CA2710293A1 - Dosage regimens and pharmaceutical compositions and packages for emergency contraception - Google Patents
Dosage regimens and pharmaceutical compositions and packages for emergency contraception Download PDFInfo
- Publication number
- CA2710293A1 CA2710293A1 CA2710293A CA2710293A CA2710293A1 CA 2710293 A1 CA2710293 A1 CA 2710293A1 CA 2710293 A CA2710293 A CA 2710293A CA 2710293 A CA2710293 A CA 2710293A CA 2710293 A1 CA2710293 A1 CA 2710293A1
- Authority
- CA
- Canada
- Prior art keywords
- dosage
- tanaproget
- hours
- nonsteroidal progestin
- nonsteroidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 8
- 239000000583 progesterone congener Substances 0.000 claims abstract description 123
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- PYVFWTPEBMRKSR-UHFFFAOYSA-N tanaproget Chemical compound CN1C(C#N)=CC=C1C1=CC=C(NC(=S)OC2(C)C)C2=C1 PYVFWTPEBMRKSR-UHFFFAOYSA-N 0.000 claims description 94
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- HZEQBCVBILBTEP-ZFINNJDLSA-N estropipate Chemical compound C1CNCCN1.OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 HZEQBCVBILBTEP-ZFINNJDLSA-N 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 229930182480 glucuronide Natural products 0.000 description 1
- 150000008134 glucuronides Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- 102000027411 intracellular receptors Human genes 0.000 description 1
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- 235000015110 jellies Nutrition 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
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- 235000011090 malic acid Nutrition 0.000 description 1
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- 239000000594 mannitol Substances 0.000 description 1
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- 239000011159 matrix material Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003791 organic solvent mixture Substances 0.000 description 1
- 229940094984 other estrogen in atc Drugs 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000005426 pharmaceutical component Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 150000004885 piperazines Chemical class 0.000 description 1
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- 239000004014 plasticizer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000000270 postfertilization Effects 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000002379 progesterone receptor modulator Substances 0.000 description 1
- 102000003998 progesterone receptors Human genes 0.000 description 1
- 108090000468 progesterone receptors Proteins 0.000 description 1
- 230000002294 pubertal effect Effects 0.000 description 1
- PWZUUYSISTUNDW-VAFBSOEGSA-N quinestrol Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@]4(O)C#C)C)CC2=CC=3OC1CCCC1 PWZUUYSISTUNDW-VAFBSOEGSA-N 0.000 description 1
- 229960001424 quinestrol Drugs 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000006215 rectal suppository Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 150000003444 succinic acids Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000000522 vaginal cream Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US828707P | 2007-12-20 | 2007-12-20 | |
| US61/008,287 | 2007-12-20 | ||
| PCT/US2008/013933 WO2009082478A1 (en) | 2007-12-20 | 2008-12-19 | Dosage regimens and pharmaceutical compositions and packages for emergency contraception |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2710293A1 true CA2710293A1 (en) | 2009-07-02 |
Family
ID=40799234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2710293A Abandoned CA2710293A1 (en) | 2007-12-20 | 2008-12-19 | Dosage regimens and pharmaceutical compositions and packages for emergency contraception |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090170823A1 (OSRAM) |
| EP (1) | EP2234491A4 (OSRAM) |
| JP (2) | JP2011507853A (OSRAM) |
| AU (1) | AU2008341138A1 (OSRAM) |
| BR (1) | BRPI0819571A2 (OSRAM) |
| CA (1) | CA2710293A1 (OSRAM) |
