CA2697520A1 - Utilisation des diaminophenothiazines reduites lyophilisees dans le traitement des troubles neurologiques a mediation par tau - Google Patents
Utilisation des diaminophenothiazines reduites lyophilisees dans le traitement des troubles neurologiques a mediation par tau Download PDFInfo
- Publication number
- CA2697520A1 CA2697520A1 CA2697520A CA2697520A CA2697520A1 CA 2697520 A1 CA2697520 A1 CA 2697520A1 CA 2697520 A CA2697520 A CA 2697520A CA 2697520 A CA2697520 A CA 2697520A CA 2697520 A1 CA2697520 A1 CA 2697520A1
- Authority
- CA
- Canada
- Prior art keywords
- phenothiazine
- gly
- lys
- ser
- pro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000011282 treatment Methods 0.000 title claims 9
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- 230000001404 mediated effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract 12
- 208000034799 Tauopathies Diseases 0.000 claims abstract 5
- 102000039446 nucleic acids Human genes 0.000 claims abstract 2
- 108020004707 nucleic acids Proteins 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 2
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 claims 16
- 229950000688 phenothiazine Drugs 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 15
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- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
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- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
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- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical group [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims 2
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- PGWTYMLATMNCCZ-UHFFFAOYSA-M azure A Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 PGWTYMLATMNCCZ-UHFFFAOYSA-M 0.000 claims 1
- KFZNPGQYVZZSNV-UHFFFAOYSA-M azure B Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(NC)=CC=C3N=C21 KFZNPGQYVZZSNV-UHFFFAOYSA-M 0.000 claims 1
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- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
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- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
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GB0101049.5 | 2001-01-15 | ||
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CA2434067A CA2434067C (fr) | 2001-01-15 | 2002-01-15 | Materiaux et methodes permettant l'agregation des proteines dans une maladie neurogenerative |
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CA2434067A Division CA2434067C (fr) | 2001-01-15 | 2002-01-15 | Materiaux et methodes permettant l'agregation des proteines dans une maladie neurogenerative |
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CA2434067A Expired - Lifetime CA2434067C (fr) | 2001-01-15 | 2002-01-15 | Materiaux et methodes permettant l'agregation des proteines dans une maladie neurogenerative |
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GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
GB0100119D0 (en) | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
GB0106953D0 (en) | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
EP1521831B1 (fr) * | 2002-07-12 | 2008-04-09 | Axon Neuroscience Forschungs- und Entwicklungs Gmbh | Animal transgenique exprimant la proteine tau tronquée de la maladie d'alzheimer |
CN101084204B (zh) | 2004-09-23 | 2012-12-05 | 卫思道制药有限公司 | 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法 |
ES2409683T3 (es) | 2004-09-23 | 2013-06-27 | Wista Laboratories Ltd. | Procedimientos de síntesis química y purificación de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (CMT) |
AU2013200732B2 (en) * | 2006-03-29 | 2015-04-09 | Wista Laboratories Ltd. | 3,7-diamino-10H-phenothiazine salts and their use |
PL2853293T3 (pl) * | 2006-03-29 | 2018-05-30 | Wista Laboratories Ltd. | Związki tioniny i ich zastosowanie |
