CA2658533C - Device for processing samples - Google Patents
Device for processing samples Download PDFInfo
- Publication number
- CA2658533C CA2658533C CA2658533A CA2658533A CA2658533C CA 2658533 C CA2658533 C CA 2658533C CA 2658533 A CA2658533 A CA 2658533A CA 2658533 A CA2658533 A CA 2658533A CA 2658533 C CA2658533 C CA 2658533C
- Authority
- CA
- Canada
- Prior art keywords
- module
- sample
- vessels
- vessel
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000012545 processing Methods 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 178
- 230000008569 process Effects 0.000 claims abstract description 163
- 230000003750 conditioning effect Effects 0.000 claims abstract description 33
- 238000002360 preparation method Methods 0.000 claims abstract description 21
- 238000003860 storage Methods 0.000 claims description 36
- 238000004458 analytical method Methods 0.000 claims description 27
- 238000012546 transfer Methods 0.000 claims description 25
- 238000000605 extraction Methods 0.000 claims description 22
- 230000009089 cytolysis Effects 0.000 claims description 21
- 230000003321 amplification Effects 0.000 claims description 19
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 19
- 238000007885 magnetic separation Methods 0.000 claims description 11
- 238000011144 upstream manufacturing Methods 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 6
- 238000002604 ultrasonography Methods 0.000 claims description 4
- 239000000523 sample Substances 0.000 abstract description 137
- 239000012472 biological sample Substances 0.000 abstract description 24
- 239000012491 analyte Substances 0.000 abstract description 21
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 description 51
- 239000003153 chemical reaction reagent Substances 0.000 description 25
- 239000002245 particle Substances 0.000 description 20
- 239000011159 matrix material Substances 0.000 description 19
- 238000003752 polymerase chain reaction Methods 0.000 description 19
- 102000039446 nucleic acids Human genes 0.000 description 18
- 108020004707 nucleic acids Proteins 0.000 description 18
- 150000007523 nucleic acids Chemical class 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 16
- 239000000243 solution Substances 0.000 description 14
- 238000001179 sorption measurement Methods 0.000 description 14
- 239000000470 constituent Substances 0.000 description 12
- 238000010828 elution Methods 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 238000012423 maintenance Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 8
- 102000053602 DNA Human genes 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 238000010606 normalization Methods 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 229920002477 rna polymer Polymers 0.000 description 7
- 108020004459 Small interfering RNA Proteins 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 108091005461 Nucleic proteins Proteins 0.000 description 3
- 102000015636 Oligopeptides Human genes 0.000 description 3
- 108010038807 Oligopeptides Proteins 0.000 description 3
- 230000001143 conditioned effect Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000010924 continuous production Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 239000011859 microparticle Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 108090000994 Catalytic RNA Proteins 0.000 description 2
- 102000053642 Catalytic RNA Human genes 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 108020004688 Small Nuclear RNA Proteins 0.000 description 2
- 102000039471 Small Nuclear RNA Human genes 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000010804 cDNA synthesis Methods 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000002934 lysing effect Effects 0.000 description 2
- 239000006249 magnetic particle Substances 0.000 description 2
- 238000010297 mechanical methods and process Methods 0.000 description 2
- 230000005226 mechanical processes and functions Effects 0.000 description 2
- 108091070501 miRNA Proteins 0.000 description 2
