WO2009009768A8 - METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUNDS - Google Patents

METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUNDS Download PDF

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Publication number
WO2009009768A8
WO2009009768A8 PCT/US2008/069878 US2008069878W WO2009009768A8 WO 2009009768 A8 WO2009009768 A8 WO 2009009768A8 US 2008069878 W US2008069878 W US 2008069878W WO 2009009768 A8 WO2009009768 A8 WO 2009009768A8
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WIPO (PCT)
Prior art keywords
amyloid
formation
methods
inhibiting
diffusable
Prior art date
Application number
PCT/US2008/069878
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French (fr)
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WO2009009768A3 (en
WO2009009768A2 (en
Inventor
Gary Charles Look
Lauri Schultz
Alexandre Mikhaylovich Polozov
Nikhil Bhagat
Jian Wang
David E. Zembower
William F. Goure
Todd Pray
Grant A. Krafft
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Acumen Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from US11/777,266 external-priority patent/US8962677B2/en
Priority claimed from US11/777,264 external-priority patent/US9006283B2/en
Application filed by Acumen Pharmaceuticals, Inc. filed Critical Acumen Pharmaceuticals, Inc.
Priority to US12/668,174 priority Critical patent/US20110098309A1/en
Priority to EP08826259A priority patent/EP2194975A2/en
Priority to CA 2692801 priority patent/CA2692801A1/en
Priority to MX2010000370A priority patent/MX2010000370A/en
Publication of WO2009009768A2 publication Critical patent/WO2009009768A2/en
Publication of WO2009009768A3 publication Critical patent/WO2009009768A3/en
Publication of WO2009009768A8 publication Critical patent/WO2009009768A8/en

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Abstract

Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ß1-42 oligomers from amyloid ß1-42 monomers using acylhydrazidecompounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ß1-42 oligomers using acylhydrazidecompounds.
PCT/US2008/069878 2007-07-12 2008-07-11 METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS WO2009009768A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/668,174 US20110098309A1 (en) 2007-07-12 2008-07-11 Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds
EP08826259A EP2194975A2 (en) 2007-07-12 2008-07-11 METHODS OF INHIBITING THE FORMATION OF AMYLOID-ß DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUNDS
CA 2692801 CA2692801A1 (en) 2007-07-12 2008-07-11 Methods of inhibiting the formation of amyloid-.beta. diffusable ligands using acylhydrazide compounds
MX2010000370A MX2010000370A (en) 2007-07-12 2008-07-11 METHODS OF INHIBITING THE FORMATION OF AMYLOID-beta DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS.

Applications Claiming Priority (8)

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US11/777,266 US8962677B2 (en) 2007-07-12 2007-07-12 Methods of restoring cognitive ability using non-peptidic compounds
US11/777,264 2007-07-12
US11/777,266 2007-07-12
US11/777,264 US9006283B2 (en) 2007-07-12 2007-07-12 Methods of modifying amyloid β oligomers using non-peptidic compounds
US95072407P 2007-07-19 2007-07-19
US95081007P 2007-07-19 2007-07-19
US60/950,724 2007-07-19
US60/950,810 2007-07-19

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US9217024B2 (en) 2007-12-18 2015-12-22 Acumen Pharmaceuticals, Inc. ADDL receptor polypeptides, polynucleotides and host cells for recombinant production

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DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
KR20180058863A (en) 2005-11-30 2018-06-01 애브비 인코포레이티드 Monoclonal antibodies against amyloid beta protein and uses thereof
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US20100311767A1 (en) 2007-02-27 2010-12-09 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
CN103298833B (en) 2010-08-14 2015-12-16 Abbvie公司 Amyloid beta associated proteins
US20170144965A1 (en) * 2014-06-05 2017-05-25 The University Of Kansas Marmelin analogs and methods of use in cancer treatment

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AU2002210385A1 (en) * 2000-10-16 2002-04-29 Novo-Nordisk A/S Furazanyl-triazole derivates for the treatment of diseases
DE10348044A1 (en) * 2003-10-15 2005-05-19 Imtm Gmbh Dual alanyl aminopeptidase and dipeptidyl peptidase IV inhibitors for the functional influence of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
DE10348023A1 (en) * 2003-10-15 2005-05-19 Imtm Gmbh New alanyl aminopeptidase inhibitors for the functional manipulation of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
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US9217024B2 (en) 2007-12-18 2015-12-22 Acumen Pharmaceuticals, Inc. ADDL receptor polypeptides, polynucleotides and host cells for recombinant production

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