CA2629664A1 - Modulation of gene expression by oligomers targeted to chromosomal dna - Google Patents

Modulation of gene expression by oligomers targeted to chromosomal dna Download PDF

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Publication number
CA2629664A1
CA2629664A1 CA002629664A CA2629664A CA2629664A1 CA 2629664 A1 CA2629664 A1 CA 2629664A1 CA 002629664 A CA002629664 A CA 002629664A CA 2629664 A CA2629664 A CA 2629664A CA 2629664 A1 CA2629664 A1 CA 2629664A1
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target
oligomer
gene
cell
promoter
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CA002629664A
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English (en)
French (fr)
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David Reid Corey
David S. Shames
Bethany A. Janowski
John D. Minna
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University of Texas System
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002629664A 2005-11-17 2006-11-13 Modulation of gene expression by oligomers targeted to chromosomal dna Abandoned CA2629664A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73810305P 2005-11-17 2005-11-17
US60/738,103 2005-11-17
PCT/US2006/044042 WO2007086990A2 (en) 2005-11-17 2006-11-13 Modulation of gene expression by oligomers targeted to chromosomal dna

Publications (1)

Publication Number Publication Date
CA2629664A1 true CA2629664A1 (en) 2007-08-02

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CA002629664A Abandoned CA2629664A1 (en) 2005-11-17 2006-11-13 Modulation of gene expression by oligomers targeted to chromosomal dna

Country Status (7)

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US (2) US7709456B2 (enExample)
EP (3) EP2431467A3 (enExample)
JP (2) JP5066095B2 (enExample)
AU (2) AU2006336624B2 (enExample)
CA (1) CA2629664A1 (enExample)
DK (1) DK2641970T3 (enExample)
WO (1) WO2007086990A2 (enExample)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
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