CA2692801A1 - Methods of inhibiting the formation of amyloid-.beta. diffusable ligands using acylhydrazide compounds - Google Patents

Methods of inhibiting the formation of amyloid-.beta. diffusable ligands using acylhydrazide compounds Download PDF

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Publication number
CA2692801A1
CA2692801A1 CA 2692801 CA2692801A CA2692801A1 CA 2692801 A1 CA2692801 A1 CA 2692801A1 CA 2692801 CA2692801 CA 2692801 CA 2692801 A CA2692801 A CA 2692801A CA 2692801 A1 CA2692801 A1 CA 2692801A1
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Prior art keywords
hydroxy
group
alkyl
aryl
substituted
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CA 2692801
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English (en)
French (fr)
Inventor
Gary Charles Look
Lauri Schultz
Alexandre Mikhaylovich Polozov
Nikhil Bhagat
Jian Wang
David E. Zembower
William F. Goure
Todd Pray
Grant A. Krafft
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Acumen Pharmaceuticals Inc
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Individual
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Priority claimed from US11/777,264 external-priority patent/US9006283B2/en
Priority claimed from US11/777,266 external-priority patent/US8962677B2/en
Application filed by Individual filed Critical Individual
Publication of CA2692801A1 publication Critical patent/CA2692801A1/en
Abandoned legal-status Critical Current

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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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CA 2692801 2007-07-12 2008-07-11 Methods of inhibiting the formation of amyloid-.beta. diffusable ligands using acylhydrazide compounds Abandoned CA2692801A1 (en)

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US11/777,264 2007-07-12
US11/777,264 US9006283B2 (en) 2007-07-12 2007-07-12 Methods of modifying amyloid β oligomers using non-peptidic compounds
US11/777,266 2007-07-12
US11/777,266 US8962677B2 (en) 2007-07-12 2007-07-12 Methods of restoring cognitive ability using non-peptidic compounds
US95072407P 2007-07-19 2007-07-19
US95081007P 2007-07-19 2007-07-19
US60/950,724 2007-07-19
US60/950,810 2007-07-19
PCT/US2008/069878 WO2009009768A2 (en) 2007-07-12 2008-07-11 METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS

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DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
CN117903302A (zh) 2005-11-30 2024-04-19 Abbvie 公司 抗-Aβ球聚体抗体，其相关产品，生产所述抗体的方法，所述抗体的应用以及使用方法
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2486928A1 (de) 2007-02-27 2012-08-15 Abbott GmbH & Co. KG Verfahren zur Behandlung von Amyloidosen
WO2009079566A2 (en) 2007-12-18 2009-06-25 Acumen Pharmaceuticals, Inc. Novel addl receptor polypeptides, polynucleotides and host cells for recombinant production
CA2796339C (en) 2010-04-15 2020-03-31 Abbott Laboratories Amyloid-beta binding proteins
CA2808187A1 (en) 2010-08-14 2012-02-23 Abbvie Inc. Amyloid-beta binding proteins
WO2015188130A1 (en) * 2014-06-05 2015-12-10 The University Of Kansas Marmelin analogs and methods of use in cancer treatment

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