CA2707047C - Carboxamide, sulfonamide and amine compounds for metabolic disorders - Google Patents

Carboxamide, sulfonamide and amine compounds for metabolic disorders Download PDF

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Publication number
CA2707047C
CA2707047C CA2707047A CA2707047A CA2707047C CA 2707047 C CA2707047 C CA 2707047C CA 2707047 A CA2707047 A CA 2707047A CA 2707047 A CA2707047 A CA 2707047A CA 2707047 C CA2707047 C CA 2707047C
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CA
Canada
Prior art keywords
alkyl
pyrido
piperidin
tetrahydro
carboxamide
Prior art date
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Active
Application number
CA2707047A
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English (en)
French (fr)
Other versions
CA2707047A1 (en
Inventor
Ihab S. Darwish
Jiaxin Yu
Hui Hong
Rajinder Singh
Sambaiah Thota
Xiang Xu
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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Publication of CA2707047A1 publication Critical patent/CA2707047A1/en
Application granted granted Critical
Publication of CA2707047C publication Critical patent/CA2707047C/en
Active legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2707047A 2007-12-12 2008-12-12 Carboxamide, sulfonamide and amine compounds for metabolic disorders Active CA2707047C (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US1312407P 2007-12-12 2007-12-12
US1311407P 2007-12-12 2007-12-12
US61/013,124 2007-12-12
US61/013,114 2007-12-12
US1640207P 2007-12-21 2007-12-21
US1640607P 2007-12-21 2007-12-21
US1640507P 2007-12-21 2007-12-21
US61/016,406 2007-12-21
US61/016,405 2007-12-21
US61/016,402 2007-12-21
US7820908P 2008-07-03 2008-07-03
US61/078,209 2008-07-03
PCT/US2008/086673 WO2009076631A1 (en) 2007-12-12 2008-12-12 Carboxamide, sulfonamide and amine compounds for metabolic disorders

Publications (2)

Publication Number Publication Date
CA2707047A1 CA2707047A1 (en) 2009-06-18
CA2707047C true CA2707047C (en) 2017-11-28

Family

ID=40364381

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2707047A Active CA2707047C (en) 2007-12-12 2008-12-12 Carboxamide, sulfonamide and amine compounds for metabolic disorders

Country Status (6)

Country Link
US (3) US8129390B2 (cg-RX-API-DMAC7.html)
EP (1) EP2231666B1 (cg-RX-API-DMAC7.html)
JP (1) JP5650540B2 (cg-RX-API-DMAC7.html)
CA (1) CA2707047C (cg-RX-API-DMAC7.html)
ES (1) ES2553340T3 (cg-RX-API-DMAC7.html)
WO (1) WO2009076631A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
US8557822B2 (en) 2013-10-15
EP2231666B1 (en) 2015-07-29
US20140045882A1 (en) 2014-02-13
ES2553340T3 (es) 2015-12-07
US8895578B2 (en) 2014-11-25
HK1148524A1 (en) 2011-09-09
JP5650540B2 (ja) 2015-01-07
EP2231666A1 (en) 2010-09-29
CA2707047A1 (en) 2009-06-18
US20120108606A1 (en) 2012-05-03
US20090163511A1 (en) 2009-06-25
US8129390B2 (en) 2012-03-06
JP2011506480A (ja) 2011-03-03
WO2009076631A1 (en) 2009-06-18

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