DK2013191T6 (en) * | 2006-03-29 | 2019-04-23 | Wista Lab Ltd | 3,7-Diamino-10H-phenothiazine salts and their use |
CA2645946C (fr) * | 2006-03-29 | 2014-04-01 | Wista Laboratories Ltd. | Inhibiteurs de l'agregation de proteines |
PT2457904E (pt) | 2006-07-11 | 2015-02-27 | Wista Lab Ltd | Processos de síntese e/ou purificação de compostos diaminofenotiazínio |
CN101820884B (zh) * | 2007-06-19 | 2013-08-28 | 维斯塔实验室有限公司 | 用于治疗轻度认知缺损的吩噻嗪化合物 |
AU2008306688B2 (en) * | 2007-10-03 | 2014-05-22 | Wista Laboratories Ltd. | Therapeutic use of diaminophenothiazines |
WO2010021755A2 (fr) * | 2008-08-20 | 2010-02-25 | Oligomerix, Inc. | Compositions de protéase tau et procédés |
ES2540536T3 (es) | 2008-09-23 | 2015-07-10 | Wista Laboratories Ltd. | Ligandos para moléculas tau agregadas |
WO2010067078A2 (fr) * | 2008-12-10 | 2010-06-17 | Wista Laboratories Ltd. | Sels de xanthylium disubstitués en 3 et 6 |
US8691979B2 (en) | 2009-05-12 | 2014-04-08 | Wista Laboratories Ltd. | Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants |
US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
EP2470211B1 (fr) * | 2009-08-28 | 2016-01-27 | The Board of Regents of The University of Texas System | Anticorps liant les oligomères de la protéine tau |
PT3792254T (pt) | 2009-09-24 | 2023-10-19 | Wista Lab Ltd | Hidratos de cloreto de metiltionínio cristalino |
JP5868955B2 (ja) | 2010-04-30 | 2016-02-24 | プロセッタ アンチバイラル インコーポレイテッド | 抗ウイルス化合物 |
WO2012051498A2 (fr) | 2010-10-15 | 2012-04-19 | The Board Of Regents Of The University Of Texas System | Anticorps qui lient des oligomères amyloïdes |
JP6093707B2 (ja) | 2010-11-30 | 2017-03-08 | ウィスタ ラボラトリーズ リミテッド | 化合物製剤 |
ES2714692T3 (es) | 2011-01-31 | 2019-05-29 | Tau Bio Logic Corp | Tratamiento de tauopatías |
EA025033B1 (ru) | 2011-02-11 | 2016-11-30 | Уиста Лэборэтэриз Лтд. | Диаминиевые соли фенотиазина и их применение |
EP2699241B1 (fr) | 2011-04-20 | 2016-07-27 | Prosetta Antiviral Inc. | Composés antiviraux |
LT2885010T (lt) | 2012-08-16 | 2020-04-27 | Ipierian, Inc. | Tautopatijos gydymo būdai |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
US9988418B2 (en) * | 2013-02-06 | 2018-06-05 | Agency For Science, Technology And Research | Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations |
GB201317702D0 (en) | 2013-10-07 | 2013-11-20 | Wista Lab Ltd | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
US10765755B1 (en) | 2013-11-20 | 2020-09-08 | University Of South Florida | Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies |
JP2017505756A (ja) * | 2013-12-13 | 2017-02-23 | ザ ジェネラル ホスピタル コーポレイション | 可溶性高分子量(hmw)タウ種およびその用途 |
NZ630610A (en) | 2014-02-14 | 2019-05-31 | Ipierian Inc | Tau peptides, anti-tau antibodies, and methods of use thereof |
CN103864717B (zh) * | 2014-04-04 | 2015-11-11 | 山东理工大学 | 一种针状亚甲基白晶体的制备方法 |
GB201512678D0 (en) | 2015-07-20 | 2015-08-26 | Wista Lab Ltd | Methods of chemical synthesis |
EP4335517A2 (fr) | 2016-07-25 | 2024-03-13 | WisTa Laboratories Ltd. | Administration et dosage de diaminophénothiazines |
GB201614834D0 (en) | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
GB201621817D0 (en) | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
CA3107349A1 (fr) * | 2018-07-23 | 2020-01-30 | Enclear Therapies, Inc. | Methodes de traitement de troubles neurologiques |
EP3826650A4 (fr) | 2018-07-23 | 2022-07-27 | Enclear Therapies, Inc. | Méthodes de traitement de troubles neurologiques |
EP4364801A2 (fr) | 2018-07-26 | 2024-05-08 | WisTa Laboratories Ltd. | Dosage optimisé de diaminophénothiazines dans des populations |
WO2020201828A1 (fr) | 2019-04-05 | 2020-10-08 | Tauc3 Biologics Limited | Anticorps anti-tauc3 et leurs utilisations |
AU2020271894A1 (en) | 2019-04-11 | 2021-12-02 | Enclear Therapies, Inc. | Methods of amelioration of cerebrospinal fluid and devices and systems therefor |
GB201909393D0 (en) | 2019-06-28 | 2019-08-14 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
