CA2607185A1 - Intracellular active agents - Google Patents
Intracellular active agents Download PDFInfo
- Publication number
- CA2607185A1 CA2607185A1 CA002607185A CA2607185A CA2607185A1 CA 2607185 A1 CA2607185 A1 CA 2607185A1 CA 002607185 A CA002607185 A CA 002607185A CA 2607185 A CA2607185 A CA 2607185A CA 2607185 A1 CA2607185 A1 CA 2607185A1
- Authority
- CA
- Canada
- Prior art keywords
- helix
- nucleic acid
- section
- hmga
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000013543 active substance Substances 0.000 title claims abstract description 32
- 230000003834 intracellular effect Effects 0.000 title claims description 56
- 150000007523 nucleic acids Chemical class 0.000 claims description 366
- 102000039446 nucleic acids Human genes 0.000 claims description 365
- 108020004707 nucleic acids Proteins 0.000 claims description 365
- 239000002773 nucleotide Substances 0.000 claims description 266
- 125000003729 nucleotide group Chemical group 0.000 claims description 247
- 102000009012 HMGA Proteins Human genes 0.000 claims description 209
- 108010049069 HMGA Proteins Proteins 0.000 claims description 209
- 230000027455 binding Effects 0.000 claims description 196
- NPOAOTPXWNWTSH-UHFFFAOYSA-N 3-hydroxy-3-methylglutaric acid Chemical group OC(=O)CC(O)(C)CC(O)=O NPOAOTPXWNWTSH-UHFFFAOYSA-N 0.000 claims description 175
- 108091027076 Spiegelmer Proteins 0.000 claims description 152
- 206010028980 Neoplasm Diseases 0.000 claims description 123
- 229920002873 Polyethylenimine Polymers 0.000 claims description 72
- 238000000034 method Methods 0.000 claims description 59
- 239000000693 micelle Substances 0.000 claims description 58
- 201000011510 cancer Diseases 0.000 claims description 57
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 54
- 102000027411 intracellular receptors Human genes 0.000 claims description 53
- 108091008582 intracellular receptors Proteins 0.000 claims description 53
- 239000000203 mixture Substances 0.000 claims description 48
- 102100029009 High mobility group protein HMG-I/HMG-Y Human genes 0.000 claims description 44
- 101000986380 Homo sapiens High mobility group protein HMG-I/HMG-Y Proteins 0.000 claims description 44
- 201000010099 disease Diseases 0.000 claims description 43
- 239000003981 vehicle Substances 0.000 claims description 38
- 102000005962 receptors Human genes 0.000 claims description 34
- 108020003175 receptors Proteins 0.000 claims description 34
- 238000009396 hybridization Methods 0.000 claims description 31
- 239000000543 intermediate Substances 0.000 claims description 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 28
- 239000005557 antagonist Substances 0.000 claims description 27
- 239000000556 agonist Substances 0.000 claims description 26
- 238000001514 detection method Methods 0.000 claims description 26
- 108700039143 HMGA2 Proteins 0.000 claims description 24
- 238000011282 treatment Methods 0.000 claims description 24
- 101150073387 Hmga2 gene Proteins 0.000 claims description 23
- 230000015572 biosynthetic process Effects 0.000 claims description 21
- 102000040945 Transcription factor Human genes 0.000 claims description 20
- 108091023040 Transcription factor Proteins 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 18
- 230000004048 modification Effects 0.000 claims description 17
- 238000012986 modification Methods 0.000 claims description 17
- 229920001184 polypeptide Polymers 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 15
- 150000002632 lipids Chemical class 0.000 claims description 14
- 102000018802 High Mobility Group Proteins Human genes 0.000 claims description 13
- 108010052512 High Mobility Group Proteins Proteins 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 12
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 12
- 206010027476 Metastases Diseases 0.000 claims description 11
- 150000001720 carbohydrates Chemical class 0.000 claims description 11
- 235000014633 carbohydrates Nutrition 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 230000002503 metabolic effect Effects 0.000 claims description 11
- 206010003210 Arteriosclerosis Diseases 0.000 claims description 10
- 108700039142 HMGA1a Proteins 0.000 claims description 10
- 102000049983 HMGA1a Human genes 0.000 claims description 10
- 208000011775 arteriosclerosis disease Diseases 0.000 claims description 10
- 210000004072 lung Anatomy 0.000 claims description 10
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims description 9
- 108700020911 DNA-Binding Proteins Proteins 0.000 claims description 9
- 210000000481 breast Anatomy 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 230000001404 mediated effect Effects 0.000 claims description 9
- 239000002105 nanoparticle Substances 0.000 claims description 8
- 210000000496 pancreas Anatomy 0.000 claims description 8
- 230000010837 receptor-mediated endocytosis Effects 0.000 claims description 8
- 238000012216 screening Methods 0.000 claims description 8
- 102100028999 High mobility group protein HMGI-C Human genes 0.000 claims description 7
- 206010024612 Lipoma Diseases 0.000 claims description 7
- 108010006519 Molecular Chaperones Proteins 0.000 claims description 7
- 206010046798 Uterine leiomyoma Diseases 0.000 claims description 7
- 201000010260 leiomyoma Diseases 0.000 claims description 7
- 239000002502 liposome Substances 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 7
- 201000007954 uterine fibroid Diseases 0.000 claims description 7
- 229920000858 Cyclodextrin Polymers 0.000 claims description 6
- 206010025323 Lymphomas Diseases 0.000 claims description 6
- 208000016160 chondroid hamartoma Diseases 0.000 claims description 6
- 229940097362 cyclodextrins Drugs 0.000 claims description 6
- 239000000032 diagnostic agent Substances 0.000 claims description 6
- 229940039227 diagnostic agent Drugs 0.000 claims description 6
- 208000016018 endometrial polyp Diseases 0.000 claims description 6
- 238000011534 incubation Methods 0.000 claims description 6
- 208000032839 leukemia Diseases 0.000 claims description 6
- 208000009091 myxoma Diseases 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
- 208000004333 pleomorphic adenoma Diseases 0.000 claims description 6
- 210000003079 salivary gland Anatomy 0.000 claims description 6
- 210000001685 thyroid gland Anatomy 0.000 claims description 6
- 206010046811 uterine polyp Diseases 0.000 claims description 6
- 201000009030 Carcinoma Diseases 0.000 claims description 5
- 208000021994 Diffuse astrocytoma Diseases 0.000 claims description 5
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 claims description 5
- 208000006050 Hemangiopericytoma Diseases 0.000 claims description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 206010029260 Neuroblastoma Diseases 0.000 claims description 5
- 210000003679 cervix uteri Anatomy 0.000 claims description 5
- 210000001072 colon Anatomy 0.000 claims description 5
- 238000004520 electroporation Methods 0.000 claims description 5
- 201000001169 fibrillary astrocytoma Diseases 0.000 claims description 5
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 5
- 210000001672 ovary Anatomy 0.000 claims description 5
- 210000002307 prostate Anatomy 0.000 claims description 5
- 210000000664 rectum Anatomy 0.000 claims description 5
- 210000002784 stomach Anatomy 0.000 claims description 5
- 230000009385 viral infection Effects 0.000 claims description 5
- 208000011691 Burkitt lymphomas Diseases 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 4
- 239000000412 dendrimer Substances 0.000 claims description 4
- 229920000736 dendritic polymer Polymers 0.000 claims description 4
- 230000000799 fusogenic effect Effects 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 239000011859 microparticle Substances 0.000 claims description 4
- 201000000849 skin cancer Diseases 0.000 claims description 4
- 239000007790 solid phase Substances 0.000 claims description 4
- 230000001960 triggered effect Effects 0.000 claims description 4
- 238000002604 ultrasonography Methods 0.000 claims description 4
- 239000012071 phase Substances 0.000 claims description 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000035939 shock Effects 0.000 claims description 2
- 108700039144 HMGA1b Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 description 153
- 108090000623 proteins and genes Proteins 0.000 description 91
- 102000004169 proteins and genes Human genes 0.000 description 59
- 235000018102 proteins Nutrition 0.000 description 58
- 108091023037 Aptamer Proteins 0.000 description 54
- 241000282414 Homo sapiens Species 0.000 description 51
- 230000014509 gene expression Effects 0.000 description 43
- 210000001519 tissue Anatomy 0.000 description 32
- 239000000872 buffer Substances 0.000 description 31
- 230000000694 effects Effects 0.000 description 31
- 230000003993 interaction Effects 0.000 description 29
- 108020004414 DNA Proteins 0.000 description 23
- 238000003556 assay Methods 0.000 description 20
- 210000000170 cell membrane Anatomy 0.000 description 20
- 238000009826 distribution Methods 0.000 description 20
- 229920001223 polyethylene glycol Polymers 0.000 description 20
- 108700020796 Oncogene Proteins 0.000 description 19
- 150000001875 compounds Chemical class 0.000 description 19
- 230000035755 proliferation Effects 0.000 description 19
- 102000049982 HMGA2 Human genes 0.000 description 18
- 239000002202 Polyethylene glycol Substances 0.000 description 18
- 241001465754 Metazoa Species 0.000 description 17
- 239000000243 solution Substances 0.000 description 17
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 16
- 108091034117 Oligonucleotide Proteins 0.000 description 16
- 210000000172 cytosol Anatomy 0.000 description 16
- 230000005764 inhibitory process Effects 0.000 description 16
- 230000032258 transport Effects 0.000 description 16
- 102000043276 Oncogene Human genes 0.000 description 15
- 101100184710 Xenopus laevis cdc25-1-a gene Proteins 0.000 description 15
- 238000013459 approach Methods 0.000 description 15
- 238000004904 shortening Methods 0.000 description 15
- 108010029485 Protein Isoforms Proteins 0.000 description 14
- 102000001708 Protein Isoforms Human genes 0.000 description 14
- 210000002381 plasma Anatomy 0.000 description 14
- 239000000523 sample Substances 0.000 description 14
- 230000004614 tumor growth Effects 0.000 description 14
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 13
- 238000003745 diagnosis Methods 0.000 description 12
- 210000001163 endosome Anatomy 0.000 description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 238000001890 transfection Methods 0.000 description 12
- 241000700605 Viruses Species 0.000 description 11
- 230000033228 biological regulation Effects 0.000 description 11
- 230000000875 corresponding effect Effects 0.000 description 11
- 230000008878 coupling Effects 0.000 description 11
- 238000010168 coupling process Methods 0.000 description 11
- 238000005859 coupling reaction Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 229920001213 Polysorbate 20 Polymers 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- 239000000499 gel Substances 0.000 description 10
- 239000012528 membrane Substances 0.000 description 10
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 10
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 10
- 108010090804 Streptavidin Proteins 0.000 description 9
- 229940024606 amino acid Drugs 0.000 description 9
- 235000001014 amino acid Nutrition 0.000 description 9
- 150000001413 amino acids Chemical class 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 9
- 230000008859 change Effects 0.000 description 9
- 210000003527 eukaryotic cell Anatomy 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 238000001727 in vivo Methods 0.000 description 9
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 210000000056 organ Anatomy 0.000 description 9
- 238000012856 packing Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 101710088194 Dehydrogenase Proteins 0.000 description 8
- 102000003960 Ligases Human genes 0.000 description 8
- 108090000364 Ligases Proteins 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 8
- 239000011575 calcium Substances 0.000 description 8
- 239000006143 cell culture medium Substances 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- 239000012634 fragment Substances 0.000 description 8
- 108020001507 fusion proteins Proteins 0.000 description 8
- 102000037865 fusion proteins Human genes 0.000 description 8
- 238000000338 in vitro Methods 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- 108020004999 messenger RNA Proteins 0.000 description 8
- 238000000159 protein binding assay Methods 0.000 description 8
- 238000013518 transcription Methods 0.000 description 8
- 230000035897 transcription Effects 0.000 description 8
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 7
- 101710163270 Nuclease Proteins 0.000 description 7
- 101000595993 Phyllomedusa sauvagei Phylloseptin-S1 Proteins 0.000 description 7
- 230000000692 anti-sense effect Effects 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 7
- 238000001556 precipitation Methods 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- -1 Aspartate oxidosqualene Chemical compound 0.000 description 6
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
- 238000009510 drug design Methods 0.000 description 6
- 239000000975 dye Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 238000011835 investigation Methods 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 210000001236 prokaryotic cell Anatomy 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 5
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 5
- 102100032912 CD44 antigen Human genes 0.000 description 5
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 5
- 101000936546 Homo sapiens Anion exchange protein 2 Proteins 0.000 description 5
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 5
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 5
- 102000004357 Transferases Human genes 0.000 description 5
- 108090000992 Transferases Proteins 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 5
- 230000004075 alteration Effects 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 210000004899 c-terminal region Anatomy 0.000 description 5
- 231100000504 carcinogenesis Toxicity 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 231100000673 dose–response relationship Toxicity 0.000 description 5
- 238000001415 gene therapy Methods 0.000 description 5
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 5
- 230000010189 intracellular transport Effects 0.000 description 5
- 230000001394 metastastic effect Effects 0.000 description 5
- 206010061289 metastatic neoplasm Diseases 0.000 description 5
- 239000002853 nucleic acid probe Substances 0.000 description 5
- 230000002018 overexpression Effects 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 101100026251 Caenorhabditis elegans atf-2 gene Proteins 0.000 description 4
- 208000005623 Carcinogenesis Diseases 0.000 description 4
- 102000006786 Chloride-Bicarbonate Antiporters Human genes 0.000 description 4
- 102000053602 DNA Human genes 0.000 description 4
- 230000004568 DNA-binding Effects 0.000 description 4
- 101100352278 Danio rerio pitx2 gene Proteins 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 description 4
