) 1984-06-23 1989-12-20 Nissan Chemical Industries Ltd. Process for producing 2-tert.-butyl-4,5-dichloro-3(2h)-pyridazinone
JPH07116161B2 (ja) 1984-07-04 1995-12-13 日産化学工業株式会社 ピリダジノン誘導体
DE3578304D1 (de) 1984-11-29 1990-07-26 Nissan Chemical Ind Ltd Pyridazinonderivate, deren herstellung und insektizidische, acaricidische, nematicidische, fungizidische zusammensetzungen.
JPS61130275A (ja) 1984-11-29 1986-06-18 Nissan Chem Ind Ltd ピリダジノン誘導体,その製造法および殺虫・殺ダニ・殺菌剤
CA1265798A (en) 1984-12-10 1990-02-13 Motoo Mutsukado 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it
US5393512A (en) 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
JPH0641454B2 (ja) 1985-02-27 1994-06-01 日産化学工業株式会社 ピリダジノン誘導体
JPS61260018A (ja) 1985-05-14 1986-11-18 Nissan Chem Ind Ltd 抗アレルギ−剤
JPH0739397B2 (ja) 1985-07-30 1995-05-01 日産化学工業株式会社 ピリダジノン誘導体および害虫防除剤
TR22638A (tr) 1985-07-30 1988-01-29 Nissan Chemical Ind Ltd Piridazinon tuerevleri,bunlarin ve hasarat oeldueruecue bilesiklerin hazirlanmasina mahsus usul
AU6621586A (en) 1985-11-18 1987-06-02 University Of Texas System, The Polychelating agents for image and spectral enhancement (and spectral shift)
JPS6315974A (ja) 1986-07-09 1988-01-23 小泉コンピユ−タ−株式会社 ボ−リングゲ−ム点数表表示装置
US5252317A (en) 1986-11-10 1993-10-12 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid
US5567411A (en) 1986-11-10 1996-10-22 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group
JPS63159372A (ja) 1986-12-24 1988-07-02 Nissan Chem Ind Ltd ピリダジノン化合物および殺虫、殺ダニ、殺線虫剤
JPS63159374A (ja) 1986-12-24 1988-07-02 Nissan Chem Ind Ltd ピリダジノン誘導体および殺虫、殺ダニ、殺線虫剤
JPS63159373A (ja) 1986-12-24 1988-07-02 Nissan Chem Ind Ltd ピリダジノン類および殺虫、殺ダニ、殺線虫剤
DE3824210A1 (de) 1988-07-16 1990-01-18 Basf Ag 3(2h)-pyridazinonderivate zur bekaempfung von schnecken
IT1229684B (it) 1989-04-05 1991-09-06 Mini Ricerca Scient Tecnolog Piridazinoni ad attivita' insetticida ed acaricida
JPH02279676A (ja) 1989-04-19 1990-11-15 Otsuka Chem Co Ltd ピリダジノン誘導体
US5087440A (en) 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
GB8923843D0 (en) 1989-10-23 1989-12-13 Salutar Inc Compounds
US5377681A (en) * 1989-11-13 1995-01-03 University Of Florida Method of diagnosing impaired blood flow
US5088499A (en) 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5679810A (en) 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
JPH03220177A (ja) 1990-01-25 1991-09-27 Nissan Chem Ind Ltd 殺虫、殺ダニ剤組成物
GB9006977D0 (en) 1990-03-28 1990-05-23 Nycomed As Compositions
WO1992017215A1 (en) 1990-03-28 1992-10-15 Nycomed Salutar, Inc. Contrast media
JPH04235975A (ja) 1991-01-21 1992-08-25 Nissan Chem Ind Ltd ピリダジノン誘導体および害虫防除剤
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5306482A (en) 1991-04-09 1994-04-26 Merck Frosst Canada, Inc. Radiopharmaceutical bacteriostats
US5093105A (en) 1991-04-09 1992-03-03 Merck Frosst Canada, Inc. Radiopharmaceutical bacteriostats
DE69231469T2 (de) 1991-08-29 2001-01-25 Mallinckrodt Medical, Inc. Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
