CA2649122C - Pyridone sulfonamides and pyridone sulfamides as mek inhibitors - Google Patents
Pyridone sulfonamides and pyridone sulfamides as mek inhibitors Download PDFInfo
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- CA2649122C CA2649122C CA2649122A CA2649122A CA2649122C CA 2649122 C CA2649122 C CA 2649122C CA 2649122 A CA2649122 A CA 2649122A CA 2649122 A CA2649122 A CA 2649122A CA 2649122 C CA2649122 C CA 2649122C
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Landscapes
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| PCT/US2007/066894 WO2007121481A2 (en) | 2006-04-18 | 2007-04-18 | Pyridone sulfonamides and pyridone sulfamides as mek inhibitors |
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| EA009478B1 (ru) * | 2002-08-23 | 2008-02-28 | Ардеа Байосайенсиз, Инк. | Ненуклеозидные ингибиторы обратной транскриптазы |
| US7429667B2 (en) * | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
| US9095581B2 (en) | 2005-07-21 | 2015-08-04 | Ardea Biosciences, Inc. | Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof |
| US7842836B2 (en) | 2006-04-11 | 2010-11-30 | Ardea Biosciences | N-aryl-N'alkyl sulfamides as MEK inhibitors |
| AU2007237901B2 (en) * | 2006-04-18 | 2012-07-05 | Ardea Biosciences, Inc. | Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors |
| US8509487B2 (en) * | 2007-04-19 | 2013-08-13 | Avago Technologies General Ip (Singapore) Pte. Ltd. | System and method for optically measuring a parameter of an object |
| CA2694646C (en) * | 2007-07-30 | 2017-09-05 | Ardea Biosciences, Inc. | Combinations of mek inhibitors and raf kinase inhibitors and uses thereof |
| PE20100747A1 (es) * | 2008-04-21 | 2010-11-03 | Novartis Ag | Compuestos heterociclicos como inhibidores de mek |
| AU2009279940B2 (en) | 2008-08-04 | 2014-01-16 | Merck Patent Gmbh | Novel phenylamino isonicotinamide compounds |
| EP2370568B1 (en) | 2008-12-10 | 2017-07-19 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
| UY32486A (es) * | 2009-03-11 | 2010-10-29 | Ardea Biosciences Inc | Tratamiento del cáncer de páncreas |
| US8673919B2 (en) | 2009-03-27 | 2014-03-18 | Ardea Biosciences, Inc. | Dihydropyridin sulfonamides and dihydropyridin sulfamides as MEK inhibitors |
| CN102459188A (zh) * | 2009-06-15 | 2012-05-16 | 凯美隆(北京)药业技术有限公司 | 新型6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
| CN102134218A (zh) * | 2009-06-15 | 2011-07-27 | 凯美隆(北京)药业技术有限公司 | 6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
| TWI524890B (zh) | 2009-07-24 | 2016-03-11 | 亞德生化公司 | （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備 |
| US8349832B2 (en) * | 2009-09-02 | 2013-01-08 | Canthera Therapeutics | Compounds and compositions for treating cancer |
| US8318737B2 (en) | 2009-09-02 | 2012-11-27 | Canthera Therapeutics Inc. | Compounds and compositions for treating cancer |
| CA2814617C (en) | 2009-10-13 | 2017-12-19 | Allostem Therapeutics Llc | Novel mek inhibitors, useful in the treatment of diseases |
| BR112012010519A2 (pt) * | 2009-11-04 | 2017-12-05 | Novartis Ag | derivados de sulfonamida heterocíclicos |
| CA2789696C (en) | 2010-02-25 | 2017-11-07 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
| EP2545187B1 (en) | 2010-03-09 | 2018-09-05 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
| EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| US9376709B2 (en) | 2010-07-26 | 2016-06-28 | Biomatrica, Inc. | Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures |
| CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
| CN102358730A (zh) * | 2011-08-24 | 2012-02-22 | 济南赛文医药技术有限公司 | 一种小分子mek蛋白激酶抑制剂 |
| CN103204825B (zh) | 2012-01-17 | 2015-03-04 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噻唑化合物及其制备方法和用途 |
| WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| US9725703B2 (en) | 2012-12-20 | 2017-08-08 | Biomatrica, Inc. | Formulations and methods for stabilizing PCR reagents |
| US20160135446A1 (en) | 2013-06-13 | 2016-05-19 | Biomatrica, Inc. | Cell stabilization |
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- 2007-04-18 CA CA2649122A patent/CA2649122C/en not_active Expired - Fee Related
- 2007-04-18 KR KR1020087028158A patent/KR101391461B1/ko not_active Expired - Fee Related
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- 2007-04-18 JP JP2009506751A patent/JP5269762B2/ja not_active Expired - Fee Related
- 2007-04-18 CN CN2007800193159A patent/CN101454004B/zh not_active Expired - Fee Related
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| EA200870446A1 (ru) | 2009-04-28 |
| US7897624B2 (en) | 2011-03-01 |
| MX2008013097A (es) | 2008-10-27 |
| AU2007237901B2 (en) | 2012-07-05 |
| JP5269762B2 (ja) | 2013-08-21 |
| HK1128617A1 (en) | 2009-11-06 |
| EP2012786B1 (en) | 2010-10-06 |
| BRPI0710817A2 (pt) | 2011-08-23 |
| AU2007237901A1 (en) | 2007-10-25 |
| ES2354182T3 (es) | 2011-03-10 |
| KR101391461B1 (ko) | 2014-05-07 |
| DE602007009663D1 (de) | 2010-11-18 |
| EP2012786A2 (en) | 2009-01-14 |
| US20110112152A1 (en) | 2011-05-12 |
| CN101454004B (zh) | 2013-12-04 |
| IL194595A (en) | 2015-04-30 |
| US20070244164A1 (en) | 2007-10-18 |
| EP2012786A4 (en) | 2010-02-24 |
| EA016674B1 (ru) | 2012-06-29 |
| WO2007121481A3 (en) | 2008-05-22 |
| CN101454004A (zh) | 2009-06-10 |
| WO2007121481A2 (en) | 2007-10-25 |
| US8716318B2 (en) | 2014-05-06 |
| WO2007121481A8 (en) | 2008-10-16 |
| ATE483463T1 (de) | 2010-10-15 |
| JP2009534408A (ja) | 2009-09-24 |
| KR20090005193A (ko) | 2009-01-12 |
| CA2649122A1 (en) | 2007-10-25 |
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