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 description 4
- 101150107737 Hmga1 gene Proteins 0.000 description 4
- 101001045846 Homo sapiens Histone-lysine N-methyltransferase 2A Proteins 0.000 description 4
- 101000736088 Homo sapiens PC4 and SFRS1-interacting protein Proteins 0.000 description 4
- 101000572976 Homo sapiens POU domain, class 2, transcription factor 3 Proteins 0.000 description 4
- 101001093899 Homo sapiens Retinoic acid receptor RXR-alpha Proteins 0.000 description 4
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 4
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 4
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 4
- 101100189471 Mus musculus Pbx1 gene Proteins 0.000 description 4
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 4
- 102000004316 Oxidoreductases Human genes 0.000 description 4
- 108090000854 Oxidoreductases Proteins 0.000 description 4
- 102100036220 PC4 and SFRS1-interacting protein Human genes 0.000 description 4
- 102100026466 POU domain, class 2, transcription factor 3 Human genes 0.000 description 4
- 108091000080 Phosphotransferase Proteins 0.000 description 4
- 102100035178 Retinoic acid receptor RXR-alpha Human genes 0.000 description 4
- 108091006260 SLC4A2 Proteins 0.000 description 4
- 108010044012 STAT1 Transcription Factor Proteins 0.000 description 4
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 description 4
- 102100024026 Transcription factor E2F1 Human genes 0.000 description 4
- 102100023132 Transcription factor Jun Human genes 0.000 description 4
- 239000007983 Tris buffer Substances 0.000 description 4
- 108700005077 Viral Genes Proteins 0.000 description 4
- 230000001093 anti-cancer Effects 0.000 description 4
- 230000036952 cancer formation Effects 0.000 description 4
- 210000003855 cell nucleus Anatomy 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000002860 competitive effect Effects 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 238000010494 dissociation reaction Methods 0.000 description 4
- 230000005593 dissociations Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000007717 exclusion Effects 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 230000004807 localization Effects 0.000 description 4
- 230000009401 metastasis Effects 0.000 description 4
- 230000009149 molecular binding Effects 0.000 description 4
- 239000002751 oligonucleotide probe Substances 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 150000003904 phospholipids Chemical class 0.000 description 4
- 102000020233 phosphotransferase Human genes 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 230000002285 radioactive effect Effects 0.000 description 4
- 230000003252 repetitive effect Effects 0.000 description 4
- 238000003757 reverse transcription PCR Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
- 102100027468 Anion exchange protein 2 Human genes 0.000 description 3
- 101000719121 Arabidopsis thaliana Protein MEI2-like 1 Proteins 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 102000004031 Carboxy-Lyases Human genes 0.000 description 3
- 108090000489 Carboxy-Lyases Proteins 0.000 description 3
- 101000986346 Chironomus tentans High mobility group protein I Proteins 0.000 description 3
- 101150096607 Fosl2 gene Proteins 0.000 description 3
- 102100022103 Histone-lysine N-methyltransferase 2A Human genes 0.000 description 3
- 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 description 3
- 101000572986 Homo sapiens POU domain, class 3, transcription factor 2 Proteins 0.000 description 3
- 101000756346 Homo sapiens RE1-silencing transcription factor Proteins 0.000 description 3
- 101000857677 Homo sapiens Runt-related transcription factor 1 Proteins 0.000 description 3
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 3
- 101150069805 MAFG gene Proteins 0.000 description 3
- 102000001947 MafK Transcription Factor Human genes 0.000 description 3
- 108010040548 MafK Transcription Factor Proteins 0.000 description 3
- 108010074852 NF-kappa B p52 Subunit Proteins 0.000 description 3
- 102000008125 NF-kappa B p52 Subunit Human genes 0.000 description 3
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 3
- 102100026459 POU domain, class 3, transcription factor 2 Human genes 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 108010001859 Proto-Oncogene Proteins c-rel Proteins 0.000 description 3
- 102000000850 Proto-Oncogene Proteins c-rel Human genes 0.000 description 3
- 102100022940 RE1-silencing transcription factor Human genes 0.000 description 3
- 239000012980 RPMI-1640 medium Substances 0.000 description 3
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 description 3
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 3
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 description 3
- 239000006180 TBST buffer Substances 0.000 description 3
- 102100035222 Transcription initiation factor TFIID subunit 1 Human genes 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 230000001745 anti-biotin effect Effects 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 239000000090 biomarker Substances 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 230000022131 cell cycle Effects 0.000 description 3
- 238000001516 cell proliferation assay Methods 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000002759 chromosomal effect Effects 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- 230000009260 cross reactivity Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 230000013020 embryo development Effects 0.000 description 3
- 230000012202 endocytosis Effects 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 238000011813 knockout mouse model Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 210000003712 lysosome Anatomy 0.000 description 3
- 230000001868 lysosomic effect Effects 0.000 description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 description 3
- 230000001613 neoplastic effect Effects 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 210000004940 nucleus Anatomy 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000006320 pegylation Effects 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 3
- 238000004445 quantitative analysis Methods 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 229920002477 rna polymer Polymers 0.000 description 3
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 3
- 238000010254 subcutaneous injection Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 3
- 239000011534 wash buffer Substances 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- 239000002023 wood Substances 0.000 description 3
- 102000004899 14-3-3 Proteins Human genes 0.000 description 2
- 125000002124 5'-adenosyl group Chemical group N1=CN=C2N(C=NC2=C1N)[C@H]1[C@H](O)[C@H](O)[C@H](O1)C* 0.000 description 2
- 108091006112 ATPases Proteins 0.000 description 2
- 102000057234 Acyl transferases Human genes 0.000 description 2
- 108700016155 Acyl transferases Proteins 0.000 description 2
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- 108020005544 Antisense RNA Proteins 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 2
- 208000023514 Barrett esophagus Diseases 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 101710132601 Capsid protein Proteins 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 108090000994 Catalytic RNA Proteins 0.000 description 2
- 102000053642 Catalytic RNA Human genes 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 229920001651 Cyanoacrylate Polymers 0.000 description 2
- 239000003298 DNA probe Substances 0.000 description 2
- 230000033616 DNA repair Effects 0.000 description 2
- 102100022812 DNA-binding protein RFX2 Human genes 0.000 description 2
- 102100020986 DNA-binding protein RFX5 Human genes 0.000 description 2
- 102100021044 DNA-binding protein RFXANK Human genes 0.000 description 2
- 101100480530 Danio rerio tal1 gene Proteins 0.000 description 2
- 102100035078 ETS-related transcription factor Elf-2 Human genes 0.000 description 2
- 108700037623 ETS-related transcription factor Elf-3 Proteins 0.000 description 2
- 102100035079 ETS-related transcription factor Elf-3 Human genes 0.000 description 2
- 102100033167 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 102100031702 Endoplasmic reticulum membrane sensor NFE2L1 Human genes 0.000 description 2
- 102100031690 Erythroid transcription factor Human genes 0.000 description 2
- 108010041356 Estrogen Receptor beta Proteins 0.000 description 2
- 102100029951 Estrogen receptor beta Human genes 0.000 description 2
- 102100035134 Forkhead box protein J2 Human genes 0.000 description 2
- 102100023374 Forkhead box protein M1 Human genes 0.000 description 2
- 102000003817 Fos-related antigen 1 Human genes 0.000 description 2
- 108090000123 Fos-related antigen 1 Proteins 0.000 description 2
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 description 2
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 description 2
- 102100033295 Glial cell line-derived neurotrophic factor Human genes 0.000 description 2
- XYZZKVRWGOWVGO-UHFFFAOYSA-N Glycerol-phosphate Chemical compound OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 102000000849 HMGB Proteins Human genes 0.000 description 2
- 108010001860 HMGB Proteins Proteins 0.000 description 2
- 108010044429 HMGN Proteins Proteins 0.000 description 2
- 102000006491 HMGN Proteins Human genes 0.000 description 2
- 101150032268 HOXB7 gene Proteins 0.000 description 2
- 101150089759 HOXB8 gene Proteins 0.000 description 2
- 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 description 2
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 2
- 102100022649 Homeobox protein Hox-A6 Human genes 0.000 description 2
- 101000756799 Homo sapiens DNA-binding protein RFX2 Proteins 0.000 description 2
- 101001075432 Homo sapiens DNA-binding protein RFX5 Proteins 0.000 description 2
- 101001075464 Homo sapiens DNA-binding protein RFXANK Proteins 0.000 description 2
- 101000877377 Homo sapiens ETS-related transcription factor Elf-2 Proteins 0.000 description 2
- 101000907578 Homo sapiens Forkhead box protein M1 Proteins 0.000 description 2
- 101000986379 Homo sapiens High mobility group protein HMGI-C Proteins 0.000 description 2
- 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 description 2
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 2
- 101001083158 Homo sapiens Homeobox protein Hox-A11 Proteins 0.000 description 2
- 101000962622 Homo sapiens Homeobox protein Hox-A3 Proteins 0.000 description 2
- 101001077578 Homo sapiens Homeobox protein Hox-A4 Proteins 0.000 description 2
- 101001077568 Homo sapiens Homeobox protein Hox-A5 Proteins 0.000 description 2
- 101001045083 Homo sapiens Homeobox protein Hox-A6 Proteins 0.000 description 2
- 101001045116 Homo sapiens Homeobox protein Hox-A7 Proteins 0.000 description 2
- 101000614841 Homo sapiens Myocyte-specific enhancer factor 2A Proteins 0.000 description 2
- 101001075466 Homo sapiens Regulatory factor X-associated protein Proteins 0.000 description 2
- 101000665894 Homo sapiens Replication initiator 1 Proteins 0.000 description 2
- 101000640876 Homo sapiens Retinoic acid receptor RXR-beta Proteins 0.000 description 2
- 101000666775 Homo sapiens T-box transcription factor TBX3 Proteins 0.000 description 2
- 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 2
- 101000756787 Homo sapiens Transcription factor RFX3 Proteins 0.000 description 2
- 101000818569 Homo sapiens Zinc finger and BTB domain-containing protein 24 Proteins 0.000 description 2
- 101000785605 Homo sapiens Zinc finger protein 653 Proteins 0.000 description 2
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 2
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- 102000004317 Lyases Human genes 0.000 description 2
- 108090000856 Lyases Proteins 0.000 description 2
- 102100022819 MHC class II regulatory factor RFX1 Human genes 0.000 description 2
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 2
- 108060004795 Methyltransferase Proteins 0.000 description 2
- 102000016397 Methyltransferase Human genes 0.000 description 2
- 102100025751 Mothers against decapentaplegic homolog 2 Human genes 0.000 description 2
- 101710143123 Mothers against decapentaplegic homolog 2 Proteins 0.000 description 2
- 102100025748 Mothers against decapentaplegic homolog 3 Human genes 0.000 description 2
- 101710143111 Mothers against decapentaplegic homolog 3 Proteins 0.000 description 2
- 102100025725 Mothers against decapentaplegic homolog 4 Human genes 0.000 description 2
- 101710143112 Mothers against decapentaplegic homolog 4 Proteins 0.000 description 2
- 101100507933 Mus musculus Hoxc6 gene Proteins 0.000 description 2
- 101100178955 Mus musculus Hoxd4 gene Proteins 0.000 description 2
- 101100480538 Mus musculus Tal1 gene Proteins 0.000 description 2
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 2
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 2
- 102100031790 Myelin expression factor 2 Human genes 0.000 description 2
- 101710107751 Myelin expression factor 2 Proteins 0.000 description 2
- 102100021148 Myocyte-specific enhancer factor 2A Human genes 0.000 description 2
- 108010018525 NFATC Transcription Factors Proteins 0.000 description 2
- 102000002673 NFATC Transcription Factors Human genes 0.000 description 2
- 101150006407 NRF1 gene Proteins 0.000 description 2
- 101100410801 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pxr-1 gene Proteins 0.000 description 2
- 101150114527 Nkx2-5 gene Proteins 0.000 description 2
- 102100024006 Nuclear factor 1 A-type Human genes 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 102000007354 PAX6 Transcription Factor Human genes 0.000 description 2
- 108010032788 PAX6 Transcription Factor Proteins 0.000 description 2
- 101100312945 Pasteurella multocida (strain Pm70) talA gene Proteins 0.000 description 2
- 102100027584 Protein c-Fos Human genes 0.000 description 2
- 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 2
- 102100026869 RNA-binding protein MEX3B Human genes 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 108010030933 Regulatory Factor X1 Proteins 0.000 description 2
- 102100021043 Regulatory factor X-associated protein Human genes 0.000 description 2
- 102100038242 Replication initiator 1 Human genes 0.000 description 2
- 102100025192 Retinoblastoma-binding protein 5 Human genes 0.000 description 2
- 101710157309 Retinoblastoma-binding protein 5 Proteins 0.000 description 2
- 102100034253 Retinoic acid receptor RXR-beta Human genes 0.000 description 2
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 description 2
- 102100033909 Retinoic acid receptor beta Human genes 0.000 description 2
- 102100033912 Retinoic acid receptor gamma Human genes 0.000 description 2
- 108091028664 Ribonucleotide Proteins 0.000 description 2
- 102100032741 SET-binding protein Human genes 0.000 description 2
- 101710194492 SET-binding protein Proteins 0.000 description 2
- 101150063267 STAT5B gene Proteins 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 102100024474 Signal transducer and activator of transcription 5B Human genes 0.000 description 2
- 108020004459 Small interfering RNA Proteins 0.000 description 2
- 108010014480 T-box transcription factor 5 Proteins 0.000 description 2