| EA (1) | EA201070715A1 (OSRAM) |
| IL (1) | IL206465A0 (OSRAM) |
| WO (1) | WO2009082478A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008079245A2 (en) * | 2006-12-20 | 2008-07-03 | Duramed Pharmaceuticals, Inc. | Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof |
| FR2937862B1 (fr) * | 2008-11-03 | 2010-11-19 | Mohammed Ridha Chakroun | Kit contraceptif |
| EP2381947A4 (en) | 2008-12-23 | 2012-08-22 | Quest Diagnostics Invest Inc | MASS SPECTROMETRY ASSAY FOR STROGENIC COMPOUNDS |
| RU2542779C2 (ru) * | 2009-04-14 | 2015-02-27 | Лаборатуар Хра-Фарма | Способ контрацепции, используемый по мере необходимости |
| EP3943079A1 (en) | 2013-05-21 | 2022-01-26 | Predictive Therapeutics, LLC | Therapeutic and method of use |
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|---|---|---|---|---|
| US4684534A (en) * | 1985-02-19 | 1987-08-04 | Dynagram Corporation Of America | Quick-liquifying, chewable tablet |
| IE61236B1 (en) | 1986-07-15 | 1994-10-19 | American Home Prod | Combination dosage form for pre-menopausal women |
| ATE209189T1 (de) * | 1992-07-01 | 2001-12-15 | Ortho Pharma Corp | 1-arylsulfonyl-3-phenyl-1,4,5,6- tetrahydropyridazinen |
| DE4344463A1 (de) * | 1993-12-22 | 1995-06-29 | Schering Ag | Kombinationsprodukt zur Kontrazeption |
| US5633011A (en) * | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
| RO120606B1 (ro) * | 1994-10-24 | 2006-05-30 | Schering Aktiengesellschaft | Utilizare a antagoniştilor competitivi de progesteron, pentru controlul fertilităţii |
| ZA9510926B (en) * | 1994-12-23 | 1996-07-03 | Schering Ag | Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception |
| AU2558297A (en) * | 1996-05-16 | 1997-12-05 | Gynetics Inc. | Emergency contraceptive kit |
| FR2772617B1 (fr) * | 1997-12-19 | 2001-03-09 | Besins Iscovesco Lab | Comprime de progesterone et son procede de preparation |
| US6368625B1 (en) * | 1998-08-12 | 2002-04-09 | Cima Labs Inc. | Orally disintegrable tablet forming a viscous slurry |
| US6060078A (en) | 1998-09-28 | 2000-05-09 | Sae Han Pharm Co., Ltd. | Chewable tablet and process for preparation thereof |
| US6667050B1 (en) * | 1999-04-06 | 2003-12-23 | Galen (Chemicals) Limited | Chewable oral contraceptive |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6399593B1 (en) * | 1999-05-04 | 2002-06-04 | Wyeth | Cyclic regimens using cyclic urea and cyclic amide derivatives |
| US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6660726B2 (en) | 2000-03-10 | 2003-12-09 | Endeavor Pharmaceuticals | Estrogenic compounds, pharmaceutical compositions thereof, and methods of using same |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| US6316029B1 (en) * | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| HU227198B1 (en) * | 2001-11-27 | 2010-10-28 | Richter Gedeon Nyrt | Pharmaceutical composition for emergency contraception containing levonorgestrel |
| US20030158432A1 (en) * | 2002-01-08 | 2003-08-21 | Leonard Thomas W. | Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex |
| PT1482925E (pt) * | 2002-03-11 | 2007-04-30 | Bayer Schering Pharma Ag | 5-(2-hidroxi-3-'1-(3-trifluorometilfenil)-ciclopropil]-propionilamino-ftalida e compostos relacionados com actividade de modulação do receptor da progesterona para utilização no controlo de fertilidade e terapia de substituição hormonal |
| AU2003245637A1 (en) * | 2002-06-25 | 2004-01-06 | Wyeth | Use of thio-oxindole derivatives in treatment of hormone-related conditions |
| EP1515725A4 (en) * | 2002-06-25 | 2005-09-21 | Wyeth Corp | USE OF CYCLOTHIOCARBAMATE DERIVATIVES IN THE TREATMENT OF HORMONE-RELATED ILLNESSES |
| MXPA04012420A (es) * | 2002-06-25 | 2005-04-19 | Wyeth Corp | Derivados de ciclotiocabamativa como moduladores de rp y uso de los mismos para tratamiento de trastornos de la piel. |
| JP2006504736A (ja) * | 2002-10-11 | 2006-02-09 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 選択的プロゲステロンレセプター調節化合物としての５−（１’，１’−シクロアルキル／アルケニル）メチリデン１，２−ジヒドロ−５Ｈ−クロメノ［３，４−ｆ］キノリン |