- 239000002679 microRNA Substances 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 108091092562 ribozyme Proteins 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
- 241000796533 Arna Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229930182476 C-glycoside Natural products 0.000 description 1
- 150000000700 C-glycosides Chemical class 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229930182474 N-glycoside Natural products 0.000 description 1
- 102000029797 Prion Human genes 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- -1 RNA Chemical class 0.000 description 1
- 102000000574 RNA-Induced Silencing Complex Human genes 0.000 description 1
- 108010016790 RNA-Induced Silencing Complex Proteins 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 241000726445 Viroids Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000003763 chloroplast Anatomy 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001218 confocal laser scanning microscopy Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000013412 genome amplification Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000001001 laser micro-dissection Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 239000012521 purified sample Substances 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000004171 remote diagnosis Methods 0.000 description 1
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000003196 serial analysis of gene expression Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00712—Automatic status testing, e.g. at start-up or periodic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00871—Communications between instruments or with remote terminals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00326—Analysers with modular structure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0491—Position sensing, encoding; closed-loop control
- G01N2035/0493—Locating samples; identifying different tube sizes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00613—Quality control
- G01N35/00663—Quality control of consumables
Landscapes
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Quality & Reliability (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83419506P | 2006-07-28 | 2006-07-28 | |
| US60/834,195 | 2006-07-28 | ||
| EP06015812.8 | 2006-07-28 | ||
| EP06015812A EP1882948A2 (de) | 2006-07-28 | 2006-07-28 | Vorrichtung zur Probenverarbeitung |
| PCT/EP2007/006684 WO2008012104A2 (en) | 2006-07-28 | 2007-07-27 | Device for processing samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2658533A1 CA2658533A1 (en) | 2008-01-31 |
| CA2658533C true CA2658533C (en) | 2016-03-15 |
Family
ID=38596322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2658533A Active CA2658533C (en) | 2006-07-28 | 2007-07-27 | Device for processing samples |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2047282B1 (https=) |
| JP (2) | JP2009544955A (https=) |
| AU (1) | AU2007278425B2 (https=) |
| CA (1) | CA2658533C (https=) |
| WO (1) | WO2008012104A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2261650A3 (en) | 2004-09-15 | 2011-07-06 | IntegenX Inc. | Microfluidic devices |
| JP5063616B2 (ja) | 2006-02-03 | 2012-10-31 | インテジェニックス インコーポレイテッド | マイクロ流体デバイス |
| KR20100028526A (ko) | 2007-02-05 | 2010-03-12 | 마이크로칩 바이오테크놀로지스, 인크. | 마이크로유체 및 나노유체 장치, 시스템 및 응용 |
| KR20110030415A (ko) | 2008-01-22 | 2011-03-23 | 인터젠엑스 인크. | 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도 |
| CN102341691A (zh) | 2008-12-31 | 2012-02-01 | 尹特根埃克斯有限公司 | 具有微流体芯片的仪器 |
| US8388908B2 (en) | 2009-06-02 | 2013-03-05 | Integenx Inc. | Fluidic devices with diaphragm valves |
| JP2012529268A (ja) | 2009-06-05 | 2012-11-22 | インテジェンクス，インコーポレイテッド | ユニバーサルサンプル調製システムおよび統合解析システムの使用方法 |
| GB2472236A (en) * | 2009-07-29 | 2011-02-02 | Iti Scotland Ltd | Apparatus for analysing microfluidic devices |
| US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
| US9034575B2 (en) * | 2010-03-04 | 2015-05-19 | Roche Molecular Systems, Inc. | Workflow timing between modules |
