CA2655399A1 - Pyrrolidine derivatives having activity at the glyt1 transporter - Google Patents

Pyrrolidine derivatives having activity at the glyt1 transporter Download PDF

Info

Publication number
CA2655399A1
CA2655399A1 CA002655399A CA2655399A CA2655399A1 CA 2655399 A1 CA2655399 A1 CA 2655399A1 CA 002655399 A CA002655399 A CA 002655399A CA 2655399 A CA2655399 A CA 2655399A CA 2655399 A1 CA2655399 A1 CA 2655399A1
Authority
CA
Canada
Prior art keywords
phenyl
pyrrolidinyl
propyl
methyl
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002655399A
Other languages
English (en)
French (fr)
Inventor
Claire Louise Anderton
David Clapham
Trevor Raymond Keel
Leanda Jane Kindon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2655399A1 publication Critical patent/CA2655399A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002655399A 2006-06-22 2007-06-20 Pyrrolidine derivatives having activity at the glyt1 transporter Abandoned CA2655399A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0612420.0 2006-06-22
GBGB0612420.0A GB0612420D0 (en) 2006-06-22 2006-06-22 Compounds
PCT/EP2007/056106 WO2007147831A1 (en) 2006-06-22 2007-06-20 Pyrrolidine derivatives having activity at the glyt1 transporter

Publications (1)

Publication Number Publication Date
CA2655399A1 true CA2655399A1 (en) 2007-12-27

Family

ID=36803732

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002655399A Abandoned CA2655399A1 (en) 2006-06-22 2007-06-20 Pyrrolidine derivatives having activity at the glyt1 transporter

Country Status (23)

Country Link
US (1) US20080070973A1 (OSRAM)
EP (1) EP2041082B1 (OSRAM)
JP (1) JP2009541261A (OSRAM)
KR (1) KR20090019847A (OSRAM)
CN (1) CN101506156A (OSRAM)
AR (1) AR061554A1 (OSRAM)
AT (1) ATE444288T1 (OSRAM)
AU (1) AU2007263058A1 (OSRAM)
BR (1) BRPI0713311A2 (OSRAM)
CA (1) CA2655399A1 (OSRAM)
CL (1) CL2007001808A1 (OSRAM)
CR (1) CR10498A (OSRAM)
DE (1) DE602007002642D1 (OSRAM)
EA (1) EA200970044A1 (OSRAM)
ES (1) ES2333918T3 (OSRAM)
GB (1) GB0612420D0 (OSRAM)
IL (1) IL195633A0 (OSRAM)
MA (1) MA30522B1 (OSRAM)
NO (1) NO20085412L (OSRAM)
PE (1) PE20080380A1 (OSRAM)
TW (1) TW200817322A (OSRAM)
WO (1) WO2007147831A1 (OSRAM)
ZA (1) ZA200810009B (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20061156A1 (es) 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina
WO2008155334A2 (en) * 2007-06-20 2008-12-24 Glaxo Group Limited Improved process of amide formation
SG186885A1 (en) 2010-06-04 2013-02-28 Albany Molecular Res Inc Glycine transporter-1 inhibitors, methods of making them, and uses thereof
US20120035156A1 (en) * 2010-08-09 2012-02-09 Daniela Alberati Combination of glyt1 compound with antipsychotics
WO2019073052A1 (en) 2017-10-13 2019-04-18 Treeway Tw001 B.V. EDARAVONE SALT

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2746959A (en) * 1953-06-02 1956-05-22 American Home Prod Diphenylethylenediamine-penicillin salt
US3145209A (en) * 1961-07-31 1964-08-18 Olin Mathieson Substituted aminophenyl-ethylamine derivatives
NZ237443A (en) * 1990-04-10 1993-11-25 Asta Medica Ag Phenalkylethylenediamine and aminomethyltetra hydroisoquinoline derivatives, platinum (ii) and (iv) complexes, methods of preparation and pharmaceutical compositions
GB0130696D0 (en) * 2001-12-21 2002-02-06 Smithkline Beecham Plc Chemical Compounds
FR2861070B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
PE20061156A1 (es) * 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina

Also Published As

Publication number Publication date
US20080070973A1 (en) 2008-03-20
BRPI0713311A2 (pt) 2012-03-06
GB0612420D0 (en) 2006-08-02
AU2007263058A1 (en) 2007-12-27
AR061554A1 (es) 2008-09-03
DE602007002642D1 (de) 2009-11-12
IL195633A0 (en) 2009-09-01
ES2333918T3 (es) 2010-03-02
NO20085412L (no) 2009-01-22
ZA200810009B (en) 2009-11-25
CL2007001808A1 (es) 2008-01-18
EP2041082A1 (en) 2009-04-01
WO2007147831A1 (en) 2007-12-27
MA30522B1 (fr) 2009-06-01
EA200970044A1 (ru) 2009-04-28
TW200817322A (en) 2008-04-16
EP2041082B1 (en) 2009-09-30
ATE444288T1 (de) 2009-10-15
JP2009541261A (ja) 2009-11-26
CR10498A (es) 2009-03-20
KR20090019847A (ko) 2009-02-25
PE20080380A1 (es) 2008-05-31
CN101506156A (zh) 2009-08-12

Similar Documents

Publication Publication Date Title
US20090326027A1 (en) N-Phenyl-2-0X0-1,4-Diazaspiro [4.5] Dec-3-EN-1-YL Acetamide Derivatives And Their Use As Glycine Transporter Inhibitors
WO2007104775A1 (en) Compounds which inhibit the glycine transporter and uses thereof
EP2041082B1 (en) Pyrrolidine derivatives having activity at the glyt1 transporter
EP1833811B1 (en) Oxygen containing heterocycles as glycine transporter inhibiting compounds
WO2009034062A1 (en) Compounds which inhibit the glycine transporter and uses thereof in medicine
EP1838663B1 (en) Glycine transport inhibitors
US20100113545A1 (en) Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders
EP1874721A2 (en) Glycine transport inhibitors
US20090286828A1 (en) 2-amino-1-phenylethylcarboxamide derivatives
US20090221577A1 (en) Compounds having morpholinyl and piperidinyl groups for use as glyt1 inhibitors
US20100016374A1 (en) Compounds Which Inhibit the Glycine Transporter and Uses Thereof
US20090253700A1 (en) N-'4-4(4-morpholinyl) phenyl!- '(4-piperidinyl) methyl! carboxamide derivatives and their use as glycine transporter inhibitors
US20090227629A1 (en) Compounds having activity at the glycine transporter glyt1 and uses thereof
US20100048656A1 (en) Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders
WO2007147836A1 (en) Glycine transporter inhibiting compounds and uses in medicine
WO2007147839A1 (en) Glycine transporter inhibiting compounds and uses in medicine
US20100016399A1 (en) GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders
WO2007147834A1 (en) Glycine transporter inhibiting compounds and uses in medicine
US20090318447A1 (en) N-[6-(4-morpholinyl)-3-pyridinyl]-2-(tetrahydro-2h-pyran-4-yl)-n-[(1--4-piperidinyl) methyl] acetamide derivatives and related compounds as glyt1 transport inhibitors for the treatment of neurological disorders such as schizophrenia
MX2009000106A (es) Derivados de pirrolidina que tienen actividad en el transportador glyti.
WO2006002956A1 (en) Piperidine derivatives and their use as glycine transporter inhibitors

Legal Events

Date Code Title Description
FZDE Discontinued