CA2645426A1 - 1-oxo-isoindoline compounds for the treatment of spinal muscular atrophy and other uses - Google Patents
1-oxo-isoindoline compounds for the treatment of spinal muscular atrophy and other uses Download PDFInfo
- Publication number
- CA2645426A1 CA2645426A1 CA002645426A CA2645426A CA2645426A1 CA 2645426 A1 CA2645426 A1 CA 2645426A1 CA 002645426 A CA002645426 A CA 002645426A CA 2645426 A CA2645426 A CA 2645426A CA 2645426 A1 CA2645426 A1 CA 2645426A1
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- Prior art keywords
- alkyl
- group
- compound
- alkoxy
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000011282 treatment Methods 0.000 title abstract description 9
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Classifications
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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Landscapes
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| US78329206P | 2006-03-17 | 2006-03-17 | |
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| PCT/US2007/006772 WO2007109211A2 (en) | 2006-03-17 | 2007-03-16 | 1-oxo-isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
Publications (1)
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| EA018862B1 (ru) * | 2007-10-19 | 2013-11-29 | Янссен Фармацевтика, Н.В. | МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ |
| WO2009072581A1 (ja) * | 2007-12-05 | 2009-06-11 | Aska Pharmaceutical Co., Ltd. | ラクタム化合物又はその塩及びｐｐａｒ活性化剤 |
| US8722723B2 (en) | 2008-02-28 | 2014-05-13 | Research Foundation Itsuu Laboratory | Aromatic amide derivative |
| US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| US20210130285A1 (en) | 2008-03-19 | 2021-05-06 | Aurimmed Pharma, Inc. | Novel compounds advantageous in the treatment of central nervous system diseases and disorders |
| WO2009151546A2 (en) | 2008-05-27 | 2009-12-17 | Ptc Therapeutics, Inc. | Methods for treating spinal muscular atrophy |
| US8986935B2 (en) * | 2008-08-13 | 2015-03-24 | Ptc Therapeutics, Inc. | Methods for treating spinal muscular atrophy |
| GB0909672D0 (en) * | 2009-06-04 | 2009-07-22 | Xention Discovery Ltd | Compounds |
| GB0909671D0 (en) * | 2009-06-04 | 2009-07-22 | Xention Discovery Ltd | Compounds |
| EP3309152B1 (en) * | 2009-12-22 | 2020-09-09 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
| EP2651930B1 (en) * | 2010-12-16 | 2015-10-28 | Boehringer Ingelheim International GmbH | Biarylamide inhibitors of leukotriene production |
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| WO2013062028A1 (ja) * | 2011-10-25 | 2013-05-02 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害剤 |
| NZ627942A (en) | 2012-01-27 | 2016-03-31 | Gilead Sciences Inc | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| ES2697174T3 (es) * | 2012-02-10 | 2019-01-22 | Ptc Therapeutics Inc | Compuestos para tratar atrofia muscular espinal |
| WO2014012050A2 (en) * | 2012-07-13 | 2014-01-16 | Indiana University Research & Technology Corporation | Compounds for treatment of spinal muscular atrophy |
| EP2921480B1 (en) * | 2012-11-19 | 2017-10-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| WO2014102778A2 (en) * | 2012-12-24 | 2014-07-03 | Ramot At Tel-Aviv University Ltd. | Agents for treating genetic diseases resulting from nonsense mutations, and methods for identifying the same |
| WO2014134419A1 (en) | 2013-03-01 | 2014-09-04 | Gilead Sciences, Inc. | Use of ikach blockers for the treatment of cardiac diseases |
| WO2015105657A1 (en) | 2013-12-19 | 2015-07-16 | Ptc Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| US11071793B2 (en) | 2014-08-29 | 2021-07-27 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN105801556A (zh) * | 2014-12-31 | 2016-07-27 | 上海药谷药业有限公司 | 一种2,3-二氢-1,4-苯并二烷-6-羧酸化合物的制备方法 |
| US10668171B2 (en) | 2015-05-30 | 2020-06-02 | Ptc Therapeutics, Inc. | Methods for modulating RNA splicing |
| EP3322699B1 (en) * | 2015-07-14 | 2019-05-15 | H. Hoffnabb-La Roche Ag | 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors |
| WO2017066103A1 (en) * | 2015-10-16 | 2017-04-20 | Aurimmed Pharma, Inc. | Novel compounds advantageous in the treatment of central nervous system diseases and disorders |
| KR20220100719A (ko) | 2015-12-10 | 2022-07-15 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 또는 개선을 위한 조성물 |
| KR102537985B1 (ko) | 2016-09-12 | 2023-05-30 | 인테그랄 헬스 인코퍼레이티드 | Gpr120 조정제로서 유용한 단환형 화합물 |
| EP3509588B1 (en) | 2016-09-12 | 2023-06-07 | Integral Health,Inc. | Bicyclic compounds useful as gpr120 modulators |