- 102100038409 T-box transcription factor TBX3 Human genes 0.000 description 2
- 102100024755 T-box transcription factor TBX5 Human genes 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 108010022394 Threonine synthase Proteins 0.000 description 2
- 108090000340 Transaminases Proteins 0.000 description 2
- 108010048992 Transcription Factor 4 Proteins 0.000 description 2
- 108010018242 Transcription Factor AP-1 Proteins 0.000 description 2
- 102100023489 Transcription factor 4 Human genes 0.000 description 2
- 102100022821 Transcription factor RFX3 Human genes 0.000 description 2
- 108050004072 Transcription initiation factor TFIID subunit 1 Proteins 0.000 description 2
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 2
- 102000004243 Tubulin Human genes 0.000 description 2
- 108090000704 Tubulin Proteins 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- 241000145297 Vanni Species 0.000 description 2
- 101100460507 Xenopus laevis nkx-2.5 gene Proteins 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- QWXOJIDBSHLIFI-UHFFFAOYSA-N [3-(1-chloro-3'-methoxyspiro[adamantane-4,4'-dioxetane]-3'-yl)phenyl] dihydrogen phosphate Chemical compound O1OC2(C3CC4CC2CC(Cl)(C4)C3)C1(OC)C1=CC=CC(OP(O)(O)=O)=C1 QWXOJIDBSHLIFI-UHFFFAOYSA-N 0.000 description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 2
- 239000011543 agarose gel Substances 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 239000012131 assay buffer Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- RNBGYGVWRKECFJ-ARQDHWQXSA-N beta-D-fructofuranose 1,6-bisphosphate Chemical compound O[C@H]1[C@H](O)[C@@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O RNBGYGVWRKECFJ-ARQDHWQXSA-N 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 230000007541 cellular toxicity Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- WLNARFZDISHUGS-MIXBDBMTSA-N cholesteryl hemisuccinate Chemical compound C1C=C2C[C@@H](OC(=O)CCC(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 WLNARFZDISHUGS-MIXBDBMTSA-N 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000028023 exocytosis Effects 0.000 description 2
- 101150051296 foxj2 gene Proteins 0.000 description 2
- 238000001502 gel electrophoresis Methods 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 210000002288 golgi apparatus Anatomy 0.000 description 2
- 238000013537 high throughput screening Methods 0.000 description 2
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 2
- 101150003074 hoxa5 gene Proteins 0.000 description 2
- 102000043323 human PSIP1 Human genes 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000007813 immunodeficiency Effects 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 108090000865 liver X receptors Proteins 0.000 description 2
- 102000004311 liver X receptors Human genes 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 210000003632 microfilament Anatomy 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 210000005170 neoplastic cell Anatomy 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 230000007505 plaque formation Effects 0.000 description 2
- 229920005643 polyisobutyl cyanoacrylate Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 238000010837 poor prognosis Methods 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000005588 protonation Effects 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 108700042226 ras Genes Proteins 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 102000003702 retinoic acid receptors Human genes 0.000 description 2
- 108090000064 retinoic acid receptors Proteins 0.000 description 2
- 108091008726 retinoic acid receptors α Proteins 0.000 description 2
- 108091008761 retinoic acid receptors β Proteins 0.000 description 2
- 108091008760 retinoic acid receptors γ Proteins 0.000 description 2
- 239000002336 ribonucleotide Substances 0.000 description 2
- 125000002652 ribonucleotide group Chemical group 0.000 description 2
- 108091092562 ribozyme Proteins 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 230000003019 stabilising effect Effects 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 108010067247 tacrolimus binding protein 4 Proteins 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 102000014898 transaminase activity proteins Human genes 0.000 description 2
- 108091006108 transcriptional coactivators Proteins 0.000 description 2
- 230000007723 transport mechanism Effects 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- AHZQQIBUZKHEHR-FVGYRXGTSA-N (2s)-2-amino-3-(1h-indol-3-yl)propanoic acid;phosphoric acid Chemical compound OP(O)(O)=O.C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 AHZQQIBUZKHEHR-FVGYRXGTSA-N 0.000 description 1
- TYBFYWFTPNZNIS-DKWTVANSSA-N (2s)-2-aminobutanedioic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)[C@@H](N)CC(O)=O TYBFYWFTPNZNIS-DKWTVANSSA-N 0.000 description 1
- VQPIHIGAMRSAAN-WMUFLLRFSA-N (3S)-3-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3R)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O VQPIHIGAMRSAAN-WMUFLLRFSA-N 0.000 description 1
- ZKSVYBRJSMBDMV-UHFFFAOYSA-N 1,3-diphenyl-2-benzofuran Chemical compound C1=CC=CC=C1C1=C2C=CC=CC2=C(C=2C=CC=CC=2)O1 ZKSVYBRJSMBDMV-UHFFFAOYSA-N 0.000 description 1
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
- KVUXYQHEESDGIJ-UHFFFAOYSA-N 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-3,16-diol Chemical compound C1CC2CC(O)CCC2(C)C2C1C1CC(O)CC1(C)CC2 KVUXYQHEESDGIJ-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- 108700020469 14-3-3 Proteins 0.000 description 1
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 description 1
- AKWUNZFZIXEOPV-UHFFFAOYSA-N 2-[4-[[3-[7-chloro-1-(oxan-4-ylmethyl)indol-3-yl]-1,2,4-oxadiazol-5-yl]methyl]piperazin-1-yl]acetamide Chemical compound C1CN(CC(=O)N)CCN1CC1=NC(C=2C3=CC=CC(Cl)=C3N(CC3CCOCC3)C=2)=NO1 AKWUNZFZIXEOPV-UHFFFAOYSA-N 0.000 description 1
- BFFPVEVGHKMWLT-UHFFFAOYSA-N 2-amino-3,7-dihydropurin-6-one;3,7-dihydropurin-6-one Chemical compound O=C1NC=NC2=C1NC=N2.O=C1NC(N)=NC2=C1NC=N2 BFFPVEVGHKMWLT-UHFFFAOYSA-N 0.000 description 1
- 108020005345 3' Untranslated Regions Proteins 0.000 description 1
- 101150110188 30 gene Proteins 0.000 description 1
- 102100033747 39S ribosomal protein L15, mitochondrial Human genes 0.000 description 1
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 1
- 108010060511 4-Aminobutyrate Transaminase Proteins 0.000 description 1
- 102100035923 4-aminobutyrate aminotransferase, mitochondrial Human genes 0.000 description 1
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 1
- HCAJQHYUCKICQH-VPENINKCSA-N 8-Oxo-7,8-dihydro-2'-deoxyguanosine Chemical compound C1=2NC(N)=NC(=O)C=2NC(=O)N1[C@H]1C[C@H](O)[C@@H](CO)O1 HCAJQHYUCKICQH-VPENINKCSA-N 0.000 description 1
- 102000006267 AMP Deaminase Human genes 0.000 description 1
- 108700016228 AMP deaminases Proteins 0.000 description 1
- 108010088547 ARNTL Transcription Factors Proteins 0.000 description 1
- 102100030835 AT-rich interactive domain-containing protein 5B Human genes 0.000 description 1
- 101710081716 AT-rich interactive domain-containing protein 5B Proteins 0.000 description 1
- 208000006678 Abdominal Neoplasms Diseases 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 108010000700 Acetolactate synthase Proteins 0.000 description 1
- 108010003902 Acetyl-CoA C-acyltransferase Proteins 0.000 description 1
- 102000004672 Acetyl-CoA C-acyltransferase Human genes 0.000 description 1
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 1
- 108010051457 Acid Phosphatase Proteins 0.000 description 1
- 102000013563 Acid Phosphatase Human genes 0.000 description 1
- 108010009924 Aconitate hydratase Proteins 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 102000006488 Acyl-Carrier Protein S-Malonyltransferase Human genes 0.000 description 1
- 108010058912 Acyl-Carrier Protein S-Malonyltransferase Proteins 0.000 description 1
- 102100036664 Adenosine deaminase Human genes 0.000 description 1
- 102100032534 Adenosine kinase Human genes 0.000 description 1
- 108020000543 Adenylate kinase Proteins 0.000 description 1
- NRCXNPKDOMYPPJ-HYORBCNSSA-N Aflatoxin P1 Chemical compound C=1([C@@H]2C=CO[C@@H]2OC=1C=C(C1=2)O)C=2OC(=O)C2=C1CCC2=O NRCXNPKDOMYPPJ-HYORBCNSSA-N 0.000 description 1
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 102000016912 Aldehyde Reductase Human genes 0.000 description 1
- 108010053754 Aldehyde reductase Proteins 0.000 description 1
- 244000068687 Amelanchier alnifolia Species 0.000 description 1
- 235000009027 Amelanchier alnifolia Nutrition 0.000 description 1
- 102100039160 Amiloride-sensitive amine oxidase [copper-containing] Human genes 0.000 description 1
- 108010028700 Amine Oxidase (Copper-Containing) Proteins 0.000 description 1
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 description 1
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 description 1
- 101710191958 Amino-acid acetyltransferase Proteins 0.000 description 1
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 1
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 1
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 1
- 102000000412 Annexin Human genes 0.000 description 1
- 108050008874 Annexin Proteins 0.000 description 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
- 101000745634 Aplysia californica Cytoplasmic polyadenylation element-binding protein Proteins 0.000 description 1
- 102100021987 Apoptosis-stimulating of p53 protein 1 Human genes 0.000 description 1
- 102100021986 Apoptosis-stimulating of p53 protein 2 Human genes 0.000 description 1
- 102000007347 Apyrase Human genes 0.000 description 1
- 108010007730 Apyrase Proteins 0.000 description 1
- 101100004644 Arabidopsis thaliana BAT1 gene Proteins 0.000 description 1
- 101100179391 Arabidopsis thaliana EIF4G gene Proteins 0.000 description 1
- 101100295091 Arabidopsis thaliana NUDT14 gene Proteins 0.000 description 1
- 101000797612 Arabidopsis thaliana Protein MEI2-like 3 Proteins 0.000 description 1
- 102000004452 Arginase Human genes 0.000 description 1
- 108700024123 Arginases Proteins 0.000 description 1
- 102000009042 Argininosuccinate Lyase Human genes 0.000 description 1
- 102000014654 Aromatase Human genes 0.000 description 1
- 108010078554 Aromatase Proteins 0.000 description 1
- 102100027839 Aryl hydrocarbon receptor nuclear translocator 2 Human genes 0.000 description 1
- 102100021661 Aryl hydrocarbon receptor nuclear translocator-like protein 2 Human genes 0.000 description 1
- 101150010353 Ascl1 gene Proteins 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- 102100021631 B-cell lymphoma 6 protein Human genes 0.000 description 1
- 102000036365 BRCA1 Human genes 0.000 description 1
- 108700020463 BRCA1 Proteins 0.000 description 1
- 101150072950 BRCA1 gene Proteins 0.000 description 1
- 102000052609 BRCA2 Human genes 0.000 description 1
- 108700020462 BRCA2 Proteins 0.000 description 1
- 102100035687 Bile salt-activated lipase Human genes 0.000 description 1
- 101150040844 Bin1 gene Proteins 0.000 description 1
- 108010018763 Biotin carboxylase Proteins 0.000 description 1
- 101000654587 Bombyx mori Silk gland factor 3 Proteins 0.000 description 1
- 101150008921 Brca2 gene Proteins 0.000 description 1
- 102100021411 C-terminal-binding protein 2 Human genes 0.000 description 1
- 101710178053 C-terminal-binding protein 2 Proteins 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 102000019063 CCAAT-Binding Factor Human genes 0.000 description 1
- 108010026988 CCAAT-Binding Factor Proteins 0.000 description 1
- 108010014064 CCCTC-Binding Factor Proteins 0.000 description 1
- 102100033849 CCHC-type zinc finger nucleic acid binding protein Human genes 0.000 description 1
- 101710116319 CCHC-type zinc finger nucleic acid binding protein Proteins 0.000 description 1
- 101150017002 CD44 gene Proteins 0.000 description 1
- 101150035324 CDK9 gene Proteins 0.000 description 1
- 108010083123 CDX2 Transcription Factor Proteins 0.000 description 1
- 102100028226 COUP transcription factor 2 Human genes 0.000 description 1
- 102100024156 Cadherin-12 Human genes 0.000 description 1
- 101710196882 Cadherin-12 Proteins 0.000 description 1
- 101100064697 Caenorhabditis elegans efk-1 gene Proteins 0.000 description 1
- 101100450705 Caenorhabditis elegans hif-1 gene Proteins 0.000 description 1
- 101100280477 Caenorhabditis elegans lbp-1 gene Proteins 0.000 description 1
- 101100129500 Caenorhabditis elegans max-2 gene Proteins 0.000 description 1
- 101100518995 Caenorhabditis elegans pax-3 gene Proteins 0.000 description 1
- 101100262441 Caenorhabditis elegans rfl-1 gene Proteins 0.000 description 1
- 101100257372 Caenorhabditis elegans sox-3 gene Proteins 0.000 description 1
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000000584 Calmodulin Human genes 0.000 description 1
- 108010041952 Calmodulin Proteins 0.000 description 1
- 102000007590 Calpain Human genes 0.000 description 1
- 108010032088 Calpain Proteins 0.000 description 1
- 102100029968 Calreticulin Human genes 0.000 description 1
- 108090000549 Calreticulin Proteins 0.000 description 1
- 102100027313 Calsenilin Human genes 0.000 description 1
- 101100422204 Candida albicans (strain SC5314 / ATCC MYA-2876) CDC68 gene Proteins 0.000 description 1
- 101100341660 Canis lupus familiaris KRT1 gene Proteins 0.000 description 1
- 102100037403 Carbohydrate-responsive element-binding protein Human genes 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 102000007132 Carboxyl and Carbamoyl Transferases Human genes 0.000 description 1
- 108010072957 Carboxyl and Carbamoyl Transferases Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 102000008122 Casein Kinase I Human genes 0.000 description 1
- 108010049812 Casein Kinase I Proteins 0.000 description 1
- 102000052052 Casein Kinase II Human genes 0.000 description 1
- 108010010919 Casein Kinase II Proteins 0.000 description 1
- 102100035882 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000004172 Cathepsin L Human genes 0.000 description 1
- 108090000624 Cathepsin L Proteins 0.000 description 1
- 102000005600 Cathepsins Human genes 0.000 description 1
- 108010084457 Cathepsins Proteins 0.000 description 1
- 101000850997 Cavia porcellus Eosinophil granule major basic protein 2 Proteins 0.000 description 1
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 description 1
- 101150096994 Cdx1 gene Proteins 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 102100040428 Chitobiosyldiphosphodolichol beta-mannosyltransferase Human genes 0.000 description 1
- 108010077544 Chromatin Proteins 0.000 description 1
- 102100039095 Chromatin-remodeling ATPase INO80 Human genes 0.000 description 1
- 102100032920 Chromobox protein homolog 2 Human genes 0.000 description 1
- 101150065749 Churc1 gene Proteins 0.000 description 1
- 102100033361 Cilium assembly protein DZIP1 Human genes 0.000 description 1
- 102100026191 Class E basic helix-loop-helix protein 40 Human genes 0.000 description 1
- 101710130550 Class E basic helix-loop-helix protein 40 Proteins 0.000 description 1
- 102100026190 Class E basic helix-loop-helix protein 41 Human genes 0.000 description 1
- 102000005853 Clathrin Human genes 0.000 description 1
- 108010019874 Clathrin Proteins 0.000 description 1
- 101710094648 Coat protein Proteins 0.000 description 1
