JP5066095B2 - 染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節 - Google Patents
染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節 Download PDFInfo
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- JP5066095B2 JP5066095B2 JP2008541255A JP2008541255A JP5066095B2 JP 5066095 B2 JP5066095 B2 JP 5066095B2 JP 2008541255 A JP2008541255 A JP 2008541255A JP 2008541255 A JP2008541255 A JP 2008541255A JP 5066095 B2 JP5066095 B2 JP 5066095B2
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- C12N15/09—Recombinant DNA-technology
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/31—Chemical structure of the backbone
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/331—Universal or degenerate base
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
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- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Wood Science & Technology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73810305P | 2005-11-17 | 2005-11-17 | |
| US60/738,103 | 2005-11-17 | ||
| PCT/US2006/044042 WO2007086990A2 (en) | 2005-11-17 | 2006-11-13 | Modulation of gene expression by oligomers targeted to chromosomal dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011214902A Division JP2012050447A (ja) | 2005-11-17 | 2011-09-29 | 染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009516512A JP2009516512A (ja) | 2009-04-23 |
| JP2009516512A5 JP2009516512A5 (enExample) | 2011-11-17 |
| JP5066095B2 true JP5066095B2 (ja) | 2012-11-07 |
Family
ID=38309687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541255A Active JP5066095B2 (ja) | 2005-11-17 | 2006-11-13 | 染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節 |
| JP2011214902A Withdrawn JP2012050447A (ja) | 2005-11-17 | 2011-09-29 | 染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011214902A Withdrawn JP2012050447A (ja) | 2005-11-17 | 2011-09-29 | 染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7709456B2 (enExample) |
| EP (3) | EP2641970B1 (enExample) |
| JP (2) | JP5066095B2 (enExample) |
| AU (2) | AU2006336624B2 (enExample) |
| CA (1) | CA2629664A1 (enExample) |
| DK (1) | DK2641970T3 (enExample) |
| WO (1) | WO2007086990A2 (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7480382B2 (en) * | 2003-09-30 | 2009-01-20 | Microsoft Corporation | Image file container |
| US8999943B2 (en) * | 2005-03-14 | 2015-04-07 | Board Of Regents, The University Of Texas System | Antigene oligomers inhibit transcription |
| US8877721B2 (en) * | 2005-04-15 | 2014-11-04 | The Regents Of The University Of California | Small activating RNA molecules and methods of use |
| JP5066095B2 (ja) | 2005-11-17 | 2012-11-07 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節 |
| JP5713377B2 (ja) * | 2005-12-28 | 2015-05-07 | ザ スクリプス リサーチ インスティテュート | 薬物標的としての天然アンチセンスおよび非コードrna転写物 |
| HUE037173T2 (hu) | 2006-08-08 | 2018-08-28 | Univ Bonn Rheinische Friedrich Wilhelms | 5'-Foszfát-oligonukleotidok szerkezete és alkalmazása |
| WO2009046397A2 (en) * | 2007-10-04 | 2009-04-09 | Board Of Regents, The University Of Texas System | Modulating gene expression with agrna and gapmers targeting antisense transcripts |
| WO2009099942A2 (en) * | 2008-01-31 | 2009-08-13 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides and uses thereof |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| EP2297322A1 (en) | 2008-06-04 | 2011-03-23 | The Board of Regents of The University of Texas System | Modulation of gene expression through endogenous small rna targeting of gene promoters |
| EP2317847B1 (en) * | 2008-07-29 | 2019-04-17 | The Board of Regents of The University of Texas System | Selective inhibition of polyglutamine protein expression |
| CN102239260B (zh) * | 2008-10-03 | 2017-04-12 | 库尔纳公司 | 通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病 |
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| CA2755404C (en) | 2009-03-17 | 2020-03-24 | Joseph Collard | Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1 |
| WO2010121952A1 (en) | 2009-04-21 | 2010-10-28 | Basf Plant Science Company Gmbh | Rna-mediated induction of gene expression in plants |
| WO2010121956A1 (en) | 2009-04-21 | 2010-10-28 | Basf Plant Science Company Gmbh | Rna-mediated induction of gene expression in plants |
| US8815586B2 (en) * | 2009-04-24 | 2014-08-26 | The Board Of Regents Of The University Of Texas System | Modulation of gene expression using oligomers that target gene regions downstream of 3′ untranslated regions |
| EP2427553A4 (en) | 2009-05-06 | 2012-11-07 | Opko Curna Llc | TREATMENT OF LIPID TRANSPORT AND METABOLISM-RELATED DISEASES BY INHIBITING THE NATURAL ANTISENSE TRANSCRIPT AGAINST A LIPID TRANSPORT AND METABOLIC TREATMENT |
| ES2609655T3 (es) | 2009-05-06 | 2017-04-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP |
| WO2010129861A2 (en) | 2009-05-08 | 2010-11-11 | Curna, Inc. | Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family |
| US8957037B2 (en) | 2009-05-18 | 2015-02-17 | Curna, Inc. | Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor |
| CN102549158B (zh) | 2009-05-22 | 2017-09-26 | 库尔纳公司 | 通过抑制针对转录因子e3(tfe3)的天然反义转录物来治疗tfe3和胰岛素受体底物蛋白2(irs2)相关的疾病 |
| CA2764683A1 (en) | 2009-05-28 | 2010-12-02 | Joseph Collard | Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene |
| JP6128846B2 (ja) | 2009-06-16 | 2017-05-17 | クルナ・インコーポレーテッド | パラオキソナーゼ(pon1)に対する天然アンチセンス転写物の抑制によるpon1遺伝子関連疾患の治療 |
| CN102695797B (zh) | 2009-06-16 | 2018-05-25 | 库尔纳公司 | 通过抑制针对胶原基因的天然反义转录物来治疗胶原基因相关的疾病 |
| WO2010151671A2 (en) | 2009-06-24 | 2010-12-29 | Curna, Inc. | Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2 |
| ES2583691T3 (es) | 2009-06-26 | 2016-09-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con un gen del síndrome de Down mediante la inhibición de una transcripción antisentido natural a un gen del síndrome de Down |
| JP2013500017A (ja) | 2009-07-24 | 2013-01-07 | カッパーアールエヌエー,インコーポレイテッド | サ−チュイン(sirt)への天然アンチセンス転写物の阻止によるサ−チュイン(sirt)関連疾患の治療 |
| EP2462229B1 (en) | 2009-08-05 | 2016-05-11 | CuRNA, Inc. | Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins) |
| CN102625841A (zh) | 2009-08-11 | 2012-08-01 | 欧科库尔纳有限责任公司 | 通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病 |
| CA2771228C (en) | 2009-08-21 | 2020-12-29 | Opko Curna, Llc | Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip |
| KR101892760B1 (ko) | 2009-08-25 | 2018-08-28 | 큐알엔에이, 인크. | IQGAP에 대한 천연 안티센스 전사체의 억제에 의한 GTPase 활성화 단백질을 함유하는 IQ 모티프(IQGAP)와 관련된 질환의 치료 |
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| KR101853508B1 (ko) | 2009-12-29 | 2018-06-20 | 큐알엔에이, 인크. | 종양 단백질 63 (p63)에 대한 천연 안티센스 전사체의 억제에 의한 p63에 관련된 질환의 치료 |
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| CA2786535C (en) | 2010-01-11 | 2019-03-26 | Curna, Inc. | Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg |
| JP5981850B2 (ja) | 2010-01-25 | 2016-08-31 | カッパーアールエヌエー,インコーポレイテッド | RNaseH1に対する天然アンチセンス転写物の阻害によるRNaseH1関連疾患の治療 |
| CN102844435B (zh) | 2010-02-22 | 2017-05-10 | 库尔纳公司 | 通过抑制吡咯啉‑5‑羧酸还原酶1(pycr1)的天然反义转录物而治疗pycr1相关疾病 |
| RU2612884C2 (ru) | 2010-04-02 | 2017-03-13 | Курна, Инк. | Лечение заболеваний, связанных с колониестимулирующим фактором 3 (csf3), путем ингибирования природного антисмыслового транскрипта k csf3 |
| JP2013523162A (ja) | 2010-04-06 | 2013-06-17 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | Cd274/pd−l1遺伝子の発現を阻害するための組成物および方法 |
| CN102858979B (zh) | 2010-04-09 | 2018-01-26 | 库尔纳公司 | 通过抑制成纤维细胞生长因子21(fgf21)的天然反义转录物而治疗fgf21相关疾病 |
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| EP1957648B1 (en) | 2014-04-23 |
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| US8324181B2 (en) | 2012-12-04 |
| EP2641970A1 (en) | 2013-09-25 |
| JP2012050447A (ja) | 2012-03-15 |
| AU2006336624A1 (en) | 2007-08-02 |
| WO2007086990A2 (en) | 2007-08-02 |
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