GB202010620D0 (en) | 2020-07-10 | 2020-08-26 | Wista Lab Ltd | System |
WO2023232764A1 (fr) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | Traitement de troubles neurodégénératifs à l'aide de composés contenant du méthylthioninium (mt) |
WO2024063700A1 (fr) | 2022-09-21 | 2024-03-28 | Yin Sze Loh | Formulation orale de diaminophénothiazines et procédés de fabrication et d'utilisation de celle-ci dans le traitement et/ou la prévention de maladies |
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US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
GB8724412D0 (en) | 1987-10-19 | 1987-11-25 | Medical Res Council | Protein |
EP0397687B1 (fr) | 1987-12-21 | 1994-05-11 | The University Of Toledo | Transformation par l'agrobacterium de graines de plantes de germination |
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DE69230148T2 (de) | 1991-12-06 | 2000-05-04 | Max Planck Gesellschaft | Werkzeuge für die Diagnose und Behandlung der Alzheimerschen Krankheit. |
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-
2001
- 2001-01-15 GB GBGB0101049.5A patent/GB0101049D0/en not_active Ceased
-
2002
- 2002-01-15 EP EP10007601A patent/EP2305823B1/fr not_active Expired - Lifetime
- 2002-01-15 AT AT02715498T patent/ATE483814T1/de active
- 2002-01-15 CN CN028063015A patent/CN1496404B/zh not_active Expired - Lifetime
- 2002-01-15 EP EP02715498A patent/EP1352077B1/fr not_active Expired - Lifetime
- 2002-01-15 WO PCT/GB2002/000153 patent/WO2002055720A2/fr active Application Filing
- 2002-01-15 ES ES10007601T patent/ES2407204T3/es not_active Expired - Lifetime
- 2002-01-15 AU AU2002225147A patent/AU2002225147B2/en not_active Expired
- 2002-01-15 DK DK02715498.8T patent/DK1352077T3/da active
- 2002-01-15 US US10/451,782 patent/US7335505B2/en not_active Expired - Lifetime
- 2002-01-15 JP JP2002556766A patent/JP4422407B2/ja not_active Expired - Lifetime
- 2002-01-15 DE DE60237874T patent/DE60237874D1/de not_active Expired - Lifetime
- 2002-01-15 ES ES02715498T patent/ES2353202T3/es not_active Expired - Lifetime
- 2002-01-15 PT PT100076017T patent/PT2305823E/pt unknown
- 2002-01-15 PT PT02715498T patent/PT1352077E/pt unknown
- 2002-01-15 DK DK10007601.7T patent/DK2305823T3/da active
- 2002-01-15 CA CA2697520A patent/CA2697520C/fr not_active Expired - Lifetime
- 2002-01-15 CA CA2434067A patent/CA2434067C/fr not_active Expired - Lifetime
-
2003
- 2003-10-30 HK HK03107838.8A patent/HK1055605A1/xx not_active IP Right Cessation
-
2008
- 2008-01-28 US US12/010,649 patent/US7893054B2/en not_active Expired - Fee Related
- 2008-07-22 JP JP2008188134A patent/JP5160990B2/ja not_active Expired - Lifetime
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2011
- 2011-04-14 HK HK11103782.3A patent/HK1149588A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2305823B1 (fr) | 2013-03-27 |
WO2002055720A9 (fr) | 2002-12-27 |
EP1352077B1 (fr) | 2010-10-06 |
JP2009035549A (ja) | 2009-02-19 |
US20090075984A1 (en) | 2009-03-19 |
JP4422407B2 (ja) | 2010-02-24 |
CA2434067C (fr) | 2010-06-22 |
CN1496404B (zh) | 2011-10-19 |
HK1055605A1 (en) | 2004-01-16 |
DE60237874D1 (de) | 2010-11-18 |
ES2353202T3 (es) | 2011-02-28 |
DK2305823T3 (da) | 2013-06-24 |
CA2697520C (fr) | 2014-02-04 |
HK1149588A1 (en) | 2011-10-07 |
EP1352077A2 (fr) | 2003-10-15 |
JP5160990B2 (ja) | 2013-03-13 |
US7335505B2 (en) | 2008-02-26 |
JP2004524831A (ja) | 2004-08-19 |
ATE483814T1 (de) | 2010-10-15 |
US20040110250A1 (en) | 2004-06-10 |
ES2407204T3 (es) | 2013-06-12 |
US7893054B2 (en) | 2011-02-22 |
EP2305823A1 (fr) | 2011-04-06 |
CA2434067A1 (fr) | 2002-07-18 |
CN1496404A (zh) | 2004-05-12 |
PT1352077E (pt) | 2011-01-12 |
GB0101049D0 (en) | 2001-02-28 |
PT2305823E (pt) | 2013-07-08 |
WO2002055720A3 (fr) | 2002-11-21 |
AU2002225147B2 (en) | 2006-12-07 |
WO2002055720A2 (fr) | 2002-07-18 |
DK1352077T3 (da) | 2011-01-10 |
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