CA2658533C - Device for processing samples - Google Patents
Device for processing samples Download PDFInfo
- Publication number
- CA2658533C CA2658533C CA2658533A CA2658533A CA2658533C CA 2658533 C CA2658533 C CA 2658533C CA 2658533 A CA2658533 A CA 2658533A CA 2658533 A CA2658533 A CA 2658533A CA 2658533 C CA2658533 C CA 2658533C
- Authority
- CA
- Canada
- Prior art keywords
- module
- sample
- vessels
- vessel
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000012545 processing Methods 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 178
- 230000008569 process Effects 0.000 claims abstract description 163
- 230000003750 conditioning effect Effects 0.000 claims abstract description 33
- 238000002360 preparation method Methods 0.000 claims abstract description 21
- 238000003860 storage Methods 0.000 claims description 36
- 238000004458 analytical method Methods 0.000 claims description 27
- 238000012546 transfer Methods 0.000 claims description 25
- 238000000605 extraction Methods 0.000 claims description 22
- 230000009089 cytolysis Effects 0.000 claims description 21
- 230000003321 amplification Effects 0.000 claims description 19
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 19
- 238000007885 magnetic separation Methods 0.000 claims description 11
- 238000011144 upstream manufacturing Methods 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 6
- 238000002604 ultrasonography Methods 0.000 claims description 4
- 239000000523 sample Substances 0.000 abstract description 137
- 239000012472 biological sample Substances 0.000 abstract description 24
- 239000012491 analyte Substances 0.000 abstract description 21
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 description 51
- 239000003153 chemical reaction reagent Substances 0.000 description 25
- 239000002245 particle Substances 0.000 description 20
- 239000011159 matrix material Substances 0.000 description 19
- 238000003752 polymerase chain reaction Methods 0.000 description 19
- 102000039446 nucleic acids Human genes 0.000 description 18
- 108020004707 nucleic acids Proteins 0.000 description 18
- 150000007523 nucleic acids Chemical class 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 16
- 239000000243 solution Substances 0.000 description 14
- 238000001179 sorption measurement Methods 0.000 description 14
- 239000000470 constituent Substances 0.000 description 12
- 238000010828 elution Methods 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 238000012423 maintenance Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 8
- 102000053602 DNA Human genes 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 238000010606 normalization Methods 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 229920002477 rna polymer Polymers 0.000 description 7
- 108020004459 Small interfering RNA Proteins 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 108091005461 Nucleic proteins Proteins 0.000 description 3
- 102000015636 Oligopeptides Human genes 0.000 description 3
- 108010038807 Oligopeptides Proteins 0.000 description 3
- 230000001143 conditioned effect Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000010924 continuous production Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 239000011859 microparticle Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 108090000994 Catalytic RNA Proteins 0.000 description 2
- 102000053642 Catalytic RNA Human genes 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 108020004688 Small Nuclear RNA Proteins 0.000 description 2
- 102000039471 Small Nuclear RNA Human genes 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000010804 cDNA synthesis Methods 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000002934 lysing effect Effects 0.000 description 2
- 239000006249 magnetic particle Substances 0.000 description 2
- 238000010297 mechanical methods and process Methods 0.000 description 2
- 230000005226 mechanical processes and functions Effects 0.000 description 2
- 108091070501 miRNA Proteins 0.000 description 2