| WO2004035883A2 (en) * | 2002-10-17 | 2004-04-29 | Nexen Nano Tech Co., Ltd | Fibrous nano-carbon and preparation method thereof |
| NZ544007A (en) * | 2003-05-07 | 2009-05-31 | Samyang Corp | Highly plastic granules for making fast melting tablets |
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| CN1672685A (zh) * | 2004-03-26 | 2005-09-28 | 董可娟 | 一种新的避孕药物 |
| US7399870B2 (en) * | 2004-03-30 | 2008-07-15 | Wyeth | Synthesis of pyrrole-2-carbonitriles |
| BRPI0509159B1 (pt) * | 2004-04-08 | 2014-08-26 | Wyeth Llc | Processo para preparar um composto de fenoxicicloalquila |
| CA2561014C (en) * | 2004-04-08 | 2013-09-10 | Wyeth | Thioamide derivatives as progesterone receptor modulators |
| ATE409699T1 (de) * | 2004-04-08 | 2008-10-15 | Wyeth Corp | Verfahren zur minimierung von thioamidverunreinigungen |
| AR049631A1 (es) * | 2004-04-27 | 2006-08-23 | Wyeth Corp | Proceso de acoplamiento para la generacion de derivados reactivos de pirrol -2- carbonitrilo n- sustituidos con contenido de boro para producir biarilos |
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| GT200500183A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| DK1778710T3 (da) * | 2004-08-13 | 2012-04-16 | Wyeth Llc | Tanaprogetderivater, -metabolitter og anvendelser deraf |
| JP2008510722A (ja) * | 2004-08-20 | 2008-04-10 | ワイス | プロゲステロン受容体構造 |
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| ES2340610T3 (es) * | 2005-04-28 | 2010-06-07 | Wyeth Llc | Composiciones de tanaproget micronizado y procedimientos de preparacion de las mismas. |
| CN101166736B (zh) * | 2005-04-28 | 2013-02-06 | 惠氏公司 | 他那普戈特的多晶型ⅱ |
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| AR056048A1 (es) * | 2005-09-01 | 2007-09-12 | Tanabe Seiyaku Co | Compuesto tiomorfolina y procedimiento para preparar el mismo |
| US20070066628A1 (en) * | 2005-09-19 | 2007-03-22 | Wyeth | 5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators |
| US7319152B2 (en) * | 2005-09-19 | 2008-01-15 | Wyeth | 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators |
| DE102005050729A1 (de) * | 2005-10-19 | 2007-04-26 | Schering Ag | Verfahren zur präventiven bedarfsweisen hormonalen Kontrazeption |
| US20070093548A1 (en) * | 2005-10-25 | 2007-04-26 | Wyeth | Use of progesterone receptor modulators |
| US20070213526A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Purification of progesterone receptor modulators |
| TW200810231A (en) * | 2006-08-11 | 2008-02-16 | Hon Hai Prec Ind Co Ltd | Antenna device |
| WO2008079245A2 (en) * | 2006-12-20 | 2008-07-03 | Duramed Pharmaceuticals, Inc. | Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof |
-
2008
- 2008-12-19 EA EA201070715A patent/EA201070715A1/ru unknown
- 2008-12-19 CA CA2710293A patent/CA2710293A1/en not_active Abandoned
- 2008-12-19 WO PCT/US2008/013933 patent/WO2009082478A1/en not_active Ceased
- 2008-12-19 BR BRPI0819571A patent/BRPI0819571A2/pt not_active IP Right Cessation
- 2008-12-19 EP EP08865187A patent/EP2234491A4/en not_active Withdrawn
- 2008-12-19 AU AU2008341138A patent/AU2008341138A1/en not_active Abandoned
- 2008-12-19 US US12/339,329 patent/US20090170823A1/en not_active Abandoned
- 2008-12-19 JP JP2010539503A patent/JP2011507853A/ja active Pending
-
2010
- 2010-06-17 IL IL206465A patent/IL206465A0/en unknown
-
2014
- 2014-06-09 JP JP2014118432A patent/JP2014193918A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014193918A (ja) | 2014-10-09 |
| US20090170823A1 (en) | 2009-07-02 |
| EA201070715A1 (ru) | 2011-02-28 |
| JP2011507853A (ja) | 2011-03-10 |
| IL206465A0 (en) | 2010-12-30 |
| AU2008341138A1 (en) | 2009-07-02 |
| BRPI0819571A2 (pt) | 2019-09-24 |
| WO2009082478A1 (en) | 2009-07-02 |
| EP2234491A1 (en) | 2010-10-06 |
| EP2234491A4 (en) | 2010-12-22 |
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Effective date: 20131115 |
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| FZDE | Discontinued |
Effective date: 20160519 |