US5169942A (en) 1991-11-21 1992-12-08 General Electric Company Method for making 2-(18F)fluoro-2-deoxy-D-glucose
US5527798A (en) 1992-12-03 1996-06-18 Otsuka Kaguku Kabushiki Kaisha Pyridazinone derivatives, and insecticidal and miticidal composition
US5760191A (en) 1993-02-05 1998-06-02 Nycomed Imaging As Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods
CA2134549A1 (en) 1993-03-22 1994-09-29 Bruce F. Johnson Method for making 2-fluoro-2 deoxyglucose
CA2158249A1 (en) 1993-03-31 1994-10-13 James W. Brodack Radiopharmaceutical formulations having non-stannous reductants
US5417959A (en) 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
US5493026A (en) 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
EP0665223A1 (en) 1994-01-28 1995-08-02 Takeda Chemical Industries, Ltd. Antitumor agent, novel 3(2H)-pyridazinone derivatives and their preparation
JPH07252236A (ja) 1994-01-28 1995-10-03 Takeda Chem Ind Ltd 抗癌剤
WO1995033757A1 (en) 1994-06-03 1995-12-14 Mallinckrodt Medical, Inc. RAPIDLY CLEARING TECHNETIUM-99m PHOSPHONATE SKELETAL IMAGING AGENTS
US5520904A (en) 1995-01-27 1996-05-28 Mallinckrodt Medical, Inc. Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging
EP0727225A3 (en) 1995-02-14 1997-01-15 Sonus Pharma Inc Compositions and methods for directed ultrasonic imaging
US5587491A (en) 1995-03-15 1996-12-24 Regents Of The University Of Minnesota Method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins
US5801228A (en) 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
US5811073A (en) 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
US5827073A (en) 1995-07-05 1998-10-27 Ludwig Institute For Cancer Research Photoreactive peptide derivatives
US6066309A (en) 1996-02-02 2000-05-23 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
US5804161A (en) 1996-05-14 1998-09-08 Nycomed Salutar Inc. Contrast agents
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6565889B2 (en) 1996-12-02 2003-05-20 The Regents Of The University Of California Bilayer structure which encapsulates multiple containment units and uses thereof
US5961955A (en) 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
US6056939A (en) 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
ATE439838T1 (de) 1998-09-29 2009-09-15 Merck & Co Inc Radiomarkierte neurokinin-1 rezeptor antagonisten
US6645508B1 (en) 1999-06-18 2003-11-11 Jivn-Ren Chen Stable L-ascorbic acid composition
AU2001261728A1 (en) 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
WO2002020008A1 (en) 2000-09-06 2002-03-14 The Scripps Research Institute Inhibitors of nadh:ubiquinone oxidoreductase
TWI247609B (en) * 2001-01-23 2006-01-21 Nihon Mediphysics Co Ltd Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease
GB0115927D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
US20030044354A1 (en) 2001-08-16 2003-03-06 Carpenter Alan P. Gas microsphere liposome composites for ultrasound imaging and ultrasound stimulated drug release