- 239000002679 microRNA Substances 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 108091092562 ribozyme Proteins 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
- 241000796533 Arna Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229930182476 C-glycoside Natural products 0.000 description 1
- 150000000700 C-glycosides Chemical class 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229930182474 N-glycoside Natural products 0.000 description 1
- 102000029797 Prion Human genes 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- -1 RNA Chemical class 0.000 description 1
- 102000000574 RNA-Induced Silencing Complex Human genes 0.000 description 1
- 108010016790 RNA-Induced Silencing Complex Proteins 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 241000726445 Viroids Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000003763 chloroplast Anatomy 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001218 confocal laser scanning microscopy Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000013412 genome amplification Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000001001 laser micro-dissection Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 239000012521 purified sample Substances 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004171 remote diagnosis Methods 0.000 description 1
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000003196 serial analysis of gene expression Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00712—Automatic status testing, e.g. at start-up or periodic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00871—Communications between instruments or with remote terminals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00326—Analysers with modular structure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0491—Position sensing, encoding; closed-loop control
- G01N2035/0493—Locating samples; identifying different tube sizes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00613—Quality control
- G01N35/00663—Quality control of consumables
Landscapes
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Quality & Reliability (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83419506P | 2006-07-28 | 2006-07-28 | |
| EP06015812A EP1882948A2 (de) | 2006-07-28 | 2006-07-28 | Vorrichtung zur Probenverarbeitung |
| US60/834,195 | 2006-07-28 | ||
| EP06015812.8 | 2006-07-28 | ||
| PCT/EP2007/006684 WO2008012104A2 (en) | 2006-07-28 | 2007-07-27 | Device for processing samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2658533A1 CA2658533A1 (en) | 2008-01-31 |
| CA2658533C true CA2658533C (en) | 2016-03-15 |
Family
ID=38596322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2658533A Active CA2658533C (en) | 2006-07-28 | 2007-07-27 | Device for processing samples |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2047282B1 (https=) |
| JP (2) | JP2009544955A (https=) |
| AU (1) | AU2007278425B2 (https=) |
| CA (1) | CA2658533C (https=) |
| WO (1) | WO2008012104A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073002B (zh) | 2004-09-15 | 2012-08-08 | 英特基因有限公司 | 微流体装置 |
| EP1979079A4 (en) | 2006-02-03 | 2012-11-28 | Integenx Inc | MICROFLUIDIC DEVICES |
| US20110039303A1 (en) | 2007-02-05 | 2011-02-17 | Stevan Bogdan Jovanovich | Microfluidic and nanofluidic devices, systems, and applications |
| KR20110030415A (ko) | 2008-01-22 | 2011-03-23 | 인터젠엑스 인크. | 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도 |
| KR20110111449A (ko) | 2008-12-31 | 2011-10-11 | 인터젠엑스 인크. | 미세유체 칩을 갖는 기구 |
| CN102459565A (zh) | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | 具有隔膜阀的流控设备 |
| EP3586945A3 (en) | 2009-06-05 | 2020-03-04 | IntegenX Inc. | Universal sample preparation system and use in an integrated analysis system |
| GB2472236A (en) * | 2009-07-29 | 2011-02-02 | Iti Scotland Ltd | Apparatus for analysing microfluidic devices |
| US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
| JP5819617B2 (ja) | 2010-03-04 | 2015-11-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 分析器のハードウェア構成 |
| US9034575B2 (en) | 2010-03-04 | 2015-05-19 | Roche Molecular Systems, Inc. | Workflow timing between modules |