- 102100023709 Coiled-coil domain-containing protein 71 Human genes 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 108010079362 Core Binding Factor Alpha 3 Subunit Proteins 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 101001120236 Crotalus durissus cumanensis Basic phospholipase A2 10 Proteins 0.000 description 1
- 101710095468 Cyclase Proteins 0.000 description 1
- 102100023580 Cyclic AMP-dependent transcription factor ATF-4 Human genes 0.000 description 1
- 102100023582 Cyclic AMP-dependent transcription factor ATF-5 Human genes 0.000 description 1
- 102100023583 Cyclic AMP-dependent transcription factor ATF-6 alpha Human genes 0.000 description 1
- 102000016736 Cyclin Human genes 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- 108010068192 Cyclin A Proteins 0.000 description 1
- 108010068106 Cyclin T Proteins 0.000 description 1
- 102100025191 Cyclin-A2 Human genes 0.000 description 1
- 102100024112 Cyclin-T2 Human genes 0.000 description 1
- 102000001493 Cyclophilins Human genes 0.000 description 1
- 108010068682 Cyclophilins Proteins 0.000 description 1
- 102100026846 Cytidine deaminase Human genes 0.000 description 1
- 108010031325 Cytidine deaminase Proteins 0.000 description 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 1
- 102000003849 Cytochrome P450 Human genes 0.000 description 1
- 108060006006 Cytochrome-c peroxidase Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102100039868 Cytoplasmic aconitate hydratase Human genes 0.000 description 1
- 150000008574 D-amino acids Chemical class 0.000 description 1
- LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 102100029145 DNA damage-inducible transcript 3 protein Human genes 0.000 description 1
- 101710156077 DNA damage-inducible transcript 3 protein Proteins 0.000 description 1
- 101100281017 Danio rerio fgf3 gene Proteins 0.000 description 1
- 102100028559 Death domain-associated protein 6 Human genes 0.000 description 1
- 101710085792 Defensin-like protein 1 Proteins 0.000 description 1
- 102000000541 Defensins Human genes 0.000 description 1
- 108010002069 Defensins Proteins 0.000 description 1
- 108010053770 Deoxyribonucleases Proteins 0.000 description 1
- 102000016911 Deoxyribonucleases Human genes 0.000 description 1
- 101000651310 Desulfitobacterium hafniense (strain Y51) Trigger factor 2 Proteins 0.000 description 1
- 102000016680 Dioxygenases Human genes 0.000 description 1
- 108010028143 Dioxygenases Proteins 0.000 description 1
- 101100054052 Drosophila melanogaster 14-3-3epsilon gene Proteins 0.000 description 1
- 101100422210 Drosophila melanogaster dre4 gene Proteins 0.000 description 1
- 101100457919 Drosophila melanogaster stg gene Proteins 0.000 description 1
- 206010013883 Dwarfism Diseases 0.000 description 1
- 102100038913 E1A-binding protein p400 Human genes 0.000 description 1
- 102100034597 E3 ubiquitin-protein ligase TRIM22 Human genes 0.000 description 1
- 101150059401 EGR2 gene Proteins 0.000 description 1
- 101150000195 EGR3 gene Proteins 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 101150033269 ESRRG gene Proteins 0.000 description 1
- 102100023792 ETS domain-containing protein Elk-4 Human genes 0.000 description 1
- 101710130332 ETS domain-containing protein Elk-4 Proteins 0.000 description 1
- 102100039578 ETS translocation variant 4 Human genes 0.000 description 1
- 102100039247 ETS-related transcription factor Elf-4 Human genes 0.000 description 1
- 102100037114 Elongin-C Human genes 0.000 description 1
- 108050009447 Elongin-C Proteins 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 101710157062 Endoplasmic reticulum membrane sensor NFE2L1 Proteins 0.000 description 1
- 101710198510 Enoyl-[acyl-carrier-protein] reductase [NADH] Proteins 0.000 description 1
- 102100030751 Eomesodermin homolog Human genes 0.000 description 1
- 108010008655 Epstein-Barr Virus Nuclear Antigens Proteins 0.000 description 1
- 101710100588 Erythroid transcription factor Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 102100038595 Estrogen receptor Human genes 0.000 description 1
- 101710196141 Estrogen receptor Proteins 0.000 description 1
- 102100031855 Estrogen-related receptor gamma Human genes 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- 102100028166 FACT complex subunit SSRP1 Human genes 0.000 description 1
- 101150043847 FOXD1 gene Proteins 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 208000007659 Fibroadenoma Diseases 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 description 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 description 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 description 1
- 108010010285 Forkhead Box Protein L2 Proteins 0.000 description 1
- 102100021083 Forkhead box protein C2 Human genes 0.000 description 1
- 102100037057 Forkhead box protein D1 Human genes 0.000 description 1
- 102100037062 Forkhead box protein D2 Human genes 0.000 description 1
- 102100037060 Forkhead box protein D3 Human genes 0.000 description 1
- 102100020855 Forkhead box protein E3 Human genes 0.000 description 1
- 102100020848 Forkhead box protein F2 Human genes 0.000 description 1
- 102100041006 Forkhead box protein J1 Human genes 0.000 description 1
- 102100035128 Forkhead box protein J3 Human genes 0.000 description 1
- 102100035137 Forkhead box protein L2 Human genes 0.000 description 1
- 102100023371 Forkhead box protein N1 Human genes 0.000 description 1
- 102100023360 Forkhead box protein N2 Human genes 0.000 description 1
- 102100023359 Forkhead box protein N3 Human genes 0.000 description 1
- 102100028115 Forkhead box protein P2 Human genes 0.000 description 1
- 102100027581 Forkhead box protein P3 Human genes 0.000 description 1
- 102100027570 Forkhead box protein Q1 Human genes 0.000 description 1
- 101710088110 Forkhead box protein Q1 Proteins 0.000 description 1
- 102100039818 Frizzled-5 Human genes 0.000 description 1
- 101710140951 Frizzled-5 Proteins 0.000 description 1
- 108010036781 Fumarate Hydratase Proteins 0.000 description 1
- 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 description 1
- 230000010190 G1 phase Effects 0.000 description 1
- 102100035205 GA-binding protein subunit beta-1 Human genes 0.000 description 1
- HILUWRPVFKJTAD-ZGHMGGRHSA-N GA21 Chemical compound O=C(O)[C@H]1[C@@H]2[C@]3(C(=O)O)C(=O)O[C@@]2([C@H]2[C@]41CC(=C)[C@@](O)(C4)CC2)CCC3 HILUWRPVFKJTAD-ZGHMGGRHSA-N 0.000 description 1
- 101710082961 GATA-binding factor 2 Proteins 0.000 description 1
- 102000008412 GATA5 Transcription Factor Human genes 0.000 description 1
- 108010021779 GATA5 Transcription Factor Proteins 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 102000030902 Galactosyltransferase Human genes 0.000 description 1
- 108060003306 Galactosyltransferase Proteins 0.000 description 1
- 101001066288 Gallus gallus GATA-binding factor 3 Proteins 0.000 description 1
- 101000597041 Gallus gallus Transcriptional enhancer factor TEF-3 Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000013382 Gelatinases Human genes 0.000 description 1
- 108010026132 Gelatinases Proteins 0.000 description 1
- 102000004878 Gelsolin Human genes 0.000 description 1
- 108090001064 Gelsolin Proteins 0.000 description 1
- 102100032863 General transcription factor IIH subunit 3 Human genes 0.000 description 1
- 102100033299 Glia-derived nexin Human genes 0.000 description 1
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 description 1
- 108010073324 Glutaminase Proteins 0.000 description 1
- 102000009127 Glutaminase Human genes 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
- 102100034228 Grainyhead-like protein 1 homolog Human genes 0.000 description 1
- 108700010012 HMGN1 Proteins 0.000 description 1
- 101150004541 HOXC8 gene Proteins 0.000 description 1
- 208000002927 Hamartoma Diseases 0.000 description 1
- 102100034049 Heat shock factor protein 2 Human genes 0.000 description 1
- 102100039165 Heat shock protein beta-1 Human genes 0.000 description 1
- 101710100504 Heat shock protein beta-1 Proteins 0.000 description 1
- 102100031880 Helicase SRCAP Human genes 0.000 description 1
- 102100027489 Helicase-like transcription factor Human genes 0.000 description 1
- 102100021889 Helix-loop-helix protein 2 Human genes 0.000 description 1
- 108010086512 Hepatocyte Nuclear Factor 1 Proteins 0.000 description 1
- 102000006754 Hepatocyte Nuclear Factor 1 Human genes 0.000 description 1
- 102000005646 Heterogeneous-Nuclear Ribonucleoprotein K Human genes 0.000 description 1
- 108010084680 Heterogeneous-Nuclear Ribonucleoprotein K Proteins 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- 102100037907 High mobility group protein B1 Human genes 0.000 description 1
- 101710168537 High mobility group protein B1 Proteins 0.000 description 1
- 108010014095 Histidine decarboxylase Proteins 0.000 description 1
- 102100037095 Histidine decarboxylase Human genes 0.000 description 1
- 102100030445 Histone H4 transcription factor Human genes 0.000 description 1
- 101710189113 Histone H4 transcription factor Proteins 0.000 description 1
- 102100039999 Histone deacetylase 2 Human genes 0.000 description 1
- 102100021455 Histone deacetylase 3 Human genes 0.000 description 1
- 102100021454 Histone deacetylase 4 Human genes 0.000 description 1
- 102100021453 Histone deacetylase 5 Human genes 0.000 description 1
- 108010016918 Histone-Lysine N-Methyltransferase Proteins 0.000 description 1
- 108050002855 Histone-lysine N-methyltransferase 2A Proteins 0.000 description 1
- 102100039489 Histone-lysine N-methyltransferase, H3 lysine-79 specific Human genes 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 101150068639 Hnf4a gene Proteins 0.000 description 1
- 102100031671 Homeobox protein CDX-2 Human genes 0.000 description 1
- 102100031800 Homeobox protein ESX1 Human genes 0.000 description 1
- 102100030308 Homeobox protein Hox-A11 Human genes 0.000 description 1
- 102100030307 Homeobox protein Hox-A13 Human genes 0.000 description 1
- 102100039542 Homeobox protein Hox-A2 Human genes 0.000 description 1
- 102100039541 Homeobox protein Hox-A3 Human genes 0.000 description 1
- 102100025116 Homeobox protein Hox-A4 Human genes 0.000 description 1
- 102100025110 Homeobox protein Hox-A5 Human genes 0.000 description 1
- 102100022650 Homeobox protein Hox-A7 Human genes 0.000 description 1
- 102100028411 Homeobox protein Hox-B3 Human genes 0.000 description 1
- 102100028404 Homeobox protein Hox-B4 Human genes 0.000 description 1
- 102100025061 Homeobox protein Hox-B7 Human genes 0.000 description 1
- 102100029423 Homeobox protein Hox-B8 Human genes 0.000 description 1
- 102100029433 Homeobox protein Hox-B9 Human genes 0.000 description 1
- 102100020766 Homeobox protein Hox-C11 Human genes 0.000 description 1
- 102100020758 Homeobox protein Hox-C12 Human genes 0.000 description 1
- 102100020761 Homeobox protein Hox-C13 Human genes 0.000 description 1
- 102100020759 Homeobox protein Hox-C4 Human genes 0.000 description 1
- 102100020762 Homeobox protein Hox-C5 Human genes 0.000 description 1
- 102100022599 Homeobox protein Hox-C6 Human genes 0.000 description 1
- 102100022601 Homeobox protein Hox-C8 Human genes 0.000 description 1
- 102100022597 Homeobox protein Hox-C9 Human genes 0.000 description 1
- 102100040228 Homeobox protein Hox-D3 Human genes 0.000 description 1
- 102100021086 Homeobox protein Hox-D4 Human genes 0.000 description 1
- 102100034864 Homeobox protein Hox-D9 Human genes 0.000 description 1
- 102100029394 Homeobox protein PKNOX1 Human genes 0.000 description 1
- 102100029330 Homeobox protein PKNOX2 Human genes 0.000 description 1
- 102100035081 Homeobox protein TGIF1 Human genes 0.000 description 1
- 102100039704 Homeobox protein VENTX Human genes 0.000 description 1
- 102100030231 Homeobox protein cut-like 2 Human genes 0.000 description 1
- 101000964898 Homo sapiens 14-3-3 protein zeta/delta Proteins 0.000 description 1
- 101000733945 Homo sapiens 39S ribosomal protein L15, mitochondrial Proteins 0.000 description 1
- 101000752722 Homo sapiens Apoptosis-stimulating of p53 protein 1 Proteins 0.000 description 1
- 101000752711 Homo sapiens Apoptosis-stimulating of p53 protein 2 Proteins 0.000 description 1
- 101000768838 Homo sapiens Aryl hydrocarbon receptor nuclear translocator 2 Proteins 0.000 description 1
- 101000971234 Homo sapiens B-cell lymphoma 6 protein Proteins 0.000 description 1
- 101100382122 Homo sapiens CIITA gene Proteins 0.000 description 1
- 101000860860 Homo sapiens COUP transcription factor 2 Proteins 0.000 description 1
- 101000726098 Homo sapiens Calsenilin Proteins 0.000 description 1
- 101000952179 Homo sapiens Carbohydrate-responsive element-binding protein Proteins 0.000 description 1
- 101000891557 Homo sapiens Chitobiosyldiphosphodolichol beta-mannosyltransferase Proteins 0.000 description 1
- 101001033682 Homo sapiens Chromatin-remodeling ATPase INO80 Proteins 0.000 description 1
- 101000797586 Homo sapiens Chromobox protein homolog 2 Proteins 0.000 description 1
- 101000980066 Homo sapiens Cilia- and flagella-associated protein 410 Proteins 0.000 description 1
- 101000926718 Homo sapiens Cilium assembly protein DZIP1 Proteins 0.000 description 1
- 101000765033 Homo sapiens Class E basic helix-loop-helix protein 41 Proteins 0.000 description 1
- 101000978332 Homo sapiens Coiled-coil domain-containing protein 71 Proteins 0.000 description 1
- 101000974934 Homo sapiens Cyclic AMP-dependent transcription factor ATF-2 Proteins 0.000 description 1
- 101000905743 Homo sapiens Cyclic AMP-dependent transcription factor ATF-4 Proteins 0.000 description 1
- 101000905746 Homo sapiens Cyclic AMP-dependent transcription factor ATF-5 Proteins 0.000 description 1
- 101000905751 Homo sapiens Cyclic AMP-dependent transcription factor ATF-6 alpha Proteins 0.000 description 1
- 101001132307 Homo sapiens DNA repair protein RAD51 homolog 2 Proteins 0.000 description 1
- 101000915428 Homo sapiens Death domain-associated protein 6 Proteins 0.000 description 1
- 101000848629 Homo sapiens E3 ubiquitin-protein ligase TRIM22 Proteins 0.000 description 1
- 101000813747 Homo sapiens ETS translocation variant 4 Proteins 0.000 description 1
- 101000813135 Homo sapiens ETS-related transcription factor Elf-4 Proteins 0.000 description 1
- 101001056455 Homo sapiens Endosome-associated-trafficking regulator 1 Proteins 0.000 description 1
- 101001064167 Homo sapiens Eomesodermin homolog Proteins 0.000 description 1
- 101000697353 Homo sapiens FACT complex subunit SSRP1 Proteins 0.000 description 1
- 101000818305 Homo sapiens Forkhead box protein C2 Proteins 0.000 description 1
- 101001029314 Homo sapiens Forkhead box protein D2 Proteins 0.000 description 1
- 101001029308 Homo sapiens Forkhead box protein D3 Proteins 0.000 description 1
- 101000931489 Homo sapiens Forkhead box protein E3 Proteins 0.000 description 1
- 101000931482 Homo sapiens Forkhead box protein F2 Proteins 0.000 description 1
- 101000892910 Homo sapiens Forkhead box protein J1 Proteins 0.000 description 1
- 101001023387 Homo sapiens Forkhead box protein J3 Proteins 0.000 description 1
- 101000907576 Homo sapiens Forkhead box protein N1 Proteins 0.000 description 1
- 101000907593 Homo sapiens Forkhead box protein N2 Proteins 0.000 description 1
- 101000907594 Homo sapiens Forkhead box protein N3 Proteins 0.000 description 1
- 101001059881 Homo sapiens Forkhead box protein P2 Proteins 0.000 description 1