US7344702B2 (en) * 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US20030082191A1 (en) 2001-08-29 2003-05-01 Poduslo Joseph F. Treatment for central nervous system disorders
WO2003032912A2 (en) * 2001-10-16 2003-04-24 Hypnion, Inc. Treatment of cns disorders using cns target modulators
TWI266634B (en) * 2002-02-06 2006-11-21 Univ Johns Hopkins Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
BR0308945A (pt) 2002-03-29 2005-01-04 Janssen Pharmaceutica Nv Derivados radiomarcados de quinolina e quinolinona e uso dos mesmos como ligantes para receptores de glutamato metabotrópicos
AU2003224747A1 (en) 2002-04-08 2003-10-27 Biostream, Inc. Technetium-labeled rotenone derivatives, and methods of use thereof
GB0229683D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Preparation of radiopharmaceuticals
WO2005007632A1 (en) 2003-07-18 2005-01-27 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
KR101106533B1 (ko) 2003-07-24 2012-01-20 브라코 이미징 에스.피.에이. 안정한 방사성의약 조성물 및 제조 방법
GB0317920D0 (en) 2003-07-31 2003-09-03 Amersham Plc Solid-phase synthesis
US7927616B2 (en) 2004-01-16 2011-04-19 Thomas T. Yamashita Pesticide compositions and methods for their use
EP2388017B1 (en) 2004-02-24 2014-12-24 The General Hospital Corporation Catalytic radiofluorination
AU2005219784B2 (en) 2004-03-05 2010-09-02 Msd K.K. Pyridone derivative
AT500838B1 (de) 2004-04-20 2007-11-15 Veterinaermedizinische Uni Wie Multiple hse
CN1976728A (zh) * 2004-04-28 2007-06-06 布里斯托尔-迈尔斯斯奎布药品公司 心肌灌注成像的造影剂
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US20060083681A1 (en) 2004-10-18 2006-04-20 Ajay Purohit Compounds for myocardial perfusion imaging
KR100789847B1 (ko) 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
US7837982B2 (en) 2005-06-23 2010-11-23 Emory University Imaging agents
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
JP2007112725A (ja) 2005-10-18 2007-05-10 Inst Nuclear Energy Research Rocaec 無支持体の18Fで標識したアミノ酸O−(2−[18F]fluoroethyl)−L−Tyrosineの製造方法。
US7871623B2 (en) 2005-12-21 2011-01-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for imaging pain and stress in vivo
WO2008118122A2 (en) 2006-05-08 2008-10-02 Molecular Neuroimaging, Llc Compounds and amyloid probes thereof for therapeutic and imaging uses
CA2654369C (en) 2006-06-21 2014-10-14 Ge Healthcare Limited Radiopharmaceutical products
NZ575520A (en) 2006-08-25 2012-03-30 Boehringer Ingelheim Int New pyridone derivatives with mch antagonistic activity and medicaments comprising these compounds
JP5504563B2 (ja) 2006-12-27 2014-05-28 住友化学株式会社 組成物及び該組成物を用いてなる発光素子
GB0718386D0 (en) 2007-09-21 2007-10-31 Ge Healthcare As Improved radiopharmaceutical formulation
KR101068835B1 (ko) 2007-10-26 2011-09-30 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를가지는 이소인돌론 화합물 및 이의 제조 방법
CL2008003785A1 (es) 2007-12-21 2009-10-09 Du Pont Compuestos derivados de piridazina; composiciones herbicidas que comprenden a dichos compuestos; y método para controlar el crecimiento de la vegetación indeseada.