| US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
| DE112011102524T5 (de) | 2010-07-29 | 2013-07-11 | Roche Diagnostics Gmbh | Präparation generischer Proben |
| US9725754B2 (en) | 2010-07-29 | 2017-08-08 | Sean F. Boyle | Generic sample preparation |
| EP2606154B1 (en) | 2010-08-20 | 2019-09-25 | Integenx Inc. | Integrated analysis system |
| WO2012024657A1 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
| JP5690543B2 (ja) * | 2010-10-05 | 2015-03-25 | 株式会社日立ハイテクノロジーズ | 検体検査自動化装置，自動分析装置およびシステム |
| CN103370627B (zh) | 2010-10-29 | 2016-05-11 | 恩姆菲舍尔科技公司 | 用于样品制备和分析的自动化系统的系统布局 |
| US9164114B2 (en) * | 2011-04-19 | 2015-10-20 | Roche Molecular Systems, Inc. | Supply unit for continuous loading |
| JP5789441B2 (ja) * | 2011-08-01 | 2015-10-07 | 株式会社日立ハイテクノロジーズ | 遺伝子検査システム |
| US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
| US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
| BR112014026735B1 (pt) | 2012-04-27 | 2021-11-23 | Cepheid | Aparelho de processamento de amostra biológica, e, método para operar um aparelho de processamento de amostra |
| EP2857843A1 (de) * | 2013-10-07 | 2015-04-08 | Eppendorf Ag | System aufweisend mindestens zwei Laborgeräte zur gerätegesteuerten Bearbeitung einer Teilaufgabe bei einem Behandlungsprozess beinhaltend Behandlungen mindestens einer Laborprobe, Laborgerät und Verfahren |
| DK2857841T3 (da) | 2013-10-07 | 2021-07-26 | Eppendorf Ag | Laboratorieapparat til apparatstyret behandling af mindst én laboratorieprøve, og en fremgangsmåde til konfigurering af laboratorieapparatet ved hjælp af konfigurationsstyringen |
| ES2904524T3 (es) | 2013-10-07 | 2022-04-05 | Eppendorf Ag | Instrumento de laboratorio, sistema y método para el procesamiento controlado por el instrumento de al menos una muestra de laboratorio mediante el uso de al menos un consumible |
| EP2857842B1 (de) | 2013-10-07 | 2022-09-21 | Eppendorf SE | Zugriffssteuerung für ein Laborgerät, Laborgerät mit Zugriffssteuerung und Verfahren zur gerätegesteuerten Behandlung von Laborproben |
| CN114471756B (zh) | 2013-11-18 | 2024-04-16 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
| US9771571B2 (en) | 2014-02-28 | 2017-09-26 | Gen-Probe Incorporated | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| US9771572B2 (en) | 2014-02-28 | 2017-09-26 | Gen-Probe Incorporated | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| DE102015017080B3 (de) | 2014-02-28 | 2024-01-04 | Gen-Probe Incorporated | Verfahren zur Isolierung von Nukleinsäure von zytologischen Proben in flüssigen Konservierungsmitteln, die Formaldehyd enthalten |
| CN111484992B (zh) | 2014-02-28 | 2024-04-02 | 简·探针公司 | 从含有甲醛的液基细胞学防腐剂中的样本分离核酸的方法 |
| WO2015179098A1 (en) | 2014-05-21 | 2015-11-26 | Integenx Inc. | Fluidic cartridge with valve mechanism |
| JP6110445B2 (ja) | 2014-08-29 | 2017-04-05 | シスメックス株式会社 | 検査システムおよび検査方法 |
| CN107106983B (zh) | 2014-10-22 | 2021-04-16 | 尹特根埃克斯有限公司 | 用于样品制备、处理和分析的系统和方法 |
| JP6937116B2 (ja) * | 2016-12-15 | 2021-09-22 | シスメックス株式会社 | 前処理装置及び前処理方法 |
| WO2018181487A1 (ja) * | 2017-03-29 | 2018-10-04 | ユニバーサル・バイオ・リサーチ株式会社 | 検体処理測定システム |
| EP3845907A4 (en) * | 2018-08-29 | 2022-06-08 | Hitachi High-Tech Corporation | AUTOMATIC ANALYZER |
| US11331660B2 (en) * | 2019-01-04 | 2022-05-17 | Funai Electric Co. Ltd. | Digital dispense system |
| JP7317522B2 (ja) * | 2019-03-06 | 2023-07-31 | マルヤス工業株式会社 | 自動ろ過装置 |
| CN110865018B (zh) * | 2019-08-08 | 2023-03-28 | 上海交通大学医学院附属新华医院 | 一种样品后处理系统、设备和方法 |
| EP3789772B1 (en) | 2019-09-05 | 2025-03-26 | Roche Diagnostics GmbH | Method for determining a position of a rack on a rack placement unit of a laboratory handling system and laboratory handling system |
| JP7415908B2 (ja) * | 2020-12-15 | 2024-01-17 | 株式会社島津製作所 | 試料前処理装置 |
| CN114574323B (zh) * | 2022-03-31 | 2023-04-07 | 江苏莱尔生物医药科技有限公司 | 一种细胞分离装置 |
| JP2025520068A (ja) * | 2022-05-27 | 2025-07-01 | スリーエム イノベイティブ プロパティズ カンパニー | 病原体サンプル収集デバイス |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428470A (en) * | 1992-07-17 | 1995-06-27 | Beckman Instruments, Inc. | Modular system and method for an automatic analyzer |