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 description 1
- 101001022098 Homo sapiens GA-binding protein subunit beta-1 Proteins 0.000 description 1
- 101000666405 Homo sapiens General transcription factor IIH subunit 1 Proteins 0.000 description 1
- 101000655398 Homo sapiens General transcription factor IIH subunit 2 Proteins 0.000 description 1
- 101000655391 Homo sapiens General transcription factor IIH subunit 3 Proteins 0.000 description 1
- 101000655406 Homo sapiens General transcription factor IIH subunit 4 Proteins 0.000 description 1
- 101000655402 Homo sapiens General transcription factor IIH subunit 5 Proteins 0.000 description 1
- 101000997803 Homo sapiens Glia-derived nexin Proteins 0.000 description 1
- 101000997829 Homo sapiens Glial cell line-derived neurotrophic factor Proteins 0.000 description 1
- 101001069933 Homo sapiens Grainyhead-like protein 1 homolog Proteins 0.000 description 1
- 101100395337 Homo sapiens HMGA2 gene Proteins 0.000 description 1
- 101001016883 Homo sapiens Heat shock factor protein 2 Proteins 0.000 description 1
- 101000704158 Homo sapiens Helicase SRCAP Proteins 0.000 description 1
- 101001081105 Homo sapiens Helicase-like transcription factor Proteins 0.000 description 1
- 101000897700 Homo sapiens Helix-loop-helix protein 2 Proteins 0.000 description 1
- 101001046967 Homo sapiens Histone acetyltransferase KAT2A Proteins 0.000 description 1
- 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 description 1
- 101000899282 Homo sapiens Histone deacetylase 3 Proteins 0.000 description 1
- 101000899259 Homo sapiens Histone deacetylase 4 Proteins 0.000 description 1
- 101000899255 Homo sapiens Histone deacetylase 5 Proteins 0.000 description 1
- 101001028782 Homo sapiens Histone-lysine N-methyltransferase EZH1 Proteins 0.000 description 1
- 101000963360 Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific Proteins 0.000 description 1
- 101000920856 Homo sapiens Homeobox protein ESX1 Proteins 0.000 description 1
- 101001083156 Homo sapiens Homeobox protein Hox-A1 Proteins 0.000 description 1
- 101001083164 Homo sapiens Homeobox protein Hox-A10 Proteins 0.000 description 1
- 101001083162 Homo sapiens Homeobox protein Hox-A13 Proteins 0.000 description 1
- 101000962636 Homo sapiens Homeobox protein Hox-A2 Proteins 0.000 description 1
- 101001041174 Homo sapiens Homeobox protein Hox-A9 Proteins 0.000 description 1
- 101000839775 Homo sapiens Homeobox protein Hox-B3 Proteins 0.000 description 1
- 101000839788 Homo sapiens Homeobox protein Hox-B4 Proteins 0.000 description 1
- 101001077539 Homo sapiens Homeobox protein Hox-B7 Proteins 0.000 description 1
- 101000988994 Homo sapiens Homeobox protein Hox-B8 Proteins 0.000 description 1
- 101000989000 Homo sapiens Homeobox protein Hox-B9 Proteins 0.000 description 1
- 101001003015 Homo sapiens Homeobox protein Hox-C11 Proteins 0.000 description 1
- 101001002991 Homo sapiens Homeobox protein Hox-C12 Proteins 0.000 description 1
- 101001002988 Homo sapiens Homeobox protein Hox-C13 Proteins 0.000 description 1
- 101001002994 Homo sapiens Homeobox protein Hox-C4 Proteins 0.000 description 1
- 101001002966 Homo sapiens Homeobox protein Hox-C5 Proteins 0.000 description 1
- 101001045154 Homo sapiens Homeobox protein Hox-C6 Proteins 0.000 description 1
- 101001045158 Homo sapiens Homeobox protein Hox-C8 Proteins 0.000 description 1
- 101001045140 Homo sapiens Homeobox protein Hox-C9 Proteins 0.000 description 1
- 101001037158 Homo sapiens Homeobox protein Hox-D3 Proteins 0.000 description 1
- 101001041136 Homo sapiens Homeobox protein Hox-D4 Proteins 0.000 description 1
- 101001019766 Homo sapiens Homeobox protein Hox-D9 Proteins 0.000 description 1
- 101001125957 Homo sapiens Homeobox protein PKNOX1 Proteins 0.000 description 1
- 101001125949 Homo sapiens Homeobox protein PKNOX2 Proteins 0.000 description 1
- 101000596925 Homo sapiens Homeobox protein TGIF1 Proteins 0.000 description 1
- 101000667986 Homo sapiens Homeobox protein VENTX Proteins 0.000 description 1
- 101000726714 Homo sapiens Homeobox protein cut-like 2 Proteins 0.000 description 1
- 101001021527 Homo sapiens Huntingtin-interacting protein 1 Proteins 0.000 description 1
- 101001033233 Homo sapiens Interleukin-10 Proteins 0.000 description 1
- 101001046537 Homo sapiens Kinesin-like protein KIFC2 Proteins 0.000 description 1
- 101001006895 Homo sapiens Krueppel-like factor 11 Proteins 0.000 description 1
- 101001006886 Homo sapiens Krueppel-like factor 12 Proteins 0.000 description 1
- 101001046564 Homo sapiens Krueppel-like factor 13 Proteins 0.000 description 1
- 101001046593 Homo sapiens Krueppel-like factor 16 Proteins 0.000 description 1
- 101001139146 Homo sapiens Krueppel-like factor 2 Proteins 0.000 description 1
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 description 1
- 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 description 1
- 101001139117 Homo sapiens Krueppel-like factor 7 Proteins 0.000 description 1
- 101001020544 Homo sapiens LIM/homeobox protein Lhx2 Proteins 0.000 description 1
- 101000619914 Homo sapiens LIM/homeobox protein Lhx5 Proteins 0.000 description 1
- 101000619910 Homo sapiens LIM/homeobox protein Lhx6 Proteins 0.000 description 1
- 101001044093 Homo sapiens Lipopolysaccharide-induced tumor necrosis factor-alpha factor Proteins 0.000 description 1
- 101000624625 Homo sapiens M-phase inducer phosphatase 1 Proteins 0.000 description 1
- 101100456961 Homo sapiens MEX3B gene Proteins 0.000 description 1
- 101001005664 Homo sapiens Mastermind-like protein 1 Proteins 0.000 description 1
- 101001033726 Homo sapiens Methyl-CpG-binding protein 2 Proteins 0.000 description 1
- 101000928479 Homo sapiens Microtubule organization protein AKNA Proteins 0.000 description 1
- 101000958041 Homo sapiens Musculin Proteins 0.000 description 1
- 101001128495 Homo sapiens Myeloid zinc finger 1 Proteins 0.000 description 1
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 description 1
- 101000589002 Homo sapiens Myogenin Proteins 0.000 description 1
- 101000979909 Homo sapiens NMDA receptor synaptonuclear signaling and neuronal migration factor Proteins 0.000 description 1
- 101000603702 Homo sapiens Neurogenin-3 Proteins 0.000 description 1
- 101000634537 Homo sapiens Neuronal PAS domain-containing protein 2 Proteins 0.000 description 1
- 101001111328 Homo sapiens Nuclear factor 1 A-type Proteins 0.000 description 1
- 101000979347 Homo sapiens Nuclear factor 1 X-type Proteins 0.000 description 1
- 101000588303 Homo sapiens Nuclear factor erythroid 2-related factor 3 Proteins 0.000 description 1
- 101000973177 Homo sapiens Nuclear factor interleukin-3-regulated protein Proteins 0.000 description 1
- 101000602930 Homo sapiens Nuclear receptor coactivator 2 Proteins 0.000 description 1
- 101000582254 Homo sapiens Nuclear receptor corepressor 2 Proteins 0.000 description 1
- 101000633516 Homo sapiens Nuclear receptor subfamily 2 group F member 6 Proteins 0.000 description 1
- 101001000780 Homo sapiens POU domain, class 2, transcription factor 1 Proteins 0.000 description 1
- 101001000773 Homo sapiens POU domain, class 2, transcription factor 2 Proteins 0.000 description 1
- 101000572989 Homo sapiens POU domain, class 3, transcription factor 3 Proteins 0.000 description 1
- 101000572950 Homo sapiens POU domain, class 3, transcription factor 4 Proteins 0.000 description 1
- 101001094737 Homo sapiens POU domain, class 4, transcription factor 3 Proteins 0.000 description 1
- 101000738966 Homo sapiens POU domain, class 6, transcription factor 1 Proteins 0.000 description 1
- 101000595669 Homo sapiens Pituitary homeobox 2 Proteins 0.000 description 1
- 101000595674 Homo sapiens Pituitary homeobox 3 Proteins 0.000 description 1
- 101001047090 Homo sapiens Potassium voltage-gated channel subfamily H member 2 Proteins 0.000 description 1
- 101000619116 Homo sapiens Proline-rich protein 12 Proteins 0.000 description 1
- 101000892360 Homo sapiens Protein AF-17 Proteins 0.000 description 1
- 101000721172 Homo sapiens Protein DBF4 homolog A Proteins 0.000 description 1
- 101001133957 Homo sapiens Putative POU domain, class 5, transcription factor 1B Proteins 0.000 description 1
- 101000968552 Homo sapiens Putative double homeobox protein 3 Proteins 0.000 description 1
- 101000629813 Homo sapiens RNA-binding protein MEX3B Proteins 0.000 description 1
- 101000640882 Homo sapiens Retinoic acid receptor RXR-gamma Proteins 0.000 description 1
- 101000703463 Homo sapiens Rho GTPase-activating protein 35 Proteins 0.000 description 1
- 101000703425 Homo sapiens Rho GTPase-activating protein 39 Proteins 0.000 description 1
- 101000703439 Homo sapiens Rho GTPase-activating protein 42 Proteins 0.000 description 1
- 101000857682 Homo sapiens Runt-related transcription factor 2 Proteins 0.000 description 1
- 101000694550 Homo sapiens RuvB-like 1 Proteins 0.000 description 1
- 101000711466 Homo sapiens SAM pointed domain-containing Ets transcription factor Proteins 0.000 description 1
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
- 101000688996 Homo sapiens Ski-like protein Proteins 0.000 description 1
- 101000851696 Homo sapiens Steroid hormone receptor ERR2 Proteins 0.000 description 1
- 101000713590 Homo sapiens T-box transcription factor TBX1 Proteins 0.000 description 1
- 101000653635 Homo sapiens T-box transcription factor TBX18 Proteins 0.000 description 1
- 101000713596 Homo sapiens T-box transcription factor TBX19 Proteins 0.000 description 1
- 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 description 1
- 101000625913 Homo sapiens T-box transcription factor TBX4 Proteins 0.000 description 1
- 101000625859 Homo sapiens T-box transcription factor TBX6 Proteins 0.000 description 1
- 101000655119 Homo sapiens T-cell leukemia homeobox protein 3 Proteins 0.000 description 1
- 101000596086 Homo sapiens TATA box-binding protein-associated factor RNA polymerase I subunit D Proteins 0.000 description 1
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 description 1
- 101000663444 Homo sapiens Transcription elongation factor SPT4 Proteins 0.000 description 1
- 101000655403 Homo sapiens Transcription factor CP2-like protein 1 Proteins 0.000 description 1
- 101000837845 Homo sapiens Transcription factor E3 Proteins 0.000 description 1
- 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 description 1
- 101000723923 Homo sapiens Transcription factor HIVEP2 Proteins 0.000 description 1
- 101001023770 Homo sapiens Transcription factor NF-E2 45 kDa subunit Proteins 0.000 description 1
- 101001075434 Homo sapiens Transcription factor RFX4 Proteins 0.000 description 1
- 101000800860 Homo sapiens Transcription initiation factor IIB Proteins 0.000 description 1
- 101000596093 Homo sapiens Transcription initiation factor TFIID subunit 1 Proteins 0.000 description 1
- 101000652707 Homo sapiens Transcription initiation factor TFIID subunit 4 Proteins 0.000 description 1
- 101000636213 Homo sapiens Transcriptional activator Myb Proteins 0.000 description 1
- 101001131930 Homo sapiens Transcriptional activator protein Pur-beta Proteins 0.000 description 1
- 101000652684 Homo sapiens Transcriptional adapter 3 Proteins 0.000 description 1
- 101000653735 Homo sapiens Transcriptional enhancer factor TEF-1 Proteins 0.000 description 1
- 101000597043 Homo sapiens Transcriptional enhancer factor TEF-5 Proteins 0.000 description 1
- 101000796673 Homo sapiens Transformation/transcription domain-associated protein Proteins 0.000 description 1
- 101000971144 Homo sapiens Tyrosine-protein kinase BAZ1B Proteins 0.000 description 1
- 101000671637 Homo sapiens Upstream stimulatory factor 1 Proteins 0.000 description 1
- 101000671649 Homo sapiens Upstream stimulatory factor 2 Proteins 0.000 description 1
- 101100377226 Homo sapiens ZBTB16 gene Proteins 0.000 description 1
- 101100321437 Homo sapiens ZFAT gene Proteins 0.000 description 1
- 101000785559 Homo sapiens Zinc finger and SCAN domain-containing protein 26 Proteins 0.000 description 1
- 101000976577 Homo sapiens Zinc finger protein 124 Proteins 0.000 description 1
- 101000759226 Homo sapiens Zinc finger protein 143 Proteins 0.000 description 1
- 101000760175 Homo sapiens Zinc finger protein 35 Proteins 0.000 description 1
- 101000964713 Homo sapiens Zinc finger protein 395 Proteins 0.000 description 1
- 101000964706 Homo sapiens Zinc finger protein 398 Proteins 0.000 description 1
- 101000782464 Homo sapiens Zinc finger protein 444 Proteins 0.000 description 1
- 101000964736 Homo sapiens Zinc finger protein 7 Proteins 0.000 description 1
- 101000964726 Homo sapiens Zinc finger protein 76 Proteins 0.000 description 1
- 101000743811 Homo sapiens Zinc finger protein 85 Proteins 0.000 description 1
- 101000857273 Homo sapiens Zinc finger protein GLIS2 Proteins 0.000 description 1
- 101000730644 Homo sapiens Zinc finger protein PLAGL2 Proteins 0.000 description 1
- 101000873785 Homo sapiens mRNA-decapping enzyme 1A Proteins 0.000 description 1
- 101000687642 Homo sapiens snRNA-activating protein complex subunit 1 Proteins 0.000 description 1
- 101000687648 Homo sapiens snRNA-activating protein complex subunit 2 Proteins 0.000 description 1
- 101000825856 Homo sapiens snRNA-activating protein complex subunit 3 Proteins 0.000 description 1
- 101000825848 Homo sapiens snRNA-activating protein complex subunit 4 Proteins 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 241001502974 Human gammaherpesvirus 8 Species 0.000 description 1
- 102100035957 Huntingtin-interacting protein 1 Human genes 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 102000006933 Hydroxymethyl and Formyl Transferases Human genes 0.000 description 1
- 108010072462 Hydroxymethyl and Formyl Transferases Proteins 0.000 description 1
- 102100031612 Hypermethylated in cancer 1 protein Human genes 0.000 description 1
- 101710133850 Hypermethylated in cancer 1 protein Proteins 0.000 description 1
- 101150027427 ICP4 gene Proteins 0.000 description 1
- 108010087227 IMP Dehydrogenase Proteins 0.000 description 1
- 102000006674 IMP dehydrogenase Human genes 0.000 description 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
- 108010075418 Immunoglobulin J Recombination Signal Sequence Binding Protein Proteins 0.000 description 1
- 102000008047 Immunoglobulin J Recombination Signal Sequence Binding Protein Human genes 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102100027636 Insulin-like growth factor-binding protein 1 Human genes 0.000 description 1
- 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 description 1
- 102000003815 Interleukin-11 Human genes 0.000 description 1
- 108090000177 Interleukin-11 Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 108020003285 Isocitrate lyase Proteins 0.000 description 1
- 102000004195 Isomerases Human genes 0.000 description 1
- 108090000769 Isomerases Proteins 0.000 description 1
- 101150026829 JUNB gene Proteins 0.000 description 1
- 101150021395 JUND gene Proteins 0.000 description 1
- 102000001399 Kallikrein Human genes 0.000 description 1
- 108060005987 Kallikrein Proteins 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 102100022251 Kinesin-like protein KIFC2 Human genes 0.000 description 1
- 102100022248 Krueppel-like factor 1 Human genes 0.000 description 1