| CA3043755A1 (en) | 2016-11-28 | 2018-05-31 | Ptc Therapeutics, Inc. | Methods for modulating rna splicing |
| AU2018282154B2 (en) | 2017-06-05 | 2022-04-07 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| KR20200017476A (ko) | 2017-06-14 | 2020-02-18 | 피티씨 테라퓨틱스, 인크. | Rna 스플라이싱의 변경 방법 |
| WO2019005993A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| CA3067591A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| AU2019243048A1 (en) | 2018-03-27 | 2020-10-15 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| IL279688B2 (en) | 2018-06-27 | 2025-01-01 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
| WO2020005882A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| BR112020026534A2 (pt) | 2018-06-27 | 2021-03-23 | Ptc Therapeutics, Inc. | Compostos de heteroarila para o tratamento da doença de huntington |
| CN114245794B (zh) | 2019-05-13 | 2024-09-13 | Ptc医疗公司 | 用于治疗亨廷顿氏病的化合物 |
| AU2020319168B2 (en) | 2019-07-25 | 2024-02-29 | Novartis Ag | Regulatable expression systems |
| KR102186761B1 (ko) * | 2020-06-03 | 2020-12-04 | 옙바이오 주식회사 | 2-(4-(1-하이드록시프로판-2-일)페닐)이소인돌린-1-온 화합물을 포함하는 파킨슨병 예방 또는 치료용 약학적 조성물 |
| US20240076291A1 (en) * | 2020-11-24 | 2024-03-07 | Merck Sharp & Dohme Llc | Modified isoindolinones as glucosylceramide synthase inhibitors |
| CN115141097A (zh) * | 2022-06-27 | 2022-10-04 | 重庆医药高等专科学校 | 一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的生产线系统 |
| CN115304472A (zh) * | 2022-06-27 | 2022-11-08 | 重庆医药高等专科学校 | 一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的合成方法 |
| KR102883783B1 (ko) * | 2022-12-15 | 2025-11-12 | 옙바이오 주식회사 | 2-(4-(1-하이드록시프로판-2-일)페닐)이소인돌린-1-온 화합물 제조방법 |
| KR102597093B1 (ko) * | 2023-06-07 | 2023-11-03 | 옙바이오 주식회사 | 줄기세포 노화 억제 신규 화합물 및 이의 약학적 용도 |
| CN117740969B (zh) * | 2023-11-30 | 2025-01-10 | 杭州志呈科技有限公司 | 一种吲哚布芬杂质检测方法及其应用 |
| CN120965663A (zh) * | 2024-05-17 | 2025-11-18 | 北京理工大学 | sEH抑制剂化合物、药物组合物及其制备方法和应用 |
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| US3641040A (en) * | 1968-03-27 | 1972-02-08 | Ciba Geigy Corp | Tertiary amino phenyl acetic acids |
| US4126691A (en) | 1968-03-27 | 1978-11-21 | Ciba-Geigy Corporation | Tertiary aminoacids |
| DE2034240C2 (de) | 1968-03-27 | 1982-12-02 | CIBA-GEIGY AG, 4002 Basel | Isoindolinderivate, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung |
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| DE2046992A1 (en) * | 1970-09-24 | 1972-03-30 | Merck Patent Gmbh, 6100 Darmstadt | Isoindolinophenyl-alkanoic acid esters and salts - - antiphlogistic, antipyretic and analgesic agents |
| DE2154525A1 (de) * | 1970-11-05 | 1972-06-15 | Carlo Erba S.P.A., Mailand (Italien) | Isoindolinderivate und Verfahren zu ihrer Herstellung |
| FI53702C (fi) * | 1971-11-22 | 1978-07-10 | Erba Carlo Spa | Foerfarande foer framstaellning av isoindolinderivat |
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-
2007
- 2007-03-13 US US12/293,268 patent/US8110681B2/en not_active Expired - Fee Related
- 2007-03-16 WO PCT/US2007/006772 patent/WO2007109211A2/en not_active Ceased
- 2007-03-16 BR BRPI0708801-9A patent/BRPI0708801A2/pt not_active IP Right Cessation
- 2007-03-16 EP EP07753404A patent/EP2027088A2/en not_active Withdrawn
- 2007-03-16 CN CNA2007800155890A patent/CN101500995A/zh active Pending
- 2007-03-16 JP JP2009500525A patent/JP2009530306A/ja active Pending
- 2007-03-16 CA CA002645426A patent/CA2645426A1/en not_active Abandoned
- 2007-03-16 AU AU2007227398A patent/AU2007227398C1/en not_active Ceased
-
2008
- 2008-09-16 IL IL194153A patent/IL194153A0/en unknown
- 2008-09-16 ZA ZA2008/07936A patent/ZA200807936B/en unknown
-
2011
- 2011-12-05 US US13/310,965 patent/US20120083495A1/en not_active Abandoned
-
2013
- 2013-01-11 JP JP2013004082A patent/JP2013116901A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL194153A0 (en) | 2009-08-03 |
| BRPI0708801A2 (pt) | 2011-06-14 |
| WO2007109211A2 (en) | 2007-09-27 |
| AU2007227398C1 (en) | 2013-05-30 |
| AU2007227398B2 (en) | 2012-09-27 |
| US8110681B2 (en) | 2012-02-07 |
| AU2007227398A1 (en) | 2007-09-27 |
| ZA200807936B (en) | 2009-12-30 |
| CN101500995A (zh) | 2009-08-05 |
| US20090312323A1 (en) | 2009-12-17 |
| JP2009530306A (ja) | 2009-08-27 |
| EP2027088A2 (en) | 2009-02-25 |
| JP2013116901A (ja) | 2013-06-13 |
| WO2007109211A8 (en) | 2009-02-12 |
| WO2007109211A3 (en) | 2007-12-13 |
| US20120083495A1 (en) | 2012-04-05 |
| AU2007227398A8 (en) | 2008-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140916 |