CA2704300A1 - Cd40 antibody formulation and methods - Google Patents

Cd40 antibody formulation and methods Download PDF

Info

Publication number
CA2704300A1
CA2704300A1 CA2704300A CA2704300A CA2704300A1 CA 2704300 A1 CA2704300 A1 CA 2704300A1 CA 2704300 A CA2704300 A CA 2704300A CA 2704300 A CA2704300 A CA 2704300A CA 2704300 A1 CA2704300 A1 CA 2704300A1
Authority
CA
Canada
Prior art keywords
ser
antibody
val
thr
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2704300A
Other languages
English (en)
French (fr)
Inventor
Vahe Bedian
John Daniel Cusmano
Ronald Paul Gladue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc.
Vahe Bedian
John Daniel Cusmano
Ronald Paul Gladue
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34738672&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2704300(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc., Vahe Bedian, John Daniel Cusmano, Ronald Paul Gladue filed Critical Pfizer Products Inc.
Publication of CA2704300A1 publication Critical patent/CA2704300A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2704300A 2003-12-22 2004-12-09 Cd40 antibody formulation and methods Abandoned CA2704300A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53163903P 2003-12-22 2003-12-22
US60/531,639 2003-12-22
CA2549652A CA2549652C (en) 2003-12-22 2004-12-09 Cd40 antibody formulation and methods

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2549652A Division CA2549652C (en) 2003-12-22 2004-12-09 Cd40 antibody formulation and methods

Publications (1)

Publication Number Publication Date
CA2704300A1 true CA2704300A1 (en) 2005-07-14

Family

ID=34738672

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2704300A Abandoned CA2704300A1 (en) 2003-12-22 2004-12-09 Cd40 antibody formulation and methods
CA2549652A Active CA2549652C (en) 2003-12-22 2004-12-09 Cd40 antibody formulation and methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2549652A Active CA2549652C (en) 2003-12-22 2004-12-09 Cd40 antibody formulation and methods

Country Status (20)

Country Link
US (4) US20050136055A1 (es)
EP (3) EP1706143A1 (es)
JP (3) JP2007515469A (es)
KR (2) KR20080023766A (es)
CN (2) CN1897971A (es)
AU (1) AU2004308749B2 (es)
BR (1) BRPI0418029B8 (es)
CA (2) CA2704300A1 (es)
DK (1) DK2218461T3 (es)
ES (1) ES2580002T3 (es)
HU (1) HUE027717T2 (es)
IL (2) IL175540A (es)
NO (1) NO343797B1 (es)
NZ (2) NZ547162A (es)
PL (1) PL2218461T3 (es)
RU (1) RU2355421C2 (es)
SI (1) SI2218461T1 (es)
TW (1) TWI359671B (es)
WO (1) WO2005063289A1 (es)
ZA (1) ZA200603804B (es)