- 102100027798 Krueppel-like factor 10 Human genes 0.000 description 1
- 101710166468 Krueppel-like factor 10 Proteins 0.000 description 1
- 102100027797 Krueppel-like factor 11 Human genes 0.000 description 1
- 102100027792 Krueppel-like factor 12 Human genes 0.000 description 1
- 102100022254 Krueppel-like factor 13 Human genes 0.000 description 1
- 102100022324 Krueppel-like factor 16 Human genes 0.000 description 1
- 102100020675 Krueppel-like factor 2 Human genes 0.000 description 1
- 102100020678 Krueppel-like factor 3 Human genes 0.000 description 1
- 101710116712 Krueppel-like factor 3 Proteins 0.000 description 1
- 102100020677 Krueppel-like factor 4 Human genes 0.000 description 1
- 102100020680 Krueppel-like factor 5 Human genes 0.000 description 1
- 102100020679 Krueppel-like factor 6 Human genes 0.000 description 1
- 102100020692 Krueppel-like factor 7 Human genes 0.000 description 1
- 108010049058 Kruppel-Like Factor 6 Proteins 0.000 description 1
- 102000015335 Ku Autoantigen Human genes 0.000 description 1
- 108010025026 Ku Autoantigen Proteins 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- 150000008575 L-amino acids Chemical class 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 102100036132 LIM/homeobox protein Lhx2 Human genes 0.000 description 1
- 102100022139 LIM/homeobox protein Lhx5 Human genes 0.000 description 1
- 102100022098 LIM/homeobox protein Lhx6 Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 102100032241 Lactotransferrin Human genes 0.000 description 1
- 229920006063 Lamide® Polymers 0.000 description 1
- 108010028275 Leukocyte Elastase Proteins 0.000 description 1
- 102100021607 Lipopolysaccharide-induced tumor necrosis factor-alpha factor Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 102000003820 Lipoxygenases Human genes 0.000 description 1
- 108090000128 Lipoxygenases Proteins 0.000 description 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
- 108090001093 Lymphoid enhancer-binding factor 1 Proteins 0.000 description 1
- 102100037611 Lysophospholipase Human genes 0.000 description 1
- 102100023326 M-phase inducer phosphatase 1 Human genes 0.000 description 1
- 101150022636 MAFB gene Proteins 0.000 description 1
- 102100026371 MHC class II transactivator Human genes 0.000 description 1
- 108700002010 MHC class II transactivator Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 108010026217 Malate Dehydrogenase Proteins 0.000 description 1
- 102000013460 Malate Dehydrogenase Human genes 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 102000001696 Mannosidases Human genes 0.000 description 1
- 108010054377 Mannosidases Proteins 0.000 description 1
- 102100025129 Mastermind-like protein 1 Human genes 0.000 description 1
- 102100030200 Matrix metalloproteinase-16 Human genes 0.000 description 1
- 108090000561 Matrix metalloproteinase-16 Proteins 0.000 description 1
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
- 102000006890 Methyl-CpG-Binding Protein 2 Human genes 0.000 description 1
- 108010072388 Methyl-CpG-Binding Protein 2 Proteins 0.000 description 1
- 102100036470 Microtubule organization protein AKNA Human genes 0.000 description 1
- 102100030610 Mothers against decapentaplegic homolog 5 Human genes 0.000 description 1
- 101710143113 Mothers against decapentaplegic homolog 5 Proteins 0.000 description 1
- 102100030590 Mothers against decapentaplegic homolog 6 Human genes 0.000 description 1
- 101710143114 Mothers against decapentaplegic homolog 6 Proteins 0.000 description 1
- 102100030608 Mothers against decapentaplegic homolog 7 Human genes 0.000 description 1
- 101150118570 Msx2 gene Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 101100220214 Mus musculus Cdx4 gene Proteins 0.000 description 1
- 101100444898 Mus musculus Egr1 gene Proteins 0.000 description 1
- 101100445099 Mus musculus Emx1 gene Proteins 0.000 description 1
- 101100445103 Mus musculus Emx2 gene Proteins 0.000 description 1
- 101100446506 Mus musculus Fgf3 gene Proteins 0.000 description 1
- 101100121434 Mus musculus Gcm1 gene Proteins 0.000 description 1
- 101100176745 Mus musculus Gsc2 gene Proteins 0.000 description 1
- 101100018264 Mus musculus Hoxb4 gene Proteins 0.000 description 1
- 101100451915 Mus musculus Hoxb5 gene Proteins 0.000 description 1
- 101100451924 Mus musculus Hoxb6 gene Proteins 0.000 description 1
- 101100289867 Mus musculus Lyl1 gene Proteins 0.000 description 1
- 101100405118 Mus musculus Nr4a1 gene Proteins 0.000 description 1
- 101100518987 Mus musculus Pax1 gene Proteins 0.000 description 1
- 101100518992 Mus musculus Pax2 gene Proteins 0.000 description 1
- 101100518997 Mus musculus Pax3 gene Proteins 0.000 description 1
- 101100351020 Mus musculus Pax5 gene Proteins 0.000 description 1
- 101100351033 Mus musculus Pax7 gene Proteins 0.000 description 1
- 101100462885 Mus musculus Pax9 gene Proteins 0.000 description 1
- 101100521345 Mus musculus Prop1 gene Proteins 0.000 description 1
- 101100310657 Mus musculus Sox1 gene Proteins 0.000 description 1
- 101100366231 Mus musculus Sox12 gene Proteins 0.000 description 1
- 101100310648 Mus musculus Sox17 gene Proteins 0.000 description 1
- 101100257376 Mus musculus Sox3 gene Proteins 0.000 description 1
- 101100043050 Mus musculus Sox4 gene Proteins 0.000 description 1
- 101100043062 Mus musculus Sox7 gene Proteins 0.000 description 1
- 102100038169 Musculin Human genes 0.000 description 1
- 102100034711 Myb-related protein A Human genes 0.000 description 1
- 101710115158 Myb-related protein A Proteins 0.000 description 1
- 102100038893 Myelin transcription factor 1 Human genes 0.000 description 1
- 101710104371 Myelin transcription factor 1 Proteins 0.000 description 1
- 108700041619 Myeloid Ecotropic Viral Integration Site 1 Proteins 0.000 description 1
- 102000047831 Myeloid Ecotropic Viral Integration Site 1 Human genes 0.000 description 1
- 102100031827 Myeloid zinc finger 1 Human genes 0.000 description 1
- 108010075393 Myeloid-Lymphoid Leukemia Protein Proteins 0.000 description 1
- 102100035077 Myoblast determination protein 1 Human genes 0.000 description 1
- 102100030217 Myocardin Human genes 0.000 description 1
- 108010081823 Myocardin Proteins 0.000 description 1
- 108091005975 Myofilaments Proteins 0.000 description 1
- 102100038380 Myogenic factor 5 Human genes 0.000 description 1
- 101710099061 Myogenic factor 5 Proteins 0.000 description 1
- 102100038379 Myogenic factor 6 Human genes 0.000 description 1
- 102100032970 Myogenin Human genes 0.000 description 1
- 108010034119 Myosin Subfragments Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 108700026495 N-Myc Proto-Oncogene Proteins 0.000 description 1
- 102100030124 N-myc proto-oncogene protein Human genes 0.000 description 1
- 102000004960 NAD(P)H dehydrogenase (quinone) Human genes 0.000 description 1
- 108020000284 NAD(P)H dehydrogenase (quinone) Proteins 0.000 description 1
- 102000002250 NAD+ Nucleosidase Human genes 0.000 description 1
- 108010000193 NAD+ Nucleosidase Proteins 0.000 description 1
- 108010071380 NF-E2-Related Factor 1 Proteins 0.000 description 1
- 108010057466 NF-kappa B Proteins 0.000 description 1
- 101150111110 NKX2-1 gene Proteins 0.000 description 1
- 102100024546 NMDA receptor synaptonuclear signaling and neuronal migration factor Human genes 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 102000048850 Neoplasm Genes Human genes 0.000 description 1
- 108700019961 Neoplasm Genes Proteins 0.000 description 1
- 206010029098 Neoplasm skin Diseases 0.000 description 1
- 102100038553 Neurogenin-3 Human genes 0.000 description 1
- 102100029045 Neuronal PAS domain-containing protein 2 Human genes 0.000 description 1
- 101100043306 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) ctc-2 gene Proteins 0.000 description 1
- 101100445499 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) erg-1 gene Proteins 0.000 description 1
- 101100287577 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) gpe-1 gene Proteins 0.000 description 1
- 102100033174 Neutrophil elastase Human genes 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 101150095442 Nr1h2 gene Proteins 0.000 description 1
- 108010077850 Nuclear Localization Signals Proteins 0.000 description 1
- 102000007999 Nuclear Proteins Human genes 0.000 description 1
- 108010089610 Nuclear Proteins Proteins 0.000 description 1
- 108090001146 Nuclear Receptor Coactivator 1 Proteins 0.000 description 1
- 108090001145 Nuclear Receptor Coactivator 3 Proteins 0.000 description 1
- 108010016592 Nuclear Respiratory Factor 1 Proteins 0.000 description 1
- 101710205482 Nuclear factor 1 A-type Proteins 0.000 description 1
- 102100023049 Nuclear factor 1 X-type Human genes 0.000 description 1
- 101710140810 Nuclear factor 1 X-type Proteins 0.000 description 1
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 description 1
- 102100031700 Nuclear factor erythroid 2-related factor 3 Human genes 0.000 description 1
- 102100022163 Nuclear factor interleukin-3-regulated protein Human genes 0.000 description 1
- 102100035413 Nuclear factor of activated T-cells 5 Human genes 0.000 description 1
- 108050006769 Nuclear factor of activated T-cells 5 Proteins 0.000 description 1
- 102100037223 Nuclear receptor coactivator 1 Human genes 0.000 description 1
- 102100037226 Nuclear receptor coactivator 2 Human genes 0.000 description 1
- 102100022883 Nuclear receptor coactivator 3 Human genes 0.000 description 1
- 102100022929 Nuclear receptor coactivator 6 Human genes 0.000 description 1
- 101710115514 Nuclear receptor coactivator 6 Proteins 0.000 description 1
- 102100030569 Nuclear receptor corepressor 2 Human genes 0.000 description 1
- 102100023171 Nuclear receptor subfamily 1 group D member 2 Human genes 0.000 description 1
- 102100029528 Nuclear receptor subfamily 2 group F member 6 Human genes 0.000 description 1
- 102100022679 Nuclear receptor subfamily 4 group A member 1 Human genes 0.000 description 1
- 102100034408 Nuclear transcription factor Y subunit alpha Human genes 0.000 description 1
- 101710115878 Nuclear transcription factor Y subunit alpha Proteins 0.000 description 1
- 108010025568 Nucleophosmin Proteins 0.000 description 1
- 101710141454 Nucleoprotein Proteins 0.000 description 1
- IGROSIFOXXJJJJ-QMMMGPOBSA-N OCN([C@@H](CCSC)C(=O)O)C(CCCC(=O)O)=O Chemical compound OCN([C@@H](CCSC)C(=O)O)C(CCCC(=O)O)=O IGROSIFOXXJJJJ-QMMMGPOBSA-N 0.000 description 1
- 101150092239 OTX2 gene Proteins 0.000 description 1
- 108010058765 Oncogene Protein pp60(v-src) Proteins 0.000 description 1
- 108010078627 Oncogene Protein v-crk Proteins 0.000 description 1
- 108010072293 Oncogene Proteins v-mos Proteins 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 101150041192 Otx1 gene Proteins 0.000 description 1
- 102000004020 Oxygenases Human genes 0.000 description 1
- 108090000417 Oxygenases Proteins 0.000 description 1
- 102000017946 PGC-1 Human genes 0.000 description 1
- 108700038399 PGC-1 Proteins 0.000 description 1
- 101150062967 PHOX2A gene Proteins 0.000 description 1
- 102100030476 POU domain class 2-associating factor 1 Human genes 0.000 description 1
- 101710114665 POU domain class 2-associating factor 1 Proteins 0.000 description 1
- 102100035593 POU domain, class 2, transcription factor 1 Human genes 0.000 description 1
- 102100035591 POU domain, class 2, transcription factor 2 Human genes 0.000 description 1
- 102100026456 POU domain, class 3, transcription factor 3 Human genes 0.000 description 1
- 102100026450 POU domain, class 3, transcription factor 4 Human genes 0.000 description 1
- 102100035398 POU domain, class 4, transcription factor 3 Human genes 0.000 description 1
- 102100037483 POU domain, class 6, transcription factor 1 Human genes 0.000 description 1
- 102000025443 POZ domain binding proteins Human genes 0.000 description 1
- 108091014659 POZ domain binding proteins Proteins 0.000 description 1
- 101150012195 PREB gene Proteins 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 101100536300 Pasteurella multocida (strain Pm70) talB gene Proteins 0.000 description 1
- 102100020739 Peptidyl-prolyl cis-trans isomerase FKBP4 Human genes 0.000 description 1
- 108010020062 Peptidylprolyl Isomerase Proteins 0.000 description 1
- 102000009658 Peptidylprolyl Isomerase Human genes 0.000 description 1
- 102100038824 Peroxisome proliferator-activated receptor delta Human genes 0.000 description 1
- 108030002254 Phosphate acyltransferases Proteins 0.000 description 1
- 108010069394 Phosphatidate Phosphatase Proteins 0.000 description 1
- 102000001107 Phosphatidate Phosphatase Human genes 0.000 description 1
- 102000001105 Phosphofructokinases Human genes 0.000 description 1
- 108010069341 Phosphofructokinases Proteins 0.000 description 1
- 102000009569 Phosphoglucomutase Human genes 0.000 description 1
- 102000011420 Phospholipase D Human genes 0.000 description 1
- 108090000553 Phospholipase D Proteins 0.000 description 1
- 108010058864 Phospholipases A2 Proteins 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- ZYFVNVRFVHJEIU-UHFFFAOYSA-N PicoGreen Chemical compound CN(C)CCCN(CCCN(C)C)C1=CC(=CC2=[N+](C3=CC=CC=C3S2)C)C2=CC=CC=C2N1C1=CC=CC=C1 ZYFVNVRFVHJEIU-UHFFFAOYSA-N 0.000 description 1
- 102100036090 Pituitary homeobox 2 Human genes 0.000 description 1
- 102100036088 Pituitary homeobox 3 Human genes 0.000 description 1
- 102100038124 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 1
- 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 description 1
- 208000037062 Polyps Diseases 0.000 description 1
- 108010013381 Porins Proteins 0.000 description 1
- 102000017033 Porins Human genes 0.000 description 1
- 108010012271 Positive Transcriptional Elongation Factor B Proteins 0.000 description 1
- 102000019014 Positive Transcriptional Elongation Factor B Human genes 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102100022807 Potassium voltage-gated channel subfamily H member 2 Human genes 0.000 description 1
- 101710083689 Probable capsid protein Proteins 0.000 description 1
- 102100022637 Proline-rich protein 12 Human genes 0.000 description 1
- 108700003766 Promyelocytic Leukemia Zinc Finger Proteins 0.000 description 1
- 102100038567 Properdin Human genes 0.000 description 1
- 108010005642 Properdin Proteins 0.000 description 1
- 108700017836 Prophet of Pit-1 Proteins 0.000 description 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 102100040638 Protein AF-17 Human genes 0.000 description 1
- 102100025198 Protein DBF4 homolog A Human genes 0.000 description 1
- 102100027171 Protein SET Human genes 0.000 description 1
- 101710148582 Protein SET Proteins 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 102100034145 Putative POU domain, class 5, transcription factor 1B Human genes 0.000 description 1
- 102100021168 Putative double homeobox protein 3 Human genes 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 108020005115 Pyruvate Kinase Proteins 0.000 description 1
- 102000013009 Pyruvate Kinase Human genes 0.000 description 1
- 108091008730 RAR-related orphan receptors β Proteins 0.000 description 1
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 description 1
- 108091008103 RNA aptamers Proteins 0.000 description 1
- 102100023544 Ras-responsive element-binding protein 1 Human genes 0.000 description 1