| JP5819617B2 (ja) | 2010-03-04 | 2015-11-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 分析器のハードウェア構成 |
| US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
| US9725754B2 (en) | 2010-07-29 | 2017-08-08 | Sean F. Boyle | Generic sample preparation |
| CN103025891A (zh) | 2010-07-29 | 2013-04-03 | 霍夫曼-拉罗奇有限公司 | 通用样品制备 |
| WO2012024657A1 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
| US9121058B2 (en) | 2010-08-20 | 2015-09-01 | Integenx Inc. | Linear valve arrays |
| JP5690543B2 (ja) * | 2010-10-05 | 2015-03-25 | 株式会社日立ハイテクノロジーズ | 検体検査自動化装置，自動分析装置およびシステム |
| DE202011111050U1 (de) | 2010-10-29 | 2018-11-20 | Thermo Fisher Scientific Oy | Automatisiertes System zur Probenaufbereitung und -analyse |
| US9164114B2 (en) * | 2011-04-19 | 2015-10-20 | Roche Molecular Systems, Inc. | Supply unit for continuous loading |
| JP5789441B2 (ja) * | 2011-08-01 | 2015-10-07 | 株式会社日立ハイテクノロジーズ | 遺伝子検査システム |
| US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
| US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
| US10132728B2 (en) | 2012-04-27 | 2018-11-20 | Cepheid | Apparatus with heterogeneous processing modules |
| DK2857841T3 (da) | 2013-10-07 | 2021-07-26 | Eppendorf Ag | Laboratorieapparat til apparatstyret behandling af mindst én laboratorieprøve, og en fremgangsmåde til konfigurering af laboratorieapparatet ved hjælp af konfigurationsstyringen |
| EP2857843A1 (de) * | 2013-10-07 | 2015-04-08 | Eppendorf Ag | System aufweisend mindestens zwei Laborgeräte zur gerätegesteuerten Bearbeitung einer Teilaufgabe bei einem Behandlungsprozess beinhaltend Behandlungen mindestens einer Laborprobe, Laborgerät und Verfahren |
| EP2857844B1 (de) | 2013-10-07 | 2021-12-01 | Eppendorf AG | Laborgerät, System und Verfahren zur gerätegesteuerten Behandlung mindestens einer Laborprobe unter Verwendung mindestens eines Verbrauchsartikels |
| EP2857842B1 (de) | 2013-10-07 | 2022-09-21 | Eppendorf SE | Zugriffssteuerung für ein Laborgerät, Laborgerät mit Zugriffssteuerung und Verfahren zur gerätegesteuerten Behandlung von Laborproben |
| CN105873681B (zh) | 2013-11-18 | 2019-10-11 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
| US9771572B2 (en) | 2014-02-28 | 2017-09-26 | Gen-Probe Incorporated | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| US9771571B2 (en) | 2014-02-28 | 2017-09-26 | Gen-Probe Incorporated | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| EP3670664B1 (en) | 2014-02-28 | 2022-09-07 | Gen-Probe Incorporated | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| DE102015203606C5 (de) | 2014-02-28 | 2023-12-21 | Gen-Probe Incorporated | Verfahren zur Isolierung von Nukleinsäure von zytologischen Proben in flüssigen Konservierungsmitteln, die Formaldehyd enthalten |
| WO2015179098A1 (en) | 2014-05-21 | 2015-11-26 | Integenx Inc. | Fluidic cartridge with valve mechanism |
| JP6110445B2 (ja) * | 2014-08-29 | 2017-04-05 | シスメックス株式会社 | 検査システムおよび検査方法 |
| US10690627B2 (en) | 2014-10-22 | 2020-06-23 | IntegenX, Inc. | Systems and methods for sample preparation, processing and analysis |
| JP6937116B2 (ja) | 2016-12-15 | 2021-09-22 | シスメックス株式会社 | 前処理装置及び前処理方法 |
| JP7050757B2 (ja) * | 2017-03-29 | 2022-04-08 | ユニバーサル・バイオ・リサーチ株式会社 | 検体処理測定システム |
| WO2020044790A1 (ja) * | 2018-08-29 | 2020-03-05 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| US11331660B2 (en) * | 2019-01-04 | 2022-05-17 | Funai Electric Co. Ltd. | Digital dispense system |
| JP7317522B2 (ja) * | 2019-03-06 | 2023-07-31 | マルヤス工業株式会社 | 自動ろ過装置 |
| CN110865018B (zh) * | 2019-08-08 | 2023-03-28 | 上海交通大学医学院附属新华医院 | 一种样品后处理系统、设备和方法 |
| EP3789772B1 (en) * | 2019-09-05 | 2025-03-26 | Roche Diagnostics GmbH | Method for determining a position of a rack on a rack placement unit of a laboratory handling system and laboratory handling system |
| JP7415908B2 (ja) * | 2020-12-15 | 2024-01-17 | 株式会社島津製作所 | 試料前処理装置 |
| CN114574323B (zh) * | 2022-03-31 | 2023-04-07 | 江苏莱尔生物医药科技有限公司 | 一种细胞分离装置 |