| JP2947146B2 (ja) * | 1995-09-29 | 1999-09-13 | 株式会社島津製作所 | オ−トサンプラ |
| JP3032159B2 (ja) * | 1996-09-24 | 2000-04-10 | 株式会社日立製作所 | 分析システム |
| JPH11304812A (ja) * | 1998-04-20 | 1999-11-05 | Hitachi Ltd | 検体処理システム |
| ES2286750T3 (es) * | 1998-05-01 | 2007-12-01 | Gen-Probe Incorporated | Dispositivo para agitar el contenido liquido de un contenedor. |
| JP4101466B2 (ja) * | 1998-07-27 | 2008-06-18 | 株式会社日立製作所 | 生体サンプルの分析装置 |
| WO2000060362A1 (en) * | 1999-04-08 | 2000-10-12 | Chung Chang Young | Apparatus for fast preparation and analysis of nucleic acids |
| JP3587124B2 (ja) * | 2000-04-12 | 2004-11-10 | 松下電器産業株式会社 | 分注装置および分注方法 |
| AU2002324289A1 (en) * | 2001-07-24 | 2003-02-17 | Societe D'amenagement Urbain Et Rural | Automated process for detecting pathogenic organisms in water |
| US6881579B2 (en) * | 2001-07-30 | 2005-04-19 | Agilent Technologies, Inc. | Sample processing apparatus and methods |
| JP3771840B2 (ja) * | 2001-12-27 | 2006-04-26 | アロカ株式会社 | マイクロプレート搬送装置 |
| JP2005523692A (ja) * | 2002-04-26 | 2005-08-11 | アボット・ラボラトリーズ | 生物学的検定において磁性粒子を処理するための構造体および方法 |
| JP2004166555A (ja) * | 2002-11-19 | 2004-06-17 | Sanyo Electric Co Ltd | インキュベータ |
| WO2004055521A1 (en) * | 2002-12-16 | 2004-07-01 | Thermo Crs Ltd. | An automatic storage device with a cylindrical rack |
| DE10331254B4 (de) * | 2003-07-10 | 2006-05-04 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Vorrichtung und Verfahren zum Abtrennen von magnetischen oder magnetisierbaren Partikeln aus einer Flüssigkeit |
-
2007
- 2007-07-27 WO PCT/EP2007/006684 patent/WO2008012104A2/en not_active Ceased
- 2007-07-27 JP JP2009521171A patent/JP2009544955A/ja active Pending
- 2007-07-27 CA CA2658533A patent/CA2658533C/en active Active
- 2007-07-27 AU AU2007278425A patent/AU2007278425B2/en active Active
- 2007-07-27 EP EP07786396.7A patent/EP2047282B1/en active Active
-
2013
- 2013-05-08 JP JP2013098383A patent/JP5886787B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2047282B1 (en) | 2014-05-07 |
| JP2013172736A (ja) | 2013-09-05 |
| AU2007278425A1 (en) | 2008-01-31 |
| WO2008012104A3 (en) | 2008-05-29 |
| CA2658533A1 (en) | 2008-01-31 |
| JP5886787B2 (ja) | 2016-03-16 |
| EP2047282A2 (en) | 2009-04-15 |
| JP2009544955A (ja) | 2009-12-17 |
| AU2007278425B2 (en) | 2011-11-17 |
| WO2008012104A2 (en) | 2008-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2658533C (en) | Device for processing samples | |
| US10458998B2 (en) | Device for processing samples | |
| AU785010B2 (en) | System and method for manipulating magnetically responsive particles in fluid samples to collect DNA or RNA from a sample | |
| CN108103057B (zh) | 用于纯化核酸的方法和试剂盒 | |
| US9028777B2 (en) | Automated cellular material preparation | |
| EP1955079B1 (en) | Compact apparatus, compositions and methods for purifying nucleic acids | |
| CN101010592B (zh) | 将磁性粒子与流体分离、混合和浓缩的设备和方法及其在提纯方法中的用途 | |
| EP1282469B1 (en) | System and method for manipulating magnetically responsive particles in fluid samples to collect dna or rna from a sample | |
| US20090176308A1 (en) | Apparatus and method for the purification of biomolecules | |
| US20030203491A1 (en) | Gravitational flow purification system | |
| CN101747397A (zh) | 用于自动提取核酸的系统和方法 | |
| US20150152405A1 (en) | Suspension container for binding particles for the isolation of biological material | |
| EP3759244B1 (en) | Method and system for high-throughput particle handling by use of magnetic fields | |
| CN219689719U (zh) | 一种核酸提取扩增一体化系统及试剂盒 | |
| EP2423688B1 (en) | Suspension container for binding particles for the isolation of biological material | |
| EP4244596A1 (en) | System and method for polynucleotide purification | |
| Cardona et al. | Design considerations in high-throughput automation for biotechnology | |
| EP2535712A1 (en) | Analytical system for the preparation of biological material | |
| Wells et al. | Automation of Sample | |
| HK1218573B (en) | Method and kit for purifying nucleic acids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |