CA2619438A1 - Amorphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino(4,5-b) indole-1-acetamide - Google Patents
Amorphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino(4,5-b) indole-1-acetamide Download PDFInfo
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- CA2619438A1 CA2619438A1 CA002619438A CA2619438A CA2619438A1 CA 2619438 A1 CA2619438 A1 CA 2619438A1 CA 002619438 A CA002619438 A CA 002619438A CA 2619438 A CA2619438 A CA 2619438A CA 2619438 A1 CA2619438 A1 CA 2619438A1
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- prevention
- treatment
- solid dispersion
- dispersion according
- therapeutically effective
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- Abandoned
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Classifications
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- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71215005P | 2005-08-29 | 2005-08-29 | |
| US60/712,150 | 2005-08-29 | ||
| PCT/US2006/033022 WO2007027494A2 (en) | 2005-08-29 | 2006-08-24 | Morphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino [4, 5-b] indole-1-acetamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2619438A1 true CA2619438A1 (en) | 2007-03-08 |
Family
ID=37499538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002619438A Abandoned CA2619438A1 (en) | 2005-08-29 | 2006-08-24 | Amorphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino(4,5-b) indole-1-acetamide |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7713548B2 (https=) |
| EP (1) | EP1926476B1 (https=) |
| JP (1) | JP5026426B2 (https=) |
| KR (1) | KR20080061354A (https=) |
| CN (1) | CN101272767B (https=) |
| AR (1) | AR055615A1 (https=) |
| AU (1) | AU2006285111B8 (https=) |
| BR (1) | BRPI0615609A2 (https=) |
| CA (1) | CA2619438A1 (https=) |
| CR (1) | CR9750A (https=) |
| DK (1) | DK1926476T3 (https=) |
| EA (1) | EA015715B1 (https=) |
| EC (1) | ECSP088203A (https=) |
| ES (1) | ES2414434T3 (https=) |
| HN (1) | HN2008000360A (https=) |
| HR (1) | HRP20130533T1 (https=) |
| IL (1) | IL189587A (https=) |
| MA (1) | MA29783B1 (https=) |
| ME (1) | ME01560B (https=) |
| NO (1) | NO20081364L (https=) |
| NZ (1) | NZ566313A (https=) |
| PL (1) | PL1926476T3 (https=) |
| PT (1) | PT1926476E (https=) |
| RS (1) | RS52914B (https=) |
| SI (1) | SI1926476T1 (https=) |
| TN (1) | TNSN08069A1 (https=) |
| TW (1) | TWI398250B (https=) |
| UA (1) | UA93517C2 (https=) |
| WO (1) | WO2007027494A2 (https=) |
| ZA (1) | ZA200801893B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| EP2674428B1 (en) | 2006-04-07 | 2016-04-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| CN101702878B (zh) * | 2007-05-11 | 2012-11-28 | 弗·哈夫曼-拉罗切有限公司 | 可溶性差的药物的药物组合物 |
| CA2717326C (en) * | 2008-03-11 | 2018-10-23 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
| RU2011110241A (ru) * | 2008-08-18 | 2012-09-27 | САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи (US) | СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФА 7-ХЛОР-N,N,5-ТРИМЕТИЛ-4-ОКСО-3-ФЕНИЛ-3,5-ДИГИДРО-4Н-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-АЦЕТАМИДА |
| SI2826776T1 (sl) * | 2010-03-25 | 2021-02-26 | Vertex Pharmaceuticals Incorporated | Trdna disperzija amorfne oblike (R)-1(2,2-difluorobenzo(D)(1,3)dioksol-5-il)-N-(1-(2,3-dihidroksipropil) -6-fluoro-2-(1-hidroksi-2-metilpropan-2-il)-1H-indol-5-il)- ciklopropankarboksamida |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| US9801855B2 (en) | 2012-03-07 | 2017-10-31 | National Institute Of Pharmaceutical Education And Research (Niper) | Nanocrystalline solid dispersion compositions and process of preparation thereof |
| KR101986683B1 (ko) | 2012-12-13 | 2019-06-10 | 한미약품 주식회사 | 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체 |
| CN105493092A (zh) * | 2013-08-30 | 2016-04-13 | 慧与发展有限责任合伙企业 | 实时移动与模式分布的比较 |
| CN106232144B (zh) * | 2014-03-18 | 2019-12-06 | 武田药品工业株式会社 | 固体分散体 |
| RU2744460C2 (ru) | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости |
| EP4049660B1 (en) | 2016-02-29 | 2025-02-19 | F. Hoffmann-La Roche AG | Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase |
| AU2018296476B2 (en) * | 2017-07-04 | 2023-11-02 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition and method for preparing same |
| JP2025008679A (ja) * | 2023-07-05 | 2025-01-20 | 学校法人 名城大学 | 非晶質性化有機化合物を含む複合粒子の製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091381A (en) * | 1991-04-12 | 1992-02-25 | Biomeasure, Inc. | 2H-1,3,4-benzotriazepin-2-ones |
| TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
| FR2766823B1 (fr) | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
| ATE364374T1 (de) * | 1997-08-11 | 2007-07-15 | Pfizer Prod Inc | Feste pharmazeutische dispersionen mit erhöhter bioverfügbarkeit |
| AUPP278498A0 (en) * | 1998-04-03 | 1998-04-30 | Australian Nuclear Science & Technology Organisation | Peripheral benzodiazepine receptor binding agents |
| FR2788696B1 (fr) * | 1999-01-26 | 2004-03-05 | Synthelabo | Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central |
| ES2306646T3 (es) | 1999-02-09 | 2008-11-16 | Pfizer Products Inc. | Composiciones de farmacos basicos con biodisponibilidad incrementada. |
| EP1027886B1 (en) | 1999-02-10 | 2008-07-09 | Pfizer Products Inc. | Pharmaceutical solid dispersions |
| ES2310164T3 (es) * | 1999-02-10 | 2009-01-01 | Pfizer Products Inc. | Dispositivo de liberacion controlada por la matriz. |
| EP1120109A3 (en) * | 2000-01-24 | 2002-07-10 | Pfizer Products Inc. | Rapidly disintegrating and fast dissolving solid dosage form |
| FR2829939B3 (fr) * | 2001-09-21 | 2003-11-28 | Sanofi Synthelabo | Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| WO2005034999A2 (en) * | 2003-10-10 | 2005-04-21 | Bvm Holding Co. | Composition comprising association complex of a pharmaceutical and a poloxamer |
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2006
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- 2006-08-24 UA UAA200803944A patent/UA93517C2/ru unknown
- 2006-08-24 PT PT68022151T patent/PT1926476E/pt unknown
- 2006-08-24 ES ES06802215T patent/ES2414434T3/es active Active
- 2006-08-24 HR HRP20130533TT patent/HRP20130533T1/hr unknown
- 2006-08-24 ME MEP-2013-80A patent/ME01560B/me unknown
- 2006-08-24 CA CA002619438A patent/CA2619438A1/en not_active Abandoned
- 2006-08-24 BR BRPI0615609-6A patent/BRPI0615609A2/pt not_active IP Right Cessation
- 2006-08-24 SI SI200631605T patent/SI1926476T1/sl unknown
- 2006-08-24 EA EA200800713A patent/EA015715B1/ru not_active IP Right Cessation
- 2006-08-24 KR KR1020087004952A patent/KR20080061354A/ko not_active Abandoned
- 2006-08-24 PL PL06802215T patent/PL1926476T3/pl unknown
- 2006-08-24 CN CN2006800317142A patent/CN101272767B/zh not_active Expired - Fee Related
- 2006-08-24 JP JP2008529117A patent/JP5026426B2/ja not_active Expired - Fee Related
- 2006-08-24 DK DK06802215.1T patent/DK1926476T3/da active
- 2006-08-24 AU AU2006285111A patent/AU2006285111B8/en not_active Ceased
- 2006-08-24 ZA ZA200801893A patent/ZA200801893B/xx unknown
- 2006-08-24 RS RS20130288A patent/RS52914B/sr unknown
- 2006-08-24 WO PCT/US2006/033022 patent/WO2007027494A2/en not_active Ceased
- 2006-08-28 AR ARP060103739A patent/AR055615A1/es not_active Application Discontinuation
- 2006-08-29 TW TW095131682A patent/TWI398250B/zh not_active IP Right Cessation
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2008
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- 2008-02-19 EC EC2008008203A patent/ECSP088203A/es unknown
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- 2008-03-17 MA MA30752A patent/MA29783B1/fr unknown
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| Date | Code | Title | Description |
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Effective date: 20160824 |