| JP2025520068A (ja) * | 2022-05-27 | 2025-07-01 | スリーエム イノベイティブ プロパティズ カンパニー | 病原体サンプル収集デバイス |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428470A (en) * | 1992-07-17 | 1995-06-27 | Beckman Instruments, Inc. | Modular system and method for an automatic analyzer |
| JP2947146B2 (ja) * | 1995-09-29 | 1999-09-13 | 株式会社島津製作所 | オ−トサンプラ |
| JP3032159B2 (ja) * | 1996-09-24 | 2000-04-10 | 株式会社日立製作所 | 分析システム |
| JPH11304812A (ja) * | 1998-04-20 | 1999-11-05 | Hitachi Ltd | 検体処理システム |
| DE10011529T1 (de) * | 1998-05-01 | 2011-09-01 | Gen-Probe Incorporated | Automatisches Diagnoseanalysegerät und Verfahren |
| JP4101466B2 (ja) * | 1998-07-27 | 2008-06-18 | 株式会社日立製作所 | 生体サンプルの分析装置 |
| AU4226900A (en) * | 1999-04-08 | 2000-10-23 | Joseph L. Chan | Apparatus for fast preparation and analysis of nucleic acids |
| JP3587124B2 (ja) * | 2000-04-12 | 2004-11-10 | 松下電器産業株式会社 | 分注装置および分注方法 |
| AU2002324289A1 (en) * | 2001-07-24 | 2003-02-17 | Societe D'amenagement Urbain Et Rural | Automated process for detecting pathogenic organisms in water |
| US6881579B2 (en) * | 2001-07-30 | 2005-04-19 | Agilent Technologies, Inc. | Sample processing apparatus and methods |
| JP3771840B2 (ja) * | 2001-12-27 | 2006-04-26 | アロカ株式会社 | マイクロプレート搬送装置 |
| US7718072B2 (en) * | 2002-04-26 | 2010-05-18 | Abbott Laboratories | Structure and method for handling magnetic particles in biological assays |
| JP2004166555A (ja) * | 2002-11-19 | 2004-06-17 | Sanyo Electric Co Ltd | インキュベータ |
| EP1573340B1 (en) * | 2002-12-16 | 2012-09-26 | Thermo CRS Ltd. | An automatic storage device with a cylindrical rack |
| DE10331254B4 (de) * | 2003-07-10 | 2006-05-04 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Vorrichtung und Verfahren zum Abtrennen von magnetischen oder magnetisierbaren Partikeln aus einer Flüssigkeit |
-
2007
- 2007-07-27 EP EP07786396.7A patent/EP2047282B1/en active Active
- 2007-07-27 WO PCT/EP2007/006684 patent/WO2008012104A2/en not_active Ceased
- 2007-07-27 JP JP2009521171A patent/JP2009544955A/ja active Pending
- 2007-07-27 CA CA2658533A patent/CA2658533C/en active Active
- 2007-07-27 AU AU2007278425A patent/AU2007278425B2/en active Active
-
2013
- 2013-05-08 JP JP2013098383A patent/JP5886787B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008012104A3 (en) | 2008-05-29 |
| JP2009544955A (ja) | 2009-12-17 |
| AU2007278425B2 (en) | 2011-11-17 |
| CA2658533A1 (en) | 2008-01-31 |
| AU2007278425A1 (en) | 2008-01-31 |
| JP2013172736A (ja) | 2013-09-05 |
| JP5886787B2 (ja) | 2016-03-16 |
| EP2047282A2 (en) | 2009-04-15 |
| WO2008012104A2 (en) | 2008-01-31 |
| EP2047282B1 (en) | 2014-05-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2658533C (en) | Device for processing samples | |
| US10458998B2 (en) | Device for processing samples | |
| AU785010B2 (en) | System and method for manipulating magnetically responsive particles in fluid samples to collect DNA or RNA from a sample | |
| CN108103057B (zh) | 用于纯化核酸的方法和试剂盒 | |
| US9028777B2 (en) | Automated cellular material preparation | |
| EP1955079B1 (en) | Compact apparatus, compositions and methods for purifying nucleic acids | |
| CN101010592B (zh) | 将磁性粒子与流体分离、混合和浓缩的设备和方法及其在提纯方法中的用途 | |
| EP1282469B1 (en) | System and method for manipulating magnetically responsive particles in fluid samples to collect dna or rna from a sample | |
| US20090176308A1 (en) | Apparatus and method for the purification of biomolecules | |
| US20030203491A1 (en) | Gravitational flow purification system | |
| EP3759244B1 (en) | Method and system for high-throughput particle handling by use of magnetic fields | |
| CN219689719U (zh) | 一种核酸提取扩增一体化系统及试剂盒 | |
| EP2423688B1 (en) | Suspension container for binding particles for the isolation of biological material | |
| EP4244596A1 (en) | System and method for polynucleotide purification | |
| Cardona et al. | Design considerations in high-throughput automation for biotechnology | |
| EP2535712A1 (en) | Analytical system for the preparation of biological material | |
| Wells et al. | Automation of Sample | |
| HK1218573B (en) | Method and kit for purifying nucleic acids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |