CA2620380C - Capsule formulation of pirfenidone and pharmaceutically acceptable excipients - Google Patents
Capsule formulation of pirfenidone and pharmaceutically acceptable excipients Download PDFInfo
- Publication number
- CA2620380C CA2620380C CA2620380A CA2620380A CA2620380C CA 2620380 C CA2620380 C CA 2620380C CA 2620380 A CA2620380 A CA 2620380A CA 2620380 A CA2620380 A CA 2620380A CA 2620380 C CA2620380 C CA 2620380C
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- Prior art keywords
- capsule
- pirfenidone
- binder
- formulation
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2762013A CA2762013C (en) | 2005-09-22 | 2006-09-22 | Granulation of pirfenidone and pharmaceutically acceptable excipients |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72025705P | 2005-09-22 | 2005-09-22 | |
| US60/720,257 | 2005-09-22 | ||
| PCT/US2006/037057 WO2007038315A2 (en) | 2005-09-22 | 2006-09-22 | Capsule formulation of pirfenidone and pharmaceutically acceptable excipients |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2762013A Division CA2762013C (en) | 2005-09-22 | 2006-09-22 | Granulation of pirfenidone and pharmaceutically acceptable excipients |
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| CA2620380A1 CA2620380A1 (en) | 2007-04-05 |
| CA2620380C true CA2620380C (en) | 2012-10-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2620380A Active CA2620380C (en) | 2005-09-22 | 2006-09-22 | Capsule formulation of pirfenidone and pharmaceutically acceptable excipients |
| CA2762013A Active CA2762013C (en) | 2005-09-22 | 2006-09-22 | Granulation of pirfenidone and pharmaceutically acceptable excipients |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2762013A Active CA2762013C (en) | 2005-09-22 | 2006-09-22 | Granulation of pirfenidone and pharmaceutically acceptable excipients |
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Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1356816B1 (en) | 2001-01-29 | 2009-12-23 | Shionogi & Co., Ltd. | Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient |
| PH12012502411A1 (en) | 2005-05-10 | 2019-07-17 | Intermune Inc | Method of modulating stress-activated protein kinase system |
| NZ591443A (en) * | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
| PL3053580T3 (pl) | 2006-12-18 | 2021-12-20 | Intermune, Inc. | Sposób dostarczania pacjentowi terapii pirfenidonem |
| US20080242293A1 (en) * | 2007-04-02 | 2008-10-02 | Cequint, Inc. | System and method for providing caller id name display in wireless communications system |
| WO2008147169A2 (es) * | 2007-05-29 | 2008-12-04 | Cell Therapy Technology, S.A. De C.V. | Microemolsion conteniendo pirfenidona |
| WO2008157786A1 (en) | 2007-06-20 | 2008-12-24 | Auspex Pharmaceutical, Inc. | Substituted n-aryl pyridinones as fibrotic inhibitors |
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| ES2509143T3 (es) * | 2008-03-07 | 2014-10-17 | Solanan, Inc. | Tratamiento de una septicemia con 5-etil-1-fenil-2(1H)-piridona |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| US7635707B1 (en) | 2008-11-10 | 2009-12-22 | Intermune, Inc. | Pirfenidone treatment for patients with atypical liver function |
| JP2012515800A (ja) * | 2009-01-26 | 2012-07-12 | インターミューン， インコーポレイテッド | 急性心筋梗塞および関連障害を処置するための方法 |
| DK3255146T3 (da) | 2009-03-16 | 2019-08-19 | Pangu Biopharma Ltd | Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter |
| US7816383B1 (en) | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
| CN101912395B (zh) * | 2010-08-12 | 2012-09-26 | 北京凯因科技股份有限公司 | 一种含吡非尼酮的药物组合物及其制备方法 |
| DK2670242T3 (da) | 2011-01-31 | 2022-05-02 | Avalyn Pharma Inc | Aerosolpirfenidon- og pyridonanalogforbindelser og anvendelser deraf |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| US9018232B2 (en) | 2011-03-08 | 2015-04-28 | Auspex Pharmaceuticals, Inc. | Substituted N-aryl pyridinones |
| CN102670632A (zh) * | 2011-03-12 | 2012-09-19 | 赵海静 | 吡非尼酮在抑制皮肤瘢痕形成的医药用途 |
| MX2011007675A (es) * | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| WO2013090439A1 (en) * | 2011-12-12 | 2013-06-20 | Orbis Biosciences, Inc. | Sustained release particle formulations of guaifenesin |
| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
| CA2819967C (en) * | 2012-08-31 | 2016-03-22 | Intermune, Inc. | Use of pirfenidone concomitantly with ciprofloxacin |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CA2907046C (en) | 2013-03-15 | 2021-04-20 | Atyr Pharma, Inc. | Histidyl-trna synthetase-fc conjugates |
| US9682071B2 (en) | 2013-03-15 | 2017-06-20 | Intermune, Inc. | Methods of improving microvascular integrity |
| SG10202104627UA (en) | 2013-12-13 | 2021-06-29 | Novartis Ag | Pharmaceutical dosage forms |
| AU2015204558B2 (en) | 2014-01-10 | 2020-04-30 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| US9937240B2 (en) * | 2014-04-11 | 2018-04-10 | Gemvax & Kael Co., Ltd. | Peptide having fibrosis inhibitory activity and composition containing same |
| US20170224667A1 (en) * | 2014-10-15 | 2017-08-10 | Arata AZUMA | Cancer chemopreventive agent |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| TWI745396B (zh) * | 2016-07-12 | 2021-11-11 | 日商鹽野義製藥股份有限公司 | 吸入用醫藥組成物 |
| KR102051559B1 (ko) * | 2016-12-09 | 2019-12-05 | 재단법인 아산사회복지재단 | 섬유증의 진단 또는 치료를 위한 스테아르산의 용도 |
| KR20180100869A (ko) * | 2017-03-02 | 2018-09-12 | 영진약품 주식회사 | 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법 |
| WO2018195338A1 (en) * | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
| MX366086B (es) | 2017-08-15 | 2019-06-27 | Cell Therapy And Tech S A De C V | Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel. |
| ES2900457T3 (es) * | 2018-01-12 | 2022-03-17 | Tiefenbacher Alfred E Gmbh & Co Kg | Formulación de comprimidos y cápsulas que contienen pirfenidona |
| US20210205253A1 (en) * | 2018-05-31 | 2021-07-08 | The Asan Foundation | Use Of Stearic Acid For Preventing Or Treating Pulmonary Fibrosis |
| US20210267955A1 (en) * | 2018-06-29 | 2021-09-02 | Zenvision Pharma Llp | Low dose oral pharmaceutical composition of pirfenidone or salt thereof |
| WO2020115774A1 (en) | 2018-12-06 | 2020-06-11 | Cipla Limited | High drug load extended release formulations |
| AU2020397207A1 (en) | 2019-12-04 | 2022-07-21 | Idorsia Pharmaceuticals Ltd | Combination of an azetidine LPA1 receptor antagonist with pirfenidone and/or nintedanib for use in the treatment of fibrotic diseases |
| US20230065106A1 (en) * | 2020-02-06 | 2023-03-02 | Ribomic Inc. | Therapeutic agent for subretinal hyperreflective material or retinal disorders accompanying subretinal hyperreflective material |
| CA3171622A1 (en) * | 2020-03-13 | 2021-09-16 | Puretech Lyt 100, Inc. | Methods of treating respiratory disease with deupirfenidone |
| US20230135671A1 (en) | 2020-04-01 | 2023-05-04 | Boehringer Ingelheim International Gmbh | Use of biomarkers in the treatment of fibrotic conditions |
| BR112022020821A2 (pt) * | 2020-04-14 | 2022-12-20 | Excalibur Pharmaceuticals Inc | Pirfenidona para tratamento de coronavírus |
| KR102584268B1 (ko) * | 2020-04-22 | 2023-10-05 | 영진약품 주식회사 | 안전성과 안정성이 개선된 피르페니돈을 포함하는 장용성 제제 및 이의 제조방법 |
| WO2022158956A1 (ko) | 2021-01-25 | 2022-07-28 | 주식회사 나이벡 | 섬유화 예방 및 치료용 펩타이드 |
| CN117224429B (zh) * | 2023-11-15 | 2024-02-06 | 南京天纵易康生物科技股份有限公司 | 一种含羟乙基纤维素作为崩解剂的烟酰胺/肽类固液分离护肤组合物及其制备方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052509A (en) | 1972-12-18 | 1977-10-04 | Affiliated Medical Research, Inc. | Method for reducing serum uric acid levels |
| CA1049411A (en) | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| US4042699A (en) | 1972-12-18 | 1977-08-16 | Affiliated Medical Research, Inc. | Method for reducing serum glucose levels |
| JPH02215719A (ja) * | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
| US5310562A (en) * | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| US5518729A (en) * | 1989-11-22 | 1996-05-21 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5716632A (en) * | 1989-11-22 | 1998-02-10 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| EP0702551B1 (en) | 1993-05-07 | 2002-09-25 | MARGOLIN, Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5591766A (en) * | 1993-12-03 | 1997-01-07 | Cheil Foods & Chemicals, Inc. | Solid oral formulations of pyridone carboxylic acids |
| US6090822A (en) * | 1995-03-03 | 2000-07-18 | Margolin; Solomon B. | Treatment of cytokine growth factor caused disorders |
| JPH11512699A (ja) * | 1995-09-19 | 1999-11-02 | ビー マーゴリン、ソロモン | 腫瘍壊死因子アルファの阻止 |
| US5962478A (en) * | 1995-09-19 | 1999-10-05 | Margolin; Solomon B. | Inhibition of tumor necrosis factor α |
| WO2001072285A1 (en) * | 2000-03-27 | 2001-10-04 | Kyowa Hakko Kogyo Co., Ltd. | Easy-to-take granule |
| EP1356816B1 (en) | 2001-01-29 | 2009-12-23 | Shionogi & Co., Ltd. | Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient |
| WO2002087549A1 (fr) * | 2001-04-25 | 2002-11-07 | Taisho Pharmaceutical Co., Ltd. | Comprimes a liberation prolongee du type a unites multiples |
| US7007089B2 (en) * | 2001-06-06 | 2006-02-28 | Akarnai Technologies, Inc. | Content delivery network map generation using passive measurement data |
| US7512702B1 (en) * | 2002-03-19 | 2009-03-31 | Cisco Technology, Inc. | Method and apparatus providing highly scalable server load balancing |
| US7139840B1 (en) * | 2002-06-14 | 2006-11-21 | Cisco Technology, Inc. | Methods and apparatus for providing multiple server address translation |
| WO2004019758A2 (en) | 2002-08-27 | 2004-03-11 | Intermune, Inc. | Methods of treating idiopathic pulmonary fibrosis |
| US20060110358A1 (en) * | 2002-08-28 | 2006-05-25 | Hsu Henry H | Combination therapy for treatment of fibrotic disorders |
| US7159034B1 (en) * | 2003-03-03 | 2007-01-02 | Novell, Inc. | System broadcasting ARP request from a server using a different IP address to balance incoming traffic load from clients via different network interface cards |
| HRP20050902A2 (en) * | 2003-03-31 | 2005-12-31 | Pliva-Lachema A.S. | Pharmaceutical composition containing platinum complex as active substance and method of manufacturing thereof |
| US20050008691A1 (en) * | 2003-05-14 | 2005-01-13 | Arturo Siles Ortega | Bicalutamide compositions |
| EP1633317A4 (en) | 2003-05-16 | 2008-08-20 | Intermune Inc | Synthetic chemokine receptor ligands and methods of use therefor |
| US20070092488A1 (en) | 2003-05-16 | 2007-04-26 | Intermune Inc. | Methods of treating idiopathic pulmonary fibrosis |
| WO2005004763A1 (en) * | 2003-07-01 | 2005-01-20 | Pharmacia & Upjohn Company Llc. | Diffusion layer modulated solids |
| WO2005040758A2 (en) | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| AU2003284808B2 (en) | 2003-11-14 | 2009-01-22 | Catalyst Biosciences, Inc. | The derivatives of pyridone and the use of them |
| SE0400235D0 (sv) * | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New composition containing quinoline compounds |
| US8642079B2 (en) * | 2004-02-23 | 2014-02-04 | Hormos Medical Corporation | Solid formulations of ospemifene |
| US7584435B2 (en) * | 2004-03-03 | 2009-09-01 | Omniture, Inc. | Web usage overlays for third-party web plug-in content |
| GEP20105124B (en) * | 2005-07-25 | 2010-11-25 | Array Biopharma Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
| NZ591443A (en) * | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
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2005
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2006
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