CA2655139A1 - Epoxide inhibitors of cysteine proteases - Google Patents
Epoxide inhibitors of cysteine proteases Download PDFInfo
- Publication number
- CA2655139A1 CA2655139A1 CA002655139A CA2655139A CA2655139A1 CA 2655139 A1 CA2655139 A1 CA 2655139A1 CA 002655139 A CA002655139 A CA 002655139A CA 2655139 A CA2655139 A CA 2655139A CA 2655139 A1 CA2655139 A1 CA 2655139A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- group
- infection
- alkyl
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US81363906P | 2006-06-13 | 2006-06-13 | |
| US60/813,639 | 2006-06-13 | ||
| PCT/US2007/071145 WO2008042480A2 (en) | 2006-06-13 | 2007-06-13 | Epoxide inhibitors of cysteine proteases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2655139A1 true CA2655139A1 (en) | 2008-04-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002655139A Abandoned CA2655139A1 (en) | 2006-06-13 | 2007-06-13 | Epoxide inhibitors of cysteine proteases |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8673904B2 (OSRAM) |
| EP (1) | EP2029135A4 (OSRAM) |
| JP (1) | JP2010500962A (OSRAM) |
| KR (1) | KR20090029725A (OSRAM) |
| CN (1) | CN101808634A (OSRAM) |
| AU (1) | AU2007305138A1 (OSRAM) |
| BR (1) | BRPI0712868A2 (OSRAM) |
| CA (1) | CA2655139A1 (OSRAM) |
| IL (1) | IL195782A0 (OSRAM) |
| RU (1) | RU2009100878A (OSRAM) |
| WO (1) | WO2008042480A2 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2462131B1 (en) | 2009-08-07 | 2014-10-15 | American Life Science Pharmaceuticals, Inc. | Compositions and methods for treating beta-amyloid related diseases |
| WO2011075678A1 (en) | 2009-12-18 | 2011-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Specific inhibitors and active site probes for legumain |
| WO2012142003A2 (en) | 2011-04-15 | 2012-10-18 | Life Technologies Corporation | Chemical ligation |
| EP2811999B1 (en) | 2012-02-01 | 2021-10-27 | The Trustees of Columbia University in the City of New York | Novel cysteine protease inhibitors and uses thereof |
| CN104211666B (zh) * | 2013-05-31 | 2017-11-14 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,3‑环氧丁二酰胺类化合物、其制备方法和用途 |
| CN107151236B (zh) * | 2016-03-03 | 2021-04-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种2,3-环氧丁二酰衍生物及其制备方法和用途 |
| WO2019055884A2 (en) * | 2017-09-15 | 2019-03-21 | Ampersand Biopharmaceuticals, Inc. | INHIBITION OF SPONTANEOUS METASTASES BY PROTEIN INHIBITORS OF CYSTEINE PROTEASES |
| US20190083386A1 (en) | 2017-09-15 | 2019-03-21 | Ampersand Biopharmaceuticals, Inc. | Methods and formulations for transdermal administration of buffering agents |
| CN110241438A (zh) * | 2018-03-08 | 2019-09-17 | 天津大学 | 泡沫铜担载钯铜合金纳米笼催化剂及其制备方法 |
| US11905249B2 (en) | 2021-01-25 | 2024-02-20 | Jackson State University | Covalent inhibitors of equine encephalitis virus |
| KR20230165715A (ko) | 2022-05-27 | 2023-12-05 | 서울대학교산학협력단 | 기생충 감염증의 예방 또는 치료용 약학 조성물 |
| CN120813388A (zh) * | 2023-03-02 | 2025-10-17 | 日本医事物理股份有限公司 | 放射性金属标记抗体、放射性药物及化合物 |
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| GB1469797A (en) * | 1974-11-07 | 1977-04-06 | Pfizer Ltd | Antibacterial cephalosporin derivatives |
| US4172896A (en) | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
| JPS55115878A (en) * | 1979-02-27 | 1980-09-06 | Taisho Pharmaceut Co Ltd | Epoxysuccinic acid derivative |
| JPS55153778A (en) | 1979-05-17 | 1980-11-29 | Taisho Pharmaceut Co Ltd | Epoxysuccinylamino acid derivative |
| JPS57169478A (en) | 1981-04-10 | 1982-10-19 | Nippon Chemiphar Co Ltd | Piperazine derivative |
| JPS6276A (ja) | 1985-03-26 | 1987-01-06 | Toyo Jozo Co Ltd | 酵素阻害性新規物質 |
| JP2808877B2 (ja) * | 1990-09-29 | 1998-10-08 | 大正製薬株式会社 | エポキシスクシナム酸誘導体およびその中間体 |
| GB9217295D0 (en) | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
| US5358970A (en) | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
| US5541231A (en) | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
| GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
| US5556853A (en) * | 1993-10-29 | 1996-09-17 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives |
| JPH08104683A (ja) * | 1993-10-29 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸誘導体 |
| EP0763029A1 (en) | 1994-05-31 | 1997-03-19 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives, their production and use |
| JPH08104684A (ja) * | 1994-05-31 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸関連化合物 |
| JP3338452B2 (ja) * | 1995-12-12 | 2002-10-28 | 大鵬薬品工業株式会社 | エポキシコハク酸アミド誘導体又はその塩及びこれを含有する医薬 |
| JP3410476B2 (ja) * | 1997-04-18 | 2003-05-26 | 大鵬薬品工業株式会社 | 新規なエポキシコハク酸アミド誘導体又はその塩 |
| JPH11263783A (ja) * | 1998-01-09 | 1999-09-28 | Taisho Pharmaceut Co Ltd | エポキシスクシナム酸誘導体 |
| WO1999038504A1 (en) | 1998-01-29 | 1999-08-05 | Sepracor Inc. | Pharmaceutical uses of optically pure (-)-bupropion |
| AU2002232681A1 (en) | 2000-11-10 | 2002-05-21 | The Regents Of The Univeristy Of California | Activity-dependent cysteine protease profiling reagent |
| KR100854544B1 (ko) | 2001-09-12 | 2008-08-26 | 다우 글로벌 테크놀로지스 인크. | 에폭시-말단의 에스테르를 포함하는 망상구조 중합체 |
| US20030212003A1 (en) | 2002-02-14 | 2003-11-13 | Hermann Lubbert | Cathepsin Y for the development of a medicament for the treatment of pain |
| WO2006074466A2 (en) | 2005-01-10 | 2006-07-13 | The Board Of Trustees Of The Lelands Stanford Junior University | Synthesis of epoxide based inhibitors of cysteine proteases |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2010500962A (ja) | 2010-01-14 |
| AU2007305138A1 (en) | 2008-04-10 |
| BRPI0712868A2 (pt) | 2013-05-07 |
| US8673904B2 (en) | 2014-03-18 |
| US20080176841A1 (en) | 2008-07-24 |
| WO2008042480A3 (en) | 2008-08-14 |
| EP2029135A2 (en) | 2009-03-04 |
| CN101808634A (zh) | 2010-08-18 |
| RU2009100878A (ru) | 2010-07-20 |
| IL195782A0 (en) | 2009-09-01 |
| EP2029135A4 (en) | 2011-08-17 |
| WO2008042480A2 (en) | 2008-04-10 |
| KR20090029725A (ko) | 2009-03-23 |
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