- 101710132554 Ras-responsive element-binding protein 1 Proteins 0.000 description 1
- 101100065098 Rattus norvegicus Egr4 gene Proteins 0.000 description 1
- 101100016889 Rattus norvegicus Hes2 gene Proteins 0.000 description 1
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 description 1
- 101100533701 Rattus norvegicus Smad1 gene Proteins 0.000 description 1
- 101100480477 Rattus norvegicus Taar7d gene Proteins 0.000 description 1
- 101100431670 Rattus norvegicus Ybx3 gene Proteins 0.000 description 1
- 101710138742 Receptor-type tyrosine-protein phosphatase H Proteins 0.000 description 1
- 108700025701 Retinoblastoma Genes Proteins 0.000 description 1
- 102100034262 Retinoic acid receptor RXR-gamma Human genes 0.000 description 1
- 108091008770 Rev-ErbAß Proteins 0.000 description 1
- 102100030676 Rho GTPase-activating protein 35 Human genes 0.000 description 1
- 102100030748 Rho GTPase-activating protein 39 Human genes 0.000 description 1
- 102100030757 Rho GTPase-activating protein 42 Human genes 0.000 description 1
- 108091078243 Rho family Proteins 0.000 description 1
- 102000042463 Rho family Human genes 0.000 description 1
- 108010041388 Ribonucleotide Reductases Proteins 0.000 description 1
- 102000000505 Ribonucleotide Reductases Human genes 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 102100025368 Runt-related transcription factor 2 Human genes 0.000 description 1
- 102100025369 Runt-related transcription factor 3 Human genes 0.000 description 1
- 102100027160 RuvB-like 1 Human genes 0.000 description 1
- 230000018199 S phase Effects 0.000 description 1
- 102100034018 SAM pointed domain-containing Ets transcription factor Human genes 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- 101700026522 SMAD7 Proteins 0.000 description 1
- 101700031501 SMAD9 Proteins 0.000 description 1
- 101150073471 SOX14 gene Proteins 0.000 description 1
- 101150106167 SOX9 gene Proteins 0.000 description 1
- 101150097243 SPT16 gene Proteins 0.000 description 1
- 102000004265 STAT2 Transcription Factor Human genes 0.000 description 1
- 108010081691 STAT2 Transcription Factor Proteins 0.000 description 1
- 101150058731 STAT5A gene Proteins 0.000 description 1
- 102000013968 STAT6 Transcription Factor Human genes 0.000 description 1
- 108010011005 STAT6 Transcription Factor Proteins 0.000 description 1
- 102100024793 SWI/SNF complex subunit SMARCC1 Human genes 0.000 description 1
- 101710169053 SWI/SNF complex subunit SMARCC1 Proteins 0.000 description 1
- 102100025746 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Human genes 0.000 description 1
- 101710199691 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Proteins 0.000 description 1
- 102100024777 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Human genes 0.000 description 1
- 101710188233 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Proteins 0.000 description 1
- 101100333774 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ERR3 gene Proteins 0.000 description 1
- 101100122755 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) NPA3 gene Proteins 0.000 description 1
- 101100528938 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ker1 gene Proteins 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
- 108010034546 Serratia marcescens nuclease Proteins 0.000 description 1
- 102100024481 Signal transducer and activator of transcription 5A Human genes 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 102100024451 Ski-like protein Human genes 0.000 description 1
- 102000049870 Smad8 Human genes 0.000 description 1
- 101150117830 Sox5 gene Proteins 0.000 description 1
- 108010019965 Spectrin Proteins 0.000 description 1
- 102000005890 Spectrin Human genes 0.000 description 1
- 108010071698 Spermine synthase Proteins 0.000 description 1
- 102100037616 Spermine synthase Human genes 0.000 description 1
- 102000005782 Squalene Monooxygenase Human genes 0.000 description 1
- 108020003891 Squalene monooxygenase Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 102100036831 Steroid hormone receptor ERR2 Human genes 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 108010055297 Sterol Esterase Proteins 0.000 description 1
- 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 description 1
- 108010074438 Sterol Regulatory Element Binding Protein 2 Proteins 0.000 description 1
- 102100026839 Sterol regulatory element-binding protein 1 Human genes 0.000 description 1
- 102100026841 Sterol regulatory element-binding protein 2 Human genes 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 102000011929 Succinate-CoA Ligases Human genes 0.000 description 1
- 108010075728 Succinate-CoA Ligases Proteins 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 108700025695 Suppressor Genes Proteins 0.000 description 1
- 108010029625 T-Box Domain Protein 2 Proteins 0.000 description 1
- 102100036771 T-box transcription factor TBX1 Human genes 0.000 description 1
- 102100029848 T-box transcription factor TBX18 Human genes 0.000 description 1
- 102100036773 T-box transcription factor TBX19 Human genes 0.000 description 1
- 102100038721 T-box transcription factor TBX2 Human genes 0.000 description 1
- 102100036840 T-box transcription factor TBX21 Human genes 0.000 description 1
- 102100024754 T-box transcription factor TBX4 Human genes 0.000 description 1
- 102100024751 T-box transcription factor TBX6 Human genes 0.000 description 1
- 102100032568 T-cell leukemia homeobox protein 3 Human genes 0.000 description 1
- 102100035207 TATA box-binding protein-associated factor RNA polymerase I subunit D Human genes 0.000 description 1
- 108010030965 Tartrate dehydrogenase Proteins 0.000 description 1
- 102100036407 Thioredoxin Human genes 0.000 description 1
- 108060008245 Thrombospondin Proteins 0.000 description 1
- 102000002938 Thrombospondin Human genes 0.000 description 1
- 102000005497 Thymidylate Synthase Human genes 0.000 description 1
- 101001023030 Toxoplasma gondii Myosin-D Proteins 0.000 description 1
- 102100040396 Transcobalamin-1 Human genes 0.000 description 1
- 101710124861 Transcobalamin-1 Proteins 0.000 description 1
- 102100031027 Transcription activator BRG1 Human genes 0.000 description 1
- 102100038997 Transcription elongation factor SPT4 Human genes 0.000 description 1
- 102100033121 Transcription factor 21 Human genes 0.000 description 1
- 101710119687 Transcription factor 21 Proteins 0.000 description 1
- 108050005285 Transcription factor 7-like 1 Proteins 0.000 description 1
- 102100026155 Transcription factor A, mitochondrial Human genes 0.000 description 1
- 101710106416 Transcription factor A, mitochondrial Proteins 0.000 description 1
- 102100032866 Transcription factor CP2-like protein 1 Human genes 0.000 description 1
- 102100038313 Transcription factor E2-alpha Human genes 0.000 description 1
- 102100028507 Transcription factor E3 Human genes 0.000 description 1
- 102100030798 Transcription factor HES-1 Human genes 0.000 description 1
- 102100028438 Transcription factor HIVEP2 Human genes 0.000 description 1
- 102100028336 Transcription factor HIVEP3 Human genes 0.000 description 1
- 101710177551 Transcription factor HIVEP3 Proteins 0.000 description 1
- 102100035412 Transcription factor NF-E2 45 kDa subunit Human genes 0.000 description 1
- 102100027654 Transcription factor PU.1 Human genes 0.000 description 1
- 102100020984 Transcription factor RFX4 Human genes 0.000 description 1
- 102100028604 Transcription initiation factor IIA subunit 2 Human genes 0.000 description 1
- 101710145409 Transcription initiation factor IIA subunit 2 Proteins 0.000 description 1
- 102100030833 Transcription initiation factor TFIID subunit 4 Human genes 0.000 description 1
- 102100034748 Transcription initiation factor TFIID subunit 7 Human genes 0.000 description 1
- 101710104820 Transcription initiation factor TFIID subunit 7 Proteins 0.000 description 1
- 102100022011 Transcription intermediary factor 1-alpha Human genes 0.000 description 1
- 102100034549 Transcriptional activator protein Pur-beta Human genes 0.000 description 1
- 102100030836 Transcriptional adapter 3 Human genes 0.000 description 1
- 102100029898 Transcriptional enhancer factor TEF-1 Human genes 0.000 description 1
- 102100035147 Transcriptional enhancer factor TEF-5 Human genes 0.000 description 1
- 102100027671 Transcriptional repressor CTCF Human genes 0.000 description 1
- 102100032762 Transformation/transcription domain-associated protein Human genes 0.000 description 1
- 102100027172 Transposon Hsmar1 transposase Human genes 0.000 description 1
- 102000005924 Triose-Phosphate Isomerase Human genes 0.000 description 1
- 108700015934 Triose-phosphate isomerases Proteins 0.000 description 1
- 102000005937 Tropomyosin Human genes 0.000 description 1
- 108010030743 Tropomyosin Proteins 0.000 description 1
- 108010075344 Tryptophan synthase Proteins 0.000 description 1
- 208000035896 Twin-reversed arterial perfusion sequence Diseases 0.000 description 1
- 108010079194 Type C Phospholipases Proteins 0.000 description 1
- 102100021575 Tyrosine-protein kinase BAZ1B Human genes 0.000 description 1
- 108010065282 UDP xylose-protein xylosyltransferase Proteins 0.000 description 1
- 102100040105 Upstream stimulatory factor 1 Human genes 0.000 description 1
- 102100040103 Upstream stimulatory factor 2 Human genes 0.000 description 1
- DJJCXFVJDGTHFX-UHFFFAOYSA-N Uridinemonophosphate Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-UHFFFAOYSA-N 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 108010035430 X-Box Binding Protein 1 Proteins 0.000 description 1
- 102100038151 X-box-binding protein 1 Human genes 0.000 description 1
- 102100036973 X-ray repair cross-complementing protein 5 Human genes 0.000 description 1
- 101710124921 X-ray repair cross-complementing protein 5 Proteins 0.000 description 1
- 102100036976 X-ray repair cross-complementing protein 6 Human genes 0.000 description 1
- 101710124907 X-ray repair cross-complementing protein 6 Proteins 0.000 description 1
- 101001057161 Xenopus laevis MDS1 and EVI1 complex locus protein EVI1-A Proteins 0.000 description 1
- 101100405120 Xenopus laevis nr4a1 gene Proteins 0.000 description 1
- 101100351021 Xenopus laevis pax5 gene Proteins 0.000 description 1
- 102000010199 Xylosyltransferases Human genes 0.000 description 1
- 108010088665 Zinc Finger Protein Gli2 Proteins 0.000 description 1
- 102100040314 Zinc finger and BTB domain-containing protein 16 Human genes 0.000 description 1
- 102100021129 Zinc finger and BTB domain-containing protein 24 Human genes 0.000 description 1
- 101710096165 Zinc finger and BTB domain-containing protein 24 Proteins 0.000 description 1
- 102100026583 Zinc finger and SCAN domain-containing protein 26 Human genes 0.000 description 1
- 102100023573 Zinc finger protein 124 Human genes 0.000 description 1
- 102100023389 Zinc finger protein 143 Human genes 0.000 description 1
- 102100024672 Zinc finger protein 35 Human genes 0.000 description 1
- 102100040733 Zinc finger protein 395 Human genes 0.000 description 1
- 102100040827 Zinc finger protein 398 Human genes 0.000 description 1
- 102100035868 Zinc finger protein 444 Human genes 0.000 description 1
- 102100040726 Zinc finger protein 7 Human genes 0.000 description 1
- 102100040710 Zinc finger protein 76 Human genes 0.000 description 1
- 102100039050 Zinc finger protein 85 Human genes 0.000 description 1
- 102100035558 Zinc finger protein GLI2 Human genes 0.000 description 1
- 102100025884 Zinc finger protein GLIS2 Human genes 0.000 description 1
- 102100032571 Zinc finger protein PLAGL2 Human genes 0.000 description 1
- INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 description 1
- POOGXHSMLJDKRF-SOOFDHNKSA-N [(3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-2-phosphonooxyoxolan-3-yl] dihydrogen phosphate Chemical compound OC[C@H]1OC(OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1O POOGXHSMLJDKRF-SOOFDHNKSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- OFBHPPMPBOJXRT-VWJPMABRSA-N adenylosuccinic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C2=NC=NC(N[C@@H](CC(O)=O)C(O)=O)=C2N=C1 OFBHPPMPBOJXRT-VWJPMABRSA-N 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 description 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000002870 angiogenesis inducing agent Substances 0.000 description 1
- 239000004037 angiogenesis inhibitor Substances 0.000 description 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000000074 antisense oligonucleotide Substances 0.000 description 1
- 238000012230 antisense oligonucleotides Methods 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- KDZOASGQNOPSCU-UHFFFAOYSA-N argininosuccinate Chemical compound OC(=O)C(N)CCCN=C(N)NC(C(O)=O)CC(O)=O KDZOASGQNOPSCU-UHFFFAOYSA-N 0.000 description 1
- 101150024767 arnT gene Proteins 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 206010064097 avian influenza Diseases 0.000 description 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 210000000234 capsid Anatomy 0.000 description 1
- FFQKYPRQEYGKAF-UHFFFAOYSA-N carbamoyl phosphate Chemical compound NC(=O)OP(O)(O)=O FFQKYPRQEYGKAF-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 101150069072 cdc25 gene Proteins 0.000 description 1
- 101150073031 cdk2 gene Proteins 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000006369 cell cycle progression Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000004709 cell invasion Effects 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000007248 cellular mechanism Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 230000004700 cellular uptake Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 210000003483 chromatin Anatomy 0.000 description 1
- 230000010428 chromatin condensation Effects 0.000 description 1
- 229930193282 clathrin Natural products 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 201000010989 colorectal carcinoma Diseases 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 101150089047 cutA gene Proteins 0.000 description 1
- IERHLVCPSMICTF-XVFCMESISA-N cytidine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 IERHLVCPSMICTF-XVFCMESISA-N 0.000 description 1
- 230000002559 cytogenic effect Effects 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 150000001982 diacylglycerols Chemical class 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 102000004419 dihydrofolate reductase Human genes 0.000 description 1
- UFIVEPVSAGBUSI-UHFFFAOYSA-N dihydroorotic acid Chemical compound OC(=O)C1CC(=O)NC(=O)N1 UFIVEPVSAGBUSI-UHFFFAOYSA-N 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 108010089558 erythroid Kruppel-like factor Proteins 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000011536 extraction buffer Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 101150064107 fosB gene Proteins 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000008303 genetic mechanism Effects 0.000 description 1
- 150000002305 glucosylceramides Chemical class 0.000 description 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 208000037824 growth disorder Diseases 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 101150008103 hal gene Proteins 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 235000014304 histidine Nutrition 0.000 description 1
- 108010021685 homeobox protein HOXA13 Proteins 0.000 description 1
- 102000051196 human CFAP410 Human genes 0.000 description 1
- 102000056688 human ENTR1 Human genes 0.000 description 1
- 102000051789 human HMGA2 Human genes 0.000 description 1
- 102000049285 human KMT2A Human genes 0.000 description 1
- 102000056573 human MYB Human genes 0.000 description 1
- 102000048577 human RAD51B Human genes 0.000 description 1
- 102000051381 human SLC4A2 Human genes 0.000 description 1
- 102000054983 human ZBTB24 Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000008611 intercellular interaction Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 102100035856 mRNA-decapping enzyme 1A Human genes 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 101150029117 meox2 gene Proteins 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 101150094258 mxi1 gene Proteins 0.000 description 1
- 208000025113 myeloid leukemia Diseases 0.000 description 1
- 108010084677 myogenic factor 6 Proteins 0.000 description 1
- UPSFMJHZUCSEHU-JYGUBCOQSA-N n-[(2s,3r,4r,5s,6r)-2-[(2r,3s,4r,5r,6s)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OC=2C=C3OC(=O)C=C(C)C3=CC=2)O[C@@H]1CO UPSFMJHZUCSEHU-JYGUBCOQSA-N 0.000 description 1
- MRWXACSTFXYYMV-FDDDBJFASA-N nebularine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC=C2N=C1 MRWXACSTFXYYMV-FDDDBJFASA-N 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 108010010765 nuclear factor-jun Proteins 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000003154 papilloma Diseases 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000009057 passive transport Effects 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000009589 pathological growth Effects 0.000 description 1
- 101150098999 pax8 gene Proteins 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 125000001151 peptidyl group Chemical group 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 description 1
- 108091008765 peroxisome proliferator-activated receptors β/δ Proteins 0.000 description 1
- 108010078226 phenylalanine oxidase Proteins 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000004713 phosphodiesters Chemical group 0.000 description 1
- 229930029653 phosphoenolpyruvate Natural products 0.000 description 1
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 description 1
- 108010064607 phosphoglucokinase Proteins 0.000 description 1
- 108091000115 phosphomannomutase Proteins 0.000 description 1
- 150000008300 phosphoramidites Chemical class 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000012268 protein inhibitor Substances 0.000 description 1
- 229940121649 protein inhibitor Drugs 0.000 description 1
- 108010008370 protein phosphatase 4 Proteins 0.000 description 1
- 108010008929 proto-oncogene protein Spi-1 Proteins 0.000 description 1
- 239000002212 purine nucleoside Substances 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- ZLIBICFPKPWGIZ-UHFFFAOYSA-N pyrimethanil Chemical compound CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 ZLIBICFPKPWGIZ-UHFFFAOYSA-N 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000022983 regulation of cell cycle Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 108010060966 silk gland factor-1 Proteins 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 102000030938 small GTPase Human genes 0.000 description 1
- 108060007624 small GTPase Proteins 0.000 description 1
- 102100024840 snRNA-activating protein complex subunit 1 Human genes 0.000 description 1
- 102100024838 snRNA-activating protein complex subunit 2 Human genes 0.000 description 1
- 102100022779 snRNA-activating protein complex subunit 3 Human genes 0.000 description 1
- 102100022780 snRNA-activating protein complex subunit 4 Human genes 0.000 description 1
- 101150055666 sox6 gene Proteins 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000036435 stunted growth Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 101150115978 tbx5 gene Proteins 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 108020002982 thioesterase Proteins 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 108010014677 transcription factor TFIIE Proteins 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 108010071511 transcriptional intermediary factor 1 Proteins 0.000 description 1
- 238000003151 transfection method Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 230000007733 viral latency Effects 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 238000012982 x-ray structure analysis Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005020874 | 2005-05-04 | ||
| DE102005020874.6 | 2005-05-04 | ||
| PCT/EP2006/004180 WO2006117217A2 (de) | 2005-05-04 | 2006-05-04 | Neue verwendung von spiegelmeren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2607185A1 true CA2607185A1 (en) | 2006-11-09 |
Family
ID=36928624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002607185A Abandoned CA2607185A1 (en) | 2005-05-04 | 2006-05-04 | Intracellular active agents |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8497250B2 (https=) |
| EP (2) | EP1877069A2 (https=) |
| JP (2) | JP2008540363A (https=) |
| KR (2) | KR101418369B1 (https=) |
| CN (2) | CN101217967B (https=) |
| AU (1) | AU2006243334A1 (https=) |
| BR (1) | BRPI0610367A2 (https=) |
| CA (1) | CA2607185A1 (https=) |
| MX (1) | MX2007013760A (https=) |
| SG (1) | SG161311A1 (https=) |
| WO (1) | WO2006117217A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| WO2007070682A2 (en) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
| CA2648099C (en) | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| EP2134830A2 (en) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
| JP2010523595A (ja) | 2007-04-04 | 2010-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | ポリ（アミノ酸）ターゲッティング部分 |
| JP2011500569A (ja) | 2007-10-12 | 2011-01-06 | マサチューセッツ インスティテュート オブ テクノロジー | ワクチンナノテクノロジー |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| BRPI1012036A2 (pt) | 2009-05-27 | 2017-10-10 | Selecta Biosciences Inc | nanocarreadores que possuem componentes com diferentes taxas de liberação |
| WO2011098262A2 (en) * | 2010-02-09 | 2011-08-18 | Universität Bremen | P19arf, hmga2 and mdm2 for use in the diagnosis and treatment of aberrant cell growth |
| EP2561079A1 (en) | 2010-04-21 | 2013-02-27 | Noxxon Pharma AG | Lipid binding nucleic acids |
| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| CN102375064A (zh) * | 2010-08-26 | 2012-03-14 | 杭州华得森生物技术有限公司 | 用酶联免疫法检测人体中hmga2含量的体外诊断试剂盒 |
| DE102010056610A1 (de) * | 2010-12-31 | 2012-07-05 | Volker A. Erdmann | Pharmazeutische Zusammensetzung enthaltend L-DNA |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| JP2014533098A (ja) * | 2011-10-21 | 2014-12-11 | ノクソン・ファルマ・アクチエンゲゼルシャフト | グルカゴン結合核酸 |
| BR112014016939A2 (pt) * | 2012-01-10 | 2019-09-24 | Noxxon Pharma Ag | ácidos nucleicos que se ligam especificamente a cgrp |
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| US9233119B2 (en) * | 2012-09-27 | 2016-01-12 | Miami University | Use of HGMA-targeted phosphorothioate DNA aptamers to suppress carcinogenic activity and increase sensitivity to chemotherapy agents in human cancer cells |
| WO2014193964A2 (en) * | 2013-05-28 | 2014-12-04 | Marsha Rosner | Prognostic and predictive breast cancer signature |
| US10679730B2 (en) | 2013-05-28 | 2020-06-09 | The University Of Chicago | Prognostic and predictive breast cancer signature |
| DK3092256T3 (da) | 2014-01-10 | 2022-06-20 | Birdie Biopharmaceuticals Inc | Forbindelser og sammensætninger til immunterapi |
| CN105233291A (zh) | 2014-07-09 | 2016-01-13 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
| CN121243402A (zh) | 2014-07-09 | 2026-01-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1组合 |
| KR101755617B1 (ko) | 2014-07-23 | 2017-07-10 | 한국과학기술연구원 | 삼차원 자기조립 핵산 나노입자 구조를 갖는 약물전달체 |
| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| JP2017538728A (ja) * | 2014-12-19 | 2017-12-28 | ケミン、インダストリーズ、インコーポレーテッドＫｅｍｉｎ Ｉｎｄｕｓｔｒｉｅｓ， Ｉｎｃ． | イオントフォレシスを用いた生物活性分子の眼内送達 |
| US20180153884A1 (en) | 2015-05-31 | 2018-06-07 | Curegenix Corporation | Combination compositions for immunotherapy |
| US10221249B2 (en) | 2015-09-10 | 2019-03-05 | Affigen, Llc | Method of making patient specific anti-idiotype antibodies |
| DE17829597T1 (de) * | 2016-11-30 | 2019-12-05 | Noxxon Pharma Ag | Verfahren zur polyalkoxylierung von nukleinsäuren zur rückgewinnung und wiederverwendung einer überschüssigen polyalkoxylierungsreagenz |
| WO2020055663A1 (en) * | 2018-09-11 | 2020-03-19 | The Texas A&M University System | L-oligonucleotide inhibitors of polycomb repressive complex 2 (prc2) |
| KR20230005908A (ko) * | 2020-04-30 | 2023-01-10 | 벨라니디 테크놀로지스 엘엘씨 | 생물학적 또는 화학적 독립체 또는 이벤트를 검출하기 위한 분자 와이어 |
| CN112725438B (zh) * | 2021-02-05 | 2023-08-22 | 深圳市宝安区妇幼保健院 | 子宫内膜息肉甲基化标志物组合、检测试剂盒及应用 |
| CN114807183B (zh) * | 2021-12-06 | 2023-06-02 | 西藏自治区农牧科学院农业研究所 | 一种青稞矢车菊素氧甲基转移酶基因的新用途 |
| CN118311277B (zh) * | 2024-06-11 | 2024-12-31 | 北京卫未科学技术有限公司 | 一种用于癌症早筛和辅助诊断的试剂盒及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622828A (en) * | 1990-06-11 | 1997-04-22 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to secretory phospholipase A2 (sPLA2) |
| JPH09502354A (ja) * | 1993-09-08 | 1997-03-11 | ネクスター ファーマスーティカルズ，インコーポレイテッド | 核酸リガンドと、同リガンドを製造するための改良された方法 |
| AU728176B2 (en) * | 1995-05-04 | 2001-01-04 | Gilead Sciences, Inc. | Nucleic acid ligand complexes |
| US5780611A (en) * | 1995-09-15 | 1998-07-14 | Ramareddy Venkata Guntaka | Oligomers which inhibit expression of collagen genes |
| US6171779B1 (en) | 1996-07-12 | 2001-01-09 | University Of Medicine & Dentistry Of New Jersey | HMGI proteins in cancer |
| DE59708838D1 (de) * | 1996-08-30 | 2003-01-09 | Jens Peter Fuerste | Spiegelselektion und spiegelevolution von nucleinsäuren |
| DE19726186A1 (de) * | 1997-06-20 | 1998-12-24 | Boehringer Ingelheim Int | Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen |
| CN1479632A (zh) * | 2000-10-09 | 2004-03-03 | 用于将核酸导入细胞的复合物 | |
| DE10118452A1 (de) * | 2001-04-12 | 2002-10-31 | Joern Bullerdiek | Nukleinsäuresequenzen von Hyperplasien und Tumoren der Schilddrüse |
| ATE469164T1 (de) * | 2001-10-26 | 2010-06-15 | Noxxon Pharma Ag | Modifizierte l-nukleinsäure |
| DE50212280D1 (de) * | 2001-12-19 | 2008-06-26 | Alcedo Biotech Gmbh | Verwendung von hmgb-proteinen und dafür codierenden nukleinsäuren |
| DE10211558A1 (de) * | 2002-03-15 | 2003-10-09 | Noxxon Pharma Ag | Neue Formen RNAi |
| WO2003094973A1 (de) * | 2002-05-08 | 2003-11-20 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Mittel und verfahren zum transport von biologisch aktiven molekülen in zellen |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| WO2004061456A2 (de) * | 2003-01-03 | 2004-07-22 | Alcedo Biotech Gmbh | Verwendungen von hmgb, hmgn, hmga proteinen |
| NZ542687A (en) * | 2003-04-13 | 2010-02-26 | Enzon Pharmaceuticals Inc | Polymeric oligonucleotide prodrugs |
| AU2004238076A1 (en) * | 2003-05-09 | 2004-11-25 | Novosom Ag | Injectable liposomal depots for delivering active ingredients |
| CA2526853A1 (en) * | 2003-05-23 | 2005-03-03 | Board Of Regents - The University Of Texas System | Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting ap-1 transcription factors |
| US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| JP2007519724A (ja) * | 2004-01-26 | 2007-07-19 | シヴィダ・インコーポレイテッド | 核酸を基剤とする治療剤の制御送達および持続的送達 |
| WO2006069782A2 (en) * | 2004-12-27 | 2006-07-06 | Silence Therapeutics Ag. | Lipid complexes coated with peg and their use |
-
2006
- 2006-05-04 KR KR1020077025457A patent/KR101418369B1/ko not_active Expired - Fee Related
- 2006-05-04 EP EP06742799A patent/EP1877069A2/de not_active Ceased
- 2006-05-04 CA CA002607185A patent/CA2607185A1/en not_active Abandoned
- 2006-05-04 SG SG201002837-1A patent/SG161311A1/en unknown
- 2006-05-04 WO PCT/EP2006/004180 patent/WO2006117217A2/de not_active Ceased
- 2006-05-04 AU AU2006243334A patent/AU2006243334A1/en not_active Abandoned
- 2006-05-04 EP EP09016125A patent/EP2206501A3/de not_active Withdrawn
- 2006-05-04 US US11/913,526 patent/US8497250B2/en not_active Expired - Fee Related
- 2006-05-04 JP JP2008509380A patent/JP2008540363A/ja active Pending
- 2006-05-04 KR KR1020147008135A patent/KR101418367B1/ko not_active Expired - Fee Related
- 2006-05-04 MX MX2007013760A patent/MX2007013760A/es unknown
- 2006-05-04 CN CN200680024585.4A patent/CN101217967B/zh not_active Expired - Fee Related
- 2006-05-04 BR BRPI0610367-7A patent/BRPI0610367A2/pt not_active IP Right Cessation
- 2006-05-04 CN CN201410395203.5A patent/CN104293780A/zh active Pending
-
2013
- 2013-06-20 JP JP2013129800A patent/JP5766750B2/ja not_active Expired - Fee Related
- 2013-07-30 US US13/953,797 patent/US9074214B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006117217A2 (de) | 2006-11-09 |
| CN101217967A (zh) | 2008-07-09 |
| JP5766750B2 (ja) | 2015-08-19 |
| EP1877069A2 (de) | 2008-01-16 |
| MX2007013760A (es) | 2008-01-28 |
| AU2006243334A1 (en) | 2006-11-09 |
| WO2006117217A3 (de) | 2007-08-09 |
| CN101217967B (zh) | 2014-09-10 |
| KR101418369B1 (ko) | 2014-07-24 |
| KR20080009276A (ko) | 2008-01-28 |
| US9074214B2 (en) | 2015-07-07 |
| KR20140042941A (ko) | 2014-04-07 |
| EP2206501A3 (de) | 2010-09-29 |
| JP2013224319A (ja) | 2013-10-31 |
| EP2206501A2 (de) | 2010-07-14 |
| SG161311A1 (en) | 2010-05-27 |
| US20130337049A1 (en) | 2013-12-19 |
| KR101418367B1 (ko) | 2014-07-25 |
| CN104293780A (zh) | 2015-01-21 |
| US8497250B2 (en) | 2013-07-30 |
| JP2008540363A (ja) | 2008-11-20 |
| BRPI0610367A2 (pt) | 2010-06-15 |
| US20090192100A1 (en) | 2009-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9074214B2 (en) | Use of spiegelmers | |
| EP3049523B1 (en) | Multiaptamer target detection | |
| Alecki et al. | RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2 | |
| Tang et al. | In vitro selection of DNA aptamer against abrin toxin and aptamer-based abrin direct detection | |
| Thiviyanathan et al. | Aptamers and the next generation of diagnostic reagents | |
| US20060292560A1 (en) | Transcription factor target gene discovery | |
| Gunaratne et al. | Key RNA-binding domains in the La protein establish tRNA modification levels in Trypanosoma brucei | |
| Clark et al. | Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain | |
| Cho et al. | In vitro selection of specific RNA aptamers for the NFAT DNA binding domain | |
| AU2012241062A1 (en) | Novel use of spiegelmers | |
| HK1119388A (en) | Novel use of spiegelmers | |
| CN116970694B (zh) | miR-9及其类似物在制备诊断和/或治疗细胞炎症的药物中的应用 | |
| Palchetti et al. | Electrochemical nucleic acid aptamer–based biosensors | |
| Faure et al. | Cell‐to‐Cell Contact Activates the Long Terminal Repeat of Human Immunodeficiency Virus 1 Through its κB Motif | |
| REGINA STOLTENBURG | Development of aptamers as new receptors for environmental biosensors | |
| HK1227430B (en) | Multiaptamer target detection | |
| HK1227430A1 (en) | Multiaptamer target detection | |
| Xie | Aptamers for parallel measurements of cellular molecules | |
| Class et al. | Patent application title: Multiaptamer Target Detection Inventors: Urs A. Ochsner (Denver, CO, US) Louis S. Green (Lafayette, CO, US) Larry Gold (Boulder, CO, US) Nebojsa Janjic (Boulder, CO, US) Nebojsa Janjic (Boulder, CO, US) Evaldas Katilius (Superior, AZ, US) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20160923 |