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US20090074711A1 (en) * 2006-09-07 2009-03-19 University Of Southhampton Human therapies using chimeric agonistic anti-human cd40 antibody
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JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
US20110311525A1 (en) * 2008-08-29 2011-12-22 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Delivery of a cd40 agonist to a tumor draining lymph node of a subject
US9561214B2 (en) * 2008-10-16 2017-02-07 Array Biopharma Inc. Method of treatment using inhibitors of mitosis
WO2011101332A1 (en) 2010-02-16 2011-08-25 Proyecto De Biomedicina Cima, S.L. Compositions based on the fibronectin extracellular domain a for the treatment of melanoma
WO2012123269A1 (en) 2011-03-11 2012-09-20 Proyecto De Biomedicina Cima, S.L. Immunogenic compositions and methods for their use
EP2505640A1 (en) 2011-03-29 2012-10-03 Neo Virnatech, S.L. Vaccine compositions for birnavirus-borne diseases
CN106928362B (zh) 2011-04-29 2021-10-26 埃派斯进有限公司 抗-cd40抗体及其使用方法
SG11201406592QA (en) 2012-05-04 2014-11-27 Pfizer Prostate-associated antigens and vaccine-based immunotherapy regimens
FR2994390B1 (fr) 2012-08-10 2014-08-15 Adocia Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee
ES2879552T3 (es) 2012-10-30 2021-11-22 Apexigen Inc Anticuerpos anti-CD40 y métodos de uso
US9856319B2 (en) 2012-12-28 2018-01-02 Abbvie Inc. Monovalent binding proteins
WO2014121099A1 (en) 2013-01-31 2014-08-07 Thomas Jefferson University Agonist fusion protein for cd40 ox40 and uses thereof
DK3030575T3 (en) 2013-08-08 2018-10-22 Cytune Pharma IL-15 AND IL-15R-ALFA-SUSHI DOMAIN-BASED MODULOKINES
IL299075A (en) 2014-10-29 2023-02-01 Seagen Inc Dosage and administration of non-fucosylated anti-CD40 antibodies
WO2017009843A2 (en) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Compositions, articles of manufacture and methods for treating cancer
JP7208492B2 (ja) 2016-03-10 2023-01-19 シージー オンコロジー, インコーポレイテッド 併用療法によって固形腫瘍又はリンパ系腫瘍を処置する方法
CA3026880A1 (en) 2016-06-08 2017-12-14 Paul Foster Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b
CA3026477A1 (en) 2016-06-20 2017-12-28 Kymab Limited Anti-pd-l1 antibodies
US11905331B2 (en) 2016-11-11 2024-02-20 Kumho Ht, Inc. Antibody binding specifically to CD40 and use thereof
WO2018162450A1 (en) 2017-03-06 2018-09-13 Fundación Para La Investigación Médica Aplicada New inmunostimulatory compositions comprising an entity of cold inducible rna-binding protein with an antigen for the activation of dendritic cells
CN111344304B (zh) * 2017-06-01 2023-09-01 Pb免疫治疗公司 新型抗cd40抗体及其用途
EP3418302A1 (en) * 2017-06-19 2018-12-26 F. Hoffmann-La Roche AG Administration routes for immune agonists
CN110506058A (zh) * 2017-06-02 2019-11-26 豪夫迈·罗氏有限公司 免疫激动剂的施用路径
CA3097007A1 (en) 2018-04-20 2019-10-24 Lyvgen Biopharma Co., Ltd. Anti-cd40 antibodies and uses thereof
MA52889A (fr) 2018-06-15 2021-04-21 Flagship Pioneering Innovations V Inc Augmentation de l'activité immunitaire par modulation de facteurs de signalisation post-cellulaires
CN112996818B (zh) 2018-09-28 2022-06-21 礼进生物医药科技(上海)有限公司 具有经过工程化的Fc结构域的抗CD40结合分子及其治疗用途
CN112839961B (zh) * 2018-11-30 2023-04-04 江苏恒瑞医药股份有限公司 一种cd40抗体药物组合物及其用途
EP3962493A2 (en) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
US20230114107A1 (en) 2019-12-17 2023-04-13 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
EP4106819A1 (en) 2020-02-21 2022-12-28 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
CN116234575A (zh) * 2020-06-04 2023-06-06 赛尔疫苗私人有限公司 激动剂抗cd40抗体
US20230355804A1 (en) 2020-06-29 2023-11-09 Flagship Pioneering Innovations V, Inc. Viruses engineered to promote thanotransmission and their use in treating cancer
WO2022006327A1 (en) 2020-07-01 2022-01-06 Silverback Therapeutics, Inc. Anti-asgr1 antibody conjugates and uses thereof
AU2022246895A1 (en) 2021-03-31 2023-10-19 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
WO2023278641A1 (en) 2021-06-29 2023-01-05 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
US20240174732A1 (en) 2022-10-05 2024-05-30 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer

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Also Published As

Publication number Publication date
TWI359671B (en) 2012-03-11
AU2004308749B2 (en) 2010-10-28
TW200521142A (en) 2005-07-01
JP2011184446A (ja) 2011-09-22
WO2005063289A1 (en) 2005-07-14
NZ583179A (en) 2011-06-30
RU2355421C2 (ru) 2009-05-20
PL2218461T3 (pl) 2016-09-30
CA2549652C (en) 2013-11-12
NO20063373L (no) 2006-09-21
KR20080023766A (ko) 2008-03-14
ZA200603804B (en) 2007-09-26
IL175540A (en) 2011-10-31
JP5634321B2 (ja) 2014-12-03
IL201409A0 (en) 2010-05-31
KR20070012626A (ko) 2007-01-26
ES2580002T3 (es) 2016-08-18
JP2014205692A (ja) 2014-10-30
IL175540A0 (en) 2006-09-05
KR100847944B1 (ko) 2008-07-22
US20050136055A1 (en) 2005-06-23
JP2007515469A (ja) 2007-06-14
SI2218461T1 (sl) 2016-08-31
BRPI0418029B1 (pt) 2018-12-26
DK2218461T3 (en) 2016-05-17
EP2218461B1 (en) 2016-04-20
EP3081933A1 (en) 2016-10-19
NO343797B1 (no) 2019-06-11
CA2549652A1 (en) 2005-07-14
NZ547162A (en) 2010-03-26
AU2004308749A1 (en) 2005-07-14
EP2218461A1 (en) 2010-08-18
CN1897971A (zh) 2007-01-17
EP1706143A1 (en) 2006-10-04
US20110104182A1 (en) 2011-05-05
BRPI0418029A (pt) 2007-04-17
US20090311254A1 (en) 2009-12-17
US20120263732A1 (en) 2012-10-18
RU2006120950A (ru) 2008-01-27
CN102552905A (zh) 2012-07-11
BRPI0418029B8 (pt) 2021-05-25
HUE027717T2 (en) 2016-10-28

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Effective date: 20150925