WO2009103478A1 (en) 2008-02-19 2009-08-27 Boehringer Ingelheim International Gmbh Pyridone and pyridazinone derivatives as mch antagonists
WO2010011367A2 (en) 2008-02-22 2010-01-28 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
ES2767973T3 (es) 2008-02-29 2020-06-19 Lantheus Medical Imaging Inc Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión
US8258134B2 (en) 2008-04-16 2012-09-04 Hoffmann-La Roche Inc. Pyridazinone glucokinase activators
EP2406233B1 (en) 2009-03-09 2013-11-13 Bristol-Myers Squibb Company Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists
DK2419096T3 (da) 2009-04-15 2020-02-03 Lantheus Medical Imaging Inc Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre
CN101555232B (zh) 2009-05-21 2011-01-05 北京师范大学 氟-18标记哒嗪酮类化合物及制备方法和应用
CN102471176A (zh) 2009-07-11 2012-05-23 拜耳医药股份有限公司 非极性和极性离去基团
AU2011213568B2 (en) 2010-02-08 2016-05-12 Lantheus Medical Imaging, Inc. Methods and apparatus for synthesizing imaging agents, and intermediates thereof
JP5842594B2 (ja) 2010-12-27 2016-01-13 住友化学株式会社 ピリダジノン化合物、それを含有する除草剤及び有害節足動物防除剤
CA3123737A1 (en) 2011-09-09 2013-03-14 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CA2852395C (en) 2011-10-21 2020-04-28 Lantheus Medical Imaging, Inc. Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents

Also Published As

Publication number Publication date
CN102014969B (zh) 2014-07-09
US20110091374A1 (en) 2011-04-21
JP2015061842A (ja) 2015-04-02
CN102014969A (zh) 2011-04-13
WO2009108376A2 (en) 2009-09-03
AU2009220244A1 (en) 2009-09-11
JP2011513306A (ja) 2011-04-28
JP5922207B2 (ja) 2016-05-24
US20160361448A1 (en) 2016-12-15
US9408927B2 (en) 2016-08-09
WO2009110984A2 (en) 2009-09-11
CA2967254A1 (en) 2009-09-11
US20180133347A9 (en) 2018-05-17
KR101616139B1 (ko) 2016-04-27
WO2009108376A3 (en) 2009-11-19
PT2257315T (pt) 2020-01-27
EP2257315A4 (en) 2013-04-17
JP5946992B2 (ja) 2016-07-06
CA2967254C (en) 2019-03-26
DK2257315T3 (da) 2020-01-27
EP2257315B1 (en) 2019-10-23
IL207853A (en) 2015-05-31
CA2716354A1 (en) 2009-09-11
EP2257315A2 (en) 2010-12-08
KR20100121530A (ko) 2010-11-17
ES2767973T3 (es) 2020-06-19
JP2016164182A (ja) 2016-09-08
WO2009110984A3 (en) 2009-12-10
AU2009220244B2 (en) 2014-10-09
IL207853A0 (en) 2010-12-30
US10245332B2 (en) 2019-04-02

Similar Documents

Publication Publication Date Title
CA2716354C (en) Contrast agents for applications including perfusion imaging
KR102527562B1 (ko) 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR102850587B1 (ko) 전립선 특이 막 항원 결합 이중 모드 방사선 추적자 및 치료법
Pichika et al. Nicotinic α4β2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F] fluoro-3-[2-((S)-3-pyrrolinyl) methoxy] pyridine (18F-nifene) in rodents and imaging by PET in nonhuman primate
US20090004107A1 (en) Beta-amyloid and neurofibrillary tangle imaging agents
Zeng et al. Synthesis and evaluation of [18F]-fluoromethyl triphenylphosphonium cation as a novel mitochondria-specific positron emission tomography tracer
AU2015200027B2 (en) Contrast agents for applications including perfusion imaging
Sivapackiam et al. Synthesis, molecular structure, and validation of metalloprobes for assessment of MDR1 P-glycoprotein-mediated functional transport
EP3177598B1 (en) Macrocyclic complexes, their process of preparation and use as pet imaging agents
Singh et al. A homodimeric bivalent radioligand derived from 1-(2-methoxyphenyl) piperazine with high affinity for in vivo 5-HT1A receptor imaging
HK1151458B (en) Contrast agents for applications including perfusion imaging
HK1151458A (en) Contrast agents for applications including perfusion imaging
WO2016164921A1 (en) Pet imaging tracer for imaging prostate cancer
Henderson et al. 3-Pyridyl ethers as SPECT radioligands for imaging nicotinic acetylcholine receptors
Mukherjee et al. Nicotinic α4β2 receptor imaging agents
HK1200030B (en) Compositions, methods, and systems for the synthesis and use of imaging agents
WO2011124713A1 (en) Labelled huprine derivatives and their use in medical imaging

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140225