CA2679882C - Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof - Google Patents
Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof Download PDFInfo
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- CA2679882C CA2679882C CA2679882A CA2679882A CA2679882C CA 2679882 C CA2679882 C CA 2679882C CA 2679882 A CA2679882 A CA 2679882A CA 2679882 A CA2679882 A CA 2679882A CA 2679882 C CA2679882 C CA 2679882C
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Urology & Nephrology (AREA)
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| US90596307P | 2007-03-08 | 2007-03-08 | |
| US60/905,963 | 2007-03-08 | ||
| PCT/US2008/003092 WO2008112164A2 (en) | 2007-03-08 | 2008-03-07 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
Publications (2)
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| CA2679882A1 CA2679882A1 (en) | 2008-09-18 |
| CA2679882C true CA2679882C (en) | 2015-12-29 |
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| WO (1) | WO2008112164A2 (enExample) |
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| EP2126574B1 (en) | 2007-03-08 | 2015-12-23 | The Board of Trustees of the Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| WO2010028175A1 (en) | 2008-09-08 | 2010-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| EP2349279A4 (en) * | 2008-10-28 | 2013-12-25 | Univ Leland Stanford Junior | MODIFIERS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF |
| US20140088187A1 (en) * | 2010-12-14 | 2014-03-27 | Beth Israel Deaconess Medical Center | Androgen receptor inhibitors and methods of use thereof |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| TWI567061B (zh) | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
| EP2887968A2 (en) * | 2012-08-24 | 2015-07-01 | The Board of Trustees of the Leland Stanford Junior University | Methods and compositions for treating pain |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| CN103191103A (zh) * | 2013-04-15 | 2013-07-10 | 中南大学 | 乙醛脱氢酶激活物alda-1的合成方法及其用途 |
| CN103923077B (zh) * | 2013-07-05 | 2016-03-02 | 高尔医药科技(上海)有限公司 | 两种乙醛脱氢酶激动剂、其制备方法及用途 |
| JP6261278B2 (ja) * | 2013-10-16 | 2018-01-17 | 国立大学法人広島大学 | アルデヒドデヒドロゲナーゼの活性を増強するための医薬組成物 |
| WO2015084731A1 (en) * | 2013-12-02 | 2015-06-11 | The Board Of Trustees Of The Leland Stanford Junior University | Aldehyde dehydrogenase inhibitors and methods of use thereof |
| ES2833157T3 (es) * | 2014-02-19 | 2021-06-14 | Aviv Therapeutics Inc | Amidas políciclicas de unión a aldehído deshidrogenasa 2 mitocondrial (aldh2) y su uso para el tratamiento del cáncer |
| FR3054564B1 (fr) * | 2016-07-28 | 2018-08-31 | Advanced Biodesign | Substrat specifique d'une isoenzyme de l'aldh |
| WO2019098288A1 (ja) * | 2017-11-15 | 2019-05-23 | 学校法人 慶應義塾 | 抗腫瘍剤及び配合剤 |
| MX2020006628A (es) | 2018-01-31 | 2020-09-14 | Eisai R&D Man Co Ltd | Activador de aldehido deshidrogenasa 2 (aldh2). |
| CN114149386A (zh) * | 2018-06-04 | 2022-03-08 | 中国人民解放军第二军医大学 | 芳基戊二烯酰胺类醛脱氢酶抑制剂、其合成方法及用途 |
| CN111909138A (zh) * | 2019-05-09 | 2020-11-10 | 上海仕谱生物科技有限公司 | 抑制tdg活性的化合物 |
| CN114144493A (zh) * | 2019-05-23 | 2022-03-04 | Ekyj Ii 咨询有限责任公司 | 治疗和减轻酒精诱导的皮肤潮红的组合物和方法 |
| MX2023002714A (es) | 2020-11-02 | 2023-03-28 | Alchemedicine Inc | Compuesto, agente de activacion de aldehido deshidrogenasa 2, composicion farmaceutica y farmaco terapeutico y/o profilactico. |
| CN118591526A (zh) | 2022-04-22 | 2024-09-03 | 亚克医药株式会社 | 化合物、乙醛脱氢酶2激活剂、药物组合物以及治疗及/或预防药 |
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| KR20090117950A (ko) | 2009-11-16 |
| EP2126574A4 (en) | 2012-02-22 |
| EP2126574B1 (en) | 2015-12-23 |
| CN101669030A (zh) | 2010-03-10 |
| US20150105456A1 (en) | 2015-04-16 |
| US20090082431A1 (en) | 2009-03-26 |
| EP2126574A2 (en) | 2009-12-02 |
| WO2008112164A2 (en) | 2008-09-18 |
| JP2015061836A (ja) | 2015-04-02 |
| WO2008112164A3 (en) | 2008-11-13 |
| JP2010523476A (ja) | 2010-07-15 |
| CA2679882A1 (en) | 2008-09-18 |
| AU2008226947B2 (en) | 2014-07-17 |
| US9102651B2 (en) | 2015-08-11 |
| US20120010248A1 (en) | 2012-01-12 |
| CN101669030B (zh) | 2016-01-13 |
| AU2008226947A1 (en) | 2008-09-18 |
| US20110105602A2 (en) | 2011-05-05 |
| US9315484B2 (en) | 2016